UniProtKB - Q8ND24 (RN214_HUMAN)

BLAST

>sp|Q8ND24|RN214_HUMAN RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLSTKDSAQKQKNSPLLSVSSQTITKE
NNRNVHLEHSEQNPGSSAGDTSAAHQVVLGENLIATALCLSGSGSQSDLKDVASTAGEEG
DTSLRESLHPVTRSLKAGCHTKQLASRNCSEEKSPQTSILKEGNRDTSLDFRPVVSPANG
VEGVRVDQDDDQDSSSLKLSQNIAVQTDFKTADSEVNTDQDIEKNLDKMMTERTLLKERY
QEVLDKQRQVENQLQVQLKQLQQRREEEMKNHQEILKAIQDVTIKREETKKKIEKEKKEF
LQKEQDLKAEIEKLCEKGRREVWEMELDRLKNQDGEINRNIMEETERAWKAEILSLESRK
ELLVLKLEEAEKEAELHLTYLKSTPPTLETVRSKQEWETRLNGVRIMKKNVRDQFNSHIQ
LVRNGAKLSSLPQIPTPTLPPPPSETDFMLQVFQPSPSLAPRMPFSIGQVTMPMVMPSAD
PRSLSFPILNPALSQPSQPSSPLPGSHGRNSPGLGSLVSPHGPHMPPAASIPPPPGLGGV
KASAETPRPQPVDKLEKILEKLLTRFPQCNKAQMTNILQQIKTARTTMAGLTMEELIQLV
AARLAEHERVAASTQPLGRIRALFPAPLAQISTPMFLPSAQVSYPGRSSHAPATCKLCLM
CQKLVQPSELHPMACTHVLHKECIKFWAQTNTNDTCPFCPTLK

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History
Entry version 126 (07 Nov 2018)
Sequence version 2 (20 Mar 2007)
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Protein

RING finger protein 214

Gene

RNF214

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	658 – 700	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		43

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
ubiquitin-protein transferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RING finger protein 214
Gene namesⁱ	Name:RNF214
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167257.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25335 RNF214
neXtProtⁱ	NX_Q8ND24

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000167257
PharmGKBⁱ	PA162401772

Polymorphism and mutation databases

BioMutaⁱ	RNF214
DMDMⁱ	134035028

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000280546	2 – 703	RING finger protein 214Add BLAST		702

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	15	PhosphoserineCombined sources	1
Modified residueⁱ	40	PhosphoserineCombined sources	1
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	54	PhosphoserineCombined sources	1
Modified residueⁱ	176	PhosphoserineCombined sources	1
Modified residueⁱ	196	PhosphoserineBy similarity	1
Modified residueⁱ	497	PhosphoserineCombined sources	1
Modified residueⁱ	511	PhosphoserineCombined sources	1
Modified residueⁱ	516	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8ND24
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8ND24
PaxDbⁱ	Q8ND24
PeptideAtlas More...PeptideAtlasⁱ	Q8ND24
PRIDEⁱ	Q8ND24
ProteomicsDBⁱ	72975

PTM databases

iPTMnetⁱ	Q8ND24
PhosphoSitePlusⁱ	Q8ND24

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167257 Expressed in 151 organ(s), highest expression level in testis
CleanExⁱ	HS_RNF214
ExpressionAtlasⁱ	Q8ND24 baseline and differential
Genevisibleⁱ	Q8ND24 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039332

HPAⁱ

HPA039332

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129202, 12 interactors
IntActⁱ	Q8ND24, 5 interactors
STRINGⁱ	9606.ENSP00000300650

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8ND24
SMRⁱ	Q8ND24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	220 – 379	Sequence analysisAdd BLAST		160

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	432 – 551	Pro-richAdd BLAST		120

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	658 – 700	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		43

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IF5G Eukaryota ENOG410ZK0J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063254
HOGENOMⁱ	HOG000060239
HOVERGENⁱ	HBG093913
InParanoidⁱ	Q8ND24
OMAⁱ	PAQKHKN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03WL
PhylomeDBⁱ	Q8ND24
TreeFamⁱ	TF333981

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8ND24-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL 
        60         70         80         90        100
SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL 
       110        120        130        140        150
SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS 
       160        170        180        190        200
EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS 
       210        220        230        240        250
QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV 
       260        270        280        290        300
ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF 
       310        320        330        340        350
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK 
       360        370        380        390        400
AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR 
       410        420        430        440        450
LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML 
       460        470        480        490        500
QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS 
       510        520        530        540        550
SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ 
       560        570        580        590        600
PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV 
       610        620        630        640        650
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH 
       660        670        680        690        700
APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP 

TLK

Length:703

Mass (Da):77,667

Last modified:March 20, 2007 - v2

Checksum:ⁱF19F79FD8EECB150

Isoform 2 (identifier: Q8ND24-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-206: Missing.

« Hide

        10         20         30         40         50
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL 
        60         70         80         90        100
STDFKTADSE VNTDQDIEKN LDKMMTERTL LKERYQEVLD KQRQVENQLQ 
       110        120        130        140        150
VQLKQLQQRR EEEMKNHQEI LKAIQDVTIK REETKKKIEK EKKEFLQKEQ 
       160        170        180        190        200
DLKAEIEKLC EKGRREVWEM ELDRLKNQDG EINRNIMEET ERAWKAEILS 
       210        220        230        240        250
LESRKELLVL KLEEAEKEAE LHLTYLKSTP PTLETVRSKQ EWETRLNGVR 
       260        270        280        290        300
IMKKNVRDQF NSHIQLVRNG AKLSSLPQIP TPTLPPPPSE TDFMLQVFQP 
       310        320        330        340        350
SPSLAPRMPF SIGQVTMPMV MPSADPRSLS FPILNPALSQ PSQPSSPLPG 
       360        370        380        390        400
SHGRNSPGLG SLVSPHGPHM PPAASIPPPP GLGGVKASAE TPRPQPVDKL 
       410        420        430        440        450
EKILEKLLTR FPQCNKAQMT NILQQIKTAR TTMAGLTMEE LIQLVAARLA 
       460        470        480        490        500
EHERVAASTQ PLGRIRALFP APLAQISTPM FLPSAQVSYP GRSSHAPATC 
       510        520        530        540 
KLCLMCQKLV QPSELHPMAC THVLHKECIK FWAQTNTNDT CPFCPTLK

Note: No experimental confirmation available.

Show »

Length:548

Mass (Da):61,318

Checksum:ⁱAAC53F8FDAFCAC59

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PN76	E9PN76_HUMAN	RING finger protein 214 RING finger protein 214	RNF214	513	Annotation score:
E9PRE9	E9PRE9_HUMAN	RING finger protein 214 RING finger protein 214	RNF214	146	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054566	52 – 206	Missing in isoform 2. 1 PublicationAdd BLAST		155

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK298923 mRNA Translation: BAG61028.1 AK300160 mRNA Translation: BAG61943.1 AP000892 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67306.1 BC031347 mRNA No translation available. BC146891 mRNA Translation: AAI46892.1 BC146901 mRNA Translation: AAI46902.1 BC064581 mRNA No translation available. AL834448 mRNA Translation: CAD39108.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41720.1 [Q8ND24-1] CCDS60976.1 [Q8ND24-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001070707.1, NM_001077239.1 [Q8ND24-1] NP_001265178.1, NM_001278249.1 [Q8ND24-2] NP_997226.2, NM_207343.3 [Q8ND24-1]
UniGeneⁱ	Hs.591934

Genome annotation databases

Ensemblⁱ	ENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1] ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2] ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]
GeneIDⁱ	257160
KEGGⁱ	hsa:257160
UCSC genome browser More...UCSCⁱ	uc001pqt.5 human [Q8ND24-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8ND24	Uncharacterized protein		HUMAN		703	UniRef100_Q8ND24
RING finger protein 214 (Fragment)		HUMAN		146

Protein	Similar proteins		Species	Score	Length	Source
Q8ND24	Uncharacterized protein		HUMAN		703	UniRef90_Q8ND24
RING finger protein 214 isoform X1		DELLE		737
Ring finger protein 214		CANLF		709
Ring finger protein 214		BOVIN		706
RING finger protein 214 isoform X1		ODORO		706
+118
Q8ND24-2	Isoform 2 of RING finger protein 214		MOUSE		548	UniRef90_Q8BFU3-2
RING finger protein 214 isoform X3		DELLE		582
RING finger protein 214 isoform X2		ODORO		551
RING finger protein 214 isoform X2		Enhydra lutris kenyoni		551
RING finger protein 214 isoform X2		URSMA		550
+80

