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Entry version 154 (31 Jul 2019)
Sequence version 1 (01 Oct 2002)
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Protein

RCC1 and BTB domain-containing protein 1

Gene

RCBTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell cycle regulation by chromatin remodeling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processCell cycle, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RCC1 and BTB domain-containing protein 1
Alternative name(s):
Chronic lymphocytic leukemia deletion region gene 7 protein
Short name:
CLL deletion region gene 7 protein
Regulator of chromosome condensation and BTB domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RCBTB1
Synonyms:CLLD7, E4.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18243 RCBTB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607867 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDN9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinal dystrophy with or without extraocular anomalies (RDEOA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by progressive retinal dystrophy, chorioretinal macular atrophy, reduced cone and rod responses on ERG, and decrease visual acuity. Extraocular anomalies are variably present in some patients and include pulmonary fibrosis, sensorineural hearing loss, and endocrine features such as goiter and primary ovarian insufficiency.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077962307V → M in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs368217569EnsemblClinVar.1
Natural variantiVAR_077963310W → C in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs772592456EnsemblClinVar.1
Natural variantiVAR_077964325H → Y in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs200826424EnsemblClinVar.1
Natural variantiVAR_077965384H → R in RDEOA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143970072EnsemblClinVar.1
Natural variantiVAR_077966388L → F in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs879255547EnsemblClinVar.1
Natural variantiVAR_077967401S → L in RDEOA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs556664001EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
55213

MalaCards human disease database

More...
MalaCardsi
RCBTB1
MIMi617175 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136144

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99002 Reticular dystrophy of the retinal pigment epithelium

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134955699

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RCBTB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751227

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066421 – 531RCC1 and BTB domain-containing protein 1Add BLAST531

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NDN9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NDN9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NDN9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDN9

PeptideAtlas

More...
PeptideAtlasi
Q8NDN9

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDN9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73045 [Q8NDN9-1]
73046 [Q8NDN9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (PubMed:11306461, PubMed:27486781). In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level) (PubMed:27486781).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136144 Expressed in 218 organ(s), highest expression level in left lobe of thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NDN9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056783

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120509, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NDN9, 10 interactors

Molecular INTeraction database

More...
MINTi
Q8NDN9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDN9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 91RCC1 1Add BLAST52
Repeati93 – 145RCC1 2Add BLAST53
Repeati147 – 198RCC1 3Add BLAST52
Repeati199 – 250RCC1 4Add BLAST52
Repeati252 – 302RCC1 5Add BLAST51
Repeati304 – 356RCC1 6Add BLAST53
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini370 – 437BTB 1PROSITE-ProRule annotationAdd BLAST68
Domaini470 – 499BTB 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1426 Eukaryota
COG5184 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155814

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065752

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDN9

KEGG Orthology (KO)

More...
KOi
K11494

Identification of Orthologs from Complete Genome Data

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OMAi
FQSHWNE

Database of Orthologous Groups

More...
OrthoDBi
1062377at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDN9

TreeFam database of animal gene trees

More...
TreeFami
TF329478

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00415 RCC1, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NDN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDVGKWPIF TLLSPQEIAS IRKACVFGTS ASEALYVTDN DEVFVFGLNY
60 70 80 90 100
SNCLGTGDNQ STLVPKKLEG LCGKKIKSLS YGSGPHVLLS TEDGVVYAWG
110 120 130 140 150
HNGYSQLGNG TTNQGIAPVQ VCTNLLIKQV VEVACGSHHS MALAADGEVF
160 170 180 190 200
AWGYNNCGQV GSGSTANQPT PRKVTNCLHI KRVVGIACGQ TSSMAVLDNG
210 220 230 240 250
EVYGWGYNGN GQLGLGNNGN QLTPVRVAAL HSVCVNQIVC GYAHTLALTD
260 270 280 290 300
EGLLYAWGAN TYGQLGTGNK NNLLSPAHIM VEKERVVEIA ACHSAHTSAA
310 320 330 340 350
KTQGGHVYMW GQCRGQSVIL PHLTHFSCTD DVFACFATPA VSWRLLSVEH
360 370 380 390 400
EDFLTVAESL KKEFDSPETA DLKFRIDGKY IHVHKAVLKI RCEHFRSMFQ
410 420 430 440 450
SYWNEDMKEV IEIDQFSYPV YRAFLQYLYT DTVDLPPEDA IGLLDLATSY
460 470 480 490 500
CENRLKKLCQ HIIKRGITVE NAFSLFSAAV RYDAEDLEEF CFKFCINHLT
510 520 530
EVTQTAAFWQ MDGPLLKEFI AKASKCGAFK N
Length:531
Mass (Da):58,252
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79CCF6B5C8F75855
GO
Isoform 2 (identifier: Q8NDN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-355: EHEDFLT → VSIVIGK
     356-531: Missing.

