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Protein

RING finger protein 214

Gene

RNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: GO_Central

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 214
Gene namesi
Name:RNF214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167257.10
HGNCiHGNC:25335 RNF214
neXtProtiNX_Q8ND24

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167257
PharmGKBiPA162401772

Polymorphism and mutation databases

BioMutaiRNF214
DMDMi134035028

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002805462 – 703RING finger protein 214Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei497PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8ND24
MaxQBiQ8ND24
PaxDbiQ8ND24
PeptideAtlasiQ8ND24
PRIDEiQ8ND24
ProteomicsDBi72975

PTM databases

iPTMnetiQ8ND24
PhosphoSitePlusiQ8ND24

Expressioni

Gene expression databases

BgeeiENSG00000167257 Expressed in 151 organ(s), highest expression level in testis
CleanExiHS_RNF214
ExpressionAtlasiQ8ND24 baseline and differential
GenevisibleiQ8ND24 HS

Organism-specific databases

HPAiHPA039332

Interactioni

Protein-protein interaction databases

BioGridi129202, 12 interactors
IntActiQ8ND24, 5 interactors
STRINGi9606.ENSP00000300650

Structurei

3D structure databases

ProteinModelPortaliQ8ND24
SMRiQ8ND24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili220 – 379Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi432 – 551Pro-richAdd BLAST120

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri658 – 700RING-type; atypicalPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5G Eukaryota
ENOG410ZK0J LUCA
GeneTreeiENSGT00530000063254
HOGENOMiHOG000060239
HOVERGENiHBG093913
InParanoidiQ8ND24
OMAiPAQKHKN
OrthoDBiEOG091G03WL
PhylomeDBiQ8ND24
TreeFamiTF333981

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL
60 70 80 90 100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL
110 120 130 140 150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS
160 170 180 190 200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS
210 220 230 240 250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV
260 270 280 290 300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF
310 320 330 340 350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK
360 370 380 390 400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR
410 420 430 440 450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML
460 470 480 490 500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS
510 520 530 540 550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ
560 570 580 590 600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV
610 620 630 640 650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH
660 670 680 690 700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP

TLK
Length:703
Mass (Da):77,667
Last modified:March 20, 2007 - v2
Checksum:iF19F79FD8EECB150
GO
Isoform 2 (identifier: Q8ND24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-206: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,318
Checksum:iAAC53F8FDAFCAC59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN76E9PN76_HUMAN
RING finger protein 214
RNF214
513Annotation score:
E9PRE9E9PRE9_HUMAN
RING finger protein 214
RNF214
146Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05456652 – 206Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA Translation: BAG61028.1
AK300160 mRNA Translation: BAG61943.1
AP000892 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67306.1
BC031347 mRNA No translation available.
BC146891 mRNA Translation: AAI46892.1
BC146901 mRNA Translation: AAI46902.1
BC064581 mRNA No translation available.
AL834448 mRNA Translation: CAD39108.1
CCDSiCCDS41720.1 [Q8ND24-1]
CCDS60976.1 [Q8ND24-2]
RefSeqiNP_001070707.1, NM_001077239.1 [Q8ND24-1]
NP_001265178.1, NM_001278249.1 [Q8ND24-2]
NP_997226.2, NM_207343.3 [Q8ND24-1]
UniGeneiHs.591934

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]
GeneIDi257160
KEGGihsa:257160
UCSCiuc001pqt.5 human [Q8ND24-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298923 mRNA Translation: BAG61028.1
AK300160 mRNA Translation: BAG61943.1
AP000892 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67306.1
BC031347 mRNA No translation available.
BC146891 mRNA Translation: AAI46892.1
BC146901 mRNA Translation: AAI46902.1
BC064581 mRNA No translation available.
AL834448 mRNA Translation: CAD39108.1
CCDSiCCDS41720.1 [Q8ND24-1]
CCDS60976.1 [Q8ND24-2]
RefSeqiNP_001070707.1, NM_001077239.1 [Q8ND24-1]
NP_001265178.1, NM_001278249.1 [Q8ND24-2]
NP_997226.2, NM_207343.3 [Q8ND24-1]
UniGeneiHs.591934

3D structure databases

ProteinModelPortaliQ8ND24
SMRiQ8ND24
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129202, 12 interactors
IntActiQ8ND24, 5 interactors
STRINGi9606.ENSP00000300650

PTM databases

iPTMnetiQ8ND24
PhosphoSitePlusiQ8ND24

Polymorphism and mutation databases

BioMutaiRNF214
DMDMi134035028

Proteomic databases

EPDiQ8ND24
MaxQBiQ8ND24
PaxDbiQ8ND24
PeptideAtlasiQ8ND24
PRIDEiQ8ND24
ProteomicsDBi72975

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1]
ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2]
ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]
GeneIDi257160
KEGGihsa:257160
UCSCiuc001pqt.5 human [Q8ND24-1]

Organism-specific databases

CTDi257160
EuPathDBiHostDB:ENSG00000167257.10
GeneCardsiRNF214
H-InvDBiHIX0010164
HGNCiHGNC:25335 RNF214
HPAiHPA039332
neXtProtiNX_Q8ND24
OpenTargetsiENSG00000167257
PharmGKBiPA162401772
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5G Eukaryota
ENOG410ZK0J LUCA
GeneTreeiENSGT00530000063254
HOGENOMiHOG000060239
HOVERGENiHBG093913
InParanoidiQ8ND24
OMAiPAQKHKN
OrthoDBiEOG091G03WL
PhylomeDBiQ8ND24
TreeFamiTF333981

Miscellaneous databases

ChiTaRSiRNF214 human
GenomeRNAii257160
PROiPR:Q8ND24

Gene expression databases

BgeeiENSG00000167257 Expressed in 151 organ(s), highest expression level in testis
CleanExiHS_RNF214
ExpressionAtlasiQ8ND24 baseline and differential
GenevisibleiQ8ND24 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN214_HUMAN
AccessioniPrimary (citable) accession number: Q8ND24
Secondary accession number(s): B2RUW0, B4DTD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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