UniProtKB - Q8NDY3 (ARHL1_HUMAN)
Protein
[Protein ADP-ribosylarginine] hydrolase-like protein 1
Gene
ADPRHL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ADP-ribosylarginine hydrolase activity Source: InterPro
- magnesium ion binding Source: InterPro
GO - Biological processi
- protein de-ADP-ribosylation Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q8NDY3 |
Names & Taxonomyi
Protein namesi | Recommended name: [Protein ADP-ribosylarginine] hydrolase-like protein 1 (EC:3.2.-.-)Alternative name(s): ADP-ribosylhydrolase 2 |
Gene namesi | Name:ADPRHL1 Synonyms:ARH2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153531.13 |
HGNCi | HGNC:21303, ADPRHL1 |
MIMi | 610620, gene |
neXtProti | NX_Q8NDY3 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 113622 |
OpenTargetsi | ENSG00000153531 |
PharmGKBi | PA134870688 |
Miscellaneous databases
Pharosi | Q8NDY3, Tdark |
Polymorphism and mutation databases
BioMutai | ADPRHL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000277606 | 1 – 354 | [Protein ADP-ribosylarginine] hydrolase-like protein 1Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8NDY3 |
MassIVEi | Q8NDY3 |
MaxQBi | Q8NDY3 |
PaxDbi | Q8NDY3 |
PeptideAtlasi | Q8NDY3 |
PRIDEi | Q8NDY3 |
ProteomicsDBi | 73089 [Q8NDY3-1] 73090 [Q8NDY3-2] |
PTM databases
iPTMneti | Q8NDY3 |
PhosphoSitePlusi | Q8NDY3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153531, Expressed in left ventricle myocardium and 199 other tissues |
ExpressionAtlasi | Q8NDY3, baseline and differential |
Genevisiblei | Q8NDY3, HS |
Organism-specific databases
HPAi | ENSG00000153531, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000364567 |
Miscellaneous databases
RNActi | Q8NDY3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ADP-ribosylglycohydrolase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QPMI, Eukaryota |
GeneTreei | ENSGT00530000063627 |
HOGENOMi | CLU_047061_1_0_1 |
InParanoidi | Q8NDY3 |
OrthoDBi | 1112828at2759 |
PhylomeDBi | Q8NDY3 |
TreeFami | TF329417 |
Family and domain databases
Gene3Di | 1.10.4080.10, 1 hit |
InterProi | View protein in InterPro IPR012108, ADP-ribosylarg_hydro IPR005502, Ribosyl_crysJ1 IPR036705, Ribosyl_crysJ1_sf |
Pfami | View protein in Pfam PF03747, ADP_ribosyl_GH, 1 hit |
PIRSFi | PIRSF016939, ADP_ribslarg_hdr, 1 hit |
SUPFAMi | SSF101478, SSF101478, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NDY3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP
60 70 80 90 100
GEWPVSDNTI MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD
110 120 130 140 150
PATIEGCAQL KPNNYLLAWH TPFNEKGSGF GAATKAMCIG LRYWKPERLE
160 170 180 190 200
TLIEVSVECG RMTHNHPTGF LGSLCTALFV SFAAQGKPLV QWGRDMLRAV
210 220 230 240 250
PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD SENKAIFPDN
260 270 280 290 300
YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF
310 320 330 340 350
HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS
TEEK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQK4 | A0A0U1RQK4_HUMAN | [Protein ADP-ribosylarginine] hydro... | ADPRHL1 | 1,967 | Annotation score: | ||
X6RL45 | X6RL45_HUMAN | [Protein ADP-ribosylarginine] hydro... | ADPRHL1 | 176 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048890 | 7 | A → V. Corresponds to variant dbSNP:rs9577273EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023036 | 1 – 82 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313429 mRNA Translation: CAC86114.1 AL160251 Genomic DNA No translation available. BC009755 mRNA Translation: AAH09755.1 |
CCDSi | CCDS9535.1 [Q8NDY3-1] CCDS9536.1 [Q8NDY3-2] |
RefSeqi | NP_612439.2, NM_138430.4 [Q8NDY3-1] NP_954631.1, NM_199162.2 [Q8NDY3-2] |
Genome annotation databases
Ensembli | ENST00000356501; ENSP00000348894; ENSG00000153531 [Q8NDY3-2] ENST00000375418; ENSP00000364567; ENSG00000153531 [Q8NDY3-1] |
GeneIDi | 113622 |
KEGGi | hsa:113622 |
UCSCi | uc001vtp.2, human [Q8NDY3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ313429 mRNA Translation: CAC86114.1 AL160251 Genomic DNA No translation available. BC009755 mRNA Translation: AAH09755.1 |
CCDSi | CCDS9535.1 [Q8NDY3-1] CCDS9536.1 [Q8NDY3-2] |
RefSeqi | NP_612439.2, NM_138430.4 [Q8NDY3-1] NP_954631.1, NM_199162.2 [Q8NDY3-2] |
3D structure databases
SMRi | Q8NDY3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000364567 |
PTM databases
iPTMneti | Q8NDY3 |
PhosphoSitePlusi | Q8NDY3 |
Polymorphism and mutation databases
BioMutai | ADPRHL1 |
Proteomic databases
EPDi | Q8NDY3 |
MassIVEi | Q8NDY3 |
MaxQBi | Q8NDY3 |
PaxDbi | Q8NDY3 |
PeptideAtlasi | Q8NDY3 |
PRIDEi | Q8NDY3 |
ProteomicsDBi | 73089 [Q8NDY3-1] 73090 [Q8NDY3-2] |
Protocols and materials databases
Antibodypediai | 25929, 56 antibodies |
DNASUi | 113622 |
Genome annotation databases
Ensembli | ENST00000356501; ENSP00000348894; ENSG00000153531 [Q8NDY3-2] ENST00000375418; ENSP00000364567; ENSG00000153531 [Q8NDY3-1] |
GeneIDi | 113622 |
KEGGi | hsa:113622 |
UCSCi | uc001vtp.2, human [Q8NDY3-1] |
Organism-specific databases
CTDi | 113622 |
DisGeNETi | 113622 |
EuPathDBi | HostDB:ENSG00000153531.13 |
GeneCardsi | ADPRHL1 |
HGNCi | HGNC:21303, ADPRHL1 |
HPAi | ENSG00000153531, Tissue enhanced (heart muscle, skeletal muscle) |
MIMi | 610620, gene |
neXtProti | NX_Q8NDY3 |
OpenTargetsi | ENSG00000153531 |
PharmGKBi | PA134870688 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPMI, Eukaryota |
GeneTreei | ENSGT00530000063627 |
HOGENOMi | CLU_047061_1_0_1 |
InParanoidi | Q8NDY3 |
OrthoDBi | 1112828at2759 |
PhylomeDBi | Q8NDY3 |
TreeFami | TF329417 |
Enzyme and pathway databases
PathwayCommonsi | Q8NDY3 |
Miscellaneous databases
BioGRID-ORCSi | 113622, 5 hits in 843 CRISPR screens |
ChiTaRSi | ADPRHL1, human |
GenomeRNAii | 113622 |
Pharosi | Q8NDY3, Tdark |
PROi | PR:Q8NDY3 |
RNActi | Q8NDY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153531, Expressed in left ventricle myocardium and 199 other tissues |
ExpressionAtlasi | Q8NDY3, baseline and differential |
Genevisiblei | Q8NDY3, HS |
Family and domain databases
Gene3Di | 1.10.4080.10, 1 hit |
InterProi | View protein in InterPro IPR012108, ADP-ribosylarg_hydro IPR005502, Ribosyl_crysJ1 IPR036705, Ribosyl_crysJ1_sf |
Pfami | View protein in Pfam PF03747, ADP_ribosyl_GH, 1 hit |
PIRSFi | PIRSF016939, ADP_ribslarg_hdr, 1 hit |
SUPFAMi | SSF101478, SSF101478, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARHL1_HUMAN | |
Accessioni | Q8NDY3Primary (citable) accession number: Q8NDY3 Secondary accession number(s): Q5JUG2, Q96GD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations