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Entry version 159 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 248

Gene

ZNF248

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri240 – 264C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 402C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 543C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri548 – 570C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NDW4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 248
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF248
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13041, ZNF248

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDW4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198105.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57209

Open Targets

More...
OpenTargetsi
ENSG00000198105

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37619

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NDW4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF248

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474821 – 579Zinc finger protein 248Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NDW4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NDW4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NDW4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDW4

PeptideAtlas

More...
PeptideAtlasi
Q8NDW4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDW4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73067
73069 [Q8NDW4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198105, Expressed in forebrain and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NDW4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDW4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198105, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121447, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NDW4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379208

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NDW4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDW4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri240 – 264C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 402C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 543C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri548 – 570C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161962

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_12_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDW4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIVHMGK

Database of Orthologous Groups

More...
OrthoDBi
1770242at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDW4

TreeFam database of animal gene trees

More...
TreeFami
TF337898

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKSQEQVSF KDVCVDFTQE EWYLLDPAQK ILYRDVILEN YSNLVSVGYC
60 70 80 90 100
ITKPEVIFKI EQGEEPWILE KGFPSQCHPE RKWKVDDVLE SSQENEDDHF
110 120 130 140 150
WELLFHNNKT VSVENGDRGS KTFNLGTDPV SLRNYPYKIC DSCEMNLKNI
160 170 180 190 200
SGLIISKKNC SRKKPDEFNV CEKLLLDIRH EKIPIGEKSY KYDQKRNAIN
210 220 230 240 250
YHQDLSQPSF GQSFEYSKNG QGFHDEAAFF TNKRSQIGET VCKYNECGRT
260 270 280 290 300
FIESLKLNIS QRPHLEMEPY GCSICGKSFC MNLRFGHQRA LTKDNPYEYN
310 320 330 340 350
EYGEIFCDNS AFIIHQGAYT RKILREYKVS DKTWEKSALL KHQIVHMGGK
360 370 380 390 400
SYDYNENGSN FSKKSHLTQL RRAHTGEKTF ECGECGKTFW EKSNLTQHQR
410 420 430 440 450
THTGEKPYEC TECGKAFCQK PHLTNHQRTH TGEKPYECKQ CGKTFCVKSN
460 470 480 490 500
LTEHQRTHTG EKPYECNACG KSFCHRSALT VHQRTHTGEK PFICNECGKS
510 520 530 540 550
FCVKSNLIVH QRTHTGEKPY KCNECGKTFC EKSALTKHQR THTGEKPYEC
560 570
NACGKTFSQR SVLTKHQRIH TRVKALSTS
Length:579
Mass (Da):67,087
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BB9B20FDFC9A879
GO
Isoform 2 (identifier: Q8NDW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-579: VSVENGDRGS...HTRVKALSTS → WNLKLIKVE

Show »
Length:119
Mass (Da):14,281
Checksum:i5E987E3C2513E9F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTK3A0A087WTK3_HUMAN
Zinc finger protein 248
ZNF248
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R340S4R340_HUMAN
Zinc finger protein 248
ZNF248
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL40B1AL40_HUMAN
Zinc finger protein 248
ZNF248
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL42B1AL42_HUMAN
Zinc finger protein 248
ZNF248
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052800218K → E. Corresponds to variant dbSNP:rs11011379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045321111 – 579VSVEN…ALSTS → WNLKLIKVE in isoform 2. 2 PublicationsAdd BLAST469

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ491695 mRNA Translation: CAD36954.1
AJ492196 mRNA Translation: CAD37332.1
AJ245587 Genomic DNA Translation: CAB52547.1
AL135791 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85897.1
CH471072 Genomic DNA Translation: EAW85899.1
BC110869 mRNA Translation: AAI10870.1
BC146820 mRNA Translation: AAI46821.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58077.1 [Q8NDW4-2]
CCDS7194.1 [Q8NDW4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001254526.1, NM_001267597.1 [Q8NDW4-1]
NP_001254534.1, NM_001267605.1 [Q8NDW4-2]
NP_001254535.1, NM_001267606.1 [Q8NDW4-2]
NP_066383.1, NM_021045.2 [Q8NDW4-1]
XP_006717548.1, XM_006717485.3
XP_011517899.1, XM_011519597.2
XP_011517900.1, XM_011519598.2
XP_011517901.1, XM_011519599.1 [Q8NDW4-2]
XP_011517902.1, XM_011519600.2 [Q8NDW4-2]
XP_016871934.1, XM_017016445.1 [Q8NDW4-1]
XP_016871935.1, XM_017016446.1
XP_016871939.1, XM_017016450.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357328; ENSP00000349882; ENSG00000198105 [Q8NDW4-1]
ENST00000374648; ENSP00000363778; ENSG00000198105 [Q8NDW4-2]
ENST00000395867; ENSP00000379208; ENSG00000198105 [Q8NDW4-1]
ENST00000611278; ENSP00000484191; ENSG00000198105 [Q8NDW4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57209

