UniProtKB - Q8NE00 (TM104_HUMAN)
Protein
Transmembrane protein 104
Gene
TMEM104
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q8NE00 |
Protein family/group databases
TCDBi | 2.A.18.10.1, the amino acid/auxin permease (aaap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 104 |
Gene namesi | Name:TMEM104 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25984, TMEM104 |
neXtProti | NX_Q8NE00 |
VEuPathDBi | HostDB:ENSG00000109066.13 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 36 | ExtracellularSequence analysis | 5 | |
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 58 – 146 | CytoplasmicSequence analysisAdd BLAST | 89 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 204 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 205 – 225 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 233 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 276 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 306 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 307 – 327 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 328 – 354 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 355 – 375 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 376 – 397 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 421 | ExtracellularSequence analysis | 3 | |
Transmembranei | 422 – 442 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 443 – 470 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 471 – 491 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 492 – 496 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000109066 |
PharmGKBi | PA142670753 |
Miscellaneous databases
Pharosi | Q8NE00, Tdark |
Genetic variation databases
BioMutai | TMEM104 |
DMDMi | 117949798 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254178 | 1 – 496 | Transmembrane protein 104Add BLAST | 496 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8NE00 |
jPOSTi | Q8NE00 |
MassIVEi | Q8NE00 |
MaxQBi | Q8NE00 |
PaxDbi | Q8NE00 |
PeptideAtlasi | Q8NE00 |
PRIDEi | Q8NE00 |
ProteomicsDBi | 73106 [Q8NE00-1] 73107 [Q8NE00-2] |
PTM databases
GlyGeni | Q8NE00, 1 site |
iPTMneti | Q8NE00 |
PhosphoSitePlusi | Q8NE00 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109066, Expressed in C1 segment of cervical spinal cord and 179 other tissues |
ExpressionAtlasi | Q8NE00, baseline and differential |
Genevisiblei | Q8NE00, HS |
Organism-specific databases
HPAi | ENSG00000109066, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120217, 5 interactors |
IntActi | Q8NE00, 3 interactors |
Miscellaneous databases
RNActi | Q8NE00, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM104 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3832, Eukaryota |
GeneTreei | ENSGT00390000001244 |
HOGENOMi | CLU_025541_4_0_1 |
InParanoidi | Q8NE00 |
OMAi | DVVCDQT |
PhylomeDBi | Q8NE00 |
TreeFami | TF314030 |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NE00-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV
60 70 80 90 100
FLGFMSFVTT TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI
110 120 130 140 150
RDNYERAEKR PILSVQRRGS PNPFEITDRV EMGQMASMFF NKVGVNLFYF
160 170 180 190 200
CIIVYLYGDL AIYAAAVPFS LMQVTCSATG NDSCGVEADT KYNDTDRCWG
210 220 230 240 250
PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM RWIAFAVMIV
260 270 280 290 300
LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
310 320 330 340 350
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL
360 370 380 390 400
AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF
410 420 430 440 450
PTITLVPPVL VAFCTHDLES LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ
460 470 480 490
LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS CFIFVTANII LSETKL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QQK2 | J3QQK2_HUMAN | Transmembrane protein 104 | TMEM104 | 129 | Annotation score: | ||
B4DKL7 | B4DKL7_HUMAN | Transmembrane protein 104 | TMEM104 | 327 | Annotation score: |
Sequence cautioni
The sequence BAB84855 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028831 | 58 | V → M2 PublicationsCorresponds to variant dbSNP:rs2016126Ensembl. | 1 | |
Natural variantiVAR_028832 | 439 | A → T. Corresponds to variant dbSNP:rs3803784Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021199 | 244 – 314 | AFAVM…DYVLI → DGPPGSVMGRAEEDASPAWP RSRCRCGGKLKLNSLYPTSA TCMAPDAPGAGQVKVGVNFL CLPPHRSTRPT in isoform 2. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_021200 | 315 – 496 | Missing in isoform 2. 1 PublicationAdd BLAST | 182 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000262 mRNA Translation: BAA91039.1 AK074029 mRNA Translation: BAB84855.1 Different initiation. BC037278 mRNA Translation: AAH37278.1 AL137521 mRNA Translation: CAB70787.1 |
CCDSi | CCDS32723.1 [Q8NE00-1] CCDS82201.1 [Q8NE00-2] |
PIRi | T46367 |
RefSeqi | NP_001308193.1, NM_001321264.1 [Q8NE00-2] NP_060198.3, NM_017728.3 [Q8NE00-1] |
Genome annotation databases
Ensembli | ENST00000335464; ENSP00000334849; ENSG00000109066 [Q8NE00-1] ENST00000582330; ENSP00000461922; ENSG00000109066 [Q8NE00-1] ENST00000582773; ENSP00000463205; ENSG00000109066 [Q8NE00-2] |
GeneIDi | 54868 |
KEGGi | hsa:54868 |
UCSCi | uc002jls.5, human [Q8NE00-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000262 mRNA Translation: BAA91039.1 AK074029 mRNA Translation: BAB84855.1 Different initiation. BC037278 mRNA Translation: AAH37278.1 AL137521 mRNA Translation: CAB70787.1 |
CCDSi | CCDS32723.1 [Q8NE00-1] CCDS82201.1 [Q8NE00-2] |
PIRi | T46367 |
RefSeqi | NP_001308193.1, NM_001321264.1 [Q8NE00-2] NP_060198.3, NM_017728.3 [Q8NE00-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120217, 5 interactors |
IntActi | Q8NE00, 3 interactors |
Protein family/group databases
TCDBi | 2.A.18.10.1, the amino acid/auxin permease (aaap) family |
PTM databases
GlyGeni | Q8NE00, 1 site |
iPTMneti | Q8NE00 |
PhosphoSitePlusi | Q8NE00 |
Genetic variation databases
BioMutai | TMEM104 |
DMDMi | 117949798 |
Proteomic databases
EPDi | Q8NE00 |
jPOSTi | Q8NE00 |
MassIVEi | Q8NE00 |
MaxQBi | Q8NE00 |
PaxDbi | Q8NE00 |
PeptideAtlasi | Q8NE00 |
PRIDEi | Q8NE00 |
ProteomicsDBi | 73106 [Q8NE00-1] 73107 [Q8NE00-2] |
Protocols and materials databases
Antibodypediai | 32018, 27 antibodies |
Genome annotation databases
Ensembli | ENST00000335464; ENSP00000334849; ENSG00000109066 [Q8NE00-1] ENST00000582330; ENSP00000461922; ENSG00000109066 [Q8NE00-1] ENST00000582773; ENSP00000463205; ENSG00000109066 [Q8NE00-2] |
GeneIDi | 54868 |
KEGGi | hsa:54868 |
UCSCi | uc002jls.5, human [Q8NE00-1] |
Organism-specific databases
CTDi | 54868 |
GeneCardsi | TMEM104 |
HGNCi | HGNC:25984, TMEM104 |
HPAi | ENSG00000109066, Low tissue specificity |
neXtProti | NX_Q8NE00 |
OpenTargetsi | ENSG00000109066 |
PharmGKBi | PA142670753 |
VEuPathDBi | HostDB:ENSG00000109066.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3832, Eukaryota |
GeneTreei | ENSGT00390000001244 |
HOGENOMi | CLU_025541_4_0_1 |
InParanoidi | Q8NE00 |
OMAi | DVVCDQT |
PhylomeDBi | Q8NE00 |
TreeFami | TF314030 |
Enzyme and pathway databases
PathwayCommonsi | Q8NE00 |
Miscellaneous databases
BioGRID-ORCSi | 54868, 5 hits in 876 CRISPR screens |
ChiTaRSi | TMEM104, human |
GenomeRNAii | 54868 |
Pharosi | Q8NE00, Tdark |
PROi | PR:Q8NE00 |
RNActi | Q8NE00, protein |
Gene expression databases
Bgeei | ENSG00000109066, Expressed in C1 segment of cervical spinal cord and 179 other tissues |
ExpressionAtlasi | Q8NE00, baseline and differential |
Genevisiblei | Q8NE00, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM104_HUMAN | |
Accessioni | Q8NE00Primary (citable) accession number: Q8NE00 Secondary accession number(s): Q8TEU1, Q9NT56, Q9NXH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families