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Protein

Serine/threonine kinase-like domain-containing protein STKLD1

Gene

STKLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NE28

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine kinase-like domain-containing protein STKLD1
Alternative name(s):
Serine/threonine kinase-like domain-containing protein 1
Sugen kinase 071
Gene namesi
Name:STKLD1
Synonyms:C9orf96, SGK071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198870.7
HGNCiHGNC:28669 STKLD1
neXtProtiNX_Q8NE28

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198870
PharmGKBiPA134891744

Polymorphism and mutation databases

DMDMi90111984

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275681 – 680Serine/threonine kinase-like domain-containing protein STKLD1Add BLAST680

Proteomic databases

EPDiQ8NE28
PaxDbiQ8NE28
PeptideAtlasiQ8NE28
PRIDEiQ8NE28
ProteomicsDBi73118
73119 [Q8NE28-2]
73120 [Q8NE28-3]

PTM databases

iPTMnetiQ8NE28
PhosphoSitePlusiQ8NE28

Expressioni

Gene expression databases

BgeeiENSG00000198870 Expressed in 96 organ(s), highest expression level in right testis
GenevisibleiQ8NE28 HS

Organism-specific databases

HPAiHPA029902

Interactioni

Protein-protein interaction databases

BioGridi127981, 5 interactors
STRINGi9606.ENSP00000361025

Structurei

3D structure databases

ProteinModelPortaliQ8NE28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST270

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00390000018038
HOGENOMiHOG000054200
HOVERGENiHBG056774
InParanoidiQ8NE28
KOiK17546
OMAiAKWNIRA
OrthoDBiEOG091G04Q6
PhylomeDBiQ8NE28
TreeFamiTF336364

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NE28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET
60 70 80 90 100
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS
110 120 130 140 150
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH
160 170 180 190 200
LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS
210 220 230 240 250
WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG
260 270 280 290 300
SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS
310 320 330 340 350
FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK
360 370 380 390 400
RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA
410 420 430 440 450
LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES
460 470 480 490 500
LSEELQNAGL LEHILEHLNS SLESRDVCAS GLGLLWALLL DGIIVNKAPL
510 520 530 540 550
EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL
560 570 580 590 600
QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET
610 620 630 640 650
YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS
660 670 680
LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE
Length:680
Mass (Da):75,677
Last modified:March 28, 2018 - v5
Checksum:iF4A7477B98900EA8
GO
Isoform 2 (identifier: Q8NE28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.
     400-491: Missing.

Show »
Length:213
Mass (Da):22,990
Checksum:iF741B9E047CEB449
GO
Isoform 3 (identifier: Q8NE28-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-226: WMQNVLGQVL...IWSLGCIILD → IKTEGVPNTR...GLLPVWGYCE
     227-680: Missing.

Show »
Length:225
Mass (Da):25,151
Checksum:i4D9EDE4F9DF4E546
GO

Sequence cautioni

The sequence CAI12843 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041371139G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_025611473E → K. Corresponds to variant dbSNP:rs3124747Ensembl.1
Natural variantiVAR_025612568R → Q. Corresponds to variant dbSNP:rs17150554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216581 – 375Missing in isoform 2. 1 PublicationAdd BLAST375
Alternative sequenceiVSP_021660133 – 226WMQNV…CIILD → IKTEGVPNTRRFPVGDHDSR LFCRSLKFLMDSSGMLPLLS GLLPSACCCEPRGAAACTSK SCVHCLLPLCCLIALQAVYL VSFGLLPVWGYCE in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_021657227 – 680Missing in isoform 3. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_021659400 – 491Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131533 mRNA No translation available.
AK131545 mRNA Translation: BAD18679.1
AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems.
AL593848 Genomic DNA No translation available.
BC036504 mRNA Translation: AAH36504.3
CCDSiCCDS35169.1 [Q8NE28-1]
RefSeqiNP_714921.4, NM_153710.4 [Q8NE28-1]
UniGeneiHs.720195

Genome annotation databases

EnsembliENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1]
ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1]
GeneIDi169436
KEGGihsa:169436
UCSCiuc033dkl.2 human [Q8NE28-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131533 mRNA No translation available.
AK131545 mRNA Translation: BAD18679.1
AL158826 Genomic DNA Translation: CAI12843.1 Sequence problems.
AL593848 Genomic DNA No translation available.
BC036504 mRNA Translation: AAH36504.3
CCDSiCCDS35169.1 [Q8NE28-1]
RefSeqiNP_714921.4, NM_153710.4 [Q8NE28-1]
UniGeneiHs.720195

3D structure databases

ProteinModelPortaliQ8NE28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127981, 5 interactors
STRINGi9606.ENSP00000361025

PTM databases

iPTMnetiQ8NE28
PhosphoSitePlusiQ8NE28

Polymorphism and mutation databases

DMDMi90111984

Proteomic databases

EPDiQ8NE28
PaxDbiQ8NE28
PeptideAtlasiQ8NE28
PRIDEiQ8NE28
ProteomicsDBi73118
73119 [Q8NE28-2]
73120 [Q8NE28-3]

Protocols and materials databases

DNASUi169436
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371957; ENSP00000361025; ENSG00000198870 [Q8NE28-1]
ENST00000627962; ENSP00000486786; ENSG00000281245 [Q8NE28-1]
GeneIDi169436
KEGGihsa:169436
UCSCiuc033dkl.2 human [Q8NE28-1]

Organism-specific databases

CTDi169436
EuPathDBiHostDB:ENSG00000198870.7
GeneCardsiSTKLD1
H-InvDBiHIX0034803
HIX0035032
HGNCiHGNC:28669 STKLD1
HPAiHPA029902
neXtProtiNX_Q8NE28
OpenTargetsiENSG00000198870
PharmGKBiPA134891744
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00390000018038
HOGENOMiHOG000054200
HOVERGENiHBG056774
InParanoidiQ8NE28
KOiK17546
OMAiAKWNIRA
OrthoDBiEOG091G04Q6
PhylomeDBiQ8NE28
TreeFamiTF336364

Enzyme and pathway databases

SignaLinkiQ8NE28

Miscellaneous databases

ChiTaRSiSTKLD1 human
GenomeRNAii169436
PROiPR:Q8NE28

Gene expression databases

BgeeiENSG00000198870 Expressed in 96 organ(s), highest expression level in right testis
GenevisibleiQ8NE28 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTKL1_HUMAN
AccessioniPrimary (citable) accession number: Q8NE28
Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 139 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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