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Entry version 163 (02 Dec 2020)
Sequence version 3 (18 May 2010)
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Protein

Liprin-beta-2

Gene

PPFIBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8ND30

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388844, Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-beta-2
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2
Short name:
PTPRF-interacting protein-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPFIBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000166387.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9250, PPFIBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603142, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8ND30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8495

Open Targets

More...
OpenTargetsi
ENSG00000166387

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33571

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8ND30, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPFIBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910361 – 876Liprin-beta-2Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei329PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8ND30

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8ND30

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8ND30

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8ND30

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8ND30

PeptideAtlas

More...
PeptideAtlasi
Q8ND30

PRoteomics IDEntifications database

More...
PRIDEi
Q8ND30

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21373
72978 [Q8ND30-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8ND30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8ND30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166387, Expressed in sural nerve and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8ND30, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8ND30, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166387, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers (PubMed:21462929).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114067, 21 interactors

Database of interacting proteins

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DIPi
DIP-42373N

Protein interaction database and analysis system

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IntActi
Q8ND30, 15 interactors

Molecular INTeraction database

More...
MINTi
Q8ND30

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299492

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8ND30, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8ND30

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini558 – 622SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini630 – 693SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini718 – 783SAM 3PROSITE-ProRule annotationAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili101 – 3131 PublicationAdd BLAST213

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1899, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011689_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8ND30

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIPRQDS

Database of Orthologous Groups

More...
OrthoDBi
558442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8ND30

TreeFam database of animal gene trees

More...
TreeFami
TF314207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR029515, Liprin
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR030435, PPFIBP2
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587, PTHR12587, 1 hit
PTHR12587:SF18, PTHR12587:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8ND30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASDASHALE AALEQMDGII AGTKTGADLS DGTCEPGLAS PASYMNPFPV
60 70 80 90 100
LHLIEDLRLA LEMLELPQER AALLSQIPGP TAAYIKEWFE ESLSQVNHHS
110 120 130 140 150
AASNETYQER LARLEGDKES LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ
160 170 180 190 200
VKLNAAEEML QQELLSRTSL ETQKLDLMTE VSELKLKLVG MEKEQREQEE
210 220 230 240 250
KQRKAEELLQ ELRHLKIKVE ELENERNQYE WKLKATKAEV AQLQEQVALK
260 270 280 290 300
DAEIERLHSQ LSRTAALHSE SHTERDQEIQ RLKMGMETLL LANEDKDRRI
310 320 330 340 350
EELTGLLNQY RKVKEIVMVT QGPSERTLSI NEEEPEGGFS KWNATNKDPE
360 370 380 390 400
ELFKQEMPPR CSSPTVGPPP LPQKSLETRA QKKLSCSLED LRSESVDKCM
410 420 430 440 450
DGNQPFPVLE PKDSPFLAEH KYPTLPGKLS GATPNGEAAK SPPTICQPDA
460 470 480 490 500
TGSSLLRLRD TESGWDDTAV VNDLSSTSSG TESGPQSPLT PDGKRNPKGI
510 520 530 540 550
KKFWGKIRRT QSGNFYTDTL GMAEFRRGGL RATAGPRLSR TRDSKGQKSD
560 570 580 590 600
ANAPFAQWST ERVCAWLEDF GLAQYVIFAR QWVSSGHTLL TATPQDMEKE
610 620 630 640 650
LGIKHPLHRK KLVLAVKAIN TKQEEKSALL DHIWVTRWLD DIGLPQYKDQ
660 670 680 690 700
FHESRVDRRM LQYLTVNDLL FLKVTSQLHH LSIKCAIHVL HVNKFNPHCL
710 720 730 740 750
HRRPADESNL SPSEVVQWSN HRVMEWLRSV DLAEYAPNLR GSGVHGGLII
760 770 780 790 800
LEPRFTGDTL AMLLNIPPQK TLLRRHLTTK FNALIGPEAE QEKREKMASP
810 820 830 840 850
AYTPLTTTAK VRPRKLGFSH FGNIRKKKFD ESTDYICPME PSDGVSDSHR
860 870
VYSGYRGLSP LDAPELDGLD QVGQIS
Length:876
Mass (Da):98,544
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01BF9286C6C1417
GO
Isoform 2 (identifier: Q8ND30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-124: RLEGDKESLILQ → MSSEQWPRLPGK

Show »
Length:764
Mass (Da):86,511
Checksum:i14EF7C9FE41E4BBA
GO
Isoform 3 (identifier: Q8ND30-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-162: VCLEGHQVKLNAAEEMLQQ → MGKLITRMWKLLRRRSAPK

Show »
Length:733
Mass (Da):83,204
Checksum:iE96C8C5F273C3382
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP16E9PP16_HUMAN
Liprin-beta-2
PPFIBP2
718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDJ2H0YDJ2_HUMAN
Liprin-beta-2
PPFIBP2
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI79E9PI79_HUMAN
Liprin-beta-2
PPFIBP2
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIK8E9PIK8_HUMAN
Liprin-beta-2
PPFIBP2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJA0E9PJA0_HUMAN
Liprin-beta-2
PPFIBP2
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMH3E9PMH3_HUMAN
Liprin-beta-2
PPFIBP2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDM0H0YDM0_HUMAN
Liprin-beta-2
PPFIBP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS15A0A3B3IS15_HUMAN
Liprin-beta-2
PPFIBP2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YET1H0YET1_HUMAN
Liprin-beta-2
PPFIBP2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMN3E9PMN3_HUMAN
Liprin-beta-2
PPFIBP2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128L → I in AAH21714 (PubMed:17974005).Curated1
Sequence conflicti161Q → H in BAH12419 (PubMed:14702039).Curated1
Sequence conflicti702R → L in AAC26104 (PubMed:15489334).Curated1
Sequence conflicti734E → V in AAC26104 (PubMed:15489334).Curated1
Sequence conflicti754R → L in AAC26104 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049999658R → G4 PublicationsCorresponds to variant dbSNP:rs4758209Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473821 – 143Missing in isoform 3. CuratedAdd BLAST143
Alternative sequenceiVSP_0473831 – 112Missing in isoform 2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_047384113 – 124RLEGD…SLILQ → MSSEQWPRLPGK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047385144 – 162VCLEG…EMLQQ → MGKLITRMWKLLRRRSAPK in isoform 3. CuratedAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK296718 mRNA Translation: BAH12419.1
AL834426 mRNA Translation: CAD39087.2
AC104237 Genomic DNA No translation available.
AC107884 Genomic DNA No translation available.
BC021714 mRNA Translation: AAH21714.1
AF034803 mRNA Translation: AAC26104.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31419.1 [Q8ND30-1]
CCDS58116.1 [Q8ND30-2]
CCDS58117.1 [Q8ND30-3]

NCBI Reference Sequences

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RefSeqi
NP_001243497.1, NM_001256568.1 [Q8ND30-2]
NP_003612.2, NM_003621.3 [Q8ND30-1]
XP_016873932.1, XM_017018443.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000299492; ENSP00000299492; ENSG00000166387 [Q8ND30-1]
ENST00000528883; ENSP00000435469; ENSG00000166387 [Q8ND30-2]
ENST00000530181; ENSP00000437321; ENSG00000166387 [Q8ND30-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8495

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8495

UCSC genome browser

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UCSCi
uc001mfj.6, human [Q8ND30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296718 mRNA Translation: BAH12419.1
AL834426 mRNA Translation: CAD39087.2
AC104237 Genomic DNA No translation available.
AC107884 Genomic DNA No translation available.
BC021714 mRNA Translation: AAH21714.1
AF034803 mRNA Translation: AAC26104.1
CCDSiCCDS31419.1 [Q8ND30-1]
CCDS58116.1 [Q8ND30-2]
CCDS58117.1 [Q8ND30-3]
RefSeqiNP_001243497.1, NM_001256568.1 [Q8ND30-2]
NP_003612.2, NM_003621.3 [Q8ND30-1]
XP_016873932.1, XM_017018443.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QH9X-ray2.01A198-263[»]
SMRiQ8ND30
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114067, 21 interactors
DIPiDIP-42373N
IntActiQ8ND30, 15 interactors
MINTiQ8ND30
STRINGi9606.ENSP00000299492

PTM databases

iPTMnetiQ8ND30
PhosphoSitePlusiQ8ND30

Polymorphism and mutation databases

BioMutaiPPFIBP2
DMDMi296439314

Proteomic databases

EPDiQ8ND30
jPOSTiQ8ND30
MassIVEiQ8ND30
MaxQBiQ8ND30
PaxDbiQ8ND30
PeptideAtlasiQ8ND30
PRIDEiQ8ND30
ProteomicsDBi21373
72978 [Q8ND30-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1168, 134 antibodies

The DNASU plasmid repository

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DNASUi
8495

Genome annotation databases

EnsembliENST00000299492; ENSP00000299492; ENSG00000166387 [Q8ND30-1]
ENST00000528883; ENSP00000435469; ENSG00000166387 [Q8ND30-2]
ENST00000530181; ENSP00000437321; ENSG00000166387 [Q8ND30-3]
GeneIDi8495
KEGGihsa:8495
UCSCiuc001mfj.6, human [Q8ND30-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8495
DisGeNETi8495
EuPathDBiHostDB:ENSG00000166387.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PPFIBP2
HGNCiHGNC:9250, PPFIBP2
HPAiENSG00000166387, Low tissue specificity
MIMi603142, gene
neXtProtiNX_Q8ND30
OpenTargetsiENSG00000166387
PharmGKBiPA33571

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1899, Eukaryota
GeneTreeiENSGT00990000203651
HOGENOMiCLU_011689_2_1_1
InParanoidiQ8ND30
OMAiHIPRQDS
OrthoDBi558442at2759
PhylomeDBiQ8ND30
TreeFamiTF314207

Enzyme and pathway databases

PathwayCommonsiQ8ND30
ReactomeiR-HSA-388844, Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8495, 7 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPFIBP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8495
PharosiQ8ND30, Tbio

Protein Ontology

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PROi
PR:Q8ND30
RNActiQ8ND30, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166387, Expressed in sural nerve and 212 other tissues
ExpressionAtlasiQ8ND30, baseline and differential
GenevisibleiQ8ND30, HS

Family and domain databases

CDDicd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR029515, Liprin
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR030435, PPFIBP2
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR12587, PTHR12587, 1 hit
PTHR12587:SF18, PTHR12587:SF18, 1 hit
PfamiView protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 3 hits
SUPFAMiSSF47769, SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ND30
Secondary accession number(s): B7Z433
, E9PK77, O75337, Q8WW26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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