STKLD1

Functionⁱ

Caution

Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	57	ATPPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	34 – 42	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q8NE28

SignaLinkⁱ

Q8NE28

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine kinase-like domain-containing protein STKLD1 Alternative name(s): Serine/threonine kinase-like domain-containing protein 1 Sugen kinase 071
Gene namesⁱ	Name:STKLD1 Synonyms:C9orf96, SGK071
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198870.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28669 STKLD1
neXtProtⁱ	NX_Q8NE28

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198870
PharmGKBⁱ	PA134891744

Polymorphism and mutation databases

DMDMⁱ	90111984

DMDMⁱ

90111984

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000227568	1 – 680	Serine/threonine kinase-like domain-containing protein STKLD1Add BLAST		680

Proteomic databases

EPDⁱ	Q8NE28
PaxDbⁱ	Q8NE28
PeptideAtlas More...PeptideAtlasⁱ	Q8NE28
PRIDEⁱ	Q8NE28
ProteomicsDBⁱ	73118 73119 [Q8NE28-2] 73120 [Q8NE28-3]

PTM databases

iPTMnetⁱ	Q8NE28
PhosphoSitePlusⁱ	Q8NE28

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198870
Genevisibleⁱ	Q8NE28 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029902

HPAⁱ

HPA029902

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127981, 5 interactors
STRINGⁱ	9606.ENSP00000361025

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NE28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 297	Protein kinasePROSITE-ProRule annotationAdd BLAST		270

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0589 Eukaryota ENOG410Y7JF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018038
HOGENOMⁱ	HOG000054200
HOVERGENⁱ	HBG056774
InParanoidⁱ	Q8NE28
KEGG Orthology (KO) More...KOⁱ	K17546
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Q6
PhylomeDBⁱ	Q8NE28
TreeFamⁱ	TF336364

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8NE28-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET 
        60         70         80         90        100
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS 
       110        120        130        140        150
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH 
       160        170        180        190        200
LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS 
       210        220        230        240        250
WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG 
       260        270        280        290        300
SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS 
       310        320        330        340        350
FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK 
       360        370        380        390        400
RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA 
       410        420        430        440        450
LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES 
       460        470        480        490        500
LSEELQNAGL LEHILEHLNS SLESRDVCAS GLGLLWALLL DGIIVNKAPL 
       510        520        530        540        550
EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL 
       560        570        580        590        600
QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET 
       610        620        630        640        650
YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS 
       660        670        680
LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE

Length:680

Mass (Da):75,677

Last modified:March 28, 2018 - v5

Checksum:ⁱF4A7477B98900EA8

GO

Isoform 2 (identifier: Q8NE28-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-375: Missing.
400-491: Missing.

« Hide

        10         20         30         40         50
MELHDRVLDV QLCACSLLLH LLGQGIIVNK APLEKVPDLI SQVLATYPAD 
        60         70         80         90        100
GEMAEASCGV FWLLSLLGCI KEQQFEQVVA LLLQSIRLCQ DRALLVNNAY 
       110        120        130        140        150
RGLASLVKVS ELAAFKVVVQ EEGGSGLSLI KETYQLHRDD PEVVENVGML 
       160        170        180        190        200
LVHLASYEEI LPELVSSSMK ALLQEIKERF TSSLVSDSSA FSKPGLPPGG 
       210 
SPQLGCTTSG GLE

Show »

Length:213

Mass (Da):22,990

Checksum:ⁱF741B9E047CEB449

GO

Isoform 3 (identifier: Q8NE28-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
133-226: WMQNVLGQVL...IWSLGCIILD → IKTEGVPNTR...GLLPVWGYCE
227-680: Missing.

« Hide

        10         20         30         40         50
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET 
        60         70         80         90        100
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS 
       110        120        130        140        150
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEIKTEGVPN TRRFPVGDHD 
       160        170        180        190        200
SRLFCRSLKF LMDSSGMLPL LSGLLPSACC CEPRGAAACT SKSCVHCLLP 
       210        220 
LCCLIALQAV YLVSFGLLPV WGYCE

Show »

Length:225

Mass (Da):25,151

Checksum:ⁱ4D9EDE4F9DF4E546

GO

Sequence cautionⁱ

The sequence CAI12843 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041371	139	G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_025611	473	E → K. Corresponds to variant dbSNP:rs3124747Ensembl.	1
Natural variantⁱVAR_025612	568	R → Q. Corresponds to variant dbSNP:rs17150554Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021658	1 – 375	Missing in isoform 2. 1 PublicationAdd BLAST	375
Alternative sequenceⁱVSP_021660	133 – 226	WMQNV…CIILD → IKTEGVPNTRRFPVGDHDSR LFCRSLKFLMDSSGMLPLLS GLLPSACCCEPRGAAACTSK SCVHCLLPLCCLIALQAVYL VSFGLLPVWGYCE in isoform 3. 1 PublicationAdd BLAST	94
Alternative sequenceⁱVSP_021657	227 – 680	Missing in isoform 3. 1 PublicationAdd BLAST	454
Alternative sequenceⁱVSP_021659	400 – 491	Missing in isoform 2. 1 PublicationAdd BLAST	92

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK131533 mRNA No translation available. AK131545 mRNA Translation: BAD18679.1 AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems. AL593848 Genomic DNA No translation available. BC036504 mRNA Translation: AAH36504.3
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35169.1 [Q8NE28-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_714921.4, NM_153710.4 [Q8NE28-1]
UniGeneⁱ	Hs.720195

Genome annotation databases

Ensemblⁱ	ENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1] ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1]
GeneIDⁱ	169436
KEGGⁱ	hsa:169436
UCSC genome browser More...UCSCⁱ	uc033dkl.2 human [Q8NE28-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length
Q8NE28	UPI0004F211F9		PAPAN		692
Serine/threonine kinase like domain containing 1		MACMU		690
Serine/threonine kinase like domain containing 1		CERAT		690
Serine/threonine kinase-like domain-containing protein STKLD1		MACFA		690
Serine/threonine kinase like domain containing 1		MACNE		690
+21

Protein	Similar proteins		Species	Score	Length
Q8NE28	UPI0004F211F9		PAPAN		692
Serine/threonine kinase like domain containing 1		CERAT		690
Serine/threonine kinase-like domain-containing protein STKLD1		MACFA		690
Serine/threonine kinase like domain containing 1		MACMU		690
Serine/threonine kinase like domain containing 1		MACNE		690
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK131533 mRNA No translation available. AK131545 mRNA Translation: BAD18679.1 AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems. AL593848 Genomic DNA No translation available. BC036504 mRNA Translation: AAH36504.3
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35169.1 [Q8NE28-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_714921.4, NM_153710.4 [Q8NE28-1]
UniGeneⁱ	Hs.720195

3D structure databases

ProteinModelPortalⁱ	Q8NE28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127981, 5 interactors
STRINGⁱ	9606.ENSP00000361025

PTM databases

iPTMnetⁱ	Q8NE28
PhosphoSitePlusⁱ	Q8NE28

Polymorphism and mutation databases

DMDMⁱ	90111984

DMDMⁱ

90111984

Proteomic databases

EPDⁱ	Q8NE28
PaxDbⁱ	Q8NE28
PeptideAtlas More...PeptideAtlasⁱ	Q8NE28
PRIDEⁱ	Q8NE28
ProteomicsDBⁱ	73118 73119 [Q8NE28-2] 73120 [Q8NE28-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	169436
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1] ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1]
GeneIDⁱ	169436
KEGGⁱ	hsa:169436
UCSC genome browser More...UCSCⁱ	uc033dkl.2 human [Q8NE28-1]

Organism-specific databases

CTDⁱ	169436
EuPathDBⁱ	HostDB:ENSG00000198870.7
GeneCardsⁱ	STKLD1
H-InvDBⁱ	HIX0034803 HIX0035032
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28669 STKLD1
Human Protein Atlas More...HPAⁱ	HPA029902
neXtProtⁱ	NX_Q8NE28
Open Targets More...OpenTargetsⁱ	ENSG00000198870
PharmGKBⁱ	PA134891744
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0589 Eukaryota ENOG410Y7JF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018038
HOGENOMⁱ	HOG000054200
HOVERGENⁱ	HBG056774
InParanoidⁱ	Q8NE28
KEGG Orthology (KO) More...KOⁱ	K17546
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Q6
PhylomeDBⁱ	Q8NE28
TreeFamⁱ	TF336364

Enzyme and pathway databases

SignaLinkⁱ	Q8NE28

SignaLinkⁱ

Q8NE28

Miscellaneous databases

ChiTaRSⁱ	STKLD1 human
GenomeRNAiⁱ	169436
Protein Ontology More...PROⁱ	PR:Q8NE28

Gene expression databases

Bgeeⁱ	ENSG00000198870
Genevisibleⁱ	Q8NE28 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STKL1_HUMAN
Accessionⁱ	Q8NE28Primary (citable) accession number: Q8NE28 Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	March 28, 2018
	Last modified:	June 20, 2018
	This is version 137 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8NE28 (STKL1_HUMAN)

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Serine/threonine kinase-like domain-containing protein STKLD1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