UniProtKB - Q8NDQ6 (ZN540_HUMAN)
Protein
Zinc finger protein 540
Gene
ZNF540
Organism
Homo sapiens (Human)
Status
Functioni
May act as a transcriptional repressor.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 187 – 209 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- translation repressor activity, mRNA regulatory element binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of translation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NDQ6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 540 |
Gene namesi | Name:ZNF540 ORF Names:Nbla10512 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171817.16 |
HGNCi | HGNC:25331, ZNF540 |
MIMi | 613903, gene |
neXtProti | NX_Q8NDQ6 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 163255 |
OpenTargetsi | ENSG00000171817 |
PharmGKBi | PA134980975 |
Miscellaneous databases
Pharosi | Q8NDQ6, Tbio |
Polymorphism and mutation databases
BioMutai | ZNF540 |
DMDMi | 74762556 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047641 | 1 – 660 | Zinc finger protein 540Add BLAST | 660 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 109 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q8NDQ6 |
MassIVEi | Q8NDQ6 |
PaxDbi | Q8NDQ6 |
PeptideAtlasi | Q8NDQ6 |
PRIDEi | Q8NDQ6 |
ProteomicsDBi | 73050 [Q8NDQ6-1] 73051 [Q8NDQ6-2] 73052 [Q8NDQ6-4] |
PTM databases
iPTMneti | Q8NDQ6 |
PhosphoSitePlusi | Q8NDQ6 |
Expressioni
Tissue specificityi
Expressed in several fetal tissues, including gut, heart, brain, muscle, lung, testis and liver.1 Publication
Gene expression databases
Bgeei | ENSG00000171817, Expressed in middle temporal gyrus and 173 other tissues |
ExpressionAtlasi | Q8NDQ6, baseline and differential |
Genevisiblei | Q8NDQ6, HS |
Organism-specific databases
HPAi | ENSG00000171817, Tissue enhanced (pituitary) |
Interactioni
Subunit structurei
May interact with MVP.
Protein-protein interaction databases
STRINGi | 9606.ENSP00000466274 |
Miscellaneous databases
RNActi | Q8NDQ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 77 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 187 – 209 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164340 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8NDQ6 |
OMAi | VFYFKEH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NDQ6 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 17 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NDQ6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHALVTFRD VAIDFSQKEW ECLDTTQRKL YRDVMLENYN NLVSLGYSGS
60 70 80 90 100
KPDVITLLEQ GKEPCVVARD VTGRQCPGLL SRHKTKKLSS EKDIHEISLS
110 120 130 140 150
KESIIEKSKT LRLKGSIFRN EWQNKSEFEG QQGLKERSIS QKKIVSKKMS
160 170 180 190 200
TDRKRPSFTL NQRIHNSEKS CDSHLVQHGK IDSDVKHDCK ECGSTFNNVY
210 220 230 240 250
QLTLHQKIHT GEKSCKCEKC GKVFSHSYQL TLHQRFHTGE KPYECQECGK
260 270 280 290 300
TFTLYPQLNR HQKIHTGKKP YMCKKCDKGF FSRLELTQHK RIHTGKKSYE
310 320 330 340 350
CKECGKVFQL IFYFKEHERI HTGKKPYECK ECGKAFSVCG QLTRHQKIHT
360 370 380 390 400
GVKPYECKEC GKTFRLSFYL TEHRRTHAGK KPYECKECGK SFNVRGQLNR
410 420 430 440 450
HKTIHTGIKP FACKVCEKAF SYSGDLRVHS RIHTGEKPYE CKECGKAFML
460 470 480 490 500
RSVLTEHQRL HTGVKPYECK ECGKTFRVRS QISLHKKIHT DVKPYKCVRC
510 520 530 540 550
GKTFRFGFYL TEHQRIHTGE KPYKCKECGK AFIRRGNLKE HLKIHSGLKP
560 570 580 590 600
YDCKECGKSF SRRGQFTEHQ KIHTGVKPYK CKECGKAFSR SVDLRIHQRI
610 620 630 640 650
HTGEKPYECK QCGKAFRLNS HLTEHQRIHT GEKPYECKVC RKAFRQYSHL
660
YQHQKTHNVI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EK80 | K7EK80_HUMAN | Zinc finger protein 540 | ZNF540 | 552 | Annotation score: | ||
K7EQ46 | K7EQ46_HUMAN | Zinc finger protein 540 | ZNF540 | 100 | Annotation score: | ||
K7ER55 | K7ER55_HUMAN | Zinc finger protein 540 | ZNF540 hCG_1821866 | 29 | Annotation score: |
Sequence cautioni
The sequence AAH17940 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAD97942 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | E → G in CAD97942 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033575 | 53 | D → V1 PublicationCorresponds to variant dbSNP:rs1975937Ensembl. | 1 | |
