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Entry version 121 (16 Oct 2019)
Sequence version 3 (09 Jan 2007)
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Protein

Regulator of G-protein signaling 22

Gene

RGS22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G-protein alpha-subunit binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 22
Short name:
RGS22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24499 RGS22

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615650 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NE09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26166

Open Targets

More...
OpenTargetsi
ENSG00000132554

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671068

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NE09

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS22

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122064954

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002713761 – 1264Regulator of G-protein signaling 22Add BLAST1264

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NE09

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NE09

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NE09

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NE09

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NE09

PeptideAtlas

More...
PeptideAtlasi
Q8NE09

PRoteomics IDEntifications database

More...
PRIDEi
Q8NE09

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1891
73111 [Q8NE09-1]
73112 [Q8NE09-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NE09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NE09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132554 Expressed in 114 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NE09 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NE09 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNA11, GNA12 AND GNA13.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117592, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8NE09, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NE09

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini852 – 980RGS 1PROSITE-ProRule annotationAdd BLAST129
Domaini1021 – 1145RGS 2PROSITE-ProRule annotationAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1142 – 1174Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi267 – 277Poly-GluAdd BLAST11
Compositional biasi767 – 771Poly-Leu5

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEHZ Eukaryota
ENOG410XTGI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013183

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NE09

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCLDREQ

Database of Orthologous Groups

More...
OrthoDBi
240381at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NE09

TreeFam database of animal gene trees

More...
TreeFami
TF329128

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016137 RGS
IPR042651 Rgs22
IPR036305 RGS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46583 PTHR46583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00615 RGS, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00315 RGS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50132 RGS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NE09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD
60 70 80 90 100
YGVFEVANDA PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP
110 120 130 140 150
DEDETINVNY NIMCLSREEG IKWIKKERLP AFLESDCYFE YRLAKLVSQV
160 170 180 190 200
RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA TEEDNLVIMK KFYVSLGEAS
210 220 230 240 250
YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV SENFIFDDGV
260 270 280 290 300
HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD
310 320 330 340 350
VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK
360 370 380 390 400
VSFDDCFESI HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW
410 420 430 440 450
CISHRTYDIG NRKEFERFKK FIKGTLGERY WWLWMDIERL KVLKDPGRHQ
460 470 480 490 500
RHLEKMKKCY LVSNGDYYLS AEILSKFKLL DGSQWNEEHL RNIQSEVLKP
510 520 530 540 550
LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP FPQMATLLPL
560 570 580 590 600
RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS
610 620 630 640 650
KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV
660 670 680 690 700
SDVGALGGSD MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL
710 720 730 740 750
QAYHQLFYQE TLQPFKVCKQ AQYLFATYVA PSATLDIGLQ QEKKKEIYMK
760 770 780 790 800
IQPPFEDLFD TAEEYILLLL LEPWTKMVKS DQIAYKKVEL VEETRQLDST
810 820 830 840 850
YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY WDNVPAEYKH
860 870 880 890 900
FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK
910 920 930 940 950
AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV
960 970 980 990 1000
LVEIQKHVQN RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK
1010 1020 1030 1040 1050
KIGVWKPVES KWISSSCKII AFRKALLNPV TSRQFQRFVA LKGDLLENGL
1060 1070 1080 1090 1100
LFWQEVQKYK DLCHSHCDES VIQKKITTII NCFINSSIPP ALQIDIPVEQ
1110 1120 1130 1140 1150
AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN LTDENIMSVL
1160 1170 1180 1190 1200
ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ
1210 1220 1230 1240 1250
PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST
1260
MSLKKNMSAH SSQK
Length:1,264
Mass (Da):147,163
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8647E53FE14B9D5D
GO
Isoform 2 (identifier: Q8NE09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-1264: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:504
Mass (Da):58,519
Checksum:iEB2E679C9E730552
GO
Isoform 3 (identifier: Q8NE09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-198: Missing.

Note: May be due to competing donor splice site.
Show »
Length:1,252
Mass (Da):145,768
Checksum:iA7CB6BFD5C6F2E6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V112G3V112_HUMAN
Regulator of G-protein signalling 2...
RGS22 hCG_15692
1,083Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV61A0A087WV61_HUMAN
Regulator of G-protein-signaling 22
RGS22
1,251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBV2H0YBV2_HUMAN
Regulator of G-protein-signaling 22
RGS22
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGJ7E5RGJ7_HUMAN
Regulator of G-protein-signaling 22
RGS22
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFV6E5RFV6_HUMAN
Regulator of G-protein-signaling 22
RGS22
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHE4E5RHE4_HUMAN
Regulator of G-protein-signaling 22
RGS22
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ23E5RJ23_HUMAN
Regulator of G-protein-signaling 22
RGS22
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG49397 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86Missing in AAH92411 (PubMed:15489334).Curated1
Sequence conflicti131A → P in AAH47060 (PubMed:15489334).Curated1
Sequence conflicti167P → S in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti378E → K in AAH36665 (PubMed:15489334).Curated1
Sequence conflicti423K → R in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti692N → D in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti995 – 997LQK → DAW in CAB55986 (PubMed:17974005).Curated3
Sequence conflicti1070S → T in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti1233K → KK in CAB55986 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051797397R → M. Corresponds to variant dbSNP:rs2446927Ensembl.1
Natural variantiVAR_051798943H → Y. Corresponds to variant dbSNP:rs3133711Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054225187 – 198Missing in isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_022306505 – 1264Missing in isoform 2. 1 PublicationAdd BLAST760

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY009106 mRNA Translation: AAG49397.1 Frameshift.
AK292559 mRNA Translation: BAF85248.1
AC021590 Genomic DNA No translation available.
AP005356 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91794.1
BC036665 mRNA Translation: AAH36665.2
BC047060 mRNA Translation: AAH47060.1
BC092411 mRNA Translation: AAH92411.1
AL117544 mRNA Translation: CAB55986.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS43758.1 [Q8NE09-1]
CCDS69521.1 [Q8NE09-3]

Protein sequence database of the Protein Information Resource

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PIRi
T17296

NCBI Reference Sequences

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RefSeqi
NP_001273621.1, NM_001286692.1 [Q8NE09-3]
NP_056483.3, NM_015668.4 [Q8NE09-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360863; ENSP00000354109; ENSG00000132554 [Q8NE09-1]
ENST00000519725; ENSP00000427798; ENSG00000132554 [Q8NE09-2]
ENST00000523437; ENSP00000428212; ENSG00000132554 [Q8NE09-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26166

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26166

UCSC genome browser

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UCSCi
uc003yjb.2 human [Q8NE09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009106 mRNA Translation: AAG49397.1 Frameshift.
AK292559 mRNA Translation: BAF85248.1
AC021590 Genomic DNA No translation available.
AP005356 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91794.1
BC036665 mRNA Translation: AAH36665.2
BC047060 mRNA Translation: AAH47060.1
BC092411 mRNA Translation: AAH92411.1
AL117544 mRNA Translation: CAB55986.2
CCDSiCCDS43758.1 [Q8NE09-1]
CCDS69521.1 [Q8NE09-3]
PIRiT17296
RefSeqiNP_001273621.1, NM_001286692.1 [Q8NE09-3]
NP_056483.3, NM_015668.4 [Q8NE09-1]

3D structure databases

SMRiQ8NE09
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117592, 1 interactor
IntActiQ8NE09, 1 interactor
STRINGi9606.ENSP00000354109

PTM databases

iPTMnetiQ8NE09
PhosphoSitePlusiQ8NE09

Polymorphism and mutation databases

BioMutaiRGS22
DMDMi122064954

Proteomic databases

EPDiQ8NE09
jPOSTiQ8NE09
MassIVEiQ8NE09
MaxQBiQ8NE09
PaxDbiQ8NE09
PeptideAtlasiQ8NE09
PRIDEiQ8NE09
ProteomicsDBi1891
73111 [Q8NE09-1]
73112 [Q8NE09-2]

Genome annotation databases

EnsembliENST00000360863; ENSP00000354109; ENSG00000132554 [Q8NE09-1]
ENST00000519725; ENSP00000427798; ENSG00000132554 [Q8NE09-2]
ENST00000523437; ENSP00000428212; ENSG00000132554 [Q8NE09-3]
GeneIDi26166
KEGGihsa:26166
UCSCiuc003yjb.2 human [Q8NE09-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26166
DisGeNETi26166

GeneCards: human genes, protein and diseases

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GeneCardsi
RGS22
HGNCiHGNC:24499 RGS22
MIMi615650 gene
neXtProtiNX_Q8NE09
OpenTargetsiENSG00000132554
PharmGKBiPA142671068

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IEHZ Eukaryota
ENOG410XTGI LUCA
GeneTreeiENSGT00500000044936
HOGENOMiHOG000013183
InParanoidiQ8NE09
OMAiMCLDREQ
OrthoDBi240381at2759
PhylomeDBiQ8NE09
TreeFamiTF329128

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RGS22 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26166
PharosiQ8NE09

Protein Ontology

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PROi
PR:Q8NE09

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132554 Expressed in 114 organ(s), highest expression level in sperm
ExpressionAtlasiQ8NE09 baseline and differential
GenevisibleiQ8NE09 HS

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR042651 Rgs22
IPR036305 RGS_sf
PANTHERiPTHR46583 PTHR46583, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 3 hits
SMARTiView protein in SMART
SM00315 RGS, 2 hits
SUPFAMiSSF48097 SSF48097, 4 hits
PROSITEiView protein in PROSITE
PS50132 RGS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NE09
Secondary accession number(s): A8K944
, Q569L2, Q86Y71, Q9BYZ4, Q9UFN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 16, 2019
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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