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Entry version 131 (07 Apr 2021)
Sequence version 2 (31 Oct 2006)
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Protein

Transmembrane protein 104

Gene

TMEM104

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NE00

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.18.10.1, the amino acid/auxin permease (aaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM104
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25984, TMEM104

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NE00

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000109066.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 36ExtracellularSequence analysis5
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 146CytoplasmicSequence analysisAdd BLAST89
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 204ExtracellularSequence analysisAdd BLAST37
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 233CytoplasmicSequence analysis8
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 276ExtracellularSequence analysisAdd BLAST22
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 306CytoplasmicSequence analysis9
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 354ExtracellularSequence analysisAdd BLAST27
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 397CytoplasmicSequence analysisAdd BLAST22
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 421ExtracellularSequence analysis3
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 470CytoplasmicSequence analysisAdd BLAST28
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 496ExtracellularSequence analysis5

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000109066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670753

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NE00, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM104

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117949798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541781 – 496Transmembrane protein 104Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NE00

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NE00

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NE00

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NE00

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NE00

PeptideAtlas

More...
PeptideAtlasi
Q8NE00

PRoteomics IDEntifications database

More...
PRIDEi
Q8NE00

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73106 [Q8NE00-1]
73107 [Q8NE00-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8NE00, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NE00

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NE00

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109066, Expressed in C1 segment of cervical spinal cord and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NE00, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NE00, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000109066, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120217, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NE00, 3 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NE00, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM104 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3832, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025541_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NE00

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVVCDQT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NE00

TreeFam database of animal gene trees

More...
TreeFami
TF314030

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013057, AA_transpt_TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01490, Aa_trans, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NE00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV
60 70 80 90 100
FLGFMSFVTT TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI
110 120 130 140 150
RDNYERAEKR PILSVQRRGS PNPFEITDRV EMGQMASMFF NKVGVNLFYF
160 170 180 190 200
CIIVYLYGDL AIYAAAVPFS LMQVTCSATG NDSCGVEADT KYNDTDRCWG
210 220 230 240 250
PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM RWIAFAVMIV
260 270 280 290 300
LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
310 320 330 340 350
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL
360 370 380 390 400
AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF
410 420 430 440 450
PTITLVPPVL VAFCTHDLES LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ
460 470 480 490
LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS CFIFVTANII LSETKL
Length:496
Mass (Da):55,679
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4173D25DB4870426
GO
Isoform 2 (identifier: Q8NE00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-314: AFAVMIVLAL...RLVFLDYVLI → DGPPGSVMGR...LPPHRSTRPT
     315-496: Missing.

Show »
Length:314
Mass (Da):34,796
Checksum:i405BCEC0DFFCAEE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQK2J3QQK2_HUMAN
Transmembrane protein 104
TMEM104
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DKL7B4DKL7_HUMAN
Transmembrane protein 104
TMEM104
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84855 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02883158V → M2 PublicationsCorresponds to variant dbSNP:rs2016126Ensembl.1
Natural variantiVAR_028832439A → T. Corresponds to variant dbSNP:rs3803784Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021199244 – 314AFAVM…DYVLI → DGPPGSVMGRAEEDASPAWP RSRCRCGGKLKLNSLYPTSA TCMAPDAPGAGQVKVGVNFL CLPPHRSTRPT in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_021200315 – 496Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000262 mRNA Translation: BAA91039.1
AK074029 mRNA Translation: BAB84855.1 Different initiation.
BC037278 mRNA Translation: AAH37278.1
AL137521 mRNA Translation: CAB70787.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32723.1 [Q8NE00-1]
CCDS82201.1 [Q8NE00-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46367

NCBI Reference Sequences

More...
RefSeqi
NP_001308193.1, NM_001321264.1 [Q8NE00-2]
NP_060198.3, NM_017728.3 [Q8NE00-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335464; ENSP00000334849; ENSG00000109066 [Q8NE00-1]
ENST00000582330; ENSP00000461922; ENSG00000109066 [Q8NE00-1]
ENST00000582773; ENSP00000463205; ENSG00000109066 [Q8NE00-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54868

UCSC genome browser

More...
UCSCi
uc002jls.5, human [Q8NE00-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000262 mRNA Translation: BAA91039.1
AK074029 mRNA Translation: BAB84855.1 Different initiation.
BC037278 mRNA Translation: AAH37278.1
AL137521 mRNA Translation: CAB70787.1
CCDSiCCDS32723.1 [Q8NE00-1]
CCDS82201.1 [Q8NE00-2]
PIRiT46367
RefSeqiNP_001308193.1, NM_001321264.1 [Q8NE00-2]
NP_060198.3, NM_017728.3 [Q8NE00-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120217, 5 interactors
IntActiQ8NE00, 3 interactors

Protein family/group databases

TCDBi2.A.18.10.1, the amino acid/auxin permease (aaap) family

PTM databases

GlyGeniQ8NE00, 1 site
iPTMnetiQ8NE00
PhosphoSitePlusiQ8NE00

Genetic variation databases

BioMutaiTMEM104
DMDMi117949798

Proteomic databases

EPDiQ8NE00
jPOSTiQ8NE00
MassIVEiQ8NE00
MaxQBiQ8NE00
PaxDbiQ8NE00
PeptideAtlasiQ8NE00
PRIDEiQ8NE00
ProteomicsDBi73106 [Q8NE00-1]
73107 [Q8NE00-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32018, 27 antibodies

Genome annotation databases

EnsembliENST00000335464; ENSP00000334849; ENSG00000109066 [Q8NE00-1]
ENST00000582330; ENSP00000461922; ENSG00000109066 [Q8NE00-1]
ENST00000582773; ENSP00000463205; ENSG00000109066 [Q8NE00-2]
GeneIDi54868
KEGGihsa:54868
UCSCiuc002jls.5, human [Q8NE00-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54868

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM104
HGNCiHGNC:25984, TMEM104
HPAiENSG00000109066, Low tissue specificity
neXtProtiNX_Q8NE00
OpenTargetsiENSG00000109066
PharmGKBiPA142670753
VEuPathDBiHostDB:ENSG00000109066.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3832, Eukaryota
GeneTreeiENSGT00390000001244
HOGENOMiCLU_025541_4_0_1
InParanoidiQ8NE00
OMAiDVVCDQT
PhylomeDBiQ8NE00
TreeFamiTF314030

Enzyme and pathway databases

PathwayCommonsiQ8NE00

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54868, 6 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM104, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54868
PharosiQ8NE00, Tdark

Protein Ontology

More...
PROi
PR:Q8NE00
RNActiQ8NE00, protein

Gene expression databases

BgeeiENSG00000109066, Expressed in C1 segment of cervical spinal cord and 179 other tissues
ExpressionAtlasiQ8NE00, baseline and differential
GenevisibleiQ8NE00, HS

Family and domain databases

InterProiView protein in InterPro
IPR013057, AA_transpt_TM
PfamiView protein in Pfam
PF01490, Aa_trans, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM104_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NE00
Secondary accession number(s): Q8TEU1, Q9NT56, Q9NXH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 7, 2021
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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