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Entry version 131 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Islet cell autoantigen 1-like protein

Gene

ICA1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • regulation of transport Source: GO_Central

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NDH6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Islet cell autoantigen 1-like protein
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICA1L
Synonyms:ALS2CR14, ALS2CR15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14442, ICA1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDH6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000163596.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
130026

Open Targets

More...
OpenTargetsi
ENSG00000163596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24738

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NDH6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ICA1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000761751 – 482Islet cell autoantigen 1-like proteinAdd BLAST482

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NDH6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NDH6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NDH6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDH6

PeptideAtlas

More...
PeptideAtlasi
Q8NDH6

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDH6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73030 [Q8NDH6-1]
73031 [Q8NDH6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDH6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDH6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163596, Expressed in bronchial epithelial cell and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NDH6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDH6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163596, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126218, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NDH6, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NDH6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDH6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 247AHPROSITE-ProRule annotationAdd BLAST204

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni365 – 393DisorderedSequence analysisAdd BLAST29
Regioni427 – 449DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi365 – 389Polar residuesSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3891, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005530

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037158_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDH6

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIHEEFT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDH6

TreeFam database of animal gene trees

More...
TreeFami
TF317186

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR024114, Islet_autoAg_Ica1/Ica1-like
IPR006723, Islet_autoAg_Ica1_C

The PANTHER Classification System

More...
PANTHERi
PTHR10164, PTHR10164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06456, Arfaptin, 1 hit
PF04629, ICA69, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01015, Arfaptin, 1 hit
SM01237, ICA69, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50870, AH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSFGQPRPE DNQSVVRRMQ KKYWKTKQVF IKATGKKEDE HLVASDAELD
60 70 80 90 100
AKLEVFHSVQ ETCTELLKII EKYQLRLNVI SEEENELGLF LKFQAERDAT
110 120 130 140 150
QAGKMMDATG KALCSSAKQR LALCTPLSRL KQEVATFSQR AVSDTLMTIN
160 170 180 190 200
RMEQARTEYR GALLWMKDVS QELDPDTLKQ MEKFRKVQMQ VRNSKASFDK
210 220 230 240 250
LKMDVCQKVD LLGASRCNML SHSLTTYQRT LLGFWKKTAR MMSQIHEACI
260 270 280 290 300
GFHPYDFVAL KQLQDTPSKI SEDNKDEQIG GFLTEQLNKL VLSDEEASFE
310 320 330 340 350
SEQANKDHNE KHSQMREFGA PQFSNSENVA KDLPVDSLEG EDFEKEFSFL
360 370 380 390 400
NNLLSSGSSS TSEFTQECQT AFGSPSASLT SQEPSMGSEP LAHSSRFLPS
410 420 430 440 450
QLFDLGFHVA GAFNNWVSQE ESELCLSHTD NQPVPSQSPK KLTRSPNNGN
460 470 480
QDMSAWFNLF ADLDPLSNPD AIGHSDDELL NA
Length:482
Mass (Da):54,407
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB54E9658DA12DCC
GO
Isoform 2 (identifier: Q8NDH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-482: Missing.

Show »
Length:187
Mass (Da):21,581
Checksum:i26EE3DD4A502225E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9Z8C9J9Z8_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAQ4C9JAQ4_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDK6C9JDK6_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDM8C9JDM8_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEN4C9JEN4_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEP0C9JEP0_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBQ1F8WBQ1_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0T2C9J0T2_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1M7C9J1M7_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5Z0C9J5Z0_HUMAN
Islet cell autoantigen 1-like prote...
ICA1L
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242M → V in BAB71062 (PubMed:14702039).Curated1
Sequence conflicti294D → N in BAB69025 (PubMed:11586298).Curated1
Sequence conflicti334P → S in BAB69025 (PubMed:11586298).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017107188 – 482Missing in isoform 2. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055978 mRNA Translation: BAB71062.1
AK092310 mRNA Translation: BAG52528.1
AL833904 mRNA Translation: CAD38760.1
AC010900 Genomic DNA Translation: AAY24286.1
AC098831 Genomic DNA Translation: AAY24091.1
AC131950 Genomic DNA Translation: AAY15007.1
CH471063 Genomic DNA Translation: EAW70313.1
BC000993 mRNA Translation: AAH00993.2
BC063876 mRNA Translation: AAH63876.1
AB053317 mRNA Translation: BAB69025.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2354.1 [Q8NDH6-1]
CCDS74632.1 [Q8NDH6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001275551.1, NM_001288622.1 [Q8NDH6-1]
NP_001275552.1, NM_001288623.1 [Q8NDH6-1]
NP_001275553.1, NM_001288624.1 [Q8NDH6-2]
NP_612477.3, NM_138468.5 [Q8NDH6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358299; ENSP00000351047; ENSG00000163596 [Q8NDH6-1]
ENST00000392237; ENSP00000376070; ENSG00000163596 [Q8NDH6-1]
ENST00000425178; ENSP00000404189; ENSG00000163596 [Q8NDH6-2]
ENST00000617388; ENSP00000478645; ENSG00000163596 [Q8NDH6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130026

UCSC genome browser

More...
UCSCi
uc002uzh.3, human [Q8NDH6-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055978 mRNA Translation: BAB71062.1
AK092310 mRNA Translation: BAG52528.1
AL833904 mRNA Translation: CAD38760.1
AC010900 Genomic DNA Translation: AAY24286.1
AC098831 Genomic DNA Translation: AAY24091.1
AC131950 Genomic DNA Translation: AAY15007.1
CH471063 Genomic DNA Translation: EAW70313.1
BC000993 mRNA Translation: AAH00993.2
BC063876 mRNA Translation: AAH63876.1
AB053317 mRNA Translation: BAB69025.1
CCDSiCCDS2354.1 [Q8NDH6-1]
CCDS74632.1 [Q8NDH6-2]
RefSeqiNP_001275551.1, NM_001288622.1 [Q8NDH6-1]
NP_001275552.1, NM_001288623.1 [Q8NDH6-1]
NP_001275553.1, NM_001288624.1 [Q8NDH6-2]
NP_612477.3, NM_138468.5 [Q8NDH6-1]

3D structure databases

SMRiQ8NDH6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126218, 12 interactors
IntActiQ8NDH6, 17 interactors
STRINGi9606.ENSP00000478645

PTM databases

iPTMnetiQ8NDH6
PhosphoSitePlusiQ8NDH6

Genetic variation databases

BioMutaiICA1L
DMDMi74751222

Proteomic databases

EPDiQ8NDH6
jPOSTiQ8NDH6
MassIVEiQ8NDH6
PaxDbiQ8NDH6
PeptideAtlasiQ8NDH6
PRIDEiQ8NDH6
ProteomicsDBi73030 [Q8NDH6-1]
73031 [Q8NDH6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34156, 94 antibodies

The DNASU plasmid repository

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DNASUi
130026

Genome annotation databases

EnsembliENST00000358299; ENSP00000351047; ENSG00000163596 [Q8NDH6-1]
ENST00000392237; ENSP00000376070; ENSG00000163596 [Q8NDH6-1]
ENST00000425178; ENSP00000404189; ENSG00000163596 [Q8NDH6-2]
ENST00000617388; ENSP00000478645; ENSG00000163596 [Q8NDH6-1]
GeneIDi130026
KEGGihsa:130026
UCSCiuc002uzh.3, human [Q8NDH6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
130026
DisGeNETi130026

GeneCards: human genes, protein and diseases

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GeneCardsi
ICA1L
HGNCiHGNC:14442, ICA1L
HPAiENSG00000163596, Low tissue specificity
neXtProtiNX_Q8NDH6
OpenTargetsiENSG00000163596
PharmGKBiPA24738
VEuPathDBiHostDB:ENSG00000163596.16

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3891, Eukaryota
GeneTreeiENSGT00390000005530
HOGENOMiCLU_037158_1_0_1
InParanoidiQ8NDH6
OMAiRIHEEFT
PhylomeDBiQ8NDH6
TreeFamiTF317186

Enzyme and pathway databases

PathwayCommonsiQ8NDH6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
130026, 4 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ICA1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
130026
PharosiQ8NDH6, Tdark

Protein Ontology

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PROi
PR:Q8NDH6
RNActiQ8NDH6, protein

Gene expression databases

BgeeiENSG00000163596, Expressed in bronchial epithelial cell and 210 other tissues
ExpressionAtlasiQ8NDH6, baseline and differential
GenevisibleiQ8NDH6, HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR010504, AH_dom
IPR024114, Islet_autoAg_Ica1/Ica1-like
IPR006723, Islet_autoAg_Ica1_C
PANTHERiPTHR10164, PTHR10164, 1 hit
PfamiView protein in Pfam
PF06456, Arfaptin, 1 hit
PF04629, ICA69, 1 hit
SMARTiView protein in SMART
SM01015, Arfaptin, 1 hit
SM01237, ICA69, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870, AH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICA1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDH6
Secondary accession number(s): B3KRW6
, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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