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Protein

Myelodysplastic syndrome 2 translocation-associated protein

Gene

MDS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myelodysplastic syndrome 2 translocation-associated protein
Gene namesi
Name:MDS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000197880.8
HGNCiHGNC:29633 MDS2
MIMi607305 gene
neXtProtiNX_Q8NDY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MDS2 is a cause of myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with ETV6.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi259283

Polymorphism and mutation databases

DMDMi74751237

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524771 – 140Myelodysplastic syndrome 2 translocation-associated proteinAdd BLAST140

Proteomic databases

PaxDbiQ8NDY4
PeptideAtlasiQ8NDY4
PRIDEiQ8NDY4
ProteomicsDBi73091

Expressioni

Tissue specificityi

Highly expressed in peripheral blood leukocytes, spleen, thymus, kidney, pancreas and lung.1 Publication

Gene expression databases

BgeeiENSG00000197880
CleanExiHS_MDS2
ExpressionAtlasiQ8NDY4 baseline and differential
GenevisibleiQ8NDY4 HS

Organism-specific databases

HPAiHPA052999

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363683

Structurei

3D structure databases

ProteinModelPortaliQ8NDY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KF2D Eukaryota
ENOG4110NT4 LUCA
HOGENOMiHOG000113512
InParanoidiQ8NDY4
OMAiFPPCEDP
OrthoDBiEOG091G0RU5
PhylomeDBiQ8NDY4

Sequencei

Sequence statusi: Complete.

Q8NDY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQAADFIER TETAGELSRG LIGVLSSQIS WCLLNVNLSK LPTRLQRLSC
60 70 80 90 100
SVLNSSPAMR GGARGRPQLT LERPLRPGCR LHSCSEAEKG GFVRRKEIIL
110 120 130 140
FPPCEDPARG WLSANPGREP SPGICWHLNL GLPSLHNCEE
Length:140
Mass (Da):15,384
Last modified:October 1, 2002 - v1
Checksum:i839BC22233659334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310434 mRNA Translation: CAD27416.1
AL451000 Genomic DNA No translation available.
RefSeqiNP_001335004.1, NM_001348075.1
UniGeneiHs.523369

Genome annotation databases

GeneIDi259283
KEGGihsa:259283
UCSCiuc057dgf.1 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiMDS2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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