UCSC genome browser

More...
UCSCi
uc001izc.5, human [Q8NDW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491695 mRNA Translation: CAD36954.1
AJ492196 mRNA Translation: CAD37332.1
AJ245587 Genomic DNA Translation: CAB52547.1
AL135791 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85897.1
CH471072 Genomic DNA Translation: EAW85899.1
BC110869 mRNA Translation: AAI10870.1
BC146820 mRNA Translation: AAI46821.1
CCDSiCCDS58077.1 [Q8NDW4-2]
CCDS7194.1 [Q8NDW4-1]
RefSeqiNP_001254526.1, NM_001267597.1 [Q8NDW4-1]
NP_001254534.1, NM_001267605.1 [Q8NDW4-2]
NP_001254535.1, NM_001267606.1 [Q8NDW4-2]
NP_066383.1, NM_021045.2 [Q8NDW4-1]
XP_006717548.1, XM_006717485.3
XP_011517899.1, XM_011519597.2
XP_011517900.1, XM_011519598.2
XP_011517901.1, XM_011519599.1 [Q8NDW4-2]
XP_011517902.1, XM_011519600.2 [Q8NDW4-2]
XP_016871934.1, XM_017016445.1 [Q8NDW4-1]
XP_016871935.1, XM_017016446.1
XP_016871939.1, XM_017016450.1

3D structure databases

SMRiQ8NDW4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121447, 11 interactors
IntActiQ8NDW4, 2 interactors
STRINGi9606.ENSP00000379208

PTM databases

iPTMnetiQ8NDW4
PhosphoSitePlusiQ8NDW4

Genetic variation databases

BioMutaiZNF248
DMDMi47606299

Proteomic databases

jPOSTiQ8NDW4
MassIVEiQ8NDW4
MaxQBiQ8NDW4
PaxDbiQ8NDW4
PeptideAtlasiQ8NDW4
PRIDEiQ8NDW4
ProteomicsDBi73067
73069 [Q8NDW4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26721, 121 antibodies

The DNASU plasmid repository

More...
DNASUi
57209

Genome annotation databases

EnsembliENST00000357328; ENSP00000349882; ENSG00000198105 [Q8NDW4-1]
ENST00000374648; ENSP00000363778; ENSG00000198105 [Q8NDW4-2]
ENST00000395867; ENSP00000379208; ENSG00000198105 [Q8NDW4-1]
ENST00000611278; ENSP00000484191; ENSG00000198105 [Q8NDW4-2]
GeneIDi57209
KEGGihsa:57209
UCSCiuc001izc.5, human [Q8NDW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57209
DisGeNETi57209

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF248
HGNCiHGNC:13041, ZNF248
HPAiENSG00000198105, Low tissue specificity
neXtProtiNX_Q8NDW4
OpenTargetsiENSG00000198105
PharmGKBiPA37619
VEuPathDBiHostDB:ENSG00000198105.11

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161962
HOGENOMiCLU_002678_0_12_1
InParanoidiQ8NDW4
OMAiQIVHMGK
OrthoDBi1770242at2759
PhylomeDBiQ8NDW4
TreeFamiTF337898

Enzyme and pathway databases

PathwayCommonsiQ8NDW4
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57209, 5 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF248, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57209
PharosiQ8NDW4, Tdark

Protein Ontology

More...
PROi
PR:Q8NDW4
RNActiQ8NDW4, protein

Gene expression databases

BgeeiENSG00000198105, Expressed in forebrain and 224 other tissues
ExpressionAtlasiQ8NDW4, baseline and differential
GenevisibleiQ8NDW4, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 7 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN248_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDW4
Secondary accession number(s): Q8NDV8, Q9UMP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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