UniProtKB - Q8ND23 (CARL3_HUMAN)
Protein
Capping protein, Arp2/3 and myosin-I linker protein 3
Gene
CARMIL3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Capping protein, Arp2/3 and myosin-I linker protein 31 PublicationAlternative name(s): Capping protein regulator and myosin 1 linker protein 3 Leucine-rich repeat-containing protein 16B |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20272, CARMIL3 |
MIMi | 614716, gene |
neXtProti | NX_Q8ND23 |
VEuPathDBi | HostDB:ENSG00000186648.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cytoplasm 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 90668 |
OpenTargetsi | ENSG00000186648 |
PharmGKBi | PA162394445 |
Miscellaneous databases
Pharosi | Q8ND23, Tdark |
Genetic variation databases
BioMutai | CARMIL3 |
DMDMi | 172045774 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324608 | 1 – 1372 | Capping protein, Arp2/3 and myosin-I linker protein 3Add BLAST | 1372 |
Proteomic databases
EPDi | Q8ND23 |
MassIVEi | Q8ND23 |
PaxDbi | Q8ND23 |
PeptideAtlasi | Q8ND23 |
PRIDEi | Q8ND23 |
ProteomicsDBi | 72972 [Q8ND23-1] 72973 [Q8ND23-2] 72974 [Q8ND23-3] |
PTM databases
iPTMneti | Q8ND23 |
PhosphoSitePlusi | Q8ND23 |
Expressioni
Tissue specificityi
Widely expressed, with much higher levels in fetal tissues than in adult ones. Up-regulated in certain cancer tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000186648, Expressed in right hemisphere of cerebellum and 197 other tissues |
Genevisiblei | Q8ND23, HS |
Organism-specific databases
HPAi | ENSG00000186648, Group enriched (brain, pituitary gland, skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124752, 1 interactor |
IntActi | Q8ND23, 1 interactor |
MINTi | Q8ND23 |
STRINGi | 9606.ENSP00000340467 |
Miscellaneous databases
RNActi | Q8ND23, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 244 – 264 | LRR 1Add BLAST | 21 | |
Repeati | 274 – 295 | LRR 2Add BLAST | 22 | |
Repeati | 303 – 323 | LRR 3Add BLAST | 21 | |
Repeati | 335 – 357 | LRR 4Add BLAST | 23 | |
Repeati | 365 – 385 | LRR 5Add BLAST | 21 | |
Repeati | 392 – 413 | LRR 6Add BLAST | 22 | |
Repeati | 424 – 444 | LRR 7Add BLAST | 21 | |
Repeati | 455 – 475 | LRR 8Add BLAST | 21 | |
Repeati | 482 – 501 | LRR 9Add BLAST | 20 | |
Repeati | 509 – 530 | LRR 10Add BLAST | 22 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1040 – 1073 | Necessary for localization at the cell membrane1 PublicationAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1070 – 1098 | Pro-richAdd BLAST | 29 | |
Compositional biasi | 1204 – 1208 | Poly-Pro | 5 |
Domaini
The C-terminus is necessary for localization to the cell membrane (PubMed:26578515).1 Publication
Sequence similaritiesi
Belongs to the CARMIL family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG4242, Eukaryota |
GeneTreei | ENSGT00940000157990 |
HOGENOMi | CLU_003119_3_2_1 |
