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Entry version 127 (16 Oct 2019)
Sequence version 3 (13 Apr 2016)
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Protein

Hemicentin-2

Gene

HMCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemicentin-2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMCN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21293 HMCN2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NDA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000148357

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671680

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NDA2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMCN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298351848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039510823 – 5059Hemicentin-2Add BLAST5037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi328N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi345N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi378N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi477N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi524N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi537 ↔ 586PROSITE-ProRule annotation
Glycosylationi546N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi628 ↔ 676PROSITE-ProRule annotation
Glycosylationi673N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi718 ↔ 764PROSITE-ProRule annotation
Disulfide bondi806 ↔ 861PROSITE-ProRule annotation
Disulfide bondi905 ↔ 954PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei911Omega-N-methylarginineBy similarity1
Modified residuei916Omega-N-methylarginineBy similarity1
Disulfide bondi996 ↔ 1045PROSITE-ProRule annotation
Glycosylationi1023N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1071N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1094 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1185 ↔ 1228PROSITE-ProRule annotation
Glycosylationi1267N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1272 ↔ 1322PROSITE-ProRule annotation
Glycosylationi1353N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1366 ↔ 1415PROSITE-ProRule annotation
Disulfide bondi1459 ↔ 1509PROSITE-ProRule annotation
Glycosylationi1536N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1553 ↔ 1602PROSITE-ProRule annotation
Glycosylationi1562N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1647 ↔ 1696PROSITE-ProRule annotation
Glycosylationi1670N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1740 ↔ 1789PROSITE-ProRule annotation
Glycosylationi1819N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1832 ↔ 1873PROSITE-ProRule annotation
Glycosylationi1908N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1915 ↔ 1964PROSITE-ProRule annotation
Disulfide bondi2007 ↔ 2058PROSITE-ProRule annotation
Glycosylationi2008N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2087N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2093N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2100 ↔ 2149PROSITE-ProRule annotation
Disulfide bondi2192 ↔ 2243PROSITE-ProRule annotation
Glycosylationi2251N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2288 ↔ 2337PROSITE-ProRule annotation
Glycosylationi2289N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2369N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2382 ↔ 2431PROSITE-ProRule annotation
Glycosylationi2443N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2475 ↔ 2524PROSITE-ProRule annotation
Glycosylationi2476N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2515N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2571 ↔ 2620PROSITE-ProRule annotation
Glycosylationi2580N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2662N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2669 ↔ 2718PROSITE-ProRule annotation
Disulfide bondi2780 ↔ 2829PROSITE-ProRule annotation
Glycosylationi2866N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2875 ↔ 2924PROSITE-ProRule annotation
Glycosylationi2960N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2967 ↔ 3016PROSITE-ProRule annotation
Disulfide bondi3062 ↔ 3111PROSITE-ProRule annotation
Disulfide bondi3154 ↔ 3203PROSITE-ProRule annotation
Disulfide bondi3247 ↔ 3298PROSITE-ProRule annotation
Disulfide bondi3343 ↔ 3392PROSITE-ProRule annotation
Glycosylationi3404N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3436 ↔ 3481PROSITE-ProRule annotation
Disulfide bondi3525 ↔ 3572PROSITE-ProRule annotation
Glycosylationi3534N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi3549N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3616 ↔ 3665PROSITE-ProRule annotation
Glycosylationi3696N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi3700N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3707 ↔ 3756PROSITE-ProRule annotation
Disulfide bondi3779 ↔ 3830PROSITE-ProRule annotation
Disulfide bondi3872 ↔ 3921PROSITE-ProRule annotation
Disulfide bondi3963 ↔ 4011PROSITE-ProRule annotation
Disulfide bondi4053 ↔ 4102PROSITE-ProRule annotation
Glycosylationi4062N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi4144 ↔ 4191PROSITE-ProRule annotation
Disulfide bondi4234 ↔ 4282PROSITE-ProRule annotation
Glycosylationi4264N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi4324 ↔ 4372PROSITE-ProRule annotation
Glycosylationi4415N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi4561N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi4632 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4639 ↔ 4652PROSITE-ProRule annotation
Disulfide bondi4654 ↔ 4667PROSITE-ProRule annotation
Disulfide bondi4673 ↔ 4686PROSITE-ProRule annotation
Disulfide bondi4680 ↔ 4695PROSITE-ProRule annotation
Disulfide bondi4699 ↔ 4711PROSITE-ProRule annotation
Disulfide bondi4717 ↔ 4730PROSITE-ProRule annotation
Disulfide bondi4724 ↔ 4739PROSITE-ProRule annotation
Disulfide bondi4760 ↔ 4771PROSITE-ProRule annotation
Disulfide bondi4767 ↔ 4780PROSITE-ProRule annotation
Disulfide bondi4782 ↔ 4795PROSITE-ProRule annotation
Glycosylationi4804N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi4867 ↔ 4877PROSITE-ProRule annotation
Disulfide bondi4873 ↔ 4886PROSITE-ProRule annotation
Disulfide bondi4888 ↔ 4901PROSITE-ProRule annotation
Glycosylationi4994N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NDA2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NDA2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NDA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NDA2

PeptideAtlas

More...
PeptideAtlasi
Q8NDA2

PRoteomics IDEntifications database

More...
PRIDEi
Q8NDA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72996 [Q8NDA2-1]
72997 [Q8NDA2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NDA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NDA2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NDA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148357 Expressed in 138 organ(s), highest expression level in islet of Langerhans

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NDA2 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053903
HPA070647

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000485357

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 205VWFAAdd BLAST168
Domaini517 – 602Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST86
Domaini607 – 690Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST84
Domaini697 – 780Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST84
Domaini785 – 879Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST95
Domaini884 – 970Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST87
Domaini975 – 1061Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST87
Domaini1066 – 1159Ig-like C2-type 7PROSITE-ProRule annotationAdd BLAST94
Domaini1164 – 1244Ig-like C2-type 8PROSITE-ProRule annotationAdd BLAST81
Domaini1265 – 1338Ig-like C2-type 9PROSITE-ProRule annotationAdd BLAST74
Domaini1343 – 1429Ig-like C2-type 10PROSITE-ProRule annotationAdd BLAST87
Domaini1436 – 1525Ig-like C2-type 11PROSITE-ProRule annotationAdd BLAST90
Domaini1530 – 1618Ig-like C2-type 12PROSITE-ProRule annotationAdd BLAST89
Domaini1623 – 1714Ig-like C2-type 13PROSITE-ProRule annotationAdd BLAST92
Domaini1717 – 1805Ig-like C2-type 14PROSITE-ProRule annotationAdd BLAST89
Domaini1810 – 1887Ig-like C2-type 15PROSITE-ProRule annotationAdd BLAST78
Domaini1894 – 1982Ig-like C2-type 16PROSITE-ProRule annotationAdd BLAST89
Domaini1985 – 2074Ig-like C2-type 17PROSITE-ProRule annotationAdd BLAST90
Domaini2079 – 2165Ig-like C2-type 18PROSITE-ProRule annotationAdd BLAST87
Domaini2170 – 2261Ig-like C2-type 19PROSITE-ProRule annotationAdd BLAST92
Domaini2264 – 2353Ig-like C2-type 20PROSITE-ProRule annotationAdd BLAST90
Domaini2358 – 2447Ig-like C2-type 21PROSITE-ProRule annotationAdd BLAST90
Domaini2452 – 2540Ig-like C2-type 22PROSITE-ProRule annotationAdd BLAST89
Domaini2545 – 2636Ig-like C2-type 23PROSITE-ProRule annotationAdd BLAST92
Domaini2641 – 2732Ig-like C2-type 24PROSITE-ProRule annotationAdd BLAST92
Domaini2739 – 2833Ig-like C2-type 25PROSITE-ProRule annotationAdd BLAST95
Domaini2849 – 2938Ig-like C2-type 26PROSITE-ProRule annotationAdd BLAST90
Domaini2945 – 3032Ig-like C2-type 27PROSITE-ProRule annotationAdd BLAST88
Domaini3037 – 3127Ig-like C2-type 28PROSITE-ProRule annotationAdd BLAST91
Domaini3131 – 3219Ig-like C2-type 29PROSITE-ProRule annotationAdd BLAST89
Domaini3224 – 3314Ig-like C2-type 30PROSITE-ProRule annotationAdd BLAST91
Domaini3319 – 3406Ig-like C2-type 31PROSITE-ProRule annotationAdd BLAST88
Domaini3412 – 3497Ig-like C2-type 32PROSITE-ProRule annotationAdd BLAST86
Domaini3502 – 3588Ig-like C2-type 33PROSITE-ProRule annotationAdd BLAST87
Domaini3593 – 3681Ig-like C2-type 34PROSITE-ProRule annotationAdd BLAST89
Domaini3686 – 3772Ig-like C2-type 35PROSITE-ProRule annotationAdd BLAST87
Domaini3777 – 3848Ig-like C2-type 36PROSITE-ProRule annotationAdd BLAST72
Domaini3851 – 3937Ig-like C2-type 37PROSITE-ProRule annotationAdd BLAST87
Domaini3942 – 4027Ig-like C2-type 38PROSITE-ProRule annotationAdd BLAST86
Domaini4031 – 4118Ig-like C2-type 39PROSITE-ProRule annotationAdd BLAST88
Domaini4123 – 4204Ig-like C2-type 40PROSITE-ProRule annotationAdd BLAST82
Domaini4212 – 4295Ig-like C2-type 41PROSITE-ProRule annotationAdd BLAST84
Domaini4303 – 4388Ig-like C2-type 42PROSITE-ProRule annotationAdd BLAST86
Domaini4392 – 4614Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST223
Domaini4628 – 4668EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini4669 – 4712EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini4713 – 4751EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini4756 – 4796EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini4863 – 4902EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172035

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NDA2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 43 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR032984 Hemicentin-2
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45889:SF4 PTHR45889:SF4, 10 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 4 hits
PF07474 G2F, 1 hit
PF07679 I-set, 31 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 6 hits
SM00682 G2F, 1 hit
SM00409 IG, 43 hits
SM00408 IGc2, 43 hits
SM00406 IGv, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 43 hits
SSF53300 SSF53300, 1 hit
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 5 hits
PS50835 IG_LIKE, 42 hits
PS50993 NIDOGEN_G2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NDA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MPGAPLLRLL TAVSAAVAVA VAGAPGTVMP PTTGDATLAF VFDVTGSMWD
60 70 80 90 100
ELMQVIDGAS RILERSLSRR SQAIANYALV PFHDPDIGPV TLTADPTVFQ
110 120 130 140 150
RELRELYVQG GGDCPEMSVG AIKAAVEVAN PGSFIYVFSD ARAKDYHKKE
160 170 180 190 200
ELLRLLQLKQ SQVVFVLTGD CGDRTHPGYL AYEEIAATSS GQVFHLDKQQ
210 220 230 240 250
VTEVLKWVES AIQASKVHLL STDHEEEGEH TWRLPFDPSL KEVTISLSGP
260 270 280 290 300
GPEIEVQDPL GRILQEDEGL NVLLNIPDSA KVVAFKPEHP GLWSIKVYSS
310 320 330 340 350
GRHSVRITGV SNIDFRAGFS TQPLLDLNHT LEWPLQGVPI SLVINSTGLK
360 370 380 390 400
APGRLDSVEL AQSSGKPLLT LPTKPLSNGS THQLWGGPPF HTPKERFYLK
410 420 430 440 450
VKGKDHEGNP LLRVSGVSYS GVAPGAPLVS MAPRIHGYLH QPLLVSCSVH
460 470 480 490 500
SALPFRLQLR RGEARLGEER HFQESGNSSW EILRASKAEE GTYECTAVSR
510 520 530 540 550
AGTGRAKAQI VVTDPPPQLV PAPNVTVSPG ETAVLSCRVL GEAPYNLTWV
560 570 580 590 600
RDWRVLPAST GRVAQLADLS LEISGIIPTD GGRYQCVASN ANGVTRASVW
610 620 630 640 650
LLVREAPQVS IHTSSQHFSQ GVEVKVSCSA SGYPTPHISW SRESQALQED
660 670 680 690 700
SRIHVDAQGT LIIQGVAPED AGNYSCQATN EVGTDQETVT LYYTDPPSVS
710 720 730 740 750
AVNAVVLVAV GEEAVLVCEA SGVPPPRVIW YRGGLEMILA PEGSSSGKLR
760 770 780 790 800
IPAAQERDAG TYTCRAVNEL GDASAEIQLA VGHAPQLTEL PRDVTVELGR
810 820 830 840 850
SALLACRATG RPPPTVTWRR GDGQPLGLRL GAGRGSRSRQ PDSGVLFFES
860 870 880 890 900
VAPEDQAPYV CEARNVFGKV QAEARLIVTG HAPPQIASSA PTVRVLEGQP
910 920 930 940 950
VSLPCIVLAG RPLPERHWLK DGRPLPPGSR HSIRADGSLH LDRALQEHAG
960 970 980 990 1000
RYSCVATNTA GSQHRDVELV VQVPPRIHPT ATHHITNEGV AASLPCVASG
1010 1020 1030 1040 1050
VPAPTITWTK ETNALTSRGP HYNVSKEGTL LIAQPSAQDA GAYVCTATNT
1060 1070 1080 1090 1100
VGFSSQEMRL SVNTKPRIHM NGSRNADVPL QVTAKAGEEV TLDCEAKGSP
1110 1120 1130 1140 1150
PPLVTWTKDS RPVPPITNRY GLLPSGSLRL AQVQVGDSGH YECTASNPAG
1160 1170 1180 1190 1200
SASHRYVLGV QVPPQVQPGP RVLKVLVGEA LDLNCVAEGN PEPQLSWSKD
1210 1220 1230 1240 1250
GVVLQGRGPQ GSVHFAAIRT SDAGRYRCEA SNSAGVDAWE VELRVLEPPH
1260 1270 1280 1290 1300
WGADETSGLL ERVAGENASL PCPARGTPKP QVTWRKGPSS EPLHGQPGVA
1310 1320 1330 1340 1350
VLEEGSLFLA SVSPADSGDY ECQATNEVGS TSRRAKLVVY VPPSIREDGR
1360 1370 1380 1390 1400
KANVSGMAGQ SLTLECDANG FPVPEIVWLK DAQLIPKVGG HRLLDEGQSL
1410 1420 1430 1440 1450
HFPRIQEGDS GLYSCRAENQ AGTAQRDFHL LVLTPPSVLG AGAAQEVLGL
1460 1470 1480 1490 1500
AGADVELQCW TSGVPTPQVE WTKDRQPVLP GGPHLQVQED GQVLRITGSH
1510 1520 1530 1540 1550
VGDEGRYQCV AFSPAGQQAR DFQLRVHAPP TIWGSNETGE VAVMEDHLVQ
1560 1570 1580 1590 1600
LLCEARGVPT PNITWFKDGA LLPTSTKVVY TRGGRQLQLG RAQSSDAGVY
1610 1620 1630 1640 1650
TCKASNAVGA AEKATRLDVY VPPTIEGAGG RPYVVKAVAG RPVALECVAR
1660 1670 1680 1690 1700
GHPSPTLSWH HEGLPVAESN ESRLETDGSV LRLESPGEAS SGLYSCVASS
1710 1720 1730 1740 1750
PAGEAVLQYS VEVQVPPQLL VAEGLGQVTT IVGQPLELPC QASGSPVPTI
1760 1770 1780 1790 1800
QWLQNGRPAE ELAGVQVASQ GTTLHIDHVE LDHSGLFACQ ATNEAGTAGA
1810 1820 1830 1840 1850
EVEVSVHEFP SVSIIGGENI TAPFLQPVTL QCIGDGVPTP SLRWWKDGVA
1860 1870 1880 1890 1900
LAAFGGNLQI EKVDLRDEGI YTCAATNLAG ESKREVALKV LVPPNIEPGP
1910 1920 1930 1940 1950
VNKAVLENAS VTLECLASGV PPPDVSWFKG HQPVSSWMGV TVSVDGRVLR
1960 1970 1980 1990 2000
IEQAQLSDAG SYRCVASNVA GSTELRYGLR VNVPPRITLP PSLPGPVLVN
2010 2020 2030 2040 2050
TPVRLTCNAT GAPSPTLMWL KDGNPVSPAG TPGLQVFPGG RVLTLASARA
2060 2070 2080 2090 2100
SDSGRYSCVA VSAVGEDRQD VVLQVHMPPS ILGEELNVSV VANESVALEC
2110 2120 2130 2140 2150
QSHAMPPPVL SWWKDGRPLE PRPGVHLSAD KALLQVDRAD VWDAGHYTCE
2160 2170 2180 2190 2200
ALNQAGHSEK HYNLNVWVAP VFPLRESHTL TVREGHPTRL SCECRGVPFP
2210 2220 2230 2240 2250
KISWRKDGQP LPGEGAGLQH VSAVGRLLYL GQAQLAQEGT YTCECSNVVG
2260 2270 2280 2290 2300
NSSQDLQLEV HVPPQIAGPR EPPTQVSVVQ DGVATLECNA TGKPPPTVTW
2310 2320 2330 2340 2350
ERDGQPVGAE LGLQLQNQGQ SLHVERAQAA HTGRYSCVAE NLAGRAERKF
2360 2370 2380 2390 2400
ELSVLVPPEL IGDLDPLTNI TAALHSPLTL LCEAMGIPPP AIRWFRGEEP
2410 2420 2430 2440 2450
VSPGEDTYLL AGGWMLKMTQ TQEQDSGLYS CLASNEAGEA RRNFSVEVLV
2460 2470 2480 2490 2500
PPSIENEDLE EVIKVLDGQT AHLMCNVTGH PQPKLTWFKD GRPLARGDAH
2510 2520 2530 2540 2550
HISPDGVLLQ VLQANLSSAG HYSCIAANAV GEKTKHFQLS VLLAPTILGG
2560 2570 2580 2590 2600
AEDSADEEVT VTVNNPISLI CEALAFPSPN ITWMKDGAPF EASRNIQLLP
2610 2620 2630 2640 2650
GTHGLQILNA QKEDAGQYTC VVTNELGEAV KNYHVEVLIP PSISKDDPLA
2660 2670 2680 2690 2700
EVGVKEVKTK VNSTLTLECE SWAVPPPTIR WYKDGQPVTP SSRLQVLGEG
2710 2720 2730 2740 2750
RLLQIQPTQV SDSGRYLCVA TNVAGEDDQD FNVLIQVPPM FQKVGDFSAA
2760 2770 2780 2790 2800
FEILSREEEA RGGVTEYREI VENNPAYLYC DTNAIPPPDL TWYREDQPLS
2810 2820 2830 2840 2850
AGDEVSVLQG GRVLQIPLVR AENAGRYSCK ASNEVGEDWL HYELLVLTPP
2860 2870 2880 2890 2900
VILGDTEELV EEVTVNASST VSLQCPALGN PVPTISWLQN GLPFSPSPRL
2910 2920 2930 2940 2950
QVLEDGQVLQ VSTAEVADAA SYMCVAENQA GSAEKLFTLR VQVPPRIAGL
2960 2970 2980 2990 3000
DLEQVTAILN SSVSLPCDVH AHPNPEVTWY KDSQALSLGE EVFLLPGTHT
3010 3020 3030 3040 3050
LQLGRARLSD SGMYTCEALN AAGRDQKLVQ LSVLVPPAFR QAPRGPQDAV
3060 3070 3080 3090 3100
LVRVGDKAVL SCETDALPEP TVTWYKDGQP LVLAQRTQAL RGGQRLEIQE
3110 3120 3130 3140 3150
AQVSDKGLYS CKVSNVAGEA VRTFTLTVQV PPTFENPKTE TVSQVAGSPL
3160 3170 3180 3190 3200
VLTCDVSGVP APTVTWLKDR MPVESSAVHG VVSRGGRLQL SRLQPAQAGT
3210 3220 3230 3240 3250
YTCVAENTQA EARKDFVVAV LVAPRIRSSG VAREHHVLEG QEVRLDCEAD
3260 3270 3280 3290 3300
GQPPPDVAWL KDGSPLGQDM GPHLRFYLDG GSLVLKGLRA SDAGAYTCVA
3310 3320 3330 3340 3350
HNPAGEDARL HTVNVLVPPT IKQGADGSGT LVSRPGELVT MVCPVRGSPP
3360 3370 3380 3390 3400
IHVSWLKDGL PLPLSQRTLL HGSGHTLRIS KVQLADAGIF TCVAASPAGV
3410 3420 3430 3440 3450
ADRNFTLQVQ VPPVLEPVEF QNDVVVVRGS LVELPCEARG VPLPLVSWMK
3460 3470 3480 3490 3500
DGEPLLSQSL EQGPSLQLEA VGAGDSGTYS CVAVSEAGEA RRHFQLTVME
3510 3520 3530 3540 3550
PPHIEDSGQP TELSLTPGAP MELLCDAQGT PQPNITWHKD GQALTRLENN
3560 3570 3580 3590 3600
SRATRVLRVE NVQVRDAGLY TCLAESPAGA IEKSFRVRVQ APPNIVGPRG
3610 3620 3630 3640 3650
PRFVVGLAPG QLVLECSVEA EPAPKITWHR DGIVLQEDAH TQFPERGRFL
3660 3670 3680 3690 3700
QLQALSTADS GDYSCTARNA AGSTSVAFRV EIHTVPTIRS GPPAVNVSVN
