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Entry version 143 (31 Jul 2019)
Sequence version 3 (02 Mar 2010)
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Protein

ATP-dependent RNA helicase TDRD9

Gene

TDRD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi155 – 162ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase TDRD9Curated (EC:3.6.4.13By similarity)
Alternative name(s):
Tudor domain-containing protein 9Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD9Imported
Synonyms:C14orf75Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20122 TDRD9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617963 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDG6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 30 (SPGF30)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia or cryptozoospermia.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
122402
MIMi618110 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156414

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134890186

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003338131 – 1382ATP-dependent RNA helicase TDRD9Add BLAST1382

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NDG6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDG6

PeptideAtlas

More...
PeptideAtlasi
Q8NDG6

PRoteomics IDEntifications database

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PRIDEi
Q8NDG6

ProteomicsDB human proteome resource

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ProteomicsDBi
73024 [Q8NDG6-1]
73025 [Q8NDG6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000156414 Expressed in 134 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NDG6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDG6 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with piRNA-associated proteins PIWIL1 and PIWIL4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125766, 3 interactors

Protein interaction database and analysis system

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IntActi
Q8NDG6, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000387303

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDG6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 308Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini377 – 544Helicase C-terminalPROSITE-ProRule annotationAdd BLAST168
Domaini944 – 1004TudorPROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi254 – 257DEAH boxBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0920 Eukaryota
COG1643 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157035

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDG6

KEGG Orthology (KO)

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KOi
K18408

Identification of Orthologs from Complete Genome Data

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OMAi
DPCRTVY

Database of Orthologous Groups

More...
OrthoDBi
278674at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NDG6

TreeFam database of animal gene trees

More...
TreeFami
TF324869

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF00567 TUDOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00333 TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50304 TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRKLTIEQI NDWFTIGKTV TNVELLGAPP AFPAGAAREE VQRQDVAPGA
60 70 80 90 100
GPAAQAPALA QAPARPAAAF ERSLSQRSSE VEYINKYRQL EAQELDVCRS
110 120 130 140 150
VQPTSGPGPR PSLAKLSSVT CIPGTTYKYP DLPISRYKEE VVSLIESNSV
160 170 180 190 200
VIIHGATGSG KSTQLPQYIL DHYVQRSAYC SIVVTQPRKI GASSIARWIS
210 220 230 240 250
KERAWTLGGV VGYQVGLEKI ATEDTRLIYM TTGVLLQKIV SAKSLMEFTH
260 270 280 290 300
IIIDEVHERT EEMDFLLLVV RKLLRTNSRF VKVVLMSATI SCKEFADYFA
310 320 330 340 350
VPVQNKMNPA YIFEVEGKPH SVEEYYLNDL EHIHHSKLSP HLLEEPVITK
360 370 380 390 400
DIYEVAVSLI QMFDDLDMKE SGNKAWSGAQ FVLERSSVLV FLPGLGEINY
410 420 430 440 450
MHELLTSLVH KRLQVYPLHS SVALEEQNNV FLSPVPGYRK IILSTNIAES
460 470 480 490 500
SVTVPDVKYV IDFCLTRTLV CDEDTNYQSL RLSWASKTSC NQRKGRAGRV
510 520 530 540 550
SRGYCYRLVH KDFWDNSIPD HVVPEMLRCP LGSTILKVKL LDMGEPRALL
560 570 580 590 600
ATALSPPGLS DIERTILLLK EVGALAVSGQ REDENPHDGE LTFLGRVLAQ
610 620 630 640 650
LPVNQQLGKL IVLGHVFGCL DECLIIAAAL SLKNFFAMPF RQHLDGYRNK
660 670 680 690 700
VNFSGSSKSD CIALVEAFKT WKACRQTGEL RYPKDELNWG RLNYIQIKRI
710 720 730 740 750
REVAELYEEL KTRISQFNMH VDSRRPVMDQ EYIYKQRFIL QVVLAGAFYP
760 770 780 790 800
NYFTFGQPDE EMAVRELAGK DPKTTVVLKH IPPYGFLYYK QLQSLFRQCG
810 820 830 840 850
QVKSIVFDGA KAFVEFSRNP TERFKTLPAV YMAIKMSQLK VSLELSVHSA
860 870 880 890 900
EEIEGKVQGM NVSKLRNTRV NVDFQKQTVD PMQVSFNTSD RSQTVTDLLL
910 920 930 940 950
TIDVTEVVEV GHFWGYRIDE NNSEILKKLT AEINQLTLVP LPTHPHPDLV
960 970 980 990 1000
CLAPFADFDK QRYFRAQVLY VSGNSAEVFF VDYGNKSHVD LHLLMEIPCQ
1010 1020 1030 1040 1050
FLELPFQALE FKICKMRPSA KSLVCGKHWS DGASQWFASL VSGCTLLVKV
1060 1070 1080 1090 1100
FSVVHSVLHV DVYQYSGVQD AINIRDVLIQ QGYAELTEES YESKQSHEVL
1110 1120 1130 1140 1150
KGLFSKSVEN MTDGSVPFPM KDDEKYLIRI LLESFSTNKL GTPNCKAELH
1160 1170 1180 1190 1200
GPFNPYELKC HSLTRISKFR CVWIEKESIN SVIISDAPED LHQRMLVAAS
1210 1220 1230 1240 1250
LSINATGSTM LLRETSLMPH IPGLPALLSM LFAPVIELRI DQNGKYYTGV
1260 1270 1280 1290 1300
LCGLGWNPAT GASILPEHDM ELAFDVQFSV EDVVEVNILR AAINKLVCDG
1310 1320 1330 1340 1350
PNGCKCLGPE RVAQLQDIAR QKLLGLFCQS KPREKIVPKW HEKPYEWNQV
1360 1370 1380
DPKLVMEQAD RESSRGKNTF LYQLHKLVVL GT
Length:1,382
Mass (Da):155,683
Last modified:March 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A48E71E4A12041F
GO
Isoform 2 (identifier: Q8NDG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1095-1285: Missing.

