UniProtKB - Q8NDZ0 (BEND2_HUMAN)
Protein
BEN domain-containing protein 2
Gene
BEND2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: BEN domain-containing protein 2 |
Gene namesi | Name:BEND2 Synonyms:CXorf20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28509, BEND2 |
neXtProti | NX_Q8NDZ0 |
VEuPathDBi | HostDB:ENSG00000177324.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 139105 |
OpenTargetsi | ENSG00000177324 |
PharmGKBi | PA164716507 |
Miscellaneous databases
Pharosi | Q8NDZ0, Tdark |
Genetic variation databases
BioMutai | BEND2 |
DMDMi | 71153248 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079730 | 1 – 799 | BEN domain-containing protein 2Add BLAST | 799 |
Proteomic databases
MassIVEi | Q8NDZ0 |
PaxDbi | Q8NDZ0 |
PeptideAtlasi | Q8NDZ0 |
PRIDEi | Q8NDZ0 |
ProteomicsDBi | 20203 73095 [Q8NDZ0-1] |
PTM databases
iPTMneti | Q8NDZ0 |
PhosphoSitePlusi | Q8NDZ0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177324, Expressed in monocyte and 64 other tissues |
Genevisiblei | Q8NDZ0, HS |
Organism-specific databases
HPAi | ENSG00000177324, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ8NDZ0
Protein-protein interaction databases
BioGRIDi | 126543, 11 interactors |
IntActi | Q8NDZ0, 6 interactors |
STRINGi | 9606.ENSP00000369372 |
Miscellaneous databases
RNActi | Q8NDZ0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 483 – 582 | BEN 1PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 667 – 765 | BEN 2PROSITE-ProRule annotationAdd BLAST | 99 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QW8J, Eukaryota |
GeneTreei | ENSGT00940000164688 |
HOGENOMi | CLU_014591_0_0_1 |
InParanoidi | Q8NDZ0 |
OMAi | GRDWKLC |
OrthoDBi | 461862at2759 |
PhylomeDBi | Q8NDZ0 |
TreeFami | TF336206 |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain IPR042810, BEND2 |
PANTHERi | PTHR47305, PTHR47305, 2 hits |
Pfami | View protein in Pfam PF10523, BEN, 2 hits |
SMARTi | View protein in SMART SM01025, BEN, 2 hits |
PROSITEi | View protein in PROSITE PS51457, BEN, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8NDZ0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSERTQEQDF VIITVDDSDD NNDCSIEMVE VSETADNSTN DIADDSTYVT
60 70 80 90 100
ADNPTDDTAT QPNFPGGNDG HHRPLQMSYG SGSVTQAGVQ WHDHSSLQPQ
110 120 130 140 150
PLGLKQFFHL SLPSSWDDRR TPPCPVAHGD QIVSQINHPV HLRRYSYNSE
160 170 180 190 200
EVDFPKRGRF YTPEVQSSIS PPAERQETHA WASPAVTSLE SAACHELQEA
210 220 230 240 250
DLSESLSYPR IVSSSSLQQY VAQGGSFPCF GMPWNFISGG AESTNAVISF
260 270 280 290 300
ANATTAVPMA VLSRRESSLA NNPGVVNYSA LPENENVGPG RALSSFCFHP
310 320 330 340 350
NLEMPERPAN SSKNSTETAN YPTLMGNYNG QNTASLSVFI PPYFAEKIIL
360 370 380 390 400
TEMPGTTETN VENNSQTVYY PALSGNTSAP YPASSYLPIT SNFESGPQMS
410 420 430 440 450
YGTMSYSTEM KNNCDQDDAS ASACLTPDFA LLPLNILVKV DTNTENSVNT
460 470 480 490 500
MNRSTLLDSD SGQDSSSSSV CIPPKYGYLG DPKRNVRVLK IHLLAVQNMA
510 520 530 540 550
KPKQAACYLV RILFSKEILI SSSVDIHLKD SQSLDPNKMA ALREYLATTF
560 570 580 590 600
PTCDLHEHGK DWQDCISGIN SMIYCLCSEG KSTPKTVRKN KKRTNRVASA
610 620 630 640 650
SADRNDQRGR DGGEGCSWMF QPMNNSKMRE KRNLQPNSNA IPEGMREPST
660 670 680 690 700
DNPEEPGEAW SYFGRPWRNI RMPCSVLTLA KTKSCASLSA RYLIQKLFTK
710 720 730 740 750
DVLVQSNVYG NLKHGLCALD PNKISALREF LQENYPICDL SENGRDWKSC
760 770 780 790
VTSINSGIRS LRHDVRRAEA RSQSLPAVTP PELEQESKPG DPDATDPST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 439 | K → E in AAH96745 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 630 | E → V in AAH37301 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022885 | 154 | F → L. Corresponds to variant dbSNP:rs17274127Ensembl. | 1 | |
Natural variantiVAR_050935 | 188 | S → F. Corresponds to variant dbSNP:rs12859329Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044653 | 303 – 393 | Missing in isoform 2. 1 PublicationAdd BLAST | 91 | |
Alternative sequenceiVSP_044654 | 729 – 799 | EFLQE…TDPST → GLLHIEYV in isoform 2. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096763 Genomic DNA No translation available. BC037301 mRNA Translation: AAH37301.1 BC096745 mRNA Translation: AAH96745.1 |
CCDSi | CCDS14184.1 [Q8NDZ0-1] CCDS55375.1 [Q8NDZ0-2] |
RefSeqi | NP_001171696.1, NM_001184767.1 [Q8NDZ0-2] NP_699177.2, NM_153346.4 [Q8NDZ0-1] |
Genome annotation databases
Ensembli | ENST00000380030; ENSP00000369369; ENSG00000177324 [Q8NDZ0-2] ENST00000380033; ENSP00000369372; ENSG00000177324 [Q8NDZ0-1] |
GeneIDi | 139105 |
KEGGi | hsa:139105 |
UCSCi | uc004cyj.5, human [Q8NDZ0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096763 Genomic DNA No translation available. BC037301 mRNA Translation: AAH37301.1 BC096745 mRNA Translation: AAH96745.1 |
CCDSi | CCDS14184.1 [Q8NDZ0-1] CCDS55375.1 [Q8NDZ0-2] |
RefSeqi | NP_001171696.1, NM_001184767.1 [Q8NDZ0-2] NP_699177.2, NM_153346.4 [Q8NDZ0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126543, 11 interactors |
IntActi | Q8NDZ0, 6 interactors |
STRINGi | 9606.ENSP00000369372 |
PTM databases
iPTMneti | Q8NDZ0 |
PhosphoSitePlusi | Q8NDZ0 |
Genetic variation databases
BioMutai | BEND2 |
DMDMi | 71153248 |
Proteomic databases
MassIVEi | Q8NDZ0 |
PaxDbi | Q8NDZ0 |
PeptideAtlasi | Q8NDZ0 |
PRIDEi | Q8NDZ0 |
ProteomicsDBi | 20203 73095 [Q8NDZ0-1] |
Protocols and materials databases
Antibodypediai | 550, 73 antibodies |
DNASUi | 139105 |
Genome annotation databases
Ensembli | ENST00000380030; ENSP00000369369; ENSG00000177324 [Q8NDZ0-2] ENST00000380033; ENSP00000369372; ENSG00000177324 [Q8NDZ0-1] |
GeneIDi | 139105 |
KEGGi | hsa:139105 |
UCSCi | uc004cyj.5, human [Q8NDZ0-1] |
Organism-specific databases
CTDi | 139105 |
DisGeNETi | 139105 |
GeneCardsi | BEND2 |
HGNCi | HGNC:28509, BEND2 |
HPAi | ENSG00000177324, Tissue enriched (testis) |
neXtProti | NX_Q8NDZ0 |
OpenTargetsi | ENSG00000177324 |
PharmGKBi | PA164716507 |
VEuPathDBi | HostDB:ENSG00000177324.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW8J, Eukaryota |
GeneTreei | ENSGT00940000164688 |
HOGENOMi | CLU_014591_0_0_1 |
InParanoidi | Q8NDZ0 |
OMAi | GRDWKLC |
OrthoDBi | 461862at2759 |
PhylomeDBi | Q8NDZ0 |
TreeFami | TF336206 |
Enzyme and pathway databases
PathwayCommonsi | Q8NDZ0 |
Miscellaneous databases
BioGRID-ORCSi | 139105, 2 hits in 498 CRISPR screens |
ChiTaRSi | BEND2, human |
GenomeRNAii | 139105 |
Pharosi | Q8NDZ0, Tdark |
PROi | PR:Q8NDZ0 |
RNActi | Q8NDZ0, protein |
Gene expression databases
Bgeei | ENSG00000177324, Expressed in monocyte and 64 other tissues |
Genevisiblei | Q8NDZ0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain IPR042810, BEND2 |
PANTHERi | PTHR47305, PTHR47305, 2 hits |
Pfami | View protein in Pfam PF10523, BEN, 2 hits |
SMARTi | View protein in SMART SM01025, BEN, 2 hits |
PROSITEi | View protein in PROSITE PS51457, BEN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BEND2_HUMAN | |
Accessioni | Q8NDZ0Primary (citable) accession number: Q8NDZ0 Secondary accession number(s): E9PFY2, Q4V9S2, Q5JXE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants