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Protein

Trinucleotide repeat-containing gene 6A protein

Gene

TNRC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.6 Publications

Miscellaneous

Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processRNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-4086398 Ca2+ pathway
R-HSA-426496 Post-transcriptional silencing by small RNAs
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723 Regulation of PTEN mRNA translation
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-8986944 Transcriptional Regulation by MECP2
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9022692 Regulation of MECP2 expression and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 6A protein
Alternative name(s):
CAG repeat protein 26
EMSY interactor protein
GW182 autoantigen
Short name:
Protein GW1
Glycine-tryptophan protein of 182 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6A
Synonyms:CAGH26, KIAA1460, TNRC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000090905.17

Human Gene Nomenclature Database

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HGNCi
HGNC:11969 TNRC6A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610739 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDV7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi313W → A: Does not impair interaction with AGO2; when associated with A-345; A-370; A-420 and A-483. 1 Publication1
Mutagenesisi345W → A: Does not impair interaction with AGO2; when associated with A-313; A-370; A-420 and A-483. 1 Publication1
Mutagenesisi370W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-420 and A-483. 1 Publication1
Mutagenesisi420W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-483. 1 Publication1
Mutagenesisi483W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-420. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27327

Open Targets

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OpenTargetsi
ENSG00000090905

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36656

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TNRC6A

Domain mapping of disease mutations (DMDM)

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DMDMi
296452846

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819801 – 1962Trinucleotide repeat-containing gene 6A proteinAdd BLAST1962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei739PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1212PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1470PhosphothreonineCombined sources1
Modified residuei1585PhosphoserineCombined sources1
Modified residuei1869PhosphoserineCombined sources1
Modified residuei1890PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NDV7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NDV7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NDV7

PeptideAtlas

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PeptideAtlasi
Q8NDV7

PRoteomics IDEntifications database

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PRIDEi
Q8NDV7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73061
73062 [Q8NDV7-2]
73063 [Q8NDV7-3]
73064 [Q8NDV7-4]
73065 [Q8NDV7-5]
73066 [Q8NDV7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By exogenous short interfering RNA (siRNA).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000090905 Expressed in 205 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NDV7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NDV7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015305
HPA017869

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560). Interacts with SND1 (PubMed:28546213).9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118141, 49 interactors

Database of interacting proteins

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DIPi
DIP-54489N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q8NDV7

Protein interaction database and analysis system

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IntActi
Q8NDV7, 85 interactors

Molecular INTeraction database

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MINTi
Q8NDV7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NDV7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDV7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1781 – 1853RRMAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 932Interaction with argonaute family proteinsAdd BLAST932
Regioni254 – 503Sufficient for interaction with AGO1, AGO3 and AGO4Add BLAST250
Regioni270 – 346Sufficient for interaction with AGO2Add BLAST77
Regioni318 – 399Sufficient for interaction with AGO2Add BLAST82
Regioni340 – 439Sufficient for interaction with AGO2Add BLAST100
Regioni409 – 495Sufficient for interaction with AGO2Add BLAST87
Regioni502 – 751Sufficient for interaction with AGO2Add BLAST250
Regioni566 – 1343Sufficient for interaction with AGO1 and AGO4Add BLAST778
Regioni1074 – 1144Sufficient for interaction with AGO2Add BLAST71
Regioni1604 – 1622PABPC1-interacting motif-2 (PAM2)Add BLAST19
Regioni1670 – 1962Sufficient for interaction with AGO2Add BLAST293

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili7 – 54Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 127Gln-richAdd BLAST35
Compositional biasi192 – 365Ser-richAdd BLAST174

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF5S Eukaryota
ENOG41110AX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158180

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062594

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NDV7

KEGG Orthology (KO)

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KOi
K18412

Identification of Orthologs from Complete Genome Data

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OMAi
SPYFDKD

Database of Orthologous Groups

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OrthoDBi
EOG091G00G6

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NDV7

TreeFam database of animal gene trees

More...
TreeFami
TF329702

Family and domain databases

Conserved Domains Database

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CDDi
cd12711 RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019486 Argonaute_hook_dom
IPR026805 GW182_M_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR032226 TNRC6_PABC-bd
IPR033501 TNRC6A
IPR034924 TNRC6A_RRM

The PANTHER Classification System

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PANTHERi
PTHR13020:SF28 PTHR13020:SF28, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10427 Ago_hook, 1 hit
PF12938 M_domain, 1 hit
PF16608 TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDV7-1) [UniParc]FASTAAdd to basket
Also known as: TNGW1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE
60 70 80 90 100
QKIKVPEQIK PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ
110 120 130 140 150
QQQPQQQQPQ QQPQPQPQQQ QPQQQPQALP RYPREVPPRF RHQEHKQLLK
160 170 180 190 200
RGQHFPVIAA NLGSAVKVLN SQSESSALTN QQPQNNGEVQ NSKNQSDINH
210 220 230 240 250
STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP SAPGSDPELA
260 270 280 290 300
SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS
310 320 330 340 350
SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS
360 370 380 390 400
SSNGGLNPST LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ
410 420 430 440 450
MPNNQSINSK VSGGSTHGTW GSLQETCESE VSGTQKVSFS GQPQNITTEM
460 470 480 490 500
TGPNNTTNFM TSSLPNSGSV QNNELPSSNT GAWRVSTMNH PQMQAPSGMN
510 520 530 540 550
GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ ANGDTVNATL
560 570 580 590 600
MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG
610 620 630 640 650
WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG
660 670 680 690 700
SATSQTNEQS SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ
710 720 730 740 750
HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ NTAWDTETSP RGERKTDNGT
760 770 780 790 800
EAWGSSATQT FNSGACIDKT SPNGNDTSSV SGWGDPKPAL RWGDSKGSNC
810 820 830 840 850
QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG DGQKSSQGWS
860 870 880 890 900
VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN
910 920 930 940 950
NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ
960 970 980 990 1000
DIVGSWGIPP ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME
1010 1020 1030 1040 1050
IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN SRSDQQAQVH QLLTPASAIS
1060 1070 1080 1090 1100
NKEASSGSGW GEPWGEPSTP ATTVDNGTSA WGKPIDSGPS WGEPIAAASS
1110 1120 1130 1140 1150
TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG WEEEEDVEIG
1160 1170 1180 1190 1200
MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW
1210 1220 1230 1240 1250
INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD
1260 1270 1280 1290 1300
YNRTVGKGPG SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL
1310 1320 1330 1340 1350
PPSNSALPNQ ALGSIAGLGM QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP
1360 1370 1380 1390 1400
PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL KYAPNNGGLN PLFGPQQVAM
1410 1420 1430 1440 1450
LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ DQQGRPLSVQ
1460 1470 1480 1490 1500
QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK
1510 1520 1530 1540 1550
GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL
1560 1570 1580 1590 1600
DQNSSKHGAI SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP
1610 1620 1630 1640 1650
NGSSSVNWPP EFRPGEPWKG YPNIDPETDP YVTPGSVINN LSINTVREVD
1660 1670 1680 1690 1700
HLRDRNSGSS SSLNTTLPST SAWSSIRASN YNVPLSSTAQ STSARNSDSK
1710 1720 1730 1740 1750
LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ KPPLSTWDNS
1760 1770 1780 1790 1800
PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL
1810 1820 1830 1840 1850
CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF
1860 1870 1880 1890 1900
ASEEEISRFF AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW
1910 1920 1930 1940 1950
NGAGLSGTNC GDLHGTSLWG TPHYSTSLWG PPSSSDPRGI SSPSPINAFL
1960
SVDHLGGGGE SM
Length:1,962
Mass (Da):210,297
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i963C054628E18592
GO
Isoform 2 (identifier: Q8NDV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Show »
Length:1,709
Mass (Da):182,053
Checksum:i6CCAC36D8FE45088
GO
Isoform 3 (identifier: Q8NDV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1232: Missing.
     1280-1328: Missing.
     1611-1962: Missing.

