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UniProtKB - Q8NDF8 (PAPD5_HUMAN)

Entry version 149 (25 May 2022)
Sequence version 2 (01 Feb 2005)
Previous versions | rss
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Protein

Terminal nucleotidyltransferase 4B

Gene

TENT4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317).

Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801).

Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716).

Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165).

Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417).

Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037).

7 Publications

Caution

Was originally thought to have DNA polymerase activity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi177Magnesium; catalyticBy similarity1
Metal bindingi179Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processCell cycle, Cell division, Mitosis, mRNA processing, rRNA processing
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.19, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NDF8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8NDF8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal nucleotidyltransferase 4BCurated
Alternative name(s):
Non-canonical poly(A) RNA polymerase PAPD5Curated (EC:2.7.7.191 Publication)
PAP-associated domain-containing protein 5
Terminal guanylyltransferaseCurated (EC:2.7.7.-1 Publication)
Terminal uridylyltransferase 3
Short name:
TUTase 3
Topoisomerase-related function protein 4-2
Short name:
TRF4-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENT4BImported
Synonyms:GLD41 Publication, PAPD5Imported, TRF4-21 Publication, TUT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30758, TENT4B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605540, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NDF8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121274

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64282

Open Targets

More...OpenTargetsi		ENSG00000121274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134949693

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NDF8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PAPD5

Domain mapping of disease mutations (DMDM)

More...DMDMi		59800139

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203101 – 572Terminal nucleotidyltransferase 4BAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki470Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei484PhosphoserineCombined sources1
Cross-linki497Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki526Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 5 (identifier: Q8NDF8-5)
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Curated

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NDF8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NDF8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NDF8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NDF8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NDF8

PeptideAtlas

More...PeptideAtlasi		Q8NDF8

PRoteomics IDEntifications database

More...PRIDEi		Q8NDF8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5240
73020 [Q8NDF8-1]
73021 [Q8NDF8-2]
73022 [Q8NDF8-3]
73023 [Q8NDF8-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NDF8, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NDF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NDF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121274, Expressed in secondary oocyte and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NDF8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NDF8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121274, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (PubMed:21855801).

Interacts with CPEB1; the interaction is required for TENT4B-mediated translational control (PubMed:28383716).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122126, 170 interactors

Database of interacting proteins

More...DIPi		DIP-59183N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q8NDF8

Protein interaction database and analysis system

More...IntActi		Q8NDF8, 18 interactors

Molecular INTeraction database

More...MINTi		Q8NDF8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NDF8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8NDF8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NDF8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini308 – 368PAP-associatedAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 105DisorderedSequence analysisAdd BLAST105
Regioni435 – 572DisorderedSequence analysisAdd BLAST138

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi557 – 563Basic, involved in binding of the RNA primer7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36Polar residuesSequence analysisAdd BLAST15
Compositional biasi45 – 59Polar residuesSequence analysisAdd BLAST15
Compositional biasi441 – 464Polar residuesSequence analysisAdd BLAST24
Compositional biasi471 – 551Polar residuesSequence analysisAdd BLAST81

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1906, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158301

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013572_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NDF8

Database of Orthologous Groups

More...OrthoDBi		1016712at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NDF8

TreeFam database of animal gene trees

More...TreeFami		TF313939

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043519, NT_sf
IPR002058, PAP_assoc
IPR002934, Polymerase_NTP_transf_dom
IPR040136, TENT4B
IPR045862, Trf4-like

The PANTHER Classification System

More...PANTHERi		PTHR23092, PTHR23092, 2 hits
PTHR23092:SF51, PTHR23092:SF51, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01909, NTP_transf_2, 1 hit
PF03828, PAP_assoc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81301, SSF81301, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP 
        60         70         80         90        100
PSASSSPHPS AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG 
       110        120        130        140        150
VVYSGTPWKR RNYNQGVVGL HEEISDFYEY MSPRPEEEKM RMEVVNRIES 
       160        170        180        190        200
VIKELWPSAD VQIFGSFKTG LYLPTSDIDL VVFGKWENLP LWTLEEALRK 
       210        220        230        240        250
HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG VRAADLIKDF 
       260        270        280        290        300
TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE 
       310        320        330        340        350
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML 
       360        370        380        390        400
DGYRPSMLYI EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK 
       410        420        430        440        450
YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGPVSSSS 
       460        470        480        490        500
ATQSSSSDVD SDATPCKTPK QLLCRPSTGN RVGSQDVSLE SSQAVGKMQS 
       510        520        530        540        550
TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM TNKQHQGKSN 
       560        570 
NQYYHGKKRK HKRDAPLSDL CR
Length:572
Mass (Da):63,267
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD205C0DE961DA701
GO
Isoform 2 (identifier: Q8NDF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-465: PVSSSSATQSSSSDVDSDATP → NETLHQVQCRPLLPHSPALVT
     466-572: Missing.

Show »
Length:465
Mass (Da):51,845
Checksum:i2C60D0E908CA56C4
GO
Isoform 3 (identifier: Q8NDF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG
     539-572: Missing.

Show »
Length:585
Mass (Da):64,197
Checksum:iD0322CF501EF428C
GO
Isoform 4 (identifier: Q8NDF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-370: NDV → IEI
     371-572: Missing.

Show »
Length:370
Mass (Da):41,157
Checksum:i6452431129087203
GO
Isoform 5 (identifier: Q8NDF8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPRPRSAPGKPRRRSRARLRSSRTPSGGASGGGGSSSSSSTATGGSGSSTGSPGGAASAPAPAPAGM
     85-85: A → ASTYGLNYSLLQP
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG

Show »
Length:698
Mass (Da):75,801
Checksum:iB35CF49F3E067CE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7N4YH79A0A7N4YH79_HUMAN
Terminal nucleotidyltransferase 4B
TENT4B
713Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC61E9PC61_HUMAN
Terminal nucleotidyltransferase 4B
TENT4B
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD45199 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA91518 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469891M → MRPRPRSAPGKPRRRSRARL RSSRTPSGGASGGGGSSSSS STATGGSGSSTGSPGGAASA PAPAPAGM in isoform 5. 1 Publication1
Alternative sequenceiVSP_04699085A → ASTYGLNYSLLQP in isoform 5. 1 Publication1
Alternative sequenceiVSP_012732368 – 370NDV → IEI in isoform 4. 1 Publication3
Alternative sequenceiVSP_012733371 – 572Missing in isoform 4. 1 PublicationAdd BLAST202
Alternative sequenceiVSP_012735444G → GNGVTLIVDTQQLDKCNNNL SEENEALGKCRSKTSESLSK HSSNSSSG in isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_012734445 – 465PVSSS…SDATP → NETLHQVQCRPLLPHSPALV T in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012736466 – 572Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_012737539 – 572Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001141 mRNA Translation: BAA91518.1 Different initiation.
AK097589 mRNA No translation available.
AK300918 mRNA Translation: BAG62550.1
AC007597 Genomic DNA No translation available.
AC007610 Genomic DNA No translation available.
AF089897 mRNA Translation: AAD45199.1 Different initiation.
AL833922 mRNA Translation: CAD38778.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS54006.1 [Q8NDF8-5]

NCBI Reference Sequences

More...RefSeqi		NP_001035374.2, NM_001040284.2 [Q8NDF8-5]
NP_001035375.2, NM_001040285.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000436909.8; ENSP00000396995.3; ENSG00000121274.14 [Q8NDF8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64282

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64282

UCSC genome browser

More...UCSCi		uc010vgo.3, human [Q8NDF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001141 mRNA Translation: BAA91518.1 Different initiation.
AK097589 mRNA No translation available.
AK300918 mRNA Translation: BAG62550.1
AC007597 Genomic DNA No translation available.
AC007610 Genomic DNA No translation available.
AF089897 mRNA Translation: AAD45199.1 Different initiation.
AL833922 mRNA Translation: CAD38778.1
CCDSiCCDS54006.1 [Q8NDF8-5]
RefSeqiNP_001035374.2, NM_001040284.2 [Q8NDF8-5]
NP_001035375.2, NM_001040285.2

3D structure databases

AlphaFoldDBiQ8NDF8
SMRiQ8NDF8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122126, 170 interactors
DIPiDIP-59183N
ELMiQ8NDF8
IntActiQ8NDF8, 18 interactors
MINTiQ8NDF8

PTM databases

GlyGeniQ8NDF8, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8NDF8
PhosphoSitePlusiQ8NDF8

Genetic variation databases

BioMutaiPAPD5
DMDMi59800139

Proteomic databases

EPDiQ8NDF8
jPOSTiQ8NDF8
MassIVEiQ8NDF8
MaxQBiQ8NDF8
PaxDbiQ8NDF8
PeptideAtlasiQ8NDF8
PRIDEiQ8NDF8
ProteomicsDBi5240
73020 [Q8NDF8-1]
73021 [Q8NDF8-2]
73022 [Q8NDF8-3]
73023 [Q8NDF8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28218, 150 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		64282

Genome annotation databases

EnsembliENST00000436909.8; ENSP00000396995.3; ENSG00000121274.14 [Q8NDF8-5]
GeneIDi64282
KEGGihsa:64282
UCSCiuc010vgo.3, human [Q8NDF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64282
DisGeNETi64282

GeneCards: human genes, protein and diseases

More...GeneCardsi		TENT4B
HGNCiHGNC:30758, TENT4B
HPAiENSG00000121274, Low tissue specificity
MIMi605540, gene
neXtProtiNX_Q8NDF8
OpenTargetsiENSG00000121274
PharmGKBiPA134949693
VEuPathDBiHostDB:ENSG00000121274

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1906, Eukaryota
GeneTreeiENSGT00940000158301
HOGENOMiCLU_013572_3_2_1
InParanoidiQ8NDF8
OrthoDBi1016712at2759
PhylomeDBiQ8NDF8
TreeFamiTF313939

Enzyme and pathway databases

BRENDAi2.7.7.19, 2681
PathwayCommonsiQ8NDF8
SignaLinkiQ8NDF8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64282, 58 hits in 1083 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PAPD5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64282
PharosiQ8NDF8, Tbio

Protein Ontology

More...PROi		PR:Q8NDF8
RNActiQ8NDF8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121274, Expressed in secondary oocyte and 224 other tissues
ExpressionAtlasiQ8NDF8, baseline and differential
GenevisibleiQ8NDF8, HS

Family and domain databases

Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR043519, NT_sf
IPR002058, PAP_assoc
IPR002934, Polymerase_NTP_transf_dom
IPR040136, TENT4B
IPR045862, Trf4-like
PANTHERiPTHR23092, PTHR23092, 2 hits
PTHR23092:SF51, PTHR23092:SF51, 2 hits
PfamiView protein in Pfam
PF01909, NTP_transf_2, 1 hit
PF03828, PAP_assoc, 1 hit
SUPFAMiSSF81301, SSF81301, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDF8
Secondary accession number(s): B4DV38, Q9NW67, Q9Y6C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 25, 2022
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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