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Entry version 164 (16 Oct 2019)
Sequence version 2 (13 Sep 2004)
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Protein

Cyclin-Y

Gene

CCNY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Wnt signaling pathway

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8ND76

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8ND76

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-Y
Short name:
Cyc-Y
Alternative name(s):
Cyclin box protein 1
Cyclin fold protein 1
cyclin-X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNY
Synonyms:C10orf9, CBCP1, CFP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23354 CCNY

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612786 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8ND76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Induces a diffuse cytoplasmic localization. 2 Publications1
Mutagenesisi3N → A: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
219771

Open Targets

More...
OpenTargetsi
ENSG00000108100

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381980

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8ND76

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3885550
CHEMBL4106161

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCNY

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71658801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805142 – 341Cyclin-YAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1 Publication1
Modified residuei30Phosphothreonine1 Publication1
Modified residuei33Phosphoserine1 Publication1
Modified residuei37PhosphothreonineCombined sources1 Publication1
Modified residuei67Phosphothreonine; by CDK141 Publication1
Modified residuei71Phosphoserine; by CDK141 Publication1
Modified residuei73Phosphoserine; by CDK141 Publication1
Modified residuei75Phosphothreonine1 Publication1
Modified residuei83Phosphoserine; by CDK14Combined sources1 Publication1
Modified residuei99Phosphoserine1 Publication1
Modified residuei100Phosphoserine1 Publication1
Modified residuei102Phosphoserine1 Publication1
Modified residuei280PhosphoserineBy similarity1
Modified residuei288Phosphoserine; by CDK141 Publication1
Modified residuei295Phosphoserine; by CDK141 Publication1
Modified residuei324Phosphoserine1 Publication1
Modified residuei326PhosphoserineCombined sources2 Publications1
Modified residuei331PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; leading to its degradation.2 Publications
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8ND76

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8ND76

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8ND76

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8ND76

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8ND76

PeptideAtlas

More...
PeptideAtlasi
Q8ND76

PRoteomics IDEntifications database

More...
PRIDEi
Q8ND76

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72984 [Q8ND76-1]
72985 [Q8ND76-2]
72986 [Q8ND76-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8ND76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8ND76

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8ND76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Enriched at G2/M.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108100 Expressed in 205 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8ND76 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8ND76 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036290

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with CAPRIN2, LRP6 AND CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587).

Interacts with CDK14 (PubMed:19524571, PubMed:20059949).

Interacts with CDK16 (PubMed:22184064).

Interacts with LRP6 (PubMed:20059949).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128575, 25 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-364 Cyclin Y-CDK14 complex

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8ND76

Protein interaction database and analysis system

More...
IntActi
Q8ND76, 14 interactors

Molecular INTeraction database

More...
MINTi
Q8ND76

STRING: functional protein association networks

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STRINGi
9606.ENSP00000363836

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8ND76

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini143 – 265Cyclin N-terminalAdd BLAST123

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin Y subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1675 Eukaryota
ENOG410XNQX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154453

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8ND76

Identification of Orthologs from Complete Genome Data

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OMAi
TPANWKR

Database of Orthologous Groups

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OrthoDBi
916284at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8ND76

TreeFam database of animal gene trees

More...
TreeFami
TF314464

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR012399 Cyclin_Y

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00134 Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028934 Cyclin_CG14939, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8ND76-1) [UniParc]FASTAAdd to basket
Also known as: b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI
60 70 80 90 100
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS
110 120 130 140 150
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH
160 170 180 190 200
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL
210 220 230 240 250
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN
260 270 280 290 300
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
310 320 330 340
KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S
Length:341
Mass (Da):39,337
Last modified:September 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i949FDE1EE45C2C6E
GO
Isoform 2 (identifier: Q8ND76-2) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,504
Checksum:iD9DC97553928235E
GO
Isoform 3 (identifier: Q8ND76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:287
Mass (Da):33,245
Checksum:i88D15913BF680A01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNF3R4GNF3_HUMAN
Cyclin-Y
CCNY
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN48R4GN48_HUMAN
Cyclin-Y
CCNY
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69224 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78R → G in AAL78998 (Ref. 4) Curated1
Sequence conflicti118Y → H in AAL78999 (Ref. 4) Curated1
Sequence conflicti155S → C in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti155S → C in AAL07802 (Ref. 3) Curated1
Sequence conflicti171I → M in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti171I → M in AAL07802 (Ref. 3) Curated1
Sequence conflicti190I → V in BAB71409 (PubMed:14702039).Curated1
Sequence conflicti216V → A in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti216V → A in AAL07802 (Ref. 3) Curated1
Sequence conflicti250N → S in BAB71409 (PubMed:14702039).Curated1
Sequence conflicti268S → F in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti268S → F in AAL07802 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0148331 – 54Missing in isoform 3. 3 PublicationsAdd BLAST54
Alternative sequenceiVSP_01483452 – 76Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY504868 mRNA Translation: AAS79427.1
AF429969 mRNA Translation: AAP97301.1
AF413522 mRNA Translation: AAL07802.1
AF465728 mRNA Translation: AAL78998.1
AF465729 mRNA Translation: AAL78999.1
AK057280 mRNA Translation: BAB71409.1
AL834355 mRNA Translation: CAD39020.2
AL592445 Genomic DNA No translation available.
AL603824 Genomic DNA No translation available.
AL117336 Genomic DNA No translation available.
AL121749 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85912.1
CH471072 Genomic DNA Translation: EAW85913.1
CH471072 Genomic DNA Translation: EAW85914.1
BC069224 mRNA Translation: AAH69224.1 Different initiation.
BC094815 mRNA Translation: AAH94815.1
BC104773 mRNA Translation: AAI04774.1
BC104801 mRNA Translation: AAI04802.1
BC143450 mRNA Translation: AAI43451.1
BC143455 mRNA Translation: AAI43456.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS60513.1 [Q8ND76-2]
CCDS7189.1 [Q8ND76-1]
CCDS7190.1 [Q8ND76-3]

NCBI Reference Sequences

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RefSeqi
NP_001269781.1, NM_001282852.1 [Q8ND76-2]
NP_001269782.1, NM_001282853.1 [Q8ND76-3]
NP_001269783.1, NM_001282854.1
NP_659449.3, NM_145012.5 [Q8ND76-1]
NP_859049.2, NM_181698.3 [Q8ND76-3]
XP_011517660.1, XM_011519358.1
XP_011517662.1, XM_011519360.2
XP_011517663.1, XM_011519361.1
XP_011517664.1, XM_011519362.1
XP_011517665.1, XM_011519363.1
XP_011517666.1, XM_011519364.1
XP_011517667.1, XM_011519365.2
XP_011517668.1, XM_011519366.1
XP_011517669.1, XM_011519367.1
XP_011517670.1, XM_011519368.2
XP_016871328.1, XM_017015839.1
XP_016871329.1, XM_017015840.1
XP_016871330.1, XM_017015841.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265375; ENSP00000265375; ENSG00000108100 [Q8ND76-3]
ENST00000339497; ENSP00000344275; ENSG00000108100 [Q8ND76-2]
ENST00000374704; ENSP00000363836; ENSG00000108100 [Q8ND76-1]
ENST00000374706; ENSP00000363838; ENSG00000108100 [Q8ND76-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
219771

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:219771

UCSC genome browser

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UCSCi
uc001iyu.6 human [Q8ND76-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504868 mRNA Translation: AAS79427.1
AF429969 mRNA Translation: AAP97301.1
AF413522 mRNA Translation: AAL07802.1
AF465728 mRNA Translation: AAL78998.1
AF465729 mRNA Translation: AAL78999.1
AK057280 mRNA Translation: BAB71409.1
AL834355 mRNA Translation: CAD39020.2
AL592445 Genomic DNA No translation available.
AL603824 Genomic DNA No translation available.
AL117336 Genomic DNA No translation available.
AL121749 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85912.1
CH471072 Genomic DNA Translation: EAW85913.1
CH471072 Genomic DNA Translation: EAW85914.1
BC069224 mRNA Translation: AAH69224.1 Different initiation.
BC094815 mRNA Translation: AAH94815.1
BC104773 mRNA Translation: AAI04774.1
BC104801 mRNA Translation: AAI04802.1
BC143450 mRNA Translation: AAI43451.1
BC143455 mRNA Translation: AAI43456.1
CCDSiCCDS60513.1 [Q8ND76-2]
CCDS7189.1 [Q8ND76-1]
CCDS7190.1 [Q8ND76-3]
RefSeqiNP_001269781.1, NM_001282852.1 [Q8ND76-2]
NP_001269782.1, NM_001282853.1 [Q8ND76-3]
NP_001269783.1, NM_001282854.1
NP_659449.3, NM_145012.5 [Q8ND76-1]
NP_859049.2, NM_181698.3 [Q8ND76-3]
XP_011517660.1, XM_011519358.1
XP_011517662.1, XM_011519360.2
XP_011517663.1, XM_011519361.1
XP_011517664.1, XM_011519362.1
XP_011517665.1, XM_011519363.1
XP_011517666.1, XM_011519364.1
XP_011517667.1, XM_011519365.2
XP_011517668.1, XM_011519366.1
XP_011517669.1, XM_011519367.1
XP_011517670.1, XM_011519368.2
XP_016871328.1, XM_017015839.1
XP_016871329.1, XM_017015840.1
XP_016871330.1, XM_017015841.1

3D structure databases

SMRiQ8ND76
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128575, 25 interactors
ComplexPortaliCPX-364 Cyclin Y-CDK14 complex
ELMiQ8ND76
IntActiQ8ND76, 14 interactors
MINTiQ8ND76
STRINGi9606.ENSP00000363836

Chemistry databases

ChEMBLiCHEMBL3885550
CHEMBL4106161

PTM databases

iPTMnetiQ8ND76
PhosphoSitePlusiQ8ND76
SwissPalmiQ8ND76

Polymorphism and mutation databases

BioMutaiCCNY
DMDMi71658801

Proteomic databases

EPDiQ8ND76
jPOSTiQ8ND76
MassIVEiQ8ND76
MaxQBiQ8ND76
PaxDbiQ8ND76
PeptideAtlasiQ8ND76
PRIDEiQ8ND76
ProteomicsDBi72984 [Q8ND76-1]
72985 [Q8ND76-2]
72986 [Q8ND76-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
219771

Genome annotation databases

EnsembliENST00000265375; ENSP00000265375; ENSG00000108100 [Q8ND76-3]
ENST00000339497; ENSP00000344275; ENSG00000108100 [Q8ND76-2]
ENST00000374704; ENSP00000363836; ENSG00000108100 [Q8ND76-1]
ENST00000374706; ENSP00000363838; ENSG00000108100 [Q8ND76-3]
GeneIDi219771
KEGGihsa:219771
UCSCiuc001iyu.6 human [Q8ND76-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
219771
DisGeNETi219771

GeneCards: human genes, protein and diseases

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GeneCardsi
CCNY
HGNCiHGNC:23354 CCNY
HPAiHPA036290
MIMi612786 gene
neXtProtiNX_Q8ND76
OpenTargetsiENSG00000108100
PharmGKBiPA162381980

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1675 Eukaryota
ENOG410XNQX LUCA
GeneTreeiENSGT00940000154453
InParanoidiQ8ND76
OMAiTPANWKR
OrthoDBi916284at2759
PhylomeDBiQ8ND76
TreeFamiTF314464

Enzyme and pathway databases

SignaLinkiQ8ND76
SIGNORiQ8ND76

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCNY human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCNY_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
219771
PharosiQ8ND76

Protein Ontology

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PROi
PR:Q8ND76

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108100 Expressed in 205 organ(s), highest expression level in sperm
ExpressionAtlasiQ8ND76 baseline and differential
GenevisibleiQ8ND76 HS

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR012399 Cyclin_Y
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF028934 Cyclin_CG14939, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNY_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ND76
Secondary accession number(s): B7ZKX9
, D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8TEX2, Q8TEX3, Q96M99, Q96P45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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