Show »
Length:329
Mass (Da):36,154
Checksum:i4A18C3669378FF04
GO
Isoform 4 (identifier: Q8NDV7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1801: Missing.

Show »
Length:161
Mass (Da):17,151
Checksum:i2725AD138B814BCE
GO
Isoform 5 (identifier: Q8NDV7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: MRELEAKATK...QKKATEQKIK → MAYFGGTLYWLIFSTPFLLLGL

Note: No experimental confirmation available.
Show »
Length:1,930
Mass (Da):206,363
Checksum:i24936EA0AD526EB1
GO
Isoform 6 (identifier: Q8NDV7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1328: Missing.

Show »
Length:1,913
Mass (Da):205,151
Checksum:i3F1228974880B3E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C269H7C269_HUMAN
Trinucleotide repeat-containing gen...
TNRC6A
906Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRT3H3BRT3_HUMAN
Trinucleotide repeat-containing gen...
TNRC6A
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L218I3L218_HUMAN
Trinucleotide repeat-containing gen...
TNRC6A
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTQ1H3BTQ1_HUMAN
Trinucleotide repeat-containing gen...
TNRC6A
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3S5I3L3S5_HUMAN
Trinucleotide repeat-containing gen...
TNRC6A
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91899 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD28525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31 – 34KKKK → TEKE in CAD37348 (Ref. 2) Curated4
Sequence conflicti1375V → VV in CAD28525 (PubMed:17974005).Curated1
Sequence conflicti1704S → F in BAA91899 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057251185N → K. Corresponds to variant dbSNP:rs11639856Ensembl.1
Natural variantiVAR_057252592A → T. Corresponds to variant dbSNP:rs6497759Ensembl.1
Natural variantiVAR_057253788P → S. Corresponds to variant dbSNP:rs3803716Ensembl.1
Natural variantiVAR_0572541268E → K. Corresponds to variant dbSNP:rs2112782Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0132921 – 1801Missing in isoform 4. 1 PublicationAdd BLAST1801
Alternative sequenceiVSP_0372871 – 1232Missing in isoform 3. 1 PublicationAdd BLAST1232
Alternative sequenceiVSP_0132941 – 253Missing in isoform 2. 1 PublicationAdd BLAST253
Alternative sequenceiVSP_0132951 – 54MRELE…EQKIK → MAYFGGTLYWLIFSTPFLLL GL in isoform 5. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0372881280 – 1328Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_0372891611 – 1962Missing in isoform 3. 1 PublicationAdd BLAST352

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY035864 mRNA Translation: AAK62026.1
AJ492221 mRNA Translation: CAD37348.1
AL713750 mRNA Translation: CAD28525.2 Different initiation.
AL833757 mRNA Translation: CAH56236.1
AC002565 Genomic DNA No translation available.
AC008731 Genomic DNA No translation available.
BC024324 mRNA Translation: AAH24324.2
BC068209 mRNA No translation available.
U80739 mRNA Translation: AAB91438.1
AB040893 mRNA Translation: BAA95984.1
AK001773 mRNA Translation: BAA91899.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10624.2 [Q8NDV7-1]
CCDS81959.1 [Q8NDV7-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001317449.1, NM_001330520.1 [Q8NDV7-6]
NP_055309.2, NM_014494.2 [Q8NDV7-1]
XP_005255314.1, XM_005255257.4 [Q8NDV7-2]
XP_016878642.1, XM_017023153.1 [Q8NDV7-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655057

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315183; ENSP00000326900; ENSG00000090905 [Q8NDV7-6]
ENST00000395799; ENSP00000379144; ENSG00000090905 [Q8NDV7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27327

UCSC genome browser

More...
UCSCi
uc002dmm.4 human [Q8NDV7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035864 mRNA Translation: AAK62026.1
AJ492221 mRNA Translation: CAD37348.1
AL713750 mRNA Translation: CAD28525.2 Different initiation.
AL833757 mRNA Translation: CAH56236.1
AC002565 Genomic DNA No translation available.
AC008731 Genomic DNA No translation available.
BC024324 mRNA Translation: AAH24324.2
BC068209 mRNA No translation available.
U80739 mRNA Translation: AAB91438.1
AB040893 mRNA Translation: BAA95984.1
AK001773 mRNA Translation: BAA91899.1 Different initiation.
CCDSiCCDS10624.2 [Q8NDV7-1]
CCDS81959.1 [Q8NDV7-6]
RefSeqiNP_001317449.1, NM_001330520.1 [Q8NDV7-6]
NP_055309.2, NM_014494.2 [Q8NDV7-1]
XP_005255314.1, XM_005255257.4 [Q8NDV7-2]
XP_016878642.1, XM_017023153.1 [Q8NDV7-2]
UniGeneiHs.655057

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W6VX-ray2.83B1073-1094[»]
ProteinModelPortaliQ8NDV7
SMRiQ8NDV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118141, 49 interactors
DIPiDIP-54489N
ELMiQ8NDV7
IntActiQ8NDV7, 85 interactors
MINTiQ8NDV7
STRINGi9606.ENSP00000379144

PTM databases

iPTMnetiQ8NDV7
PhosphoSitePlusiQ8NDV7

Polymorphism and mutation databases

BioMutaiTNRC6A
DMDMi296452846

Proteomic databases

EPDiQ8NDV7
MaxQBiQ8NDV7
PaxDbiQ8NDV7
PeptideAtlasiQ8NDV7
PRIDEiQ8NDV7
ProteomicsDBi73061
73062 [Q8NDV7-2]
73063 [Q8NDV7-3]
73064 [Q8NDV7-4]
73065 [Q8NDV7-5]
73066 [Q8NDV7-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315183; ENSP00000326900; ENSG00000090905 [Q8NDV7-6]
ENST00000395799; ENSP00000379144; ENSG00000090905 [Q8NDV7-1]
GeneIDi27327
KEGGihsa:27327
UCSCiuc002dmm.4 human [Q8NDV7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27327
DisGeNETi27327
EuPathDBiHostDB:ENSG00000090905.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNRC6A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012904
HIX0173209
HGNCiHGNC:11969 TNRC6A
HPAiHPA015305
HPA017869
MIMi610739 gene
neXtProtiNX_Q8NDV7
OpenTargetsiENSG00000090905
PharmGKBiPA36656

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF5S Eukaryota
ENOG41110AX LUCA
GeneTreeiENSGT00940000158180
HOVERGENiHBG062594
InParanoidiQ8NDV7
KOiK18412
OMAiSPYFDKD
OrthoDBiEOG091G00G6
PhylomeDBiQ8NDV7
TreeFamiTF329702

Enzyme and pathway databases

ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-4086398 Ca2+ pathway
R-HSA-426496 Post-transcriptional silencing by small RNAs
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723 Regulation of PTEN mRNA translation
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-8986944 Transcriptional Regulation by MECP2
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9022692 Regulation of MECP2 expression and activity

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNRC6A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNRC6A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27327

Protein Ontology

More...
PROi
PR:Q8NDV7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090905 Expressed in 205 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ8NDV7 baseline and differential
GenevisibleiQ8NDV7 HS

Family and domain databases

CDDicd12711 RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486 Argonaute_hook_dom
IPR026805 GW182_M_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR032226 TNRC6_PABC-bd
IPR033501 TNRC6A
IPR034924 TNRC6A_RRM
PANTHERiPTHR13020:SF28 PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427 Ago_hook, 1 hit
PF12938 M_domain, 1 hit
PF16608 TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR6A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDV7
Secondary accession number(s): C9JAR8
, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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