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Protein

Transmembrane protein 161B

Gene

TMEM161B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 161B
Gene namesi
ORF Names:UNQ679/PRO1313
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164180.13
HGNCiHGNC:28483 TMEM161B
neXtProtiNX_Q8NDZ6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164180
PharmGKBiPA145147987

Polymorphism and mutation databases

DMDMi74730190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880891 – 487Transmembrane protein 161BAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NDZ6
MaxQBiQ8NDZ6
PaxDbiQ8NDZ6
PeptideAtlasiQ8NDZ6
PRIDEiQ8NDZ6
ProteomicsDBi73102
73103 [Q8NDZ6-2]
73104 [Q8NDZ6-3]

PTM databases

iPTMnetiQ8NDZ6
PhosphoSitePlusiQ8NDZ6

Expressioni

Gene expression databases

BgeeiENSG00000164180 Expressed in 194 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_TMEM161B
ExpressionAtlasiQ8NDZ6 baseline and differential
GenevisibleiQ8NDZ6 HS

Organism-specific databases

HPAiHPA044562

Interactioni

Protein-protein interaction databases

BioGridi127493, 7 interactors
STRINGi9606.ENSP00000296595

Structurei

3D structure databases

ProteinModelPortaliQ8NDZ6
SMRiQ8NDZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM161 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3978 Eukaryota
ENOG410XPZC LUCA
GeneTreeiENSGT00390000000672
HOGENOMiHOG000273873
HOVERGENiHBG063501
InParanoidiQ8NDZ6
OMAiSIFYYLC
PhylomeDBiQ8NDZ6
TreeFamiTF314570

Family and domain databases

InterProiView protein in InterPro
IPR019395 Transmembrane_161A/B
PANTHERiPTHR13624 PTHR13624, 1 hit
PfamiView protein in Pfam
PF10268 Tmemb_161AB, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8NDZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVIGIQLVV TMVMASVMQK IIPHYSLARW LLCNGSLRWY QHPTEEELRI
60 70 80 90 100
LAGKQQKGKT KKDRKYNGHI ESKPLTIPKD IDLHLETKSV TEVDTLALHY
110 120 130 140 150
FPEYQWLVDF TVAATVVYLV TEVYYNFMKP TQEMNISLVW CLLVLSFAIK
160 170 180 190 200
VLFSLTTHYF KVEDGGERSV CVTFGFFFFV KAMAVLIVTE NYLEFGLETG
210 220 230 240 250
FTNFSDSAMQ FLEKQGLESQ SPVSKLTFKF FLAIFCSFIG AFLTFPGLRL
260 270 280 290 300
AQMHLDALNL ATEKITQTLL HINFLAPLFM VLLWVKPITK DYIMNPPLGK
310 320 330 340 350
ESIPLMTEAT FDTLRLWLII LLCALRLAMM RSHLQAYLNL AQKCVDQMKK
360 370 380 390 400
EAGRISTVEL QKMVARVFYY LCVIALQYVA PLVMLLHTTL LLKTLGNHSW
410 420 430 440 450
GIYPESISTL PVDNSLLSNS VYSELPSAEG KMKVTVTQIT VALSSLKNIF
460 470 480
TPLLFRGLLS FLTWWIAACL FSTSLFGLFY HQYLTVA
Length:487
Mass (Da):55,482
Last modified:October 1, 2002 - v1
Checksum:i18A1D716F7F87369
GO
Isoform 2 (identifier: Q8NDZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-307: SIPLMT → ISPSGR
     308-487: Missing.

Show »
Length:307
Mass (Da):35,098
Checksum:iEBFA6C6EE6BA762B
GO
Isoform 3 (identifier: Q8NDZ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     268-487: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,828
Checksum:iDDA3640E2DFBAD67
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCX5E9PCX5_HUMAN
Transmembrane protein 161B
TMEM161B
502Annotation score:
B7Z6T3B7Z6T3_HUMAN
Transmembrane protein 161B
TMEM161B
476Annotation score:
D6RAK4D6RAK4_HUMAN
Transmembrane protein 161B
TMEM161B
217Annotation score:
D6RBE8D6RBE8_HUMAN
Transmembrane protein 161B
TMEM161B
178Annotation score:
B7Z6A5B7Z6A5_HUMAN
Transmembrane protein 161B
TMEM161B
278Annotation score:
E9PFW6E9PFW6_HUMAN
Transmembrane protein 161B
TMEM161B
153Annotation score:
D6RAR3D6RAR3_HUMAN
Transmembrane protein 161B
TMEM161B
121Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0256471 – 127Missing in isoform 3. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_025648268 – 487Missing in isoform 3. 1 PublicationAdd BLAST220
Alternative sequenceiVSP_025649302 – 307SIPLMT → ISPSGR in isoform 2. 1 Publication6
Alternative sequenceiVSP_025650308 – 487Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358693 mRNA Translation: AAQ89056.1
BX648757 mRNA Translation: CAI56713.1
BC037287 mRNA Translation: AAH37287.1
CCDSiCCDS4065.1 [Q8NDZ6-1]
RefSeqiNP_699185.1, NM_153354.4 [Q8NDZ6-1]
UniGeneiHs.379972

Genome annotation databases

EnsembliENST00000296595; ENSP00000296595; ENSG00000164180 [Q8NDZ6-1]
ENST00000510089; ENSP00000423380; ENSG00000164180 [Q8NDZ6-3]
GeneIDi153396
KEGGihsa:153396
UCSCiuc003kjc.5 human [Q8NDZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiT161B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDZ6
Secondary accession number(s): Q5CZH7, Q6UWQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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