UniProtKB - Q8ND24 (RN214_HUMAN)
Protein
RING finger protein 214
Gene
RNF214
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 658 – 700 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8ND24 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 214 |
Gene namesi | Name:RNF214 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25335, RNF214 |
neXtProti | NX_Q8ND24 |
VEuPathDBi | HostDB:ENSG00000167257.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 257160 |
OpenTargetsi | ENSG00000167257 |
PharmGKBi | PA162401772 |
Miscellaneous databases
Pharosi | Q8ND24, Tdark |
Genetic variation databases
BioMutai | RNF214 |
DMDMi | 134035028 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000280546 | 2 – 703 | RING finger protein 214Add BLAST | 702 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 40 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 176 | PhosphoserineCombined sources | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 497 | PhosphoserineCombined sources | 1 | |
Modified residuei | 511 | PhosphoserineCombined sources | 1 | |
Modified residuei | 516 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8ND24 |
jPOSTi | Q8ND24 |
MassIVEi | Q8ND24 |
MaxQBi | Q8ND24 |
PaxDbi | Q8ND24 |
PeptideAtlasi | Q8ND24 |
PRIDEi | Q8ND24 |
ProteomicsDBi | 5098 72975 [Q8ND24-1] |
PTM databases
iPTMneti | Q8ND24 |
PhosphoSitePlusi | Q8ND24 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167257, Expressed in testis and 168 other tissues |
ExpressionAtlasi | Q8ND24, baseline and differential |
Genevisiblei | Q8ND24, HS |
Organism-specific databases
HPAi | ENSG00000167257, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129202, 21 interactors |
IntActi | Q8ND24, 7 interactors |
STRINGi | 9606.ENSP00000300650 |
Miscellaneous databases
RNActi | Q8ND24, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 220 – 379 | Sequence analysisAdd BLAST | 160 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 432 – 551 | Pro-richAdd BLAST | 120 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 658 – 700 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QTPR, Eukaryota |
GeneTreei | ENSGT00940000159470 |
InParanoidi | Q8ND24 |
OMAi | IEQVGFK |
PhylomeDBi | Q8ND24 |
TreeFami | TF333981 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL
60 70 80 90 100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL
110 120 130 140 150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS
160 170 180 190 200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS
210 220 230 240 250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV
260 270 280 290 300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF
310 320 330 340 350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK
360 370 380 390 400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR
410 420 430 440 450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML
460 470 480 490 500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS
510 520 530 540 550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ
560 570 580 590 600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV
610 620 630 640 650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH
660 670 680 690 700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP
TLK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PN76 | E9PN76_HUMAN | RING finger protein 214 | RNF214 | 513 | Annotation score: | ||
E9PRE9 | E9PRE9_HUMAN | RING finger protein 214 | RNF214 | 146 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054566 | 52 – 206 | Missing in isoform 2. 1 PublicationAdd BLAST | 155 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK298923 mRNA Translation: BAG61028.1 AK300160 mRNA Translation: BAG61943.1 AP000892 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67306.1 BC031347 mRNA No translation available. BC146891 mRNA Translation: AAI46892.1 BC146901 mRNA Translation: AAI46902.1 BC064581 mRNA No translation available. AL834448 mRNA Translation: CAD39108.1 |
CCDSi | CCDS41720.1 [Q8ND24-1] CCDS60976.1 [Q8ND24-2] |
RefSeqi | NP_001070707.1, NM_001077239.1 [Q8ND24-1] NP_001265178.1, NM_001278249.1 [Q8ND24-2] NP_997226.2, NM_207343.3 [Q8ND24-1] |
Genome annotation databases
Ensembli | ENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1] ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2] ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1] |
GeneIDi | 257160 |
KEGGi | hsa:257160 |
UCSCi | uc001pqt.5, human [Q8ND24-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK298923 mRNA Translation: BAG61028.1 AK300160 mRNA Translation: BAG61943.1 AP000892 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67306.1 BC031347 mRNA No translation available. BC146891 mRNA Translation: AAI46892.1 BC146901 mRNA Translation: AAI46902.1 BC064581 mRNA No translation available. AL834448 mRNA Translation: CAD39108.1 |
CCDSi | CCDS41720.1 [Q8ND24-1] CCDS60976.1 [Q8ND24-2] |
RefSeqi | NP_001070707.1, NM_001077239.1 [Q8ND24-1] NP_001265178.1, NM_001278249.1 [Q8ND24-2] NP_997226.2, NM_207343.3 [Q8ND24-1] |
3D structure databases
SMRi | Q8ND24 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129202, 21 interactors |
IntActi | Q8ND24, 7 interactors |
STRINGi | 9606.ENSP00000300650 |
PTM databases
iPTMneti | Q8ND24 |
PhosphoSitePlusi | Q8ND24 |
Genetic variation databases
BioMutai | RNF214 |
DMDMi | 134035028 |
Proteomic databases
EPDi | Q8ND24 |
jPOSTi | Q8ND24 |
MassIVEi | Q8ND24 |
MaxQBi | Q8ND24 |
PaxDbi | Q8ND24 |
PeptideAtlasi | Q8ND24 |
PRIDEi | Q8ND24 |
ProteomicsDBi | 5098 72975 [Q8ND24-1] |
Protocols and materials databases
Antibodypediai | 32345, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1] ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2] ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1] |
GeneIDi | 257160 |
KEGGi | hsa:257160 |
UCSCi | uc001pqt.5, human [Q8ND24-1] |
Organism-specific databases
CTDi | 257160 |
DisGeNETi | 257160 |
GeneCardsi | RNF214 |
HGNCi | HGNC:25335, RNF214 |
HPAi | ENSG00000167257, Low tissue specificity |
neXtProti | NX_Q8ND24 |
OpenTargetsi | ENSG00000167257 |
PharmGKBi | PA162401772 |
VEuPathDBi | HostDB:ENSG00000167257.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTPR, Eukaryota |
GeneTreei | ENSGT00940000159470 |
InParanoidi | Q8ND24 |
OMAi | IEQVGFK |
PhylomeDBi | Q8ND24 |
TreeFami | TF333981 |
Enzyme and pathway databases
PathwayCommonsi | Q8ND24 |
Miscellaneous databases
BioGRID-ORCSi | 257160, 19 hits in 884 CRISPR screens |
ChiTaRSi | RNF214, human |
GenomeRNAii | 257160 |
Pharosi | Q8ND24, Tdark |
PROi | PR:Q8ND24 |
RNActi | Q8ND24, protein |
Gene expression databases
Bgeei | ENSG00000167257, Expressed in testis and 168 other tissues |
ExpressionAtlasi | Q8ND24, baseline and differential |
Genevisiblei | Q8ND24, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RN214_HUMAN | |
Accessioni | Q8ND24Primary (citable) accession number: Q8ND24 Secondary accession number(s): B2RUW0, B4DTD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM