Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SUMO-interacting motif-containing protein 1

Gene

SIMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SUMO polymer binding Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUMO-interacting motif-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIMC1
Synonyms:C5orf25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170085.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24779 SIMC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618102 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDZ2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000170085

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596506

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIMC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
449081288

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002505811 – 872SUMO-interacting motif-containing protein 1Add BLAST872

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NDZ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NDZ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NDZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDZ2

PeptideAtlas

More...
PeptideAtlasi
Q8NDZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDZ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73096
73097 [Q8NDZ2-2]
73098 [Q8NDZ2-3]
73099 [Q8NDZ2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170085 Expressed in 198 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_C5orf25

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NDZ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037889
HPA037890

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SIM domains) with SUMO1 and SUMO2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131981, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NDZ2, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8NDZ2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NDZ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDZ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi26 – 30SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substrates5
Motifi45 – 49SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substrates5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi129 – 180Ser-richAdd BLAST52
Compositional biasi185 – 352Pro-richAdd BLAST168

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH7J Eukaryota
ENOG410XQXC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000070068

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG062235

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDZ2

Database of Orthologous Groups

More...
OrthoDBi
117288at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDZ2

TreeFam database of animal gene trees

More...
TreeFami
TF332523

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPASASGED LRKLPTMAEV NGEQDFIDLT RETRPRTKDR SGLYVIDLTR
60 70 80 90 100
AEGENRPIAT LDLTLEPVTP SQKEPTSLQT CASLSGKAVM EGHVDRSSQP
110 120 130 140 150
TARRIINSDP VDLDLVEENT FVGPPPATSI SGGSVYPTEP NCSSATFTGN
160 170 180 190 200
LSFLASLQLS SDVSSLSPTS NNSRSSSSSS NQKAPLPCPQ QDVSRPPQAL
210 220 230 240 250
PCPLRPLPCP PRASPCPPRA SSCPPRALSC PSQTMQCQLP ALTHPPQEVP
260 270 280 290 300
CPRQNIPGPP QDSLGLPQDV PGLPQSILHP QDVAYLQDMP RSPGDVPQSP
310 320 330 340 350
SDVSPSPDAP QSPGGMPHLP GDVLHSPGDM PHSSGDVTHS PRDIPHLPGD
360 370 380 390 400
RPDFTQNDVQ NRDMPMDISA LSSPSCSPSP QSETPLEKVP WLSVMETPAR
410 420 430 440 450
KEISLSEPAK PGSAHVQSRT PQGGLYNRPC LHRLKYFLRP PVHHLFFQTL
460 470 480 490 500
IPDKDTRENK GQKLEPIPHR RLRMVTNTIE ENFPLGTVQF LMDFVSPQHY
510 520 530 540 550
PPREIVAHII QKILLSGSET VDVLKEAYML LMKIQQLHPA NAKTVEWDWK
560 570 580 590 600
LLTYVMEEEG QTLPGRVLFL RYVVQTLEDD FQQTLRRQRQ HLQQSIANMV
610 620 630 640 650
LSCDKQPHNV RDVIKWLVKA VTEDGLTQPP NGNQTSSGTG ILKASSSHPS
660 670 680 690 700
SQPNLTKNTN QLIVCQLQRM LSIAVEVDRT PTCSSNKIAE MMFGFVLDIP
710 720 730 740 750
ERSQREMFFT TMESHLLRCK VLEIIFLHSC ETPTRLPLSL AQALYFLNNS
760 770 780 790 800
TSLLKCQSDK SQWQTWDELV EHLQFLLSSY QHVLREHLRS SVIDRKDLII
810 820 830 840 850
KRIKPKPQQG DDITVVDVEK QIEAFRSRLI QMLGEPLVPQ LQDKVHLLKL
860 870
LLFYAADLNP DAEPFQKGWS GS
Length:872
Mass (Da):96,838
Last modified:February 6, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD056ACDB8DD23805
GO
Isoform 2 (identifier: Q8NDZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     377-415: SPSPQSETPL...SEPAKPGSAH → TPAWGTEQDS...FNLYRTRVKN
     416-872: Missing.

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):34,867
Checksum:i74C5629A11A5D116
GO
Isoform 3 (identifier: Q8NDZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-415: Missing.
     416-458: VQSRTPQGGL...TLIPDKDTRE → MEDFIVISDD...TSGALPRRTV

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):52,294
Checksum:iED4057DCC14DF887
GO
Isoform 4 (identifier: Q8NDZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     540-559: ANAKTVEWDWKLLTYVMEEE → MPRSFEQVIILKKWFLKPYK

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,363
Checksum:iC3A3AE3BED7095D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6R0L0F6R0L0_HUMAN
SUMO-interacting motif-containing p...
SIMC1
891Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti336D → G in AK126204 (PubMed:14702039).Curated1
Sequence conflicti379S → R in AAH37298 (PubMed:15489334).Curated1
Sequence conflicti693F → L in AAH66980 (PubMed:15372022).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027568221S → F. Corresponds to variant dbSNP:rs2001605Ensembl.1
Natural variantiVAR_027569463K → R1 PublicationCorresponds to variant dbSNP:rs17857141Ensembl.1
Natural variantiVAR_059603636S → F. Corresponds to variant dbSNP:rs2001605Ensembl.1
Natural variantiVAR_027570772H → R1 PublicationCorresponds to variant dbSNP:rs17853733Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0206711 – 539Missing in isoform 4. 1 PublicationAdd BLAST539
Alternative sequenceiVSP_0206721 – 415Missing in isoform 3. 1 PublicationAdd BLAST415
Alternative sequenceiVSP_0206731 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_020674377 – 415SPSPQ…PGSAH → TPAWGTEQDSVSKKKKKKKR KEIPPNFLLFNLYRTRVKN in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_020675416 – 872Missing in isoform 2. 1 PublicationAdd BLAST457
Alternative sequenceiVSP_020676416 – 458VQSRT…KDTRE → MEDFIVISDDSGSESSGGAR PGRSRRPRRALSRTSGALPR RTV in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_020677540 – 559ANAKT…VMEEE → MPRSFEQVIILKKWFLKPYK in isoform 4. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK126204 mRNA No translation available.
AC138956 Genomic DNA No translation available.
AC139493 Genomic DNA No translation available.
BC073880 mRNA Translation: AAH73880.1
BC037298 mRNA Translation: AAH37298.1
BC032390 mRNA Translation: AAH32390.1
BC066980 mRNA Translation: AAH66980.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4398.2 [Q8NDZ2-3]
CCDS78089.1 [Q8NDZ2-1]
CCDS78090.1 [Q8NDZ2-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001295124.1, NM_001308195.1
NP_001295125.1, NM_001308196.1 [Q8NDZ2-1]
NP_001295129.1, NM_001308200.1 [Q8NDZ2-4]
NP_940969.3, NM_198567.5 [Q8NDZ2-3]
XP_016864943.1, XM_017009454.1 [Q8NDZ2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.719847

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332772; ENSP00000331311; ENSG00000170085 [Q8NDZ2-4]
ENST00000341199; ENSP00000342075; ENSG00000170085 [Q8NDZ2-3]
ENST00000430704; ENSP00000409287; ENSG00000170085 [Q8NDZ2-3]
ENST00000443967; ENSP00000406571; ENSG00000170085 [Q8NDZ2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
375484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:375484

UCSC genome browser

More...
UCSCi
uc003mdr.4 human [Q8NDZ2-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126204 mRNA No translation available.
AC138956 Genomic DNA No translation available.
AC139493 Genomic DNA No translation available.
BC073880 mRNA Translation: AAH73880.1
BC037298 mRNA Translation: AAH37298.1
BC032390 mRNA Translation: AAH32390.1
BC066980 mRNA Translation: AAH66980.1
CCDSiCCDS4398.2 [Q8NDZ2-3]
CCDS78089.1 [Q8NDZ2-1]
CCDS78090.1 [Q8NDZ2-4]
RefSeqiNP_001295124.1, NM_001308195.1
NP_001295125.1, NM_001308196.1 [Q8NDZ2-1]
NP_001295129.1, NM_001308200.1 [Q8NDZ2-4]
NP_940969.3, NM_198567.5 [Q8NDZ2-3]
XP_016864943.1, XM_017009454.1 [Q8NDZ2-1]
UniGeneiHs.719847

3D structure databases

ProteinModelPortaliQ8NDZ2
SMRiQ8NDZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131981, 28 interactors
IntActiQ8NDZ2, 8 interactors
MINTiQ8NDZ2

PTM databases

iPTMnetiQ8NDZ2
PhosphoSitePlusiQ8NDZ2

Polymorphism and mutation databases

BioMutaiSIMC1
DMDMi449081288

Proteomic databases

EPDiQ8NDZ2
jPOSTiQ8NDZ2
MaxQBiQ8NDZ2
PaxDbiQ8NDZ2
PeptideAtlasiQ8NDZ2
PRIDEiQ8NDZ2
ProteomicsDBi73096
73097 [Q8NDZ2-2]
73098 [Q8NDZ2-3]
73099 [Q8NDZ2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332772; ENSP00000331311; ENSG00000170085 [Q8NDZ2-4]
ENST00000341199; ENSP00000342075; ENSG00000170085 [Q8NDZ2-3]
ENST00000430704; ENSP00000409287; ENSG00000170085 [Q8NDZ2-3]
ENST00000443967; ENSP00000406571; ENSG00000170085 [Q8NDZ2-1]
GeneIDi375484
KEGGihsa:375484
UCSCiuc003mdr.4 human [Q8NDZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
375484
EuPathDBiHostDB:ENSG00000170085.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIMC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0024821
HGNCiHGNC:24779 SIMC1
HPAiHPA037889
HPA037890
MIMi618102 gene
neXtProtiNX_Q8NDZ2
OpenTargetsiENSG00000170085
PharmGKBiPA144596506

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH7J Eukaryota
ENOG410XQXC LUCA
GeneTreeiENSGT00940000153451
HOGENOMiHOG000070068
HOVERGENiHBG062235
InParanoidiQ8NDZ2
OrthoDBi117288at2759
PhylomeDBiQ8NDZ2
TreeFamiTF332523

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIMC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
375484

Protein Ontology

More...
PROi
PR:Q8NDZ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170085 Expressed in 198 organ(s), highest expression level in female gonad
CleanExiHS_C5orf25
ExpressionAtlasiQ8NDZ2 baseline and differential
GenevisibleiQ8NDZ2 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIMC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDZ2
Secondary accession number(s): J3KQQ8
, Q6NXN8, Q6ZTU4, Q8IZ15
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 6, 2013
Last modified: January 16, 2019
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again