3710 3720 3730 3740 3750
QTALLPCQAD GVPAPLVSWR KDRVPLDPRS PRFEILPEGS LRIQPVLAQD
3760 3770 3780 3790 3800
AGHYLCLASN SAGSDRQGRD LRVLALLPCE ASGSPKPLVV WWKDGQKLDF
3810 3820 3830 3840 3850
RLQQGAYRLL PSNALLLTAP GPQDSAQFEC VVSNEVGEAH RLYQVTVHVP
3860 3870 3880 3890 3900
PTIADDQTDF TVTMMAPVVL TCHSTGIPAP TVSWSKAGAQ LGARGSGYRV
3910 3920 3930 3940 3950
SPSGALEIGQ ALPIHAGRYT CSARNSAGVA HKHVFLTVQA SPVVKPLPSV
3960 3970 3980 3990 4000
VRAVAEEEVL LPCEASGIPR PTITWQKEGL NVATGVSTQV LPGGQLRIAH
4010 4020 4030 4040 4050
ASPEDAGNYL CIAKNSAGSA MGKTRLVVQV PPVIENGLPD LSTTEGSHAF
4060 4070 4080 4090 4100
LPCKARGSPE PNITWDKDGQ PVSGAEGKFT IQPSGELLVK NLEGQDAGTY
4110 4120 4130 4140 4150
TCTAENAVGR ARRRVHLTIL VLPVFTTLPG DRSLRLGDRL WLRCAARGSP
4160 4170 4180 4190 4200
TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA VSREDSGTYV CWAENRVGRT
4210 4220 4230 4240 4250
QAVSFVHVKE APVLQGEAFS YLVEPVGGSI QLDCVVRGDP VPDIHWIKDG
4260 4270 4280 4290 4300
LPLRGSHLRH QLQNGSLTIR RTERDDAGRY QCLAENEMGV AKKVVILVLQ
4310 4320 4330 4340 4350
SAPVFQVEPQ DMTVRSGDDV ALRCQATGEP TPTIEWLQAG QPLRASRRLR
4360 4370 4380 4390 4400
TLPDGSLWLE NVETGDAGTY DCVAHNLLGS ATARAFLVVR GEPQGSWGSM
4410 4420 4430 4440 4450
TGVINGRKFG VATLNTSVMQ EAHSGVSSIH SSIRHVPANV GPLMRVLVVT
4460 4470 4480 4490 4500
IAPIYWALAR ESGEALNGHS LTGGRFRQES HVEFATGELL TMTQVARGLD
4510 4520 4530 4540 4550
PDGLLLLDVV VNGVVPESLA DADLQVQDFE EHYVQTGPGQ LFVGSTQRFF
4560 4570 4580 4590 4600
QGGLPSFLRC NHSIQYNAAR GPQPQLVQHL RASAISSAFD PEAEALRFQL
4610 4620 4630 4640 4650
ATALQAEENE VGCPEGFELD SQGAFCVDRD ECSGGPSPCS HACLNAPGRF
4660 4670 4680 4690 4700
SCTCPTGFAL AWDDRNCRDV DECAWDAHLC REGQRCVNLL GSYRCLPDCG
4710 4720 4730 4740 4750
PGFRVADGAG CEDVDECLEG LDDCHYNQLC ENTPGGHRCS CPRGYRMQGP
4760 4770 4780 4790 4800
SLPCLDVNEC LQLPKACAYQ CHNLQGSYRC LCPPGQTLLR DGKACTSLER
4810 4820 4830 4840 4850
NGQNVTTVSH RGPLLPWLRP WASIPGTSYH AWVSLRPGPM ALSSVGRAWC
4860 4870 4880 4890 4900
PPGFIRQNGV CTDLDECRVR NLCQHACRNT EGSYQCLCPA GYRLLPSGKN
4910 4920 4930 4940 4950
CQDINECEEE SIECGPGQMC FNTRGSYQCV DTPCPATYRQ GPSPGTCFRR
4960 4970 4980 4990 5000
CSQDCGTGGP STLQYRLLPL PLGVRAHHDV ARLTAFSEVG VPANRTELSM
5010 5020 5030 5040 5050
LEPDPRSPFA LRPLRAGLGA VYTRRALTRA GLYRLTVRAA APRHQSVFVL

LIAVSPYPY
Length:5,059
Mass (Da):541,978
Last modified:April 13, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5933D04A2F9AF3D7
GO
Isoform 2 (identifier: Q8NDA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4165-4192: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4193-5059: Missing.

Note: No experimental confirmation available.
Show »
Length:4,192
Mass (Da):447,686
Checksum:i21E7E4798F36F8A6
GO
Isoform 3 (identifier: Q8NDA2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3409-3446: VQVPPVLEPV...EARGVPLPLV → CPLSWSRWSS...GAFPCLSCRG
     3447-5059: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:3,446
Mass (Da):368,616
Checksum:i8CD5815988D0749A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY63A0A087WY63_HUMAN
Hemicentin-2
HMCN2
595Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3X1H0Y3X1_HUMAN
Hemicentin-2
HMCN2
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPG1A0A096LPG1_HUMAN
Hemicentin-2
HMCN2
479Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85069 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04201 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD38854 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW87931 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3289R → W in CAD38854 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0581973409 – 3446VQVPP…PLPLV → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3. CuratedAdd BLAST38
Alternative sequenceiVSP_0581983447 – 5059Missing in isoform 3. CuratedAdd BLAST1613
Alternative sequenceiVSP_0393674165 – 4192EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0393684193 – 5059Missing in isoform 2. 1 PublicationAdd BLAST867

