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Protein

B-cell scaffold protein with ankyrin repeats

Gene

BANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in B-cell receptor (BCR)-induced Ca2+ mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein tyrosine kinase binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processB-cell activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell scaffold protein with ankyrin repeats
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BANK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000153064.11

Human Gene Nomenclature Database

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HGNCi
HGNC:18233 BANK1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610292 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8NDB2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Systemic lupus erythematosus (SLE)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNET

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DisGeNETi
55024

MalaCards human disease database

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MalaCardsi
BANK1
MIMi152700 phenotype

Open Targets

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OpenTargetsi
ENSG00000153064

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
536 NON RARE IN EUROPE: Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394677

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
BANK1

Domain mapping of disease mutations (DMDM)

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DMDMi
308153627

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519271 – 785B-cell scaffold protein with ankyrin repeatsAdd BLAST785

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosines upon BCR activation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NDB2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NDB2

PeptideAtlas

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PeptideAtlasi
Q8NDB2

PRoteomics IDEntifications database

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PRIDEi
Q8NDB2

ProteomicsDB human proteome resource

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ProteomicsDBi
73007
73008 [Q8NDB2-2]
73009 [Q8NDB2-3]
73010 [Q8NDB2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NDB2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NDB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19+ B-cells, with very low expression in other cell populations.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000153064 Expressed in 157 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_BANK1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NDB2 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LYN, ITPR1 and ITPR2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120354, 3 interactors

Protein interaction database and analysis system

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IntActi
Q8NDB2, 7 interactors

Molecular INTeraction database

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MINTi
Q8NDB2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320509

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NDB2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NDB2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini200 – 327DBBPROSITE-ProRule annotationAdd BLAST128
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati342 – 371ANK 1Add BLAST30
Repeati378 – 408ANK 2Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 154Interaction with ITPR21 PublicationAdd BLAST154

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHAS Eukaryota
ENOG410ZTCN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008787

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080888

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NDB2

Identification of Orthologs from Complete Genome Data

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OMAi
KVWCMKA

Database of Orthologous Groups

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OrthoDBi
EOG091G0125

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NDB2

TreeFam database of animal gene trees

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TreeFami
TF328570

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036770 Ankyrin_rpt-contain_sf
IPR017893 DBB_domain
IPR035897 Toll_tir_struct_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14545 DBB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01282 DBB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51376 DBB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NDB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPAAPGKGL GSPDPAPCGP APPGNTKDII MIYEEDAEEW ALYLTEVFLH
60 70 80 90 100
VVKREAILLY RLENFSFRHL ELLNLTSYKC KLLILSNSLL RDLTPKKCQF
110 120 130 140 150
LEKILHSPKS VVTLLCGVKS SDQLYELLNI SQSRWEISTE QEPEDYISVI
160 170 180 190 200
QSIIFKDSED YFEVNIPTDL RAKHSGEISE RKEIEELSEA SRNTIPLAVV
210 220 230 240 250
LPTEIPCENP GEIFIILRDE VIGDTVEVEF TSSNKRIRTR PALWNKKVWC
260 270 280 290 300
MKALEFPAGS VHVNVYCDGI VKATTKIKYY PTAKAKECLF RMADSGESLC
310 320 330 340 350
QNSIEELDGV LTSIFKHEIP YYEFQSLQTE ICSQNKYTHF KELPTLLHCA
360 370 380 390 400
AKFGLKNLAI HLLQCSGATW ASKMKNMEGS DPAHIAERHG HKELKKIFED
410 420 430 440 450
FSIQEIDINN EQENDYEEDI ASFSTYIPST QNPAFHHESR KTYGQSADGA
460 470 480 490 500
EANEMEGEGK QNGSGMETKH SPLEVGSESS EDQYDDLYVF IPGADPENNS
510 520 530 540 550
QEPLMSSRPP LPPPRPVANA FQLERPHFTL PGTMVEGQME RSQNWGHPGV
560 570 580 590 600
RQETGDEPKG EKEKKEEEKE QEEEEDPYTF AEIDDSEYDM ILANLSIKKK
610 620 630 640 650
TGSRSFIINR PPAPTPRPTS IPPKEETTPY IAQVFQQKTA RRQSDDDKFC
660 670 680 690 700
GLPKKQDRAR IESPAFSTLR GCLTDGQEEL ILLQEKVKNG KMSMDEALEK
710 720 730 740 750
FKHWQMGKSG LEMIQQEKLR QLRDCIIGKR PEEENVYNKL TIVHHPGGKE
760 770 780
TAHNENKFYN VHFSNKLPAR PQVEKEFGFC CKKDH
Length:785
Mass (Da):89,282
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4A833E4A13FC6A6
GO
Isoform 2 (identifier: Q8NDB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.
     15-23: PAPCGPAPP → MVNCHLKI

Note: No experimental confirmation available.
Show »
Length:770
Mass (Da):88,141
Checksum:i4A4B533F885A3C34
GO
Isoform 3 (identifier: Q8NDB2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:755
Mass (Da):86,460
Checksum:i08ACB3617BC22FF0
GO
Isoform 4 (identifier: Q8NDB2-4) [UniParc]FASTAAdd to basket
Also known as: delta2

The sequence of this isoform differs from the canonical sequence as follows:
     24-156: Missing.

Show »
Length:652
Mass (Da):73,674
Checksum:i5751DEA277FF9DCA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91337 differs from that shown. Reason: Frameshift at positions 571 and 681.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143P → L in BAA91337 (PubMed:14702039).Curated1
Sequence conflicti209N → D in BAC03685 (PubMed:14702039).Curated1
Sequence conflicti303S → R in BAF84822 (PubMed:14702039).Curated1
Sequence conflicti436H → R in BAB79255 (PubMed:11782428).Curated1
Sequence conflicti557E → D in BAA91337 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02772961R → H Polymorphism; may influence susceptibility to SLE. 1 PublicationCorresponds to variant dbSNP:rs10516487EnsemblClinVar.1
Natural variantiVAR_027730383A → T Polymorphism; may influence susceptibility to SLE. 2 PublicationsCorresponds to variant dbSNP:rs3733197Ensembl.1
Natural variantiVAR_027731650C → R5 PublicationsCorresponds to variant dbSNP:rs3113676Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0208031 – 30Missing in isoform 3. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_0208041 – 14Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_02080515 – 23PAPCGPAPP → MVNCHLKI in isoform 2. 1 Publication9
Alternative sequenceiVSP_03421424 – 156Missing in isoform 4. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB063170 mRNA Translation: BAB79255.1
EU051376 mRNA Translation: ABW74340.1
AK000713 mRNA Translation: BAA91337.1 Frameshift.
AK091523 mRNA Translation: BAC03685.1
AK292133 mRNA Translation: BAF84822.1
AL834291 mRNA Translation: CAD38965.2
AC093694 Genomic DNA No translation available.
AC095062 Genomic DNA No translation available.
AC109928 Genomic DNA No translation available.
AP002075 Genomic DNA No translation available.
BC032241 mRNA Translation: AAH32241.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34038.1 [Q8NDB2-1]
CCDS47115.1 [Q8NDB2-4]
CCDS47116.1 [Q8NDB2-3]

NCBI Reference Sequences

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RefSeqi
NP_001077376.2, NM_001083907.2
NP_001120979.2, NM_001127507.2
NP_060405.4, NM_017935.4
XP_016863826.1, XM_017008337.1 [Q8NDB2-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.480400

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322953; ENSP00000320509; ENSG00000153064 [Q8NDB2-1]
ENST00000428908; ENSP00000412748; ENSG00000153064 [Q8NDB2-4]
ENST00000444316; ENSP00000388817; ENSG00000153064 [Q8NDB2-3]
ENST00000504592; ENSP00000421443; ENSG00000153064 [Q8NDB2-2]
ENST00000508653; ENSP00000422314; ENSG00000153064 [Q8NDB2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55024

