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Protein

Tetratricopeptide repeat protein 21A

Gene

TTC21A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • intraciliary retrograde transport Source: GO_Central
  • protein localization to cilium Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 21A
Short name:
TPR repeat protein 21A
Alternative name(s):
Stress-inducible protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC21A
Synonyms:STI2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000168026.16

Human Gene Nomenclature Database

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HGNCi
HGNC:30761 TTC21A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611430 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8NDW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000168026

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134915959

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC21A

Domain mapping of disease mutations (DMDM)

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DMDMi
296453007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919151 – 1320Tetratricopeptide repeat protein 21AAdd BLAST1320

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NDW8

PeptideAtlas

More...
PeptideAtlasi
Q8NDW8

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDW8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73070
73071 [Q8NDW8-3]
73072 [Q8NDW8-5]
73073 [Q8NDW8-6]
73074 [Q8NDW8-7]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8NDW8-6 [Q8NDW8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168026 Expressed in 122 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

More...
CleanExi
HS_TTC21A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NDW8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDW8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035510
HPA035511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128260, 7 interactors

Protein interaction database and analysis system

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IntActi
Q8NDW8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398211

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NDW8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 38TPR 1Add BLAST35
Repeati110 – 143TPR 2Add BLAST34
Repeati146 – 180TPR 3Add BLAST35
Repeati181 – 213TPR 4Add BLAST33
Repeati215 – 247TPR 5Add BLAST33
Repeati334 – 367TPR 6Add BLAST34
Repeati502 – 534TPR 7Add BLAST33
Repeati572 – 605TPR 8Add BLAST34
Repeati728 – 761TPR 9Add BLAST34
Repeati762 – 795TPR 10Add BLAST34
Repeati797 – 828TPR 11Add BLAST32
Repeati837 – 869TPR 12Add BLAST33
Repeati889 – 922TPR 13Add BLAST34
Repeati924 – 956TPR 14Add BLAST33
Repeati957 – 990TPR 15Add BLAST34
Repeati1028 – 1061TPR 16Add BLAST34
Repeati1201 – 1234TPR 17Add BLAST34
Repeati1236 – 1268TPR 18Add BLAST33
Repeati1270 – 1303TPR 19Add BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC21 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEX1 Eukaryota
ENOG410XV69 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005979

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108607

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDW8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVPKART

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00TY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDW8

TreeFam database of animal gene trees

More...
TreeFami
TF314664

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 9 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL
60 70 80 90 100
KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS
110 120 130 140 150
LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR
160 170 180 190 200
GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL
210 220 230 240 250
EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA
260 270 280 290 300
CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK
310 320 330 340 350
KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV
360 370 380 390 400
KEALLWYSEA MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS
410 420 430 440 450
LGKSEVLIFL QALLMSRKHK GEEETTALLK EAVELHFSSM QGIPLGSEYF
460 470 480 490 500
EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV SPLLKQVAVI LNPVVKAAPA
510 520 530 540 550
LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL MCQIYLAQGN
560 570 580 590 600
FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK
610 620 630 640 650
LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI
660 670 680 690 700
NEFGGTPEEN RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM
710 720 730 740 750
ANIYLQTLRD RRLYIRCYRE LCEHLPGPHT SLLLGDALMS ILEPEKALEV
760 770 780 790 800
YDEAYRQNPH DASLASRIGH AYVKAHQYTE AIEYYEAAQK INGQDFLCCD
810 820 830 840 850
LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL LLLAKVYKSH
860 870 880 890 900
KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL
910 920 930 940 950
AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL
960 970 980 990 1000
QTEQNHETAS VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL
1010 1020 1030 1040 1050
LRRSGKLEDI PAFFELAKKV SSRVPLEPGF NYCRGIYCWH IGQPNEALKF
1060 1070 1080 1090 1100
LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV GGEAFENQGA ESNYMEKKEL
1110 1120 1130 1140 1150
EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK ANMEAALGSF
1160 1170 1180 1190 1200
IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL
1210 1220 1230 1240 1250
EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS
1260 1270 1280 1290 1300
YKDAVTNYKL AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH
1310 1320
PDYPKIREEI LEKARRSLRP
Length:1,320
Mass (Da):150,944
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFB949A8E2B702DE
GO
Isoform 3 (identifier: Q8NDW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-879: Missing.

Note: No experimental confirmation available.
Show »
Length:441
Mass (Da):50,905
Checksum:i102EA3A89D2111D8
GO
Isoform 5 (identifier: Q8NDW8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-275: Missing.
     386-396: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,302
Mass (Da):148,721
Checksum:i659D1D9077679B39
GO
Isoform 6 (identifier: Q8NDW8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-187: Missing.
     268-275: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,272
Mass (Da):145,558
Checksum:iC748B6FFC7FAC0CA
GO
Isoform 7 (identifier: Q8NDW8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,321
Mass (Da):151,001
Checksum:iC3522C1E399E1700
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1Y2A0A0B4J1Y2_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A
1,143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDN4F8WDN4_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH51A0A0C4DH51_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153V → G in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti174I → T in BAG63718 (PubMed:14702039).Curated1
Sequence conflicti802G → D in BAG63755 (PubMed:14702039).Curated1
Sequence conflicti803K → E in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti838K → R in BAG63718 (PubMed:14702039).Curated1
Sequence conflicti1095M → T in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti1165L → P in BAC04129 (PubMed:14702039).Curated1
Sequence conflicti1291E → K in BAG63755 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03287991R → Q. Corresponds to variant dbSNP:rs1112438Ensembl.1
Natural variantiVAR_032880108V → L. Corresponds to variant dbSNP:rs17855763Ensembl.1
Natural variantiVAR_032881290R → K. Corresponds to variant dbSNP:rs1274972Ensembl.1
Natural variantiVAR_032882293E → K. Corresponds to variant dbSNP:rs1274971Ensembl.1
Natural variantiVAR_032883622R → W. Corresponds to variant dbSNP:rs35581078Ensembl.1
Natural variantiVAR_059861719R → H. Corresponds to variant dbSNP:rs9861353Ensembl.1
Natural variantiVAR_032884719R → Q. Corresponds to variant dbSNP:rs9861353Ensembl.1
Natural variantiVAR_0328851055R → L1 PublicationCorresponds to variant dbSNP:rs35934336Ensembl.1
Natural variantiVAR_0328861160S → R. Corresponds to variant dbSNP:rs34201693Ensembl.1
Natural variantiVAR_0328871316R → K1 PublicationCorresponds to variant dbSNP:rs704959Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0262971 – 879Missing in isoform 3. 1 PublicationAdd BLAST879
Alternative sequenceiVSP_038428147 – 187Missing in isoform 6. CuratedAdd BLAST41
Alternative sequenceiVSP_038429268 – 275Missing in isoform 5 and isoform 6. 1 Publication8
Alternative sequenceiVSP_038430386 – 396Missing in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_038431515S → SG in isoform 5, isoform 6 and isoform 7. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ487015 mRNA Translation: CAD31647.1
AK093313 mRNA Translation: BAC04129.1 Different initiation.
AK098528 mRNA Translation: BAC05323.1
AK302408 mRNA Translation: BAG63718.1
AK302465 mRNA Translation: BAG63755.1
AC092053 Genomic DNA No translation available.
AC138124 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43068.2 [Q8NDW8-6]
CCDS46800.1 [Q8NDW8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001098983.2, NM_001105513.2 [Q8NDW8-6]
NP_665698.2, NM_145755.2 [Q8NDW8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.443935

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000431162; ENSP00000398211; ENSG00000168026 [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026 [Q8NDW8-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
199223

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:199223

UCSC genome browser

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UCSCi
uc003cjc.3 human [Q8NDW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487015 mRNA Translation: CAD31647.1
AK093313 mRNA Translation: BAC04129.1 Different initiation.
AK098528 mRNA Translation: BAC05323.1
AK302408 mRNA Translation: BAG63718.1
AK302465 mRNA Translation: BAG63755.1
AC092053 Genomic DNA No translation available.
AC138124 Genomic DNA No translation available.
CCDSiCCDS43068.2 [Q8NDW8-6]
CCDS46800.1 [Q8NDW8-1]
RefSeqiNP_001098983.2, NM_001105513.2 [Q8NDW8-6]
NP_665698.2, NM_145755.2 [Q8NDW8-1]
UniGeneiHs.443935

3D structure databases

ProteinModelPortaliQ8NDW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128260, 7 interactors
IntActiQ8NDW8, 3 interactors
STRINGi9606.ENSP00000398211

PTM databases

iPTMnetiQ8NDW8
PhosphoSitePlusiQ8NDW8

Polymorphism and mutation databases

BioMutaiTTC21A
DMDMi296453007

Proteomic databases

PaxDbiQ8NDW8
PeptideAtlasiQ8NDW8
PRIDEiQ8NDW8
ProteomicsDBi73070
73071 [Q8NDW8-3]
73072 [Q8NDW8-5]
73073 [Q8NDW8-6]
73074 [Q8NDW8-7]
TopDownProteomicsiQ8NDW8-6 [Q8NDW8-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431162; ENSP00000398211; ENSG00000168026 [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026 [Q8NDW8-6]
GeneIDi199223
KEGGihsa:199223
UCSCiuc003cjc.3 human [Q8NDW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
199223
EuPathDBiHostDB:ENSG00000168026.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TTC21A
HGNCiHGNC:30761 TTC21A
HPAiHPA035510
HPA035511
MIMi611430 gene
neXtProtiNX_Q8NDW8
OpenTargetsiENSG00000168026
PharmGKBiPA134915959

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IEX1 Eukaryota
ENOG410XV69 LUCA
GeneTreeiENSGT00390000005979
HOVERGENiHBG108607
InParanoidiQ8NDW8
OMAiQVPKART
OrthoDBiEOG091G00TY
PhylomeDBiQ8NDW8
TreeFamiTF314664

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTC21A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
199223

Protein Ontology

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PROi
PR:Q8NDW8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168026 Expressed in 122 organ(s), highest expression level in right uterine tube
CleanExiHS_TTC21A
ExpressionAtlasiQ8NDW8 baseline and differential
GenevisibleiQ8NDW8 HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 13 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 9 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTT21A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDW8
Secondary accession number(s): A1L388
, B4DYF6, B4DYJ3, D3YTE7, D4PHA5, Q6P5W8, Q8N7G5, Q8NA02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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