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Protein

Paraneoplastic antigen Ma1

Gene

PNMA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.

GO - Biological processi

  • inflammatory response to antigenic stimulus Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma1
Alternative name(s):
37 kDa neuronal protein
Neuron- and testis-specific protein 1
Gene namesi
Name:PNMA1
Synonyms:MA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176903.4
HGNCiHGNC:9158 PNMA1
MIMi604010 gene
neXtProtiNX_Q8ND90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9240
OpenTargetsiENSG00000176903
PharmGKBiPA33481

Polymorphism and mutation databases

BioMutaiPNMA1
DMDMi37999715

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001551991 – 353Paraneoplastic antigen Ma1Add BLAST353

Proteomic databases

EPDiQ8ND90
MaxQBiQ8ND90
PaxDbiQ8ND90
PeptideAtlasiQ8ND90
PRIDEiQ8ND90
ProteomicsDBi72992

PTM databases

iPTMnetiQ8ND90
PhosphoSitePlusiQ8ND90

Expressioni

Tissue specificityi

Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.2 Publications

Gene expression databases

BgeeiENSG00000176903
CleanExiHS_PNMA1
GenevisibleiQ8ND90 HS

Organism-specific databases

HPAiHPA003817
HPA015007

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q6ZN965EBI-302345,EBI-10255097
ANKRD36BP1Q96IX93EBI-302345,EBI-744859
APTXQ7Z2E33EBI-302345,EBI-847814
APTXQ7Z2E3-73EBI-302345,EBI-12298187
ARID5AQ039894EBI-302345,EBI-948603
ASMTLO956713EBI-302345,EBI-743231
ATP5OP480474EBI-302345,EBI-355815
BEX2Q9BXY83EBI-302345,EBI-745073
BYSLQ138953EBI-302345,EBI-358049
C21orf58Q0VAL73EBI-302345,EBI-10226774
C5orf30Q96GV93EBI-302345,EBI-2350695
C8orf33Q9H7E93EBI-302345,EBI-715389
CARHSP1Q9Y2V23EBI-302345,EBI-718719
CCDC146Q8IYE0-23EBI-302345,EBI-10247802
CCDC198Q9NVL83EBI-302345,EBI-10238351
CCNG1P519593EBI-302345,EBI-3905829
CDK18Q070023EBI-302345,EBI-746238
CFAP53Q96M913EBI-302345,EBI-742422
CHIC2Q9UKJ53EBI-302345,EBI-741528
CNNM3Q8NE013EBI-302345,EBI-741032
CNNM3Q8NE01-33EBI-302345,EBI-10269984
COX5BP106063EBI-302345,EBI-1053725
DAXXQ9UER74EBI-302345,EBI-77321
DCTN4Q9UJW03EBI-302345,EBI-2134033
EHHADHQ084263EBI-302345,EBI-2339219
ENKD1Q9H0I24EBI-302345,EBI-744099
FAM107AO95990-33EBI-302345,EBI-10192902
FAM110AQ9BQ893EBI-302345,EBI-1752811
FBF1Q8TES7-63EBI-302345,EBI-10244131
FBXL18Q96D165EBI-302345,EBI-744419
FEM1CQ96JP03EBI-302345,EBI-2515330
GEMP550403EBI-302345,EBI-744104
GPANK1O958723EBI-302345,EBI-751540
GPR25O001553EBI-302345,EBI-10178951
GTPBP10A4D1E94EBI-302345,EBI-5453796
HDAC4P565243EBI-302345,EBI-308629
HGSA0A0S2Z4Q43EBI-302345,EBI-16429135
HOXB9P174825EBI-302345,EBI-745290
INO80BQ9C0863EBI-302345,EBI-715611
KANSL1Q7Z3B33EBI-302345,EBI-740244
LIN37Q96GY33EBI-302345,EBI-748884
LMO3Q8TAP4-44EBI-302345,EBI-11742507
LNX1Q8TBB16EBI-302345,EBI-739832
MAB21L2Q9Y5863EBI-302345,EBI-6659161
MARK4Q96L342EBI-302345,EBI-302319
MCM7P339933EBI-302345,EBI-355924
MED8Q96G25-23EBI-302345,EBI-10286267
METTL17Q9H7H06EBI-302345,EBI-749353
METTL17Q9H7H0-25EBI-302345,EBI-11098807
MRPL10Q7Z7H83EBI-302345,EBI-723524
MRPL11Q9Y3B75EBI-302345,EBI-5453723
MRPL23Q165403EBI-302345,EBI-1046141
NPBWR2P481463EBI-302345,EBI-10210114
NUDT16L1Q9BRJ73EBI-302345,EBI-2949792
PARD3Q8TEW04EBI-302345,EBI-81968
PARD6AQ9NPB62EBI-302345,EBI-81876
PARD6BQ9BYG52EBI-302345,EBI-295391
PAUFC3PTT63EBI-302345,EBI-3505892
PIN1Q135263EBI-302345,EBI-714158
PIN4Q9Y2373EBI-302345,EBI-714599
PNMA5Q96PV45EBI-302345,EBI-10171633
PNMA6AP0CW246EBI-302345,EBI-721270
POLDIP3Q8WUT13EBI-302345,EBI-10276663
POLLQ9UGP5-23EBI-302345,EBI-10320765
POLMQ6PIY23EBI-302345,EBI-10253863
PRKCIP417432EBI-302345,EBI-286199
PRPF31Q8WWY310EBI-302345,EBI-1567797
PSMA1P257865EBI-302345,EBI-359352
RBM41Q96IZ53EBI-302345,EBI-740773
RPP25LQ8N5L83EBI-302345,EBI-10189722
RSPH9Q9H1X13EBI-302345,EBI-10305303
RSRC2Q7L4I2-23EBI-302345,EBI-10256202
RTP5Q14D335EBI-302345,EBI-10217913
RUSC1Q9BVN26EBI-302345,EBI-6257312
SCAND1P570863EBI-302345,EBI-745846
SCNM1Q9BWG67EBI-302345,EBI-748391
SDCBPO005607EBI-302345,EBI-727004
SEMA4CQ9C0C45EBI-302345,EBI-10303490
SH2D4AQ9H7885EBI-302345,EBI-747035
SHISA3A0PJX43EBI-302345,EBI-10171518
SLC25A48Q6ZT893EBI-302345,EBI-10255185
SLIRPQ9GZT33EBI-302345,EBI-1050793
SMIM3Q9BZL33EBI-302345,EBI-741850
SNRPBP14678-25EBI-302345,EBI-372475
SNRPB2P085795EBI-302345,EBI-1053651
SPATC1LQ9H0A93EBI-302345,EBI-372911
SPG7Q9UQ906EBI-302345,EBI-717201
STAMBPL1Q96FJ03EBI-302345,EBI-745021
SUV39H2Q9H5I14EBI-302345,EBI-723127
TCEANCQ8N8B73EBI-302345,EBI-954696
TEAD4A0A0S2Z4F23EBI-302345,EBI-16429215
TEAD4D3DUQ63EBI-302345,EBI-10176734
TEAD4Q155613EBI-302345,EBI-747736
TMSB4XQ0P5Q03EBI-302345,EBI-10226570
TNNI1P192375EBI-302345,EBI-746692
TRIM42Q8IWZ53EBI-302345,EBI-5235829
TSPYL4Q9UJ043EBI-302345,EBI-308511
TTC9CQ8N5M43EBI-302345,EBI-2851213
TXNDC9O145303EBI-302345,EBI-707554
UBQLN1Q9UMX04EBI-302345,EBI-741480
UBQLN1Q9UMX0-23EBI-302345,EBI-10173939
URB1-AS1Q96HZ73EBI-302345,EBI-10288943
USP2O756043EBI-302345,EBI-743272
VBP1P617583EBI-302345,EBI-357430
WDR25Q64LD23EBI-302345,EBI-744560
WDYHV1Q96HA85EBI-302345,EBI-741158
WT1-ASQ062503EBI-302345,EBI-10223946
ZC2HC1CQ53FD04EBI-302345,EBI-740767
ZCCHC12Q6PEW18EBI-302345,EBI-748373
ZFABQ9Y2603EBI-302345,EBI-750052
ZFYVE26Q68DK2-53EBI-302345,EBI-8656416
ZNF564Q8TBZ83EBI-302345,EBI-10273713
ZNF581Q9P0T47EBI-302345,EBI-745520
ZNF688A0A0S2Z5X43EBI-302345,EBI-16429014

Protein-protein interaction databases

BioGridi114667, 125 interactors
IntActiQ8ND90, 174 interactors
MINTiQ8ND90
STRINGi9606.ENSP00000318914

Structurei

3D structure databases

ProteinModelPortaliQ8ND90
SMRiQ8ND90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 341Poly-Glu7

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410IIH9 Eukaryota
ENOG410YK5I LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ8ND90
OMAiEHTNEVM
OrthoDBiEOG091G0BG9
PhylomeDBiQ8ND90
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR026528 PNMA1
PANTHERiPTHR23095 PTHR23095, 1 hit
PTHR23095:SF17 PTHR23095:SF17, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ND90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM
60 70 80 90 100
LGRMFWREEN AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE
110 120 130 140 150
FLERLHLFLA REGWTVQDVA RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ
160 170 180 190 200
PLVESIWYKR LTLFSGRDIP GPGEETFDPW LEHTNEVLEE WQVSDVEKRR
210 220 230 240 250
RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV ESSRDAQIKF
260 270 280 290 300
LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH
310 320 330 340 350
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE

GHF
Length:353
Mass (Da):39,761
Last modified:October 24, 2003 - v2
Checksum:iEB7F5B6AEDA25961
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05359554M → V. Corresponds to variant dbSNP:rs35129712Ensembl.1
Natural variantiVAR_053596215R → P. Corresponds to variant dbSNP:rs34413931Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037364 mRNA Translation: AAD13810.3
AF320308 mRNA Translation: AAN05100.1
AK290980 mRNA Translation: BAF83669.1
CH471061 Genomic DNA Translation: EAW81126.1
BC039577 mRNA Translation: AAH39577.1
AL834327 mRNA Translation: CAD38995.1
CCDSiCCDS9818.1
RefSeqiNP_006020.4, NM_006029.4
UniGeneiHs.194709

Genome annotation databases

EnsembliENST00000316836; ENSP00000318914; ENSG00000176903
GeneIDi9240
KEGGihsa:9240
UCSCiuc001xor.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPNMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8ND90
Secondary accession number(s): A8K4L5, O95144, Q8NG07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: July 18, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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