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55024

UCSC genome browser

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UCSCi
uc003hvx.4 human [Q8NDB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063170 mRNA Translation: BAB79255.1
EU051376 mRNA Translation: ABW74340.1
AK000713 mRNA Translation: BAA91337.1 Frameshift.
AK091523 mRNA Translation: BAC03685.1
AK292133 mRNA Translation: BAF84822.1
AL834291 mRNA Translation: CAD38965.2
AC093694 Genomic DNA No translation available.
AC095062 Genomic DNA No translation available.
AC109928 Genomic DNA No translation available.
AP002075 Genomic DNA No translation available.
BC032241 mRNA Translation: AAH32241.2
CCDSiCCDS34038.1 [Q8NDB2-1]
CCDS47115.1 [Q8NDB2-4]
CCDS47116.1 [Q8NDB2-3]
RefSeqiNP_001077376.2, NM_001083907.2
NP_001120979.2, NM_001127507.2
NP_060405.4, NM_017935.4
XP_016863826.1, XM_017008337.1 [Q8NDB2-3]
UniGeneiHs.480400

3D structure databases

ProteinModelPortaliQ8NDB2
SMRiQ8NDB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120354, 3 interactors
IntActiQ8NDB2, 7 interactors
MINTiQ8NDB2
STRINGi9606.ENSP00000320509

PTM databases

iPTMnetiQ8NDB2
PhosphoSitePlusiQ8NDB2

Polymorphism and mutation databases

BioMutaiBANK1
DMDMi308153627

Proteomic databases

MaxQBiQ8NDB2
PaxDbiQ8NDB2
PeptideAtlasiQ8NDB2
PRIDEiQ8NDB2
ProteomicsDBi73007
73008 [Q8NDB2-2]
73009 [Q8NDB2-3]
73010 [Q8NDB2-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55024
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322953; ENSP00000320509; ENSG00000153064 [Q8NDB2-1]
ENST00000428908; ENSP00000412748; ENSG00000153064 [Q8NDB2-4]
ENST00000444316; ENSP00000388817; ENSG00000153064 [Q8NDB2-3]
ENST00000504592; ENSP00000421443; ENSG00000153064 [Q8NDB2-2]
ENST00000508653; ENSP00000422314; ENSG00000153064 [Q8NDB2-4]
GeneIDi55024
KEGGihsa:55024
UCSCiuc003hvx.4 human [Q8NDB2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55024
DisGeNETi55024
EuPathDBiHostDB:ENSG00000153064.11

GeneCards: human genes, protein and diseases

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GeneCardsi
BANK1
HGNCiHGNC:18233 BANK1
HPAiHPA037002
MalaCardsiBANK1
MIMi152700 phenotype
610292 gene
neXtProtiNX_Q8NDB2
OpenTargetsiENSG00000153064
Orphaneti536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBiPA128394677

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHAS Eukaryota
ENOG410ZTCN LUCA
GeneTreeiENSGT00390000008787
HOVERGENiHBG080888
InParanoidiQ8NDB2
OMAiKVWCMKA
OrthoDBiEOG091G0125
PhylomeDBiQ8NDB2
TreeFamiTF328570

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BANK1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55024

Protein Ontology

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PROi
PR:Q8NDB2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153064 Expressed in 157 organ(s), highest expression level in blood
CleanExiHS_BANK1
GenevisibleiQ8NDB2 HS

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR036770 Ankyrin_rpt-contain_sf
IPR017893 DBB_domain
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF14545 DBB, 1 hit
SMARTiView protein in SMART
SM01282 DBB, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS51376 DBB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBANK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDB2
Secondary accession number(s): A8K7W8
, B0F3S2, Q8N5K8, Q8NB56, Q8WYN5, Q9NWP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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