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Protein

Zinc finger protein 280C

Gene

ZNF280C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1Add BLAST23
Zinc fingeri353 – 376C2H2-type 2Add BLAST24
Zinc fingeri383 – 406C2H2-type 3Add BLAST24
Zinc fingeri413 – 436C2H2-type 4Add BLAST24
Zinc fingeri470 – 492C2H2-type 5Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280C
Alternative name(s):
Suppressor of hairy wing homolog 3
Zinc finger protein 633
Gene namesi
Name:ZNF280C
Synonyms:SUHW3, ZNF633
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000056277.15
HGNCiHGNC:25955 ZNF280C
neXtProtiNX_Q8ND82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000056277
PharmGKBiPA162409961

Polymorphism and mutation databases

BioMutaiZNF280C
DMDMi74751215

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279751 – 737Zinc finger protein 280CAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei80PhosphoserineCombined sources1
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei223PhosphothreonineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki522Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei540PhosphothreonineCombined sources1
Cross-linki564Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki574Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8ND82
MaxQBiQ8ND82
PaxDbiQ8ND82
PeptideAtlasiQ8ND82
PRIDEiQ8ND82
ProteomicsDBi72987

PTM databases

CarbonylDBiQ8ND82
iPTMnetiQ8ND82
PhosphoSitePlusiQ8ND82

Expressioni

Gene expression databases

BgeeiENSG00000056277 Expressed in 126 organ(s), highest expression level in female gonad
CleanExiHS_ZNF280C
ExpressionAtlasiQ8ND82 baseline and differential
GenevisibleiQ8ND82 HS

Organism-specific databases

HPAiHPA051494
HPA055788

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120749, 12 interactors
ELMiQ8ND82
IntActiQ8ND82, 11 interactors
STRINGi9606.ENSP00000360017

Structurei

3D structure databases

ProteinModelPortaliQ8ND82
SMRiQ8ND82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 28Poly-Glu8
Compositional biasi67 – 227Ser-richAdd BLAST161

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri316 – 338C2H2-type 1Add BLAST23
Zinc fingeri353 – 376C2H2-type 2Add BLAST24
Zinc fingeri383 – 406C2H2-type 3Add BLAST24
Zinc fingeri413 – 436C2H2-type 4Add BLAST24
Zinc fingeri470 – 492C2H2-type 5Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ8ND82
OMAiHMKHCCP
OrthoDBiEOG091G01UE
PhylomeDBiQ8ND82
TreeFamiTF331707

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8ND82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDDKPFQPK NISKMAELFM ECEEEELEPW QKKVEETQDE DDDELIFVGE
60 70 80 90 100
ISSSKPAISN ILNRGHSSSS SKGIKSEPHS PGIPEIFRTA SQRCRDPPSN
110 120 130 140 150
PVAASPRFHL VSKSSQSSVT VENASKPDFT KNSQVGSDNS SILLFDSTQE
160 170 180 190 200
SLPPSQDIPA IFREGMKNTS YVLKHPSTSK VNSVTPKKPK TSEDVPQINP
210 220 230 240 250
STSLPLIGSP PVTSSQVMLS KGTNTSSPYD AGADYLRACP KCNVQFNLLD
260 270 280 290 300
PLKYHMKHCC PDMITKFLGV IVKSERPCDE DKTDSETGKL IMLVNEFYYG
310 320 330 340 350
RHEGVTEKEP KTYTTFKCFS CSKVLKNNIR FMNHMKHHLE LEKQNNESWE
360 370 380 390 400
NHTTCQHCYR QYPTPFQLQC HIESTHTPHE FSTICKICEL SFETEHILLQ
410 420 430 440 450
HMKDTHKPGE MPYVCQVCQF RSSTFSDVEA HFRAAHENTK NLLCPFCLKV
460 470 480 490 500
SKMATPYMNH YMKHQKKGVH RCPKCRLQFL TSKEKAEHKA QHRTFIKPKE
510 520 530 540 550
LEGLPPGAKV TIRASLGPLQ SKLPTAPFGC APGTSFLQVT PPTSQNTTAR
560 570 580 590 600
NPRKSNASRS KTSKLHATTS TASKVNTSKP RGRIAKSKAK PSYKQKRQRN
610 620 630 640 650
RKNKMSLALK NIRCRRGIHK CIECHSKIKD FASHFSIYIH CSFCKYNTNC
660 670 680 690 700
NKAFVNHMMS SHSNHPGKRF CIFKKHSGTL RGITLVCLKC DFLADSSGLD
710 720 730
RMAKHLSQRK THTCQVIIEN VSKSTSTSEP TTGCSLK
Length:737
Mass (Da):83,096
Last modified:October 1, 2002 - v1
Checksum:iD9974B7F772FE840
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UJJ2Q9UJJ2_HUMAN
Zinc finger protein 280C
ZNF280C
610Annotation score:

Sequence cautioni

The sequence BAA90947 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000102 mRNA Translation: BAA90947.1 Sequence problems.
AK290373 mRNA Translation: BAF83062.1
AL834333 mRNA Translation: CAD39001.1
AL023799 Genomic DNA No translation available.
AL139234 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11806.1
BC051728 mRNA Translation: AAH51728.1
CCDSiCCDS14622.1
RefSeqiNP_060136.1, NM_017666.4
UniGeneiHs.308418

Genome annotation databases

EnsembliENST00000370978; ENSP00000360017; ENSG00000056277
GeneIDi55609
KEGGihsa:55609
UCSCiuc004evm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000102 mRNA Translation: BAA90947.1 Sequence problems.
AK290373 mRNA Translation: BAF83062.1
AL834333 mRNA Translation: CAD39001.1
AL023799 Genomic DNA No translation available.
AL139234 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11806.1
BC051728 mRNA Translation: AAH51728.1
CCDSiCCDS14622.1
RefSeqiNP_060136.1, NM_017666.4
UniGeneiHs.308418

3D structure databases

ProteinModelPortaliQ8ND82
SMRiQ8ND82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120749, 12 interactors
ELMiQ8ND82
IntActiQ8ND82, 11 interactors
STRINGi9606.ENSP00000360017

PTM databases

CarbonylDBiQ8ND82
iPTMnetiQ8ND82
PhosphoSitePlusiQ8ND82

Polymorphism and mutation databases

BioMutaiZNF280C
DMDMi74751215

Proteomic databases

EPDiQ8ND82
MaxQBiQ8ND82
PaxDbiQ8ND82
PeptideAtlasiQ8ND82
PRIDEiQ8ND82
ProteomicsDBi72987

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370978; ENSP00000360017; ENSG00000056277
GeneIDi55609
KEGGihsa:55609
UCSCiuc004evm.4 human

Organism-specific databases

CTDi55609
EuPathDBiHostDB:ENSG00000056277.15
GeneCardsiZNF280C
HGNCiHGNC:25955 ZNF280C
HPAiHPA051494
HPA055788
neXtProtiNX_Q8ND82
OpenTargetsiENSG00000056277
PharmGKBiPA162409961
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ8ND82
OMAiHMKHCCP
OrthoDBiEOG091G01UE
PhylomeDBiQ8ND82
TreeFamiTF331707

Miscellaneous databases

ChiTaRSiZNF280C human
GenomeRNAii55609
PROiPR:Q8ND82

Gene expression databases

BgeeiENSG00000056277 Expressed in 126 organ(s), highest expression level in female gonad
CleanExiHS_ZNF280C
ExpressionAtlasiQ8ND82 baseline and differential
GenevisibleiQ8ND82 HS

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ280C_HUMAN
AccessioniPrimary (citable) accession number: Q8ND82
Secondary accession number(s): A8K2V8, Q9NXR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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