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABBA01012042 Genomic DNA No translation available.
ABBA01043973 Genomic DNA No translation available.
AL354898 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AUXG01000072 Genomic DNA No translation available.
FP565345 Genomic DNA No translation available.
KF458942 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87931.1 Sequence problems.
AK074396 mRNA Translation: BAB85069.1 Different initiation.
AK093583 mRNA Translation: BAC04201.1 Different initiation.
AL834139 mRNA Translation: CAD38854.1 Sequence problems.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000624552; ENSP00000485357; ENSG00000148357 [Q8NDA2-1]

UCSC genome browser

More...
UCSCi
uc064wnb.1 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABBA01012042 Genomic DNA No translation available.
ABBA01043973 Genomic DNA No translation available.
AL354898 Genomic DNA No translation available.
AL360004 Genomic DNA No translation available.
AUXG01000072 Genomic DNA No translation available.
FP565345 Genomic DNA No translation available.
KF458942 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87931.1 Sequence problems.
AK074396 mRNA Translation: BAB85069.1 Different initiation.
AK093583 mRNA Translation: BAC04201.1 Different initiation.
AL834139 mRNA Translation: CAD38854.1 Sequence problems.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000485357

PTM databases

iPTMnetiQ8NDA2
PhosphoSitePlusiQ8NDA2
SwissPalmiQ8NDA2

Polymorphism and mutation databases

BioMutaiHMCN2
DMDMi298351848

Proteomic databases

EPDiQ8NDA2
jPOSTiQ8NDA2
MassIVEiQ8NDA2
PaxDbiQ8NDA2
PeptideAtlasiQ8NDA2
PRIDEiQ8NDA2
ProteomicsDBi72996 [Q8NDA2-1]
72997 [Q8NDA2-2]

Genome annotation databases

EnsembliENST00000624552; ENSP00000485357; ENSG00000148357 [Q8NDA2-1]
UCSCiuc064wnb.1 human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HMCN2
HGNCiHGNC:21293 HMCN2
HPAiHPA053903
HPA070647
neXtProtiNX_Q8NDA2
OpenTargetsiENSG00000148357
PharmGKBiPA142671680

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162328
HOGENOMiHOG000172035
InParanoidiQ8NDA2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HMCN2 human
PharosiQ8NDA2

Protein Ontology

More...
PROi
PR:Q8NDA2

Gene expression databases

BgeeiENSG00000148357 Expressed in 138 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ8NDA2 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 43 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR032984 Hemicentin-2
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR036465 vWFA_dom_sf
PANTHERiPTHR45889:SF4 PTHR45889:SF4, 10 hits
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 4 hits
PF07474 G2F, 1 hit
PF07679 I-set, 31 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 6 hits
SM00682 G2F, 1 hit
SM00409 IG, 43 hits
SM00408 IGc2, 43 hits
SM00406 IGv, 14 hits
SUPFAMiSSF48726 SSF48726, 43 hits
SSF53300 SSF53300, 1 hit
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 5 hits
PS50835 IG_LIKE, 42 hits
PS50993 NIDOGEN_G2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMCN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NDA2
Secondary accession number(s): A0A096LP30, Q8N225, Q8TCI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 13, 2016
Last modified: October 16, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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