Natural variantiVAR_035586 | 275 | K → I in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_069366 | 340 | G → R1 PublicationCorresponds to variant dbSNP:rs571893947Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016036 | 1 – 77 | MAHAL…GRQCP → MLPNFKLYNFIEIFFKPLTP SKNRFHFVSYFENVNFMLCW LQENNFCLLLCFLS in isoform 4. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_016037 | 46 – 77 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131388 mRNA Translation: BAD18539.1 AK290486 mRNA Translation: BAF83175.1 AL832100 mRNA Translation: CAD91161.1 AL832315 mRNA Translation: CAD38611.1 BX537980 mRNA Translation: CAD97942.1 Frameshift. BC017940 mRNA Translation: AAH17940.1 Sequence problems. BC126478 mRNA Translation: AAI26479.1 BC126480 mRNA Translation: AAI26481.1 AB074186 mRNA Translation: BAE45743.1 |
CCDSi | CCDS12506.1 [Q8NDQ6-1] CCDS54258.1 [Q8NDQ6-2] |
RefSeqi | NP_001165696.1, NM_001172225.2 [Q8NDQ6-1] NP_001165697.1, NM_001172226.2 [Q8NDQ6-2] NP_689819.1, NM_152606.4 [Q8NDQ6-1] |
Genome annotation databases
Ensembli | ENST00000316433; ENSP00000324598; ENSG00000171817 [Q8NDQ6-1] ENST00000343599; ENSP00000343768; ENSG00000171817 [Q8NDQ6-1] ENST00000589117; ENSP00000467118; ENSG00000171817 [Q8NDQ6-2] ENST00000592533; ENSP00000466274; ENSG00000171817 [Q8NDQ6-1] |
GeneIDi | 163255 |
KEGGi | hsa:163255 |
UCSCi | uc002ogq.5, human [Q8NDQ6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131388 mRNA Translation: BAD18539.1 AK290486 mRNA Translation: BAF83175.1 AL832100 mRNA Translation: CAD91161.1 AL832315 mRNA Translation: CAD38611.1 BX537980 mRNA Translation: CAD97942.1 Frameshift. BC017940 mRNA Translation: AAH17940.1 Sequence problems. BC126478 mRNA Translation: AAI26479.1 BC126480 mRNA Translation: AAI26481.1 AB074186 mRNA Translation: BAE45743.1 |
CCDSi | CCDS12506.1 [Q8NDQ6-1] CCDS54258.1 [Q8NDQ6-2] |
RefSeqi | NP_001165696.1, NM_001172225.2 [Q8NDQ6-1] NP_001165697.1, NM_001172226.2 [Q8NDQ6-2] NP_689819.1, NM_152606.4 [Q8NDQ6-1] |
3D structure databases
SMRi | Q8NDQ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000466274 |
PTM databases
iPTMneti | Q8NDQ6 |
PhosphoSitePlusi | Q8NDQ6 |
Polymorphism and mutation databases
BioMutai | ZNF540 |
DMDMi | 74762556 |
Proteomic databases
jPOSTi | Q8NDQ6 |
MassIVEi | Q8NDQ6 |
PaxDbi | Q8NDQ6 |
PeptideAtlasi | Q8NDQ6 |
PRIDEi | Q8NDQ6 |
ProteomicsDBi | 73050 [Q8NDQ6-1] 73051 [Q8NDQ6-2] 73052 [Q8NDQ6-4] |
Protocols and materials databases
Antibodypediai | 836, 90 antibodies |
DNASUi | 163255 |
Genome annotation databases
Ensembli | ENST00000316433; ENSP00000324598; ENSG00000171817 [Q8NDQ6-1] ENST00000343599; ENSP00000343768; ENSG00000171817 [Q8NDQ6-1] ENST00000589117; ENSP00000467118; ENSG00000171817 [Q8NDQ6-2] ENST00000592533; ENSP00000466274; ENSG00000171817 [Q8NDQ6-1] |
GeneIDi | 163255 |
KEGGi | hsa:163255 |
UCSCi | uc002ogq.5, human [Q8NDQ6-1] |
Organism-specific databases
CTDi | 163255 |
DisGeNETi | 163255 |
EuPathDBi | HostDB:ENSG00000171817.16 |
GeneCardsi | ZNF540 |
HGNCi | HGNC:25331, ZNF540 |
HPAi | ENSG00000171817, Tissue enhanced (pituitary) |
MIMi | 613903, gene |
neXtProti | NX_Q8NDQ6 |
OpenTargetsi | ENSG00000171817 |
PharmGKBi | PA134980975 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164340 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8NDQ6 |
OMAi | VFYFKEH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NDQ6 |
Enzyme and pathway databases
PathwayCommonsi | Q8NDQ6 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 163255, 3 hits in 865 CRISPR screens |
ChiTaRSi | ZNF540, human |
GenomeRNAii | 163255 |
Pharosi | Q8NDQ6, Tbio |
PROi | PR:Q8NDQ6 |
RNActi | Q8NDQ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171817, Expressed in middle temporal gyrus and 173 other tissues |
ExpressionAtlasi | Q8NDQ6, baseline and differential |
Genevisiblei | Q8NDQ6, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 17 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN540_HUMAN | |
Accessioni | Q8NDQ6Primary (citable) accession number: Q8NDQ6 Secondary accession number(s): A0AVS5 Q86T31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations