UniProtKB - Q8NDC4 (MORN4_HUMAN)
Protein
MORN repeat-containing protein 4
Gene
MORN4
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.By similarity
GO - Biological processi
- response to axon injury Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8NDC4 |
Names & Taxonomyi
Protein namesi | Recommended name: MORN repeat-containing protein 4Alternative name(s): Protein 44050 Retinophilin1 Publication |
Gene namesi | Name:MORN4 Synonyms:C10orf83 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171160.17 |
HGNCi | HGNC:24001, MORN4 |
MIMi | 617736, gene |
neXtProti | NX_Q8NDC4 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- filopodium tip 1 Publication
- stereocilium By similarity
Note: Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A.1 Publication
Other locations
- cytoplasm Source: UniProtKB
- filopodium tip Source: UniProtKB
- stereocilium tip Source: UniProtKB
Keywords - Cellular componenti
Cell projection, CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 118812 |
OpenTargetsi | ENSG00000171160 |
PharmGKBi | PA162396074 |
Miscellaneous databases
Pharosi | Q8NDC4, Tdark |
Polymorphism and mutation databases
BioMutai | MORN4 |
DMDMi | 74751218 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279488 | 1 – 146 | MORN repeat-containing protein 4Add BLAST | 146 |
Proteomic databases
PaxDbi | Q8NDC4 |
PeptideAtlasi | Q8NDC4 |
PRIDEi | Q8NDC4 |
ProteomicsDBi | 73013 [Q8NDC4-1] 73014 [Q8NDC4-2] |
Expressioni
Gene expression databases
Bgeei | ENSG00000171160, Expressed in heart left ventricle and 196 other tissues |
ExpressionAtlasi | Q8NDC4, baseline and differential |
Genevisiblei | Q8NDC4, HS |
Organism-specific databases
HPAi | ENSG00000171160, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MYO3A.
1 PublicationBinary interactionsi
Hide detailsQ8NDC4
Protein-protein interaction databases
BioGRIDi | 125622, 33 interactors |
IntActi | Q8NDC4, 29 interactors |
MINTi | Q8NDC4 |
STRINGi | 9606.ENSP00000307636 |
Miscellaneous databases
RNActi | Q8NDC4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 16 – 38 | MORN 1Add BLAST | 23 | |
Repeati | 39 – 61 | MORN 2Add BLAST | 23 | |
Repeati | 62 – 84 | MORN 3Add BLAST | 23 | |
Repeati | 85 – 107 | MORN 4Add BLAST | 23 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0231, Eukaryota |
GeneTreei | ENSGT00730000111173 |
HOGENOMi | CLU_113346_0_0_1 |
InParanoidi | Q8NDC4 |
OMAi | WFPDGAK |
OrthoDBi | 1532474at2759 |
PhylomeDBi | Q8NDC4 |
TreeFami | TF323893 |
Family and domain databases
InterProi | View protein in InterPro IPR003409, MORN |
Pfami | View protein in Pfam PF02493, MORN, 4 hits |
SMARTi | View protein in SMART SM00698, MORN, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NDC4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG
60 70 80 90 100
FGVLTFSDGS RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL
110 120 130 140
TFPDGSHGIP RNEGLFENNK LLRREKCSAI VQRAQSASKS ARNLTA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8WVZ3 | Q8WVZ3_HUMAN | MORN repeat-containing protein 4 | MORN4 | 46 | Annotation score: | ||
G3V1L7 | G3V1L7_HUMAN | Chromosome 10 open reading frame 83... | MORN4 C10orf83, hCG_25157 | 66 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023457 | 1 – 22 | MTLTK…GEWKE → MAWSRAGPMRSGVAPGCLGN SQWAAGIVPSAVAQDGGVKW GNRWWRWRRARWQPGAHQRK SPRRWNPASRRDGHPERPAP in isoform 2. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ431726 mRNA Translation: CAD24475.1 AJ312050 mRNA Translation: CAC85055.1 AL834132 mRNA Translation: CAD38849.1 AL355315 Genomic DNA No translation available. BC093023 mRNA Translation: AAH93023.1 BC010230 mRNA Translation: AAH10230.1 BC040015 mRNA Translation: AAH40015.1 |
CCDSi | CCDS7468.1 [Q8NDC4-1] |
RefSeqi | NP_001092301.1, NM_001098831.1 [Q8NDC4-1] NP_849154.1, NM_178832.3 [Q8NDC4-1] XP_011537552.1, XM_011539250.2 [Q8NDC4-2] XP_011537553.1, XM_011539251.2 [Q8NDC4-1] |
Genome annotation databases
Ensembli | ENST00000307450; ENSP00000307636; ENSG00000171160 [Q8NDC4-1] |
GeneIDi | 118812 |
KEGGi | hsa:118812 |
UCSCi | uc001kob.5, human [Q8NDC4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ431726 mRNA Translation: CAD24475.1 AJ312050 mRNA Translation: CAC85055.1 AL834132 mRNA Translation: CAD38849.1 AL355315 Genomic DNA No translation available. BC093023 mRNA Translation: AAH93023.1 BC010230 mRNA Translation: AAH10230.1 BC040015 mRNA Translation: AAH40015.1 |
CCDSi | CCDS7468.1 [Q8NDC4-1] |
RefSeqi | NP_001092301.1, NM_001098831.1 [Q8NDC4-1] NP_849154.1, NM_178832.3 [Q8NDC4-1] XP_011537552.1, XM_011539250.2 [Q8NDC4-2] XP_011537553.1, XM_011539251.2 [Q8NDC4-1] |
3D structure databases
SMRi | Q8NDC4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125622, 33 interactors |
IntActi | Q8NDC4, 29 interactors |
MINTi | Q8NDC4 |
STRINGi | 9606.ENSP00000307636 |
Polymorphism and mutation databases
BioMutai | MORN4 |
DMDMi | 74751218 |
Proteomic databases
PaxDbi | Q8NDC4 |
PeptideAtlasi | Q8NDC4 |
PRIDEi | Q8NDC4 |
ProteomicsDBi | 73013 [Q8NDC4-1] 73014 [Q8NDC4-2] |
Protocols and materials databases
Antibodypediai | 30988, 45 antibodies |
DNASUi | 118812 |
Genome annotation databases
Ensembli | ENST00000307450; ENSP00000307636; ENSG00000171160 [Q8NDC4-1] |
GeneIDi | 118812 |
KEGGi | hsa:118812 |
UCSCi | uc001kob.5, human [Q8NDC4-1] |
Organism-specific databases
CTDi | 118812 |
DisGeNETi | 118812 |
EuPathDBi | HostDB:ENSG00000171160.17 |
GeneCardsi | MORN4 |
HGNCi | HGNC:24001, MORN4 |
HPAi | ENSG00000171160, Low tissue specificity |
MIMi | 617736, gene |
neXtProti | NX_Q8NDC4 |
OpenTargetsi | ENSG00000171160 |
PharmGKBi | PA162396074 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0231, Eukaryota |
GeneTreei | ENSGT00730000111173 |
HOGENOMi | CLU_113346_0_0_1 |
InParanoidi | Q8NDC4 |
OMAi | WFPDGAK |
OrthoDBi | 1532474at2759 |
PhylomeDBi | Q8NDC4 |
TreeFami | TF323893 |
Enzyme and pathway databases
PathwayCommonsi | Q8NDC4 |
Miscellaneous databases
BioGRID-ORCSi | 118812, 4 hits in 842 CRISPR screens |
ChiTaRSi | MORN4, human |
GenomeRNAii | 118812 |
Pharosi | Q8NDC4, Tdark |
PROi | PR:Q8NDC4 |
RNActi | Q8NDC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171160, Expressed in heart left ventricle and 196 other tissues |
ExpressionAtlasi | Q8NDC4, baseline and differential |
Genevisiblei | Q8NDC4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003409, MORN |
Pfami | View protein in Pfam PF02493, MORN, 4 hits |
SMARTi | View protein in SMART SM00698, MORN, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MORN4_HUMAN | |
Accessioni | Q8NDC4Primary (citable) accession number: Q8NDC4 Secondary accession number(s): Q86Y54 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM