UniProtKB - Q8NE28 (STKL1_HUMAN)
Protein
Serine/threonine kinase-like domain-containing protein STKLD1
Gene
STKLD1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 57 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NE28 |
SignaLinki | Q8NE28 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine kinase-like domain-containing protein STKLD1Alternative name(s): Serine/threonine kinase-like domain-containing protein 1 Sugen kinase 071 |
Gene namesi | Name:STKLD1 Synonyms:C9orf96, SGK071 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28669, STKLD1 |
MIMi | 618530, gene |
neXtProti | NX_Q8NE28 |
VEuPathDBi | HostDB:ENSG00000198870.7 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 169436 |
OpenTargetsi | ENSG00000198870 |
PharmGKBi | PA134891744 |
Miscellaneous databases
Pharosi | Q8NE28, Tdark |
Genetic variation databases
BioMutai | STKLD1 |
DMDMi | 90111984 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227568 | 1 – 680 | Serine/threonine kinase-like domain-containing protein STKLD1Add BLAST | 680 |
Proteomic databases
EPDi | Q8NE28 |
jPOSTi | Q8NE28 |
MassIVEi | Q8NE28 |
PaxDbi | Q8NE28 |
PeptideAtlasi | Q8NE28 |
PRIDEi | Q8NE28 |
ProteomicsDBi | 73118 [Q8NE28-1] 73119 [Q8NE28-2] 73120 [Q8NE28-3] |
PTM databases
iPTMneti | Q8NE28 |
PhosphoSitePlusi | Q8NE28 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198870, Expressed in right testis and 119 other tissues |
Genevisiblei | Q8NE28, HS |
Organism-specific databases
HPAi | ENSG00000198870, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127981, 5 interactors |
STRINGi | 9606.ENSP00000361025 |
Miscellaneous databases
RNActi | Q8NE28, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 297 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 270 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0589, Eukaryota |
GeneTreei | ENSGT00390000018038 |
HOGENOMi | CLU_013402_0_0_1 |
InParanoidi | Q8NE28 |
OMAi | QKSWMAP |
OrthoDBi | 268303at2759 |
PhylomeDBi | Q8NE28 |
TreeFami | TF336364 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8NE28-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET
60 70 80 90 100
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS
110 120 130 140 150
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH
160 170 180 190 200
LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS
210 220 230 240 250
WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG
260 270 280 290 300
SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS
310 320 330 340 350
FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK
360 370 380 390 400
RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA
410 420 430 440 450
LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES
460 470 480 490 500
LSEELQNAGL LEHILEHLNS SLESRDVCAS GLGLLWALLL DGIIVNKAPL
510 520 530 540 550
EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL
560 570 580 590 600
QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET
610 620 630 640 650
YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS
660 670 680
LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE
Sequence cautioni
The sequence CAI12843 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041371 | 139 | G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_025611 | 473 | E → K. Corresponds to variant dbSNP:rs3124747Ensembl. | 1 | |
Natural variantiVAR_025612 | 568 | R → Q. Corresponds to variant dbSNP:rs17150554Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021658 | 1 – 375 | Missing in isoform 2. 1 PublicationAdd BLAST | 375 | |
Alternative sequenceiVSP_021660 | 133 – 226 | WMQNV…CIILD → IKTEGVPNTRRFPVGDHDSR LFCRSLKFLMDSSGMLPLLS GLLPSACCCEPRGAAACTSK SCVHCLLPLCCLIALQAVYL VSFGLLPVWGYCE in isoform 3. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_021657 | 227 – 680 | Missing in isoform 3. 1 PublicationAdd BLAST | 454 | |
Alternative sequenceiVSP_021659 | 400 – 491 | Missing in isoform 2. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131533 mRNA No translation available. AK131545 mRNA Translation: BAD18679.1 AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems. AL593848 Genomic DNA No translation available. BC036504 mRNA Translation: AAH36504.3 |
CCDSi | CCDS35169.1 [Q8NE28-1] |
RefSeqi | NP_714921.4, NM_153710.4 [Q8NE28-1] |
Genome annotation databases
Ensembli | ENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1] ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1] |
GeneIDi | 169436 |
KEGGi | hsa:169436 |
UCSCi | uc033dkl.2, human [Q8NE28-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131533 mRNA No translation available. AK131545 mRNA Translation: BAD18679.1 AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems. AL593848 Genomic DNA No translation available. BC036504 mRNA Translation: AAH36504.3 |
CCDSi | CCDS35169.1 [Q8NE28-1] |
RefSeqi | NP_714921.4, NM_153710.4 [Q8NE28-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127981, 5 interactors |
STRINGi | 9606.ENSP00000361025 |
PTM databases
iPTMneti | Q8NE28 |
PhosphoSitePlusi | Q8NE28 |
Genetic variation databases
BioMutai | STKLD1 |
DMDMi | 90111984 |
Proteomic databases
EPDi | Q8NE28 |
jPOSTi | Q8NE28 |
MassIVEi | Q8NE28 |
PaxDbi | Q8NE28 |
PeptideAtlasi | Q8NE28 |
PRIDEi | Q8NE28 |
ProteomicsDBi | 73118 [Q8NE28-1] 73119 [Q8NE28-2] 73120 [Q8NE28-3] |
Protocols and materials databases
Antibodypediai | 31860, 210 antibodies |
DNASUi | 169436 |
Genome annotation databases
Ensembli | ENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1] ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1] |
GeneIDi | 169436 |
KEGGi | hsa:169436 |
UCSCi | uc033dkl.2, human [Q8NE28-1] |
Organism-specific databases
CTDi | 169436 |
DisGeNETi | 169436 |
GeneCardsi | STKLD1 |
HGNCi | HGNC:28669, STKLD1 |
HPAi | ENSG00000198870, Tissue enriched (testis) |
MIMi | 618530, gene |
neXtProti | NX_Q8NE28 |
OpenTargetsi | ENSG00000198870 |
PharmGKBi | PA134891744 |
VEuPathDBi | HostDB:ENSG00000198870.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0589, Eukaryota |
GeneTreei | ENSGT00390000018038 |
HOGENOMi | CLU_013402_0_0_1 |
InParanoidi | Q8NE28 |
OMAi | QKSWMAP |
OrthoDBi | 268303at2759 |
PhylomeDBi | Q8NE28 |
TreeFami | TF336364 |
Enzyme and pathway databases
PathwayCommonsi | Q8NE28 |
SignaLinki | Q8NE28 |
Miscellaneous databases
BioGRID-ORCSi | 169436, 4 hits in 899 CRISPR screens |
ChiTaRSi | STKLD1, human |
GenomeRNAii | 169436 |
Pharosi | Q8NE28, Tdark |
PROi | PR:Q8NE28 |
RNActi | Q8NE28, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198870, Expressed in right testis and 119 other tissues |
Genevisiblei | Q8NE28, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STKL1_HUMAN | |
Accessioni | Q8NE28Primary (citable) accession number: Q8NE28 Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families