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Protein

Protein LSM14 homolog A

Gene

LSM14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor, Ribonucleoprotein
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM14 homolog A
Alternative name(s):
Protein FAM61A
Protein SCD6 homolog
Putative alpha-synuclein-binding protein
Short name:
AlphaSNBP
RNA-associated protein 55A
Short name:
hRAP55
Short name:
hRAP55A
Gene namesi
Name:LSM14A
Synonyms:C19orf13, FAM61A, RAP55, RAP55A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000257103.8
HGNCiHGNC:24489 LSM14A
MIMi610677 gene
neXtProtiNX_Q8ND56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi26065
OpenTargetsiENSG00000257103
PharmGKBiPA134989467

Polymorphism and mutation databases

BioMutaiLSM14A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001870902 – 463Protein LSM14 homolog AAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphothreonineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei401Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8ND56
MaxQBiQ8ND56
PaxDbiQ8ND56
PeptideAtlasiQ8ND56
PRIDEiQ8ND56
ProteomicsDBi72979
72980 [Q8ND56-2]

PTM databases

iPTMnetiQ8ND56
PhosphoSitePlusiQ8ND56

Expressioni

Gene expression databases

BgeeiENSG00000257103
CleanExiHS_LSM14A
ExpressionAtlasiQ8ND56 baseline and differential
GenevisibleiQ8ND56 HS

Organism-specific databases

HPAiHPA017961

Interactioni

Subunit structurei

Component of a ribonucleoprotein (RNP) complex.By similarity

Protein-protein interaction databases

BioGridi117527, 22 interactors
IntActiQ8ND56, 9 interactors
MINTiQ8ND56
STRINGi9606.ENSP00000413964

Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 16Combined sources6
Beta strandi21 – 30Combined sources10
Turni31 – 34Combined sources4
Beta strandi35 – 46Combined sources12
Beta strandi61 – 68Combined sources8
Helixi69 – 71Combined sources3
Beta strandi72 – 77Combined sources6

3D structure databases

ProteinModelPortaliQ8ND56
SMRiQ8ND56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 320DFDFPROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi361 – 377FFD boxAdd BLAST17
Motifi380 – 400TFG boxAdd BLAST21

Domaini

The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.1 Publication

Sequence similaritiesi

Belongs to the LSM14 family.Curated

Phylogenomic databases

eggNOGiKOG1073 Eukaryota
ENOG41122RA LUCA
GeneTreeiENSGT00390000004174
HOGENOMiHOG000231251
HOVERGENiHBG054326
InParanoidiQ8ND56
KOiK18749
OMAiEWRGEEQ
OrthoDBiEOG091G0FJG
PhylomeDBiQ8ND56
TreeFamiTF313514

Family and domain databases

CDDicd01736 LSm14_N, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025761 FFD_box
IPR025609 Lsm14-like_N
IPR010920 LSM_dom_sf
IPR025768 TFG_box
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51513 FFD, 1 hit
PS51536 TFG, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8ND56-1) [UniParc]FASTAAdd to basket
Also known as: AlphaSNBP(A)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP
60 70 80 90 100
TDRPIPPRDE VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS
110 120 130 140 150
STSSFQSMGS YGPFGRMPTY SQFSPSSLVG QQFGAVGVAG SSLTSFGTET
160 170 180 190 200
SNSGTLPQSS AVGSAFTQDT RSLKTQLSQG RSSPQLDPLR KSPTMEQAVQ
210 220 230 240 250
TASAHLPAPA AVGRRSPVST RPLPSASQKA GENQEHRRAE VHKVSRPENE
260 270 280 290 300
QLRNDNKRQV APGAPSAPRR GRGGHRGGRG RFGIRRDGPM KFEKDFDFES
310 320 330 340 350
ANAQFNKEEI DREFHNKLKL KEDKLEKQEK PVNGEDKGDS GVDTQNSEGN
360 370 380 390 400
ADEEDPLGPN CYYDKTKSFF DNISCDDNRE RRPTWAEERR LNAETFGIPL
410 420 430 440 450
RPNRGRGGYR GRGGLGFRGG RGRGGGRGGT FTAPRGFRGG FRGGRGGREF
460
ADFEYRKTTA FGP
Length:463
Mass (Da):50,530
Last modified:August 2, 2005 - v3
Checksum:i703BE8E8C54799DF
GO
Isoform 2 (identifier: Q8ND56-2) [UniParc]FASTAAdd to basket
Also known as: AlphaSNBP(B)

The sequence of this isoform differs from the canonical sequence as follows:
     458-463: TTAFGP → DNKVAA

Show »
Length:463
Mass (Da):50,554
Checksum:i6A8E53E630BC99DF
GO
Isoform 3 (identifier: Q8ND56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-179: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):46,411
Checksum:iF28872726A8AC2D1
GO

Sequence cautioni

The sequence BAB55066 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17K → Q in CAD39060 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057532238R → Q2 PublicationsCorresponds to variant dbSNP:rs36006556Ensembl.1
Natural variantiVAR_022884448R → Q. Corresponds to variant dbSNP:rs2274896Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057232139 – 179Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_014650458 – 463TTAFGP → DNKVAA in isoform 2. 3 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB069974 mRNA Translation: BAC99045.1
AB069975 mRNA Translation: BAC99046.1
AK027369 mRNA Translation: BAB55066.1 Different initiation.
AK027643 mRNA Translation: BAB55259.1
AK300208 mRNA Translation: BAG61978.1
AL834398 mRNA Translation: CAD39060.2
AL117499 mRNA Translation: CAB55964.1
AC010614 Genomic DNA No translation available.
BC016842 mRNA Translation: AAH16842.1
CCDSiCCDS12435.1 [Q8ND56-2]
CCDS46040.1 [Q8ND56-1]
PIRiT17274
RefSeqiNP_001107565.1, NM_001114093.1 [Q8ND56-1]
NP_056393.2, NM_015578.2 [Q8ND56-2]
UniGeneiHs.744009

Genome annotation databases

EnsembliENST00000433627; ENSP00000413964; ENSG00000257103 [Q8ND56-1]
ENST00000540746; ENSP00000446451; ENSG00000257103 [Q8ND56-3]
ENST00000544216; ENSP00000446271; ENSG00000257103 [Q8ND56-2]
ENST00000570462; ENSP00000459843; ENSG00000262860 [Q8ND56-1]
ENST00000575811; ENSP00000461225; ENSG00000262860 [Q8ND56-2]
GeneIDi26065
KEGGihsa:26065
UCSCiuc002nva.5 human [Q8ND56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLS14A_HUMAN
AccessioniPrimary (citable) accession number: Q8ND56
Secondary accession number(s): B4DTG6
, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: August 2, 2005
Last modified: June 20, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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