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Protein

Cyclin-Y

Gene

CCNY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.4 Publications

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  • regulation of canonical Wnt signaling pathway Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ8ND76
SIGNORiQ8ND76

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-Y
Short name:
Cyc-Y
Alternative name(s):
Cyclin box protein 1
Cyclin fold protein 1
cyclin-X
Gene namesi
Name:CCNY
Synonyms:C10orf9, CBCP1, CFP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108100.17
HGNCiHGNC:23354 CCNY
MIMi612786 gene
neXtProtiNX_Q8ND76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Induces a diffuse cytoplasmic localization. 2 Publications1
Mutagenesisi3N → A: No effect on subcellular location. 1 Publication1

Organism-specific databases

DisGeNETi219771
OpenTargetsiENSG00000108100
PharmGKBiPA162381980

Chemistry databases

ChEMBLiCHEMBL3885550

Polymorphism and mutation databases

DMDMi71658801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000805142 – 341Cyclin-YAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Modified residuei21PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1 Publication1
Modified residuei30Phosphothreonine1 Publication1
Modified residuei33Phosphoserine1 Publication1
Modified residuei37PhosphothreonineCombined sources1 Publication1
Modified residuei67Phosphothreonine; by CDK141 Publication1
Modified residuei71Phosphoserine; by CDK141 Publication1
Modified residuei73Phosphoserine; by CDK141 Publication1
Modified residuei75Phosphothreonine1 Publication1
Modified residuei83Phosphoserine; by CDK14Combined sources1 Publication1
Modified residuei99Phosphoserine1 Publication1
Modified residuei100Phosphoserine1 Publication1
Modified residuei102Phosphoserine1 Publication1
Modified residuei280PhosphoserineBy similarity1
Modified residuei288Phosphoserine; by CDK141 Publication1
Modified residuei295Phosphoserine; by CDK141 Publication1
Modified residuei324Phosphoserine1 Publication1
Modified residuei326PhosphoserineCombined sources2 Publications1
Modified residuei331PhosphothreonineCombined sources1

Post-translational modificationi

Ubiquitinated; leading to its degradation.2 Publications
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8ND76
MaxQBiQ8ND76
PaxDbiQ8ND76
PeptideAtlasiQ8ND76
PRIDEiQ8ND76
ProteomicsDBi72984
72985 [Q8ND76-2]
72986 [Q8ND76-3]

PTM databases

iPTMnetiQ8ND76
PhosphoSitePlusiQ8ND76
SwissPalmiQ8ND76

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Enriched at G2/M.1 Publication

Gene expression databases

BgeeiENSG00000108100
CleanExiHS_CCNY
ExpressionAtlasiQ8ND76 baseline and differential
GenevisibleiQ8ND76 HS

Organism-specific databases

HPAiHPA036290

Interactioni

Subunit structurei

Found in a complex with CAPRIN2, LRP6 AND CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587). Interacts with CDK14 (PubMed:19524571, PubMed:20059949). Interacts with CDK16 (PubMed:22184064). Interacts with LRP6 (PubMed:20059949).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128575, 21 interactors
ComplexPortaliCPX-364 Cyclin Y-CDK14 complex
ELMiQ8ND76
IntActiQ8ND76, 5 interactors
MINTiQ8ND76
STRINGi9606.ENSP00000363836

Structurei

3D structure databases

ProteinModelPortaliQ8ND76
SMRiQ8ND76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 265Cyclin N-terminalAdd BLAST123

Sequence similaritiesi

Belongs to the cyclin family. Cyclin Y subfamily.Curated

Phylogenomic databases

eggNOGiKOG1675 Eukaryota
ENOG410XNQX LUCA
GeneTreeiENSGT00390000006626
HOVERGENiHBG058985
InParanoidiQ8ND76
OMAiNLTVVRW
OrthoDBiEOG091G0BM9
PhylomeDBiQ8ND76
TreeFamiTF314464

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR012399 Cyclin_Y
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF028934 Cyclin_CG14939, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND76-1) [UniParc]FASTAAdd to basket
Also known as: b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI
60 70 80 90 100
DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS
110 120 130 140 150
CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH
160 170 180 190 200
PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL
210 220 230 240 250
TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN
260 270 280 290 300
ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH
310 320 330 340
KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S
Length:341
Mass (Da):39,337
Last modified:September 13, 2004 - v2
Checksum:i949FDE1EE45C2C6E
GO
Isoform 2 (identifier: Q8ND76-2) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     52-76: Missing.

Show »
Length:316
Mass (Da):36,504
Checksum:iD9DC97553928235E
GO
Isoform 3 (identifier: Q8ND76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:287
Mass (Da):33,245
Checksum:i88D15913BF680A01
GO

Sequence cautioni

The sequence AAH69224 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78R → G in AAL78998 (Ref. 4) Curated1
Sequence conflicti118Y → H in AAL78999 (Ref. 4) Curated1
Sequence conflicti155S → C in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti155S → C in AAL07802 (Ref. 3) Curated1
Sequence conflicti171I → M in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti171I → M in AAL07802 (Ref. 3) Curated1
Sequence conflicti190I → V in BAB71409 (PubMed:14702039).Curated1
Sequence conflicti216V → A in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti216V → A in AAL07802 (Ref. 3) Curated1
Sequence conflicti250N → S in BAB71409 (PubMed:14702039).Curated1
Sequence conflicti268S → F in AAS79427 (PubMed:19524571).Curated1
Sequence conflicti268S → F in AAL07802 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0148331 – 54Missing in isoform 3. 3 PublicationsAdd BLAST54
Alternative sequenceiVSP_01483452 – 76Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504868 mRNA Translation: AAS79427.1
AF429969 mRNA Translation: AAP97301.1
AF413522 mRNA Translation: AAL07802.1
AF465728 mRNA Translation: AAL78998.1
AF465729 mRNA Translation: AAL78999.1
AK057280 mRNA Translation: BAB71409.1
AL834355 mRNA Translation: CAD39020.2
AL592445 Genomic DNA No translation available.
AL603824 Genomic DNA No translation available.
AL117336 Genomic DNA No translation available.
AL121749 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85912.1
CH471072 Genomic DNA Translation: EAW85913.1
CH471072 Genomic DNA Translation: EAW85914.1
BC069224 mRNA Translation: AAH69224.1 Different initiation.
BC094815 mRNA Translation: AAH94815.1
BC104773 mRNA Translation: AAI04774.1
BC104801 mRNA Translation: AAI04802.1
BC143450 mRNA Translation: AAI43451.1
BC143455 mRNA Translation: AAI43456.1
CCDSiCCDS60513.1 [Q8ND76-2]
CCDS7189.1 [Q8ND76-1]
CCDS7190.1 [Q8ND76-3]
RefSeqiNP_001269781.1, NM_001282852.1 [Q8ND76-2]
NP_001269782.1, NM_001282853.1 [Q8ND76-3]
NP_001269783.1, NM_001282854.1
NP_659449.3, NM_145012.5 [Q8ND76-1]
NP_859049.2, NM_181698.3 [Q8ND76-3]
XP_011517660.1, XM_011519358.1 [Q8ND76-3]
XP_011517662.1, XM_011519360.2 [Q8ND76-3]
XP_011517663.1, XM_011519361.1 [Q8ND76-3]
XP_011517664.1, XM_011519362.1 [Q8ND76-3]
XP_011517665.1, XM_011519363.1 [Q8ND76-3]
XP_011517666.1, XM_011519364.1 [Q8ND76-3]
XP_011517667.1, XM_011519365.2 [Q8ND76-3]
XP_011517668.1, XM_011519366.1 [Q8ND76-3]
XP_011517669.1, XM_011519367.1 [Q8ND76-3]
XP_011517670.1, XM_011519368.2 [Q8ND76-3]
XP_016871328.1, XM_017015839.1 [Q8ND76-3]
XP_016871329.1, XM_017015840.1 [Q8ND76-3]
XP_016871330.1, XM_017015841.1 [Q8ND76-3]
UniGeneiHs.14745
Hs.564123
Hs.651463
Hs.714184

Genome annotation databases

EnsembliENST00000265375; ENSP00000265375; ENSG00000108100 [Q8ND76-3]
ENST00000339497; ENSP00000344275; ENSG00000108100 [Q8ND76-2]
ENST00000374704; ENSP00000363836; ENSG00000108100 [Q8ND76-1]
ENST00000374706; ENSP00000363838; ENSG00000108100 [Q8ND76-3]
GeneIDi219771
KEGGihsa:219771
UCSCiuc001iyu.6 human [Q8ND76-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNY_HUMAN
AccessioniPrimary (citable) accession number: Q8ND76
Secondary accession number(s): B7ZKX9
, D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8TEX2, Q8TEX3, Q96M99, Q96P45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: July 18, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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