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UniProtKB - Q8NDQ6 (ZN540_HUMAN)

Entry version 154 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Zinc finger protein 540

Gene

ZNF540

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri187 – 209C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NDQ6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 540
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF540
ORF Names:Nbla10512
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000171817.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:25331, ZNF540

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613903, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NDQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		163255

Open Targets

More...OpenTargetsi		ENSG00000171817

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134980975

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NDQ6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF540

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476411 – 660Zinc finger protein 540Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NDQ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NDQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NDQ6

PeptideAtlas

More...PeptideAtlasi		Q8NDQ6

PRoteomics IDEntifications database

More...PRIDEi		Q8NDQ6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73050 [Q8NDQ6-1]
73051 [Q8NDQ6-2]
73052 [Q8NDQ6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NDQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NDQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several fetal tissues, including gut, heart, brain, muscle, lung, testis and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171817, Expressed in middle temporal gyrus and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NDQ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NDQ6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171817, Tissue enhanced (pituitary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with MVP.

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000466274

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NDQ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NDQ6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri187 – 209C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164340

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NDQ6

Identification of Orthologs from Complete Genome Data

More...OMAi		VFYFKEH

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NDQ6

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 17 hits
PS50157, ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHALVTFRD VAIDFSQKEW ECLDTTQRKL YRDVMLENYN NLVSLGYSGS 
        60         70         80         90        100
KPDVITLLEQ GKEPCVVARD VTGRQCPGLL SRHKTKKLSS EKDIHEISLS 
       110        120        130        140        150
KESIIEKSKT LRLKGSIFRN EWQNKSEFEG QQGLKERSIS QKKIVSKKMS 
       160        170        180        190        200
TDRKRPSFTL NQRIHNSEKS CDSHLVQHGK IDSDVKHDCK ECGSTFNNVY 
       210        220        230        240        250
QLTLHQKIHT GEKSCKCEKC GKVFSHSYQL TLHQRFHTGE KPYECQECGK 
       260        270        280        290        300
TFTLYPQLNR HQKIHTGKKP YMCKKCDKGF FSRLELTQHK RIHTGKKSYE 
       310        320        330        340        350
CKECGKVFQL IFYFKEHERI HTGKKPYECK ECGKAFSVCG QLTRHQKIHT 
       360        370        380        390        400
GVKPYECKEC GKTFRLSFYL TEHRRTHAGK KPYECKECGK SFNVRGQLNR 
       410        420        430        440        450
HKTIHTGIKP FACKVCEKAF SYSGDLRVHS RIHTGEKPYE CKECGKAFML 
       460        470        480        490        500
RSVLTEHQRL HTGVKPYECK ECGKTFRVRS QISLHKKIHT DVKPYKCVRC 
       510        520        530        540        550
GKTFRFGFYL TEHQRIHTGE KPYKCKECGK AFIRRGNLKE HLKIHSGLKP 
       560        570        580        590        600
YDCKECGKSF SRRGQFTEHQ KIHTGVKPYK CKECGKAFSR SVDLRIHQRI 
       610        620        630        640        650
HTGEKPYECK QCGKAFRLNS HLTEHQRIHT GEKPYECKVC RKAFRQYSHL 
       660
YQHQKTHNVI
Length:660
Mass (Da):77,094
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9115ABB3B056D9B3
GO
Isoform 2 (identifier: Q8NDQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-77: Missing.

Show »
Length:628
Mass (Da):73,708
Checksum:i9F9A840C17682706
GO
Isoform 4 (identifier: Q8NDQ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MAHALVTFRD...ARDVTGRQCP → MLPNFKLYNF...NFCLLLCFLS

