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Entry version 133 (13 Feb 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Terminal nucleotidyltransferase 4A

Gene

TENT4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037).7 Publications

Caution

Was originally thought to have DNA polymerase activity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi177Magnesium or manganese; catalyticBy similarity1
Metal bindingi179Magnesium or manganese; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: UniProtKB-KW
  • guanylyltransferase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • polynucleotide adenylyltransferase activity Source: UniProtKB
  • RNA binding Source: UniProtKB
  • telomerase RNA binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processCell cycle, Cell division, Mitosis, mRNA processing, rRNA processing
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.19 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal nucleotidyltransferase 4ACurated
Alternative name(s):
Non-canonical poly(A) RNA polymerase PAPD5Curated (EC:2.7.7.191 Publication)
PAP-associated domain-containing protein 5
Terminal guanylyltransferaseCurated (EC:2.7.7.-1 Publication)
Terminal nucleotidyltransferase 4BCurated
Terminal uridylyltransferase 3
Short name:
TUTase 3
Topoisomerase-related function protein 4-2
Short name:
TRF4-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENT4BImported
Synonyms:GLD41 Publication, PAPD5Imported, TRF4-21 Publication, TUT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121274.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30758 TENT4B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605540 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64282

Open Targets

More...
OpenTargetsi
ENSG00000121274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134949693

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAPD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59800139

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203101 – 572Terminal nucleotidyltransferase 4AAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki470Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei484PhosphoserineCombined sources1
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki526Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 5 (identifier: Q8NDF8-5)
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NDF8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NDF8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NDF8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDF8

PeptideAtlas

More...
PeptideAtlasi
Q8NDF8

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDF8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73020
73021 [Q8NDF8-2]
73022 [Q8NDF8-3]
73023 [Q8NDF8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000121274 Expressed in 212 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NDF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NDF8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042968
HPA048225

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (PubMed:21855801). Interacts with CPEB1; the interaction is required for TENT4B-mediated translational control (PubMed:28383716).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122126, 56 interactors

Database of interacting proteins

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DIPi
DIP-59183N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8NDF8

Protein interaction database and analysis system

More...
IntActi
Q8NDF8, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8NDF8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000396995

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NDF8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDF8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini308 – 368PAP-associatedAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi557 – 563Basic, involved in binding of the RNA primer7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 32Poly-Asn5
Compositional biasi45 – 76Pro/Ser-richAdd BLAST32
Compositional biasi447 – 525Ser-richAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1906 Eukaryota
COG5260 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158301

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290646

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053489

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NDF8

KEGG Orthology (KO)

More...
KOi
K03514

Identification of Orthologs from Complete Genome Data

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OMAi
DPRIAWF

Database of Orthologous Groups

More...
OrthoDBi
1016712at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NDF8

TreeFam database of animal gene trees

More...
TreeFami
TF313939

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002058 PAP_assoc
IPR040136 PAPD5
IPR002934 Polymerase_NTP_transf_dom

The PANTHER Classification System

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PANTHERi
PTHR23092:SF26 PTHR23092:SF26, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP
60 70 80 90 100
PSASSSPHPS AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG
110 120 130 140 150
VVYSGTPWKR RNYNQGVVGL HEEISDFYEY MSPRPEEEKM RMEVVNRIES
160 170 180 190 200
VIKELWPSAD VQIFGSFKTG LYLPTSDIDL VVFGKWENLP LWTLEEALRK
210 220 230 240 250
HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG VRAADLIKDF
260 270 280 290 300
TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
310 320 330 340 350
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML
360 370 380 390 400
DGYRPSMLYI EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK
410 420 430 440 450
YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGPVSSSS
460 470 480 490 500
ATQSSSSDVD SDATPCKTPK QLLCRPSTGN RVGSQDVSLE SSQAVGKMQS
510 520 530 540 550
TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM TNKQHQGKSN
560 570
NQYYHGKKRK HKRDAPLSDL CR
Length:572
Mass (Da):63,267
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD205C0DE961DA701
GO
Isoform 2 (identifier: Q8NDF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-465: PVSSSSATQSSSSDVDSDATP → NETLHQVQCRPLLPHSPALVT
     466-572: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):51,845
Checksum:i2C60D0E908CA56C4
GO
Isoform 3 (identifier: Q8NDF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG
     539-572: Missing.

Show »
Length:585
Mass (Da):64,197
Checksum:iD0322CF501EF428C
GO
Isoform 4 (identifier: Q8NDF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-370: NDV → IEI
     371-572: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,157
Checksum:i6452431129087203
GO
Isoform 5 (identifier: Q8NDF8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPRPRSAPGKPRRRSRARLRSSRTPSGGASGGGGSSSSSSTATGGSGSSTGSPGGAASAPAPAPAGM
     85-85: A → ASTYGLNYSLLQP
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG

Show »
Length:698
Mass (Da):75,801
Checksum:iB35CF49F3E067CE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQM0H3BQM0_HUMAN
Terminal nucleotidyltransferase 4A
TENT4B
588Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC61E9PC61_HUMAN
Terminal nucleotidyltransferase 4A
TENT4B
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD45199 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA91518 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469891M → MRPRPRSAPGKPRRRSRARL RSSRTPSGGASGGGGSSSSS STATGGSGSSTGSPGGAASA PAPAPAGM in isoform 5. 1 Publication1
Alternative sequenceiVSP_04699085A → ASTYGLNYSLLQP in isoform 5. 1 Publication1
Alternative sequenceiVSP_012732368 – 370NDV → IEI in isoform 4. 1 Publication3
Alternative sequenceiVSP_012733371 – 572Missing in isoform 4. 1 PublicationAdd BLAST202
Alternative sequenceiVSP_012735444G → GNGVTLIVDTQQLDKCNNNL SEENEALGKCRSKTSESLSK HSSNSSSG in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_012734445 – 465PVSSS…SDATP → NETLHQVQCRPLLPHSPALV T in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012736466 – 572Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_012737539 – 572Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK001141 mRNA Translation: BAA91518.1 Different initiation.
AK097589 mRNA No translation available.
AK300918 mRNA Translation: BAG62550.1
AC007597 Genomic DNA No translation available.
AC007610 Genomic DNA No translation available.
AF089897 mRNA Translation: AAD45199.1 Different initiation.
AL833922 mRNA Translation: CAD38778.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS54006.1 [Q8NDF8-5]

NCBI Reference Sequences

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RefSeqi
NP_001035374.2, NM_001040284.2 [Q8NDF8-5]
NP_001035375.2, NM_001040285.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.514342

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000436909; ENSP00000396995; ENSG00000121274 [Q8NDF8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64282

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64282

UCSC genome browser

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UCSCi
uc010vgo.3 human [Q8NDF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001141 mRNA Translation: BAA91518.1 Different initiation.
AK097589 mRNA No translation available.
AK300918 mRNA Translation: BAG62550.1
AC007597 Genomic DNA No translation available.
AC007610 Genomic DNA No translation available.
AF089897 mRNA Translation: AAD45199.1 Different initiation.
AL833922 mRNA Translation: CAD38778.1
CCDSiCCDS54006.1 [Q8NDF8-5]
RefSeqiNP_001035374.2, NM_001040284.2 [Q8NDF8-5]
NP_001035375.2, NM_001040285.2
UniGeneiHs.514342

3D structure databases

ProteinModelPortaliQ8NDF8
SMRiQ8NDF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122126, 56 interactors
DIPiDIP-59183N
ELMiQ8NDF8
IntActiQ8NDF8, 6 interactors
MINTiQ8NDF8
STRINGi9606.ENSP00000396995

PTM databases

iPTMnetiQ8NDF8
PhosphoSitePlusiQ8NDF8

Polymorphism and mutation databases

BioMutaiPAPD5
DMDMi59800139

Proteomic databases

EPDiQ8NDF8
jPOSTiQ8NDF8
MaxQBiQ8NDF8
PaxDbiQ8NDF8
PeptideAtlasiQ8NDF8
PRIDEiQ8NDF8
ProteomicsDBi73020
73021 [Q8NDF8-2]
73022 [Q8NDF8-3]
73023 [Q8NDF8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436909; ENSP00000396995; ENSG00000121274 [Q8NDF8-5]
GeneIDi64282
KEGGihsa:64282
UCSCiuc010vgo.3 human [Q8NDF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64282
DisGeNETi64282
EuPathDBiHostDB:ENSG00000121274.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TENT4B
HGNCiHGNC:30758 TENT4B
HPAiHPA042968
HPA048225
MIMi605540 gene
neXtProtiNX_Q8NDF8
OpenTargetsiENSG00000121274
PharmGKBiPA134949693

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1906 Eukaryota
COG5260 LUCA
GeneTreeiENSGT00940000158301
HOGENOMiHOG000290646
HOVERGENiHBG053489
InParanoidiQ8NDF8
KOiK03514
OMAiDPRIAWF
OrthoDBi1016712at2759
PhylomeDBiQ8NDF8
TreeFamiTF313939

Enzyme and pathway databases

BRENDAi2.7.7.19 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PAPD5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64282

Protein Ontology

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PROi
PR:Q8NDF8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121274 Expressed in 212 organ(s), highest expression level in liver
ExpressionAtlasiQ8NDF8 baseline and differential
GenevisibleiQ8NDF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002058 PAP_assoc
IPR040136 PAPD5
IPR002934 Polymerase_NTP_transf_dom
PANTHERiPTHR23092:SF26 PTHR23092:SF26, 2 hits
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDF8
Secondary accession number(s): B4DV38, Q9NW67, Q9Y6C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 13, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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