InParanoidi | Q8ND23 |
OMAi | NHEHEET |
OrthoDBi | 208951at2759 |
PhylomeDBi | Q8ND23 |
TreeFami | TF316381 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR029766, CARMIL3 IPR031943, CARMIL_C IPR041245, CARMIL_PH IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR24112:SF43, PTHR24112:SF43, 1 hit |
Pfami | View protein in Pfam PF17888, Carm_PH, 1 hit PF16000, CARMIL_C, 1 hit PF13516, LRR_6, 3 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8ND23-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKPSVELTR ELQDSIRRCL SQGAVLQQHH VKLETKPKKF EDRVLALTSW
60 70 80 90 100
RLHLFLLKVP AKVESSFNVL EIRAFNTLSQ NQILVETERG MVSMRLPSAE
110 120 130 140 150
SVDQVTRHVS SALSKVCPGP GCLIRRGNAD TPEGPRDTSP NSETSTSTTH
160 170 180 190 200
SVCGGFSETY AALCDYNGLH CREEVQWDVD TIYHAEDNRE FNLLDFSHLE
210 220 230 240 250
SRDLALMVAA LAYNQWFTKL YCKDLRLGSE VLEQVLHTLS KSGSLEELVL
260 270 280 290 300
DNAGLKTDFV QKLAGVFGEN GSCVLHALTL SHNPIEDKGF LSLSQQLLCF
310 320 330 340 350
PSGLTKLCLA KTAISPRGLQ ALGQTFGANP AFASSLRYLD LSKNPGLLAT
360 370 380 390 400
DEANALYSFL AQPNALVHLD LSGTDCVIDL LLGALLHGCC SHLTYLNLAR
410 420 430 440 450
NSCSHRKGRE APPAFKQFFS SAYTLSHVNL SATKLPLEAL RALLQGLSLN
460 470 480 490 500
SHLSDLHLDL SSCELRSAGA QALQEQLGAV TCVGSLDLSD NGFDSDLLTL
510 520 530 540 550
VPALGKNKSL KHLFLGKNFN VKAKTLEEIL HKLVQLIQEE DCSLQSLSVA
560 570 580 590 600
DSRLKLRTSI LINALGSNTC LAKVDLSGNG MEDIGAKMLS KALQINSSLR
610 620 630 640 650
TILWDRNNTS ALGFLDIARA LESNHTLRFM SFPVSDISQA YRSAPERTED
660 670 680 690 700
VWQKIQWCLV RNNHSQTCPQ EQAFRLQQGL VTSSAEQMLQ RLCGRVQEEV
710 720 730 740 750
RALRLCPLEP VQDELLYARD LIKDAKNSRA LFPSLYELGH VLANDGPVRQ
760 770 780 790 800
RLESVASEVS KAVDKELQVI LESMVSLTQE LCPVAMRVAE GHNKMLSNVA
810 820 830 840 850
ERVTVPRNFI RGALLEQAGQ DIQNKLDEVK LSVVTYLTSS IVDEILQELY
860 870 880 890 900
HSHKSLARHL TQLRTLSDPP GCPGQGQDLS SRGRGRNHDH EETTDDELGT
910 920 930 940 950
NIDTMAIKKQ KRCRKIRPVS AFISGSPQDM ESQLGNLGIP PGWFSGLGGS
960 970 980 990 1000
QPTASGSWEG LSELPTHGYK LRHQTQGRPR PPRTTPPGPG RPSMPAPGTR
1010 1020 1030 1040 1050
QENGMATRLD EGLEDFFSRR VLEESSSYPR TLRTVRPGLS EAPLPPLQKK
1060 1070 1080 1090 1100
RRRGLFHFRR PRSFKGDRGP GSPTTGLLLP PPPPPPPTQE SPPSPDPPSL
1110 1120 1130 1140 1150
GNNSSPCWSP EEESSLLPGF GGGRGPSFRR KMGTEGSEPG EGGPAPGTAQ
1160 1170 1180 1190 1200
QPRVHGVALP GLERAKGWSF DGKREGPGPD QEGSTQAWQK RRSSDDAGPG
1210 1220 1230 1240 1250
SWKPPPPPQS TKPSFSAMRR AEATWHIAEE SAPNHSCQSP SPASQDGEEE
1260 1270 1280 1290 1300
KEGTLFPERT LPARNAKLQD PALAPWPPKP VAVPRGRQPP QEPGVREEAE
1310 1320 1330 1340 1350
AGDAAPGVNK PRLRLSSQQD QEEPEVQGPP DPGRRTAPLK PKRTRRAQSC
1360 1370
DKLEPDRRRP PDPTGTSEPG TD
Sequence cautioni
The sequence BAB84993 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1062 | R → W in CAD38886 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039845 | 1022 | L → M. Corresponds to variant dbSNP:rs10146906Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032305 | 1 – 904 | Missing in isoform 2. 1 PublicationAdd BLAST | 904 | |
Alternative sequenceiVSP_032306 | 1 – 580 | Missing in isoform 3. 1 PublicationAdd BLAST | 580 | |
Alternative sequenceiVSP_032307 | 731 – 753 | LFPSL…RQRLE → VSPPQATLPLKSGEPKKADH AKP in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_032308 | 754 – 1372 | Missing in isoform 3. 1 PublicationAdd BLAST | 619 | |
Alternative sequenceiVSP_032309 | 1133 – 1175 | Missing in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074167 mRNA Translation: BAB84993.1 Different initiation. AL834197 mRNA Translation: CAD38886.1 AL136295 Genomic DNA No translation available. BC008134 mRNA Translation: AAH08134.2 |
CCDSi | CCDS32054.1 [Q8ND23-1] |
RefSeqi | NP_612369.3, NM_138360.3 [Q8ND23-1] |
Genome annotation databases
Ensembli | ENST00000342740; ENSP00000340467; ENSG00000186648 [Q8ND23-1] ENST00000646442; ENSP00000493710; ENSG00000284765 [Q8ND23-1] |
GeneIDi | 90668 |
KEGGi | hsa:90668 |
UCSCi | uc001wlj.3, human [Q8ND23-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074167 mRNA Translation: BAB84993.1 Different initiation. AL834197 mRNA Translation: CAD38886.1 AL136295 Genomic DNA No translation available. BC008134 mRNA Translation: AAH08134.2 |
CCDSi | CCDS32054.1 [Q8ND23-1] |
RefSeqi | NP_612369.3, NM_138360.3 [Q8ND23-1] |
3D structure databases
SMRi | Q8ND23 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124752, 1 interactor |
IntActi | Q8ND23, 1 interactor |
MINTi | Q8ND23 |
STRINGi | 9606.ENSP00000340467 |
PTM databases
iPTMneti | Q8ND23 |
PhosphoSitePlusi | Q8ND23 |
Genetic variation databases
BioMutai | CARMIL3 |
DMDMi | 172045774 |
Proteomic databases
EPDi | Q8ND23 |
MassIVEi | Q8ND23 |
PaxDbi | Q8ND23 |
PeptideAtlasi | Q8ND23 |
PRIDEi | Q8ND23 |
ProteomicsDBi | 72972 [Q8ND23-1] 72973 [Q8ND23-2] 72974 [Q8ND23-3] |
Protocols and materials databases
Antibodypediai | 22575, 39 antibodies |
Genome annotation databases
Ensembli | ENST00000342740; ENSP00000340467; ENSG00000186648 [Q8ND23-1] ENST00000646442; ENSP00000493710; ENSG00000284765 [Q8ND23-1] |
GeneIDi | 90668 |
KEGGi | hsa:90668 |
UCSCi | uc001wlj.3, human [Q8ND23-1] |
Organism-specific databases
CTDi | 90668 |
DisGeNETi | 90668 |
GeneCardsi | CARMIL3 |
HGNCi | HGNC:20272, CARMIL3 |
HPAi | ENSG00000186648, Group enriched (brain, pituitary gland, skin) |
MIMi | 614716, gene |
neXtProti | NX_Q8ND23 |
OpenTargetsi | ENSG00000186648 |
PharmGKBi | PA162394445 |
VEuPathDBi | HostDB:ENSG00000186648.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4242, Eukaryota |
GeneTreei | ENSGT00940000157990 |
HOGENOMi | CLU_003119_3_2_1 |
InParanoidi | Q8ND23 |
OMAi | NHEHEET |
OrthoDBi | 208951at2759 |
PhylomeDBi | Q8ND23 |
TreeFami | TF316381 |
Enzyme and pathway databases
PathwayCommonsi | Q8ND23 |
Miscellaneous databases
BioGRID-ORCSi | 90668, 4 hits in 869 CRISPR screens |
GenomeRNAii | 90