Protein	Similar proteins		Species	Score	Length	Source
Q8ND24	Uncharacterized protein		HUMAN		703	UniRef50_Q8ND24
RING finger protein 214 isoform X1		DELLE		737
Ring finger protein 214		CANLF		709
RING finger protein 214 isoform X1		ODORO		706
RING finger protein 214 isoform X1		LEPWE		706
+153
Q8ND24-2	RING finger protein 214		MOUSE		668	UniRef50_Q8BFU3
Uncharacterized protein		RHIBE		665
RING finger protein 214 isoform 1		CAMFR		674
Uncharacterized protein		PIG		670
Uncharacterized protein		ICTTR		669
+128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK298923 mRNA Translation: BAG61028.1 AK300160 mRNA Translation: BAG61943.1 AP000892 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67306.1 BC031347 mRNA No translation available. BC146891 mRNA Translation: AAI46892.1 BC146901 mRNA Translation: AAI46902.1 BC064581 mRNA No translation available. AL834448 mRNA Translation: CAD39108.1
CCDSⁱ	CCDS41720.1 [Q8ND24-1] CCDS60976.1 [Q8ND24-2]
RefSeqⁱ	NP_001070707.1, NM_001077239.1 [Q8ND24-1] NP_001265178.1, NM_001278249.1 [Q8ND24-2] NP_997226.2, NM_207343.3 [Q8ND24-1]
UniGeneⁱ	Hs.591934

3D structure databases

ProteinModelPortalⁱ	Q8ND24
SMRⁱ	Q8ND24
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129202, 12 interactors
IntActⁱ	Q8ND24, 5 interactors
STRINGⁱ	9606.ENSP00000300650

PTM databases

iPTMnetⁱ	Q8ND24
PhosphoSitePlusⁱ	Q8ND24

Polymorphism and mutation databases

BioMutaⁱ	RNF214
DMDMⁱ	134035028

Proteomic databases

EPDⁱ	Q8ND24
MaxQBⁱ	Q8ND24
PaxDbⁱ	Q8ND24
PeptideAtlasⁱ	Q8ND24
PRIDEⁱ	Q8ND24
ProteomicsDBⁱ	72975

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000300650; ENSP00000300650; ENSG00000167257 [Q8ND24-1] ENST00000531287; ENSP00000435361; ENSG00000167257 [Q8ND24-2] ENST00000531452; ENSP00000431643; ENSG00000167257 [Q8ND24-1]
GeneIDⁱ	257160
KEGGⁱ	hsa:257160
UCSCⁱ	uc001pqt.5 human [Q8ND24-1]

Organism-specific databases

CTDⁱ	257160
EuPathDBⁱ	HostDB:ENSG00000167257.10
GeneCardsⁱ	RNF214
H-InvDBⁱ	HIX0010164
HGNCⁱ	HGNC:25335 RNF214
HPAⁱ	HPA039332
neXtProtⁱ	NX_Q8ND24
OpenTargetsⁱ	ENSG00000167257
PharmGKBⁱ	PA162401772
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF5G Eukaryota ENOG410ZK0J LUCA
GeneTreeⁱ	ENSGT00530000063254
HOGENOMⁱ	HOG000060239
HOVERGENⁱ	HBG093913
InParanoidⁱ	Q8ND24
OMAⁱ	PAQKHKN
OrthoDBⁱ	EOG091G03WL
PhylomeDBⁱ	Q8ND24
TreeFamⁱ	TF333981

Miscellaneous databases

ChiTaRSⁱ	RNF214 human
GenomeRNAiⁱ	257160
Protein Ontology More...PROⁱ	PR:Q8ND24

Gene expression databases

Bgeeⁱ	ENSG00000167257 Expressed in 151 organ(s), highest expression level in testis
CleanExⁱ	HS_RNF214
ExpressionAtlasⁱ	Q8ND24 baseline and differential
Genevisibleⁱ	Q8ND24 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RN214_HUMAN
Accessionⁱ	Q8ND24Primary (citable) accession number: Q8ND24 Secondary accession number(s): B2RUW0, B4DTD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - Q8ND24 (RN214_HUMAN)

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RING finger protein 214

RNF214

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