Show »
Length:637
Mass (Da):74,993
Checksum:i7A0FCC9ED61BDE68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EK80K7EK80_HUMAN
Zinc finger protein 540
ZNF540
552Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ46K7EQ46_HUMAN
Zinc finger protein 540
ZNF540
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER55K7ER55_HUMAN
Zinc finger protein 540
ZNF540 hCG_1821866
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17940 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAD97942 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127E → G in CAD97942 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03357553D → V1 PublicationCorresponds to variant dbSNP:rs1975937Ensembl.1
Natural variantiVAR_035586275K → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_069366340G → R1 PublicationCorresponds to variant dbSNP:rs571893947Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160361 – 77MAHAL…GRQCP → MLPNFKLYNFIEIFFKPLTP SKNRFHFVSYFENVNFMLCW LQENNFCLLLCFLS in isoform 4. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01603746 – 77Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK131388 mRNA Translation: BAD18539.1
AK290486 mRNA Translation: BAF83175.1
AL832100 mRNA Translation: CAD91161.1
AL832315 mRNA Translation: CAD38611.1
BX537980 mRNA Translation: CAD97942.1 Frameshift.
BC017940 mRNA Translation: AAH17940.1 Sequence problems.
BC126478 mRNA Translation: AAI26479.1
BC126480 mRNA Translation: AAI26481.1
AB074186 mRNA Translation: BAE45743.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12506.1 [Q8NDQ6-1]
CCDS54258.1 [Q8NDQ6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001165696.1, NM_001172225.2 [Q8NDQ6-1]
NP_001165697.1, NM_001172226.2 [Q8NDQ6-2]
NP_689819.1, NM_152606.4 [Q8NDQ6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316433; ENSP00000324598; ENSG00000171817 [Q8NDQ6-1]
ENST00000343599; ENSP00000343768; ENSG00000171817 [Q8NDQ6-1]
ENST00000589117; ENSP00000467118; ENSG00000171817 [Q8NDQ6-2]
ENST00000592533; ENSP00000466274; ENSG00000171817 [Q8NDQ6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		163255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:163255

UCSC genome browser

More...UCSCi		uc002ogq.5, human [Q8NDQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131388 mRNA Translation: BAD18539.1
AK290486 mRNA Translation: BAF83175.1
AL832100 mRNA Translation: CAD91161.1
AL832315 mRNA Translation: CAD38611.1
BX537980 mRNA Translation: CAD97942.1 Frameshift.
BC017940 mRNA Translation: AAH17940.1 Sequence problems.
BC126478 mRNA Translation: AAI26479.1
BC126480 mRNA Translation: AAI26481.1
AB074186 mRNA Translation: BAE45743.1
CCDSiCCDS12506.1 [Q8NDQ6-1]
CCDS54258.1 [Q8NDQ6-2]
RefSeqiNP_001165696.1, NM_001172225.2 [Q8NDQ6-1]
NP_001165697.1, NM_001172226.2 [Q8NDQ6-2]
NP_689819.1, NM_152606.4 [Q8NDQ6-1]

3D structure databases

SMRiQ8NDQ6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000466274

PTM databases

iPTMnetiQ8NDQ6
PhosphoSitePlusiQ8NDQ6

Polymorphism and mutation databases

BioMutaiZNF540
DMDMi74762556

Proteomic databases

jPOSTiQ8NDQ6
MassIVEiQ8NDQ6
PaxDbiQ8NDQ6
PeptideAtlasiQ8NDQ6
PRIDEiQ8NDQ6
ProteomicsDBi73050 [Q8NDQ6-1]
73051 [Q8NDQ6-2]
73052 [Q8NDQ6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		836, 90 antibodies

The DNASU plasmid repository

More...DNASUi		163255

Genome annotation databases

EnsembliENST00000316433; ENSP00000324598; ENSG00000171817 [Q8NDQ6-1]
ENST00000343599; ENSP00000343768; ENSG00000171817 [Q8NDQ6-1]
ENST00000589117; ENSP00000467118; ENSG00000171817 [Q8NDQ6-2]
ENST00000592533; ENSP00000466274; ENSG00000171817 [Q8NDQ6-1]
GeneIDi163255
KEGGihsa:163255
UCSCiuc002ogq.5, human [Q8NDQ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		163255
DisGeNETi163255
EuPathDBiHostDB:ENSG00000171817.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF540
HGNCiHGNC:25331, ZNF540
HPAiENSG00000171817, Tissue enhanced (pituitary)
MIMi613903, gene
neXtProtiNX_Q8NDQ6
OpenTargetsiENSG00000171817
PharmGKBiPA134980975

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164340
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8NDQ6
OMAiVFYFKEH
OrthoDBi1318335at2759
PhylomeDBiQ8NDQ6

Enzyme and pathway databases

PathwayCommonsiQ8NDQ6
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		163255, 3 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF540, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		163255
PharosiQ8NDQ6, Tbio

Protein Ontology

More...PROi		PR:Q8NDQ6
RNActiQ8NDQ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171817, Expressed in middle temporal gyrus and 173 other tissues
ExpressionAtlasiQ8NDQ6, baseline and differential
GenevisibleiQ8NDQ6, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 17 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 17 hits
PS50157, ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN540_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDQ6
Secondary accession number(s): A0AVS5
, A8K371, Q05D58, Q3LIC5, Q6ZN36, Q7Z3C8, Q86T31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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