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Entry version 153 (13 Nov 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Polyhomeotic-like protein 3

Gene

PHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.1 Publication

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri776 – 810FCS-typePROSITE-ProRule annotationAdd BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyhomeotic-like protein 3
Alternative name(s):
Early development regulatory protein 3
Homolog of polyhomeotic 3
Short name:
hPH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHC3
Synonyms:EDR3, PH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15682 PHC3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDX5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80012

Open Targets

More...
OpenTargetsi
ENSG00000173889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134886018

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NDX5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74715388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762901 – 983Polyhomeotic-like protein 3Add BLAST983

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei609PhosphothreonineCombined sources1
Modified residuei614PhosphothreonineCombined sources1
Modified residuei616PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki691Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki732Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei761PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Cross-linki810Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NDX5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NDX5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NDX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDX5

PeptideAtlas

More...
PeptideAtlasi
Q8NDX5

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDX5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73079 [Q8NDX5-1]
73080 [Q8NDX5-2]
73081 [Q8NDX5-3]
73082 [Q8NDX5-4]
73083 [Q8NDX5-5]
73084 [Q8NDX5-6]
73085 [Q8NDX5-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173889 Expressed in 215 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NDX5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDX5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039162
HPA062031

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a PRC1-like complex.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O152943EBI-1223801,EBI-539828

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123068, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8NDX5

Protein interaction database and analysis system

More...
IntActi
Q8NDX5, 32 interactors

Molecular INTeraction database

More...
MINTi
Q8NDX5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1983
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDX5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini919 – 983SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi691 – 720HD1Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 26Poly-Thr8
Compositional biasi89 – 287Ser-richAdd BLAST199
Compositional biasi324 – 539Gln-richAdd BLAST216
Compositional biasi346 – 670Pro-richAdd BLAST325

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri776 – 810FCS-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZN Eukaryota
ENOG4111F0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154964

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDX5

KEGG Orthology (KO)

More...
KOi
K11458

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSPIHIH

Database of Orthologous Groups

More...
OrthoDBi
298184at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDX5

TreeFam database of animal gene trees

More...
TreeFami
TF331299

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
3.30.60.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS51024 ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTEPNPGTS SVSTTTSSTT TTTITTSSSR MQQPQISVYS GSDRHAVQVI
60 70 80 90 100
QQALHRPPSS AAQYLQQMYA AQQQHLMLHT AALQQQHLSS SQLQSLAAVQ
110 120 130 140 150
ASLSSGRPST SPTGSVTQQS SMSQTSINLS TSPTPAQLIS RSQASSSTSG
160 170 180 190 200
SITQQTMLLG STSPTLTASQ AQMYLRAQML IFTPATTVAA VQSDIPVVSS
210 220 230 240 250
SSSSSCQSAA TQVQNLTLRS QKLGVLSSSQ NGPPKSTSQT QSLTICHNKT
260 270 280 290 300
TVTSSKISQR DPSPESNKKG ESPSLESRST AVTRTSSIHQ LIAPASYSPI
310 320 330 340 350
QPHSLIKHQQ IPLHSPPSKV SHHQLILQQQ QQQIQPITLQ NSTQDPPPSQ
360 370 380 390 400
HCIPLQNHGL PPAPSNAQSQ HCSPIQSHPS PLTVSPNQSQ SAQQSVVVSP
410 420 430 440 450
PPPHSPSQSP TIIIHPQALI QPHPLVSSAL QPGPNLQQST ANQVQATAQL
460 470 480 490 500
NLPSHLPLPA SPVVHIGPVQ QSALVSPGQQ IVSPSHQQYS SLQSSPIPIA
510 520 530 540 550
SPPQMSTSPP AQIPPLPLQS MQSLQVQPEI LSQGQVLVQN ALVSEEELPA
560 570 580 590 600
AEALVQLPFQ TLPPPQTVAV NLQVQPPAPV DPPVVYQVED VCEEEMPEES
610 620 630 640 650
DECVRMDRTP PPPTLSPAAI TVGRGEDLTS EHPLLEQVEL PAVASVSASV
660 670 680 690 700
IKSPSDPSHV SVPPPPLLLP AATTRSNSTS MHSSIPSIEN KPPQAIVKPQ
710 720 730 740 750
ILTHVIEGFV IQEGLEPFPV SRSSLLIEQP VKKRPLLDNQ VINSVCVQPE
760 770 780 790 800
LQNNTKHADN SSDTEMEDMI AEETLEEMDS ELLKCEFCGK MGYANEFLRS
810 820 830 840 850
KRFCTMSCAK RYNVSCSKKF ALSRWNRKPD NQSLGHRGRR PSGPDGAARE
860 870 880 890 900
HILRQLPITY PSAEEDLASH EDSVPSAMTT RLRRQSERER ERELRDVRIR
910 920 930 940 950
KMPENSDLLP VAQTEPSIWT VDDVWAFIHS LPGCQDIADE FRAQEIDGQA
960 970 980
LLLLKEDHLM SAMNIKLGPA LKICARINSL KES
Length:983
Mass (Da):106,162
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05819632A1675049
GO
Isoform 2 (identifier: Q8NDX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-141: Missing.

Show »
Length:964
Mass (Da):104,178
Checksum:iEE515D7DDFB53E7B
GO
Isoform 3 (identifier: Q8NDX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAEFKDHSTAM
     295-321: ASYSPIQPHSLIKHQQIPLHSPPSKVS → GGIKLLLKIVVLFIFLADRAKQRMFMT
     322-983: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):35,253
Checksum:iF599992070F91F88
GO
Isoform 4 (identifier: Q8NDX5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-51: Missing.
     180-190: LIFTPATTVAA → VRYELPNFFSV
     191-983: Missing.

Show »
Length:186
Mass (Da):19,748
Checksum:i351B7AD420AA40B7
GO
Isoform 5 (identifier: Q8NDX5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAEFKDHSTAM
     127-139: INLSTSPTPAQLI → VSSLNFFFLDLKF
     140-983: Missing.

Show »
Length:151
Mass (Da):16,228
Checksum:iB0837669A1311637
GO
Isoform 6 (identifier: Q8NDX5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-51: Missing.
     127-139: INLSTSPTPAQLI → VSSLNFFFLDLKF
     140-983: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,441
Checksum:iEA82C7776AA961A5
GO
Isoform 7 (identifier: Q8NDX5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAEFKDHSTAM

Show »
Length:995
Mass (Da):107,480
Checksum:iD3A424246ADC139A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX82E7EX82_HUMAN
Polyhomeotic-like protein 3
PHC3
828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DTC4B4DTC4_HUMAN
Polyhomeotic-like protein 3
PHC3
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6H0C9J6H0_HUMAN
Polyhomeotic-like protein 3
PHC3
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAU4C9JAU4_HUMAN
Polyhomeotic-like protein 3
PHC3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYH7C9JYH7_HUMAN
Polyhomeotic-like protein 3
PHC3
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9U7G5E9U7_HUMAN
Polyhomeotic like 3 (Drosophila), i...
PHC3 hCG_2021666
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4H9H7C4H9_HUMAN
Polyhomeotic-like protein 3
PHC3
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C528H7C528_HUMAN
Polyhomeotic-like protein 3
PHC3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDA4F8WDA4_HUMAN
Polyhomeotic-like protein 3
PHC3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Isoform 5 : The sequence BAB14245 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50I → F in AAM46139 (Ref. 3) Curated1
Sequence conflicti53A → S in AAM51781 (PubMed:12167701).Curated1
Sequence conflicti310Q → R in EF560717 (PubMed:17974005).Curated1
Sequence conflicti435N → D in EF560717 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0167631M → MAEAEFKDHSTAM in isoform 3, isoform 5 and isoform 7. 3 Publications1
Alternative sequenceiVSP_01676448 – 51Missing in isoform 4 and isoform 6. 2 Publications4
Alternative sequenceiVSP_016765123 – 141Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_016766127 – 139INLST…PAQLI → VSSLNFFFLDLKF in isoform 5 and isoform 6. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_016767140 – 983Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST844
Alternative sequenceiVSP_016768180 – 190LIFTPATTVAA → VRYELPNFFSV in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_016769191 – 983Missing in isoform 4. 1 PublicationAdd BLAST793
Alternative sequenceiVSP_016770295 – 321ASYSP…PSKVS → GGIKLLLKIVVLFIFLADRA KQRMFMT in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_016771322 – 983Missing in isoform 3. 1 PublicationAdd BLAST662

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ320486 mRNA Translation: CAC86587.2
AF444193 mRNA Translation: AAM51781.1
AF380154 mRNA Translation: AAM46139.1
AK022791 mRNA Translation: BAB14245.1 Frameshift.
AK023029 mRNA Translation: BAB14365.1
BX647868 mRNA Translation: CAI46090.1
EF560717 mRNA No translation available.
AC008040 Genomic DNA No translation available.
AC023891 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78519.1
BC022325 mRNA Translation: AAH22325.1
BC070164 mRNA Translation: AAH70164.1
BC131772 mRNA Translation: AAI31773.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46952.1 [Q8NDX5-7]
CCDS77858.1 [Q8NDX5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001295045.1, NM_001308116.1 [Q8NDX5-1]
NP_079223.3, NM_024947.3 [Q8NDX5-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000494943; ENSP00000420271; ENSG00000173889 [Q8NDX5-1]
ENST00000495893; ENSP00000420294; ENSG00000173889 [Q8NDX5-7]
ENST00000497658; ENSP00000420454; ENSG00000173889 [Q8NDX5-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80012

UCSC genome browser

More...
UCSCi
uc003fgl.3 human [Q8NDX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320486 mRNA Translation: CAC86587.2
AF444193 mRNA Translation: AAM51781.1
AF380154 mRNA Translation: AAM46139.1
AK022791 mRNA Translation: BAB14245.1 Frameshift.
AK023029 mRNA Translation: BAB14365.1
BX647868 mRNA Translation: CAI46090.1
EF560717 mRNA No translation available.
AC008040 Genomic DNA No translation available.
AC023891 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78519.1
BC022325 mRNA Translation: AAH22325.1
BC070164 mRNA Translation: AAH70164.1
BC131772 mRNA Translation: AAI31773.1
CCDSiCCDS46952.1 [Q8NDX5-7]
CCDS77858.1 [Q8NDX5-1]
RefSeqiNP_001295045.1, NM_001308116.1 [Q8NDX5-1]
NP_079223.3, NM_024947.3 [Q8NDX5-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PZNX-ray2.30A/B/C/D/E914-983[»]
4PZOX-ray2.25A/B/C/D/E/F914-983[»]
SMRiQ8NDX5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123068, 40 interactors
CORUMiQ8NDX5
IntActiQ8NDX5, 32 interactors
MINTiQ8NDX5
STRINGi9606.ENSP00000420294

PTM databases

iPTMnetiQ8NDX5
PhosphoSitePlusiQ8NDX5

Polymorphism and mutation databases

BioMutaiPHC3
DMDMi74715388

Proteomic databases

jPOSTiQ8NDX5
MassIVEiQ8NDX5
MaxQBiQ8NDX5
PaxDbiQ8NDX5
PeptideAtlasiQ8NDX5
PRIDEiQ8NDX5
ProteomicsDBi73079 [Q8NDX5-1]
73080 [Q8NDX5-2]
73081 [Q8NDX5-3]
73082 [Q8NDX5-4]
73083 [Q8NDX5-5]
73084 [Q8NDX5-6]
73085 [Q8NDX5-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80012

Genome annotation databases

EnsembliENST00000494943; ENSP00000420271; ENSG00000173889 [Q8NDX5-1]
ENST00000495893; ENSP00000420294; ENSG00000173889 [Q8NDX5-7]
ENST00000497658; ENSP00000420454; ENSG00000173889 [Q8NDX5-5]
GeneIDi80012
KEGGihsa:80012
UCSCiuc003fgl.3 human [Q8NDX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80012
DisGeNETi80012

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHC3
HGNCiHGNC:15682 PHC3
HPAiHPA039162
HPA062031
neXtProtiNX_Q8NDX5
OpenTargetsiENSG00000173889
PharmGKBiPA134886018

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDZN Eukaryota
ENOG4111F0Y LUCA
GeneTreeiENSGT00940000154964
InParanoidiQ8NDX5
KOiK11458
OMAiCSPIHIH
OrthoDBi298184at2759
PhylomeDBiQ8NDX5
TreeFamiTF331299

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHC3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PHC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80012
PharosiQ8NDX5

Protein Ontology

More...
PROi
PR:Q8NDX5

Gene expression databases

BgeeiENSG00000173889 Expressed in 215 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ8NDX5 baseline and differential
GenevisibleiQ8NDX5 HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS51024 ZF_FCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDX5
Secondary accession number(s): A2RRP9
, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: November 13, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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