Note: No experimental confirmation available.
Show »
Length:1,191
Mass (Da):134,466
Checksum:i6362D3EA9EAC4D2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFS5A0A0C4DFS5_HUMAN
ATP-dependent RNA helicase TDRD9
TDRD9
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJJ2H0YJJ2_HUMAN
ATP-dependent RNA helicase TDRD9
TDRD9
918Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI28058 differs from that shown. Reason: Frameshift at position 1159.Curated
The sequence AAI28058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04182 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05047 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05144 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86372 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti758P → L in BAC05047 (PubMed:14702039).Curated1
Sequence conflicti1260T → G in AAH16796 (PubMed:15489334).Curated1
Sequence conflicti1276V → F in BAC05144 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0335521095 – 1285Missing in isoform 2. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL132712 Genomic DNA No translation available.
AL136001 Genomic DNA No translation available.
AL833915 mRNA Translation: CAD38771.1
AK093483 mRNA Translation: BAC04182.1 Different initiation.
AK097429 mRNA Translation: BAC05047.1 Different initiation.
AK097699 mRNA Translation: BAC05144.1 Different initiation.
AK125978 mRNA Translation: BAC86372.1 Different initiation.
BC016796 mRNA Translation: AAH16796.1
BC128057 mRNA Translation: AAI28058.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS9987.2 [Q8NDG6-1]

Protein sequence database of the Protein Information Resource

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PIRi
G02632

NCBI Reference Sequences

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RefSeqi
NP_694591.2, NM_153046.2 [Q8NDG6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409874; ENSP00000387303; ENSG00000156414 [Q8NDG6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
122402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122402

UCSC genome browser

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UCSCi
uc001yom.5 human [Q8NDG6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132712 Genomic DNA No translation available.
AL136001 Genomic DNA No translation available.
AL833915 mRNA Translation: CAD38771.1
AK093483 mRNA Translation: BAC04182.1 Different initiation.
AK097429 mRNA Translation: BAC05047.1 Different initiation.
AK097699 mRNA Translation: BAC05144.1 Different initiation.
AK125978 mRNA Translation: BAC86372.1 Different initiation.
BC016796 mRNA Translation: AAH16796.1
BC128057 mRNA Translation: AAI28058.1 Sequence problems.
CCDSiCCDS9987.2 [Q8NDG6-1]
PIRiG02632
RefSeqiNP_694591.2, NM_153046.2 [Q8NDG6-1]

3D structure databases

SMRiQ8NDG6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125766, 3 interactors
IntActiQ8NDG6, 1 interactor
STRINGi9606.ENSP00000387303

PTM databases

iPTMnetiQ8NDG6
PhosphoSitePlusiQ8NDG6

Polymorphism and mutation databases

BioMutaiTDRD9

Proteomic databases

jPOSTiQ8NDG6
PaxDbiQ8NDG6
PeptideAtlasiQ8NDG6
PRIDEiQ8NDG6
ProteomicsDBi73024 [Q8NDG6-1]
73025 [Q8NDG6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409874; ENSP00000387303; ENSG00000156414 [Q8NDG6-1]
GeneIDi122402
KEGGihsa:122402
UCSCiuc001yom.5 human [Q8NDG6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
122402
DisGeNETi122402

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TDRD9
HGNCiHGNC:20122 TDRD9
MIMi617963 gene
618110 phenotype
neXtProtiNX_Q8NDG6
OpenTargetsiENSG00000156414
Orphaneti399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation
PharmGKBiPA134890186

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00940000157035
InParanoidiQ8NDG6
KOiK18408
OMAiDPCRTVY
OrthoDBi278674at2759
PhylomeDBiQ8NDG6
TreeFamiTF324869

Enzyme and pathway databases

ReactomeiR-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TDRD9 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
122402

Protein Ontology

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PROi
PR:Q8NDG6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156414 Expressed in 134 organ(s), highest expression level in testis
ExpressionAtlasiQ8NDG6 baseline and differential
GenevisibleiQ8NDG6 HS

Family and domain databases

Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50304 TUDOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDG6
Secondary accession number(s): A1A4S7
, Q6ZU54, Q8N7T3, Q8N827, Q8N9V5, Q96AS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 2, 2010
Last modified: July 31, 2019
This is version 143 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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