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):37,591
Checksum:i8AE9263537803C86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118P → T in AAH38104 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02475724A → V4 PublicationsCorresponds to variant dbSNP:rs4942848Ensembl.1
Natural variantiVAR_077962307V → M in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs368217569EnsemblClinVar.1
Natural variantiVAR_077963310W → C in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs772592456EnsemblClinVar.1
Natural variantiVAR_077964325H → Y in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs200826424EnsemblClinVar.1
Natural variantiVAR_077965384H → R in RDEOA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143970072EnsemblClinVar.1
Natural variantiVAR_077966388L → F in RDEOA. 1 PublicationCorresponds to variant dbSNP:rs879255547EnsemblClinVar.1
Natural variantiVAR_077967401S → L in RDEOA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs556664001EnsemblClinVar.1
Natural variantiVAR_024830500T → I1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040263349 – 355EHEDFLT → VSIVIGK in isoform 2. 1 Publication7
Alternative sequenceiVSP_040264356 – 531Missing in isoform 2. 1 PublicationAdd BLAST176

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF334406 mRNA Translation: AAK38372.1
AJ319660 mRNA Translation: CAC40027.1
AK096654 mRNA Translation: BAC04833.1
AL833821 mRNA Translation: CAD38683.1
AL139321 Genomic DNA No translation available.
BC038104 mRNA Translation: AAH38104.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9418.1 [Q8NDN9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060661.3, NM_018191.3 [Q8NDN9-1]
XP_005266498.1, XM_005266441.2
XP_011533435.1, XM_011535133.1
XP_011533436.1, XM_011535134.1 [Q8NDN9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258646; ENSP00000258646; ENSG00000136144 [Q8NDN9-1]
ENST00000378302; ENSP00000367552; ENSG00000136144 [Q8NDN9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55213

UCSC genome browser

More...
UCSCi
uc001vde.1 human [Q8NDN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334406 mRNA Translation: AAK38372.1
AJ319660 mRNA Translation: CAC40027.1
AK096654 mRNA Translation: BAC04833.1
AL833821 mRNA Translation: CAD38683.1
AL139321 Genomic DNA No translation available.
BC038104 mRNA Translation: AAH38104.1
CCDSiCCDS9418.1 [Q8NDN9-1]
RefSeqiNP_060661.3, NM_018191.3 [Q8NDN9-1]
XP_005266498.1, XM_005266441.2
XP_011533435.1, XM_011535133.1
XP_011533436.1, XM_011535134.1 [Q8NDN9-1]

3D structure databases

SMRiQ8NDN9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120509, 17 interactors
IntActiQ8NDN9, 10 interactors
MINTiQ8NDN9
STRINGi9606.ENSP00000367552

PTM databases

iPTMnetiQ8NDN9
PhosphoSitePlusiQ8NDN9

Polymorphism and mutation databases

BioMutaiRCBTB1
DMDMi74751227

Proteomic databases

EPDiQ8NDN9
jPOSTiQ8NDN9
MaxQBiQ8NDN9
PaxDbiQ8NDN9
PeptideAtlasiQ8NDN9
PRIDEiQ8NDN9
ProteomicsDBi73045 [Q8NDN9-1]
73046 [Q8NDN9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258646; ENSP00000258646; ENSG00000136144 [Q8NDN9-1]
ENST00000378302; ENSP00000367552; ENSG00000136144 [Q8NDN9-1]
GeneIDi55213
KEGGihsa:55213
UCSCiuc001vde.1 human [Q8NDN9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55213
DisGeNETi55213

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RCBTB1
HGNCiHGNC:18243 RCBTB1
HPAiHPA056783
MalaCardsiRCBTB1
MIMi607867 gene
617175 phenotype
neXtProtiNX_Q8NDN9
OpenTargetsiENSG00000136144
Orphaneti99002 Reticular dystrophy of the retinal pigment epithelium
PharmGKBiPA134955699

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
GeneTreeiENSGT00940000155814
HOGENOMiHOG000065752
InParanoidiQ8NDN9
KOiK11494
OMAiFQSHWNE
OrthoDBi1062377at2759
PhylomeDBiQ8NDN9
TreeFamiTF329478

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RCBTB1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RCBTB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55213

Protein Ontology

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PROi
PR:Q8NDN9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136144 Expressed in 218 organ(s), highest expression level in left lobe of thyroid gland
GenevisibleiQ8NDN9 HS

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00415 RCC1, 5 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRCBT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDN9
Secondary accession number(s): Q8IY29, Q969U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 31, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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