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Protein

Zinc finger protein 740

Gene

ZNF740

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri157 – 179C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Alternative name(s):
OriLyt TD-element-binding protein 7
Gene namesi
Name:ZNF740
Synonyms:TB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139651.10
HGNCiHGNC:27465 ZNF740
neXtProtiNX_Q8NDX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139651
PharmGKBiPA143485686

Polymorphism and mutation databases

BioMutaiZNF740
DMDMi74760191

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514011 – 193Zinc finger protein 740Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei44PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NDX6
MaxQBiQ8NDX6
PaxDbiQ8NDX6
PeptideAtlasiQ8NDX6
PRIDEiQ8NDX6
ProteomicsDBi73086

PTM databases

iPTMnetiQ8NDX6
PhosphoSitePlusiQ8NDX6

Expressioni

Gene expression databases

BgeeiENSG00000139651 Expressed in 177 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF740
GenevisibleiQ8NDX6 HS

Organism-specific databases

HPAiHPA035691

Interactioni

Protein-protein interaction databases

BioGridi129530, 7 interactors
IntActiQ8NDX6, 6 interactors
STRINGi9606.ENSP00000409463

Structurei

3D structure databases

ProteinModelPortaliQ8NDX6
SMRiQ8NDX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri157 – 179C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000013198
HOVERGENiHBG061583
InParanoidiQ8NDX6
OMAiEPSHSKK
OrthoDBiEOG091G0L6G
PhylomeDBiQ8NDX6

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8NDX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC
60 70 80 90 100
SSQGHRKDSD KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN
110 120 130 140 150
FVCEHCFGAF RSSYHLKRHI LIHTGEKPFE CDICDMRFIQ KYHLERHKRV
160 170 180 190
HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ GCQSKTSDGQ FSL
Length:193
Mass (Da):21,857
Last modified:October 1, 2002 - v1
Checksum:i5FFDF18B6E322CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316575 Genomic DNA Translation: CAC86954.1
AK292744 mRNA Translation: BAF85433.1
CH471054 Genomic DNA Translation: EAW96673.1
BC053557 mRNA Translation: AAH53557.1
CCDSiCCDS44896.1
RefSeqiNP_001004304.1, NM_001004304.3
UniGeneiHs.524458

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651
GeneIDi283337
KEGGihsa:283337
UCSCiuc001scb.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316575 Genomic DNA Translation: CAC86954.1
AK292744 mRNA Translation: BAF85433.1
CH471054 Genomic DNA Translation: EAW96673.1
BC053557 mRNA Translation: AAH53557.1
CCDSiCCDS44896.1
RefSeqiNP_001004304.1, NM_001004304.3
UniGeneiHs.524458

3D structure databases

ProteinModelPortaliQ8NDX6
SMRiQ8NDX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129530, 7 interactors
IntActiQ8NDX6, 6 interactors
STRINGi9606.ENSP00000409463

PTM databases

iPTMnetiQ8NDX6
PhosphoSitePlusiQ8NDX6

Polymorphism and mutation databases

BioMutaiZNF740
DMDMi74760191

Proteomic databases

EPDiQ8NDX6
MaxQBiQ8NDX6
PaxDbiQ8NDX6
PeptideAtlasiQ8NDX6
PRIDEiQ8NDX6
ProteomicsDBi73086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651
GeneIDi283337
KEGGihsa:283337
UCSCiuc001scb.5 human

Organism-specific databases

CTDi283337
EuPathDBiHostDB:ENSG00000139651.10
GeneCardsiZNF740
HGNCiHGNC:27465 ZNF740
HPAiHPA035691
neXtProtiNX_Q8NDX6
OpenTargetsiENSG00000139651
PharmGKBiPA143485686
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000013198
HOVERGENiHBG061583
InParanoidiQ8NDX6
OMAiEPSHSKK
OrthoDBiEOG091G0L6G
PhylomeDBiQ8NDX6

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF740 human
GenomeRNAii283337
PROiPR:Q8NDX6

Gene expression databases

BgeeiENSG00000139651 Expressed in 177 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF740
GenevisibleiQ8NDX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN740_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX6
Secondary accession number(s): A8K9M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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