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UniProtKB - Q8ND24 (RN214_HUMAN)

Entry version 144 (02 Jun 2021)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
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Protein

RING finger protein 214

Gene

RNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8ND24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING finger protein 214
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF214
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25335, RNF214

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8ND24

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167257.10

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		257160

Open Targets

More...OpenTargetsi		ENSG00000167257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162401772

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8ND24, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF214

Domain mapping of disease mutations (DMDM)

More...DMDMi		134035028

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002805462 – 703RING finger protein 214Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei497PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8ND24

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8ND24

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8ND24

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8ND24

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8ND24

PeptideAtlas

More...PeptideAtlasi		Q8ND24

PRoteomics IDEntifications database

More...PRIDEi		Q8ND24

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5098
72975 [Q8ND24-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8ND24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8ND24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167257, Expressed in testis and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8ND24, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8ND24, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167257, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129202, 85 interactors

Protein interaction database and analysis system

More...IntActi		Q8ND24, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000300650

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8ND24, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8ND24

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni104 – 134DisorderedSequence analysisAdd BLAST31
Regioni146 – 197DisorderedSequence analysisAdd BLAST52
Regioni486 – 552DisorderedSequence analysisAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili220 – 379Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 59Polar residuesSequence analysisAdd BLAST23
Compositional biasi146 – 164Polar residuesSequence analysisAdd BLAST19
Compositional biasi488 – 507Polar residuesSequence analysisAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTPR, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159470

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8ND24

Identification of Orthologs from Complete Genome Data

More...OMAi		IEQVGFK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8ND24

TreeFam database of animal gene trees

More...TreeFami		TF333981

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL 
        60         70         80         90        100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL 
       110        120        130        140        150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS 
       160        170        180        190        200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS 
       210        220        230        240        250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV 
       260        270        280        290        300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF 
       310        320        330        340        350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK 
       360        370        380        390        400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR 
       410        420        430        440        450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML 
       460        470        480        490        500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS 
       510        520        530        540        550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ 
       560        570        580        590        600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV 
       610        620        630        640        650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH 
       660        670        680        690        700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP 

TLK
Length:703
Mass (Da):77,667
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF19F79FD8EECB150
GO
Isoform 2 (identifier: Q8ND24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-206: Missing.

Show »
Length:548
Mass (Da):61,318
Checksum:iAAC53F8FDAFCAC59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN76E9PN76_HUMAN
RING finger protein 214
RNF214
513Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE9E9PRE9_HUMAN
RING finger protein 214
RNF214
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05456652 – 206Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK298923 mRNA Translation: BAG61028.1
AK300160 mRNA Translation: BAG61943.1
AP000892 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67306.1
BC031347 mRNA No translation available.
BC146891 mRNA Translation: AAI46892.1
BC146901 mRNA Translation: AAI46902.1
BC064581 mRNA No translation available.
AL834448 mRNA Translation: CAD39108.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41720.1 [Q8ND24-1]
CCDS60976.1 [Q8ND24-2]

NCBI Reference Sequences

More...RefSeqi		NP_001070707.1, NM_001077239.1 [Q8ND24-1]
NP_001265178.1, NM_001278249.1 [Q8ND24-2]
NP_997226.2, NM_207343.3 [Q8ND24-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		257160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:257160

UCSC genome browser

More...UCSCi		uc001pqt.5, human [Q8ND24-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA Translation: BAG61028.1
AK300160 mRNA Translation: BAG61943.1
AP000892 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67306.1
BC031347 mRNA No translation available.
BC146891 mRNA Translation: AAI46892.1
BC146901 mRNA Translation: AAI46902.1
BC064581 mRNA No translation available.
AL834448 mRNA Translation: CAD39108.1
CCDSiCCDS41720.1 [Q8ND24-1]
CCDS60976.1 [Q8ND24-2]
RefSeqiNP_001070707.1, NM_001077239.1 [Q8ND24-1]
NP_001265178.1, NM_001278249.1 [Q8ND24-2]
NP_997226.2, NM_207343.3 [Q8ND24-1]

3D structure databases

SMRiQ8ND24
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129202, 85 interactors
IntActiQ8ND24, 7 interactors
STRINGi9606.ENSP00000300650

PTM databases

iPTMnetiQ8ND24
PhosphoSitePlusiQ8ND24

Genetic variation databases

BioMutaiRNF214
DMDMi134035028

Proteomic databases

EPDiQ8ND24
jPOSTiQ8ND24
MassIVEiQ8ND24
MaxQBiQ8ND24
PaxDbiQ8ND24
PeptideAtlasiQ8ND24
PRIDEiQ8ND24
ProteomicsDBi5098
72975 [Q8ND24-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32345, 34 antibodies

The DNASU plasmid repository

More...DNASUi		257160

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]
GeneIDi257160
KEGGihsa:257160
UCSCiuc001pqt.5, human [Q8ND24-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		257160
DisGeNETi257160

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF214
HGNCiHGNC:25335, RNF214
HPAiENSG00000167257, Low tissue specificity
neXtProtiNX_Q8ND24
OpenTargetsiENSG00000167257
PharmGKBiPA162401772
VEuPathDBiHostDB:ENSG00000167257.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTPR, Eukaryota
GeneTreeiENSGT00940000159470
InParanoidiQ8ND24
OMAiIEQVGFK
PhylomeDBiQ8ND24
TreeFamiTF333981

Enzyme and pathway databases

PathwayCommonsiQ8ND24

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		257160, 21 hits in 1005 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF214, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		257160
PharosiQ8ND24, Tdark

Protein Ontology

More...PROi		PR:Q8ND24
RNActiQ8ND24, protein

Gene expression databases

BgeeiENSG00000167257, Expressed in testis and 168 other tissues
ExpressionAtlasiQ8ND24, baseline and differential
GenevisibleiQ8ND24, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN214_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ND24
Secondary accession number(s): B2RUW0, B4DTD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 2, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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