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Protein

SLAIN motif-containing protein 1

Gene

SLAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
SLAIN motif-containing protein 1
Gene namesi
Name:SLAIN1
Synonyms:C13orf32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139737.21
HGNCiHGNC:26387 SLAIN1
MIMi610491 gene
neXtProtiNX_Q8ND83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139737
PharmGKBiPA162403440

Polymorphism and mutation databases

BioMutaiSLAIN1
DMDMi166977707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169621 – 568SLAIN motif-containing protein 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243PhosphoserineCombined sources1
Modified residuei471Asymmetric dimethylarginineBy similarity1
Modified residuei543Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8ND83
MaxQBiQ8ND83
PaxDbiQ8ND83
PeptideAtlasiQ8ND83
PRIDEiQ8ND83
ProteomicsDBi72988
72989 [Q8ND83-2]
72990 [Q8ND83-3]
72991 [Q8ND83-4]
TopDownProteomicsiQ8ND83-1 [Q8ND83-1]

PTM databases

iPTMnetiQ8ND83
PhosphoSitePlusiQ8ND83

Expressioni

Tissue specificityi

Expressed in embryonic stem cells (PubMed:16546155). Expressed in brain (PubMed:21646404).2 Publications

Gene expression databases

BgeeiENSG00000139737 Expressed in 167 organ(s), highest expression level in corpus callosum
CleanExiHS_SLAIN1
ExpressionAtlasiQ8ND83 baseline and differential
GenevisibleiQ8ND83 HS

Organism-specific databases

HPAiHPA040798

Interactioni

Subunit structurei

Interacts with MAPRE1, MAPRE2, MAPRE3 and CKAP5 (PubMed:21646404). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi125759, 7 interactors
IntActiQ8ND83, 18 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8ND83
SMRiQ8ND83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 56Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 162Pro-richAdd BLAST100

Sequence similaritiesi

Belongs to the SLAIN motif-containing family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGU1 Eukaryota
ENOG410XTEB LUCA
GeneTreeiENSGT00390000017860
HOGENOMiHOG000057277
HOVERGENiHBG072961
InParanoidiQ8ND83
KOiK16580
PhylomeDBiQ8ND83
TreeFamiTF331616

Family and domain databases

InterProiView protein in InterPro
IPR026179 Slain
PANTHERiPTHR22406 PTHR22406, 1 hit
PfamiView protein in Pfam
PF15301 SLAIN, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8ND83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAEQVKCAS AGVSSGAGSG PVVNAELEVK KLQELVRKLE KQNEQLRSRA
60 70 80 90 100
ASAAAAPHLL LLPPPPPAAP PPAGLQPLGP RSPPAATATA AASGGLGPAF
110 120 130 140 150
PGTFCLPSPA PSLLCSLAQP PEAPFVYFKP AAGFFGAGGG GPEPGGAGTP
160 170 180 190 200
PGAAAAPPSP PPTLLDEVEL LDLESVAAWR DEDDYTWLYI GSSKTFTSSE
210 220 230 240 250
KSLTPLQWCR HVLDNPTPEM EAARRSLCFR LEQGYTSRGS PLSPQSSIDS
260 270 280 290 300
ELSTSELEDD SISMGYKLQD LTDVQIMARL QEESLRQDYA STSASVSRHS
310 320 330 340 350
SSVSLSSGKK GTCSDQEYDQ YSLEDEEEFD HLPPPQPRLP RCSPFQRGIP
360 370 380 390 400
HSQTFSSIRE CRRSPSSQYF PSNNYQQQQY YSPQAQTPDQ QPNRTNGDKL
410 420 430 440 450
RRSMPNLARM PSTTAISSNI SSPVTVRNSQ SFDSSLHGAG NGISRIQSCI
460 470 480 490 500
PSPGQLQHRV HSVGHFPVSI RQPLKATAYV SPTVQGSSNM PLSNGLQLYS
510 520 530 540 550
NTGIPTPNKA AASGIMGRSA LPRPSLAING SNLPRSKIAQ PVRSFLQPPK
560
PLSSLSTLRD GNWRDGCY
Length:568
Mass (Da):60,595
Last modified:February 5, 2008 - v3
Checksum:i206E9C7C92265321
GO
Isoform 2 (identifier: Q8ND83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.

Show »
Length:305
Mass (Da):33,522
Checksum:iF32C643ACC52BC2B
GO
Isoform 3 (identifier: Q8ND83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     284-397: Missing.
     398-398: D → N

Show »
Length:191
Mass (Da):20,545
Checksum:i2AB5BA8F8347D5E5
GO
Isoform 4 (identifier: Q8ND83-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: MMAEQVKCAS...AWRDEDDYTW → MVGVGLCLRL...RSDGSLFIER

Show »
Length:426
Mass (Da):47,321
Checksum:iA775066FAC6DCEA1
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSS3A0A0A0MSS3_HUMAN
SLAIN motif-containing protein 1
SLAIN1
590Annotation score:
B7Z326B7Z326_HUMAN
SLAIN motif-containing protein 1
SLAIN1
304Annotation score:
Q5T6P1Q5T6P1_HUMAN
SLAIN motif-containing protein 1
SLAIN1
228Annotation score:
C9JUW9C9JUW9_HUMAN
SLAIN motif-containing protein 1
SLAIN1
147Annotation score:
C9JD09C9JD09_HUMAN
SLAIN motif-containing protein 1
SLAIN1
135Annotation score:
Q5T6P2Q5T6P2_HUMAN
SLAIN motif-containing protein 1
SLAIN1
111Annotation score:
C9JP03C9JP03_HUMAN
SLAIN motif-containing protein 1
SLAIN1
99Annotation score:
X6RDJ2X6RDJ2_HUMAN
SLAIN motif-containing protein 1
SLAIN1
205Annotation score:
X6RGK9X6RGK9_HUMAN
SLAIN motif-containing protein 1
SLAIN1
240Annotation score:
A0A0C4DFN6A0A0C4DFN6_HUMAN
SLAIN motif-containing protein 1
SLAIN1
349Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAI11498 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD39000 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti399K → R in BAF82403 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0308321 – 263Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST263
Alternative sequenceiVSP_0541181 – 187MMAEQ…DDYTW → MVGVGLCLRLLLFFRFKRTL DRICVLFLLGWHRKPRSDGS LFIER in isoform 4. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_043256284 – 397Missing in isoform 3. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_043257398D → N in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054608 mRNA Translation: BAB70772.1
AK289600 mRNA Translation: BAF82289.1
AK289714 mRNA Translation: BAF82403.1
AK294201 mRNA Translation: BAH11695.1
AL834203 mRNA Translation: CAD38891.1
AL834332 mRNA Translation: CAD39000.2 Different initiation.
AL354831 Genomic DNA No translation available.
BC111497 mRNA Translation: AAI11498.1 Different initiation.
CCDSiCCDS31995.2 [Q8ND83-4]
CCDS55901.1 [Q8ND83-3]
CCDS9460.1 [Q8ND83-2]
RefSeqiNP_001035243.2, NM_001040153.3 [Q8ND83-4]
NP_001229798.1, NM_001242869.1 [Q8ND83-3]
NP_001229799.1, NM_001242870.1 [Q8ND83-3]
NP_653196.1, NM_144595.3 [Q8ND83-2]
XP_011533232.1, XM_011534930.1 [Q8ND83-2]
UniGeneiHs.349955
Hs.732587

Genome annotation databases

EnsembliENST00000314070; ENSP00000314443; ENSG00000139737 [Q8ND83-3]
ENST00000358679; ENSP00000351507; ENSG00000139737 [Q8ND83-2]
ENST00000466548; ENSP00000419730; ENSG00000139737 [Q8ND83-1]
ENST00000488699; ENSP00000418707; ENSG00000139737 [Q8ND83-4]
GeneIDi122060
KEGGihsa:122060
UCSCiuc001vkm.3 human [Q8ND83-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSLAI1_HUMAN
AccessioniPrimary (citable) accession number: Q8ND83
Secondary accession number(s): A8K0Z9
, B7Z209, Q5T6P4, Q5T6P7, Q8ND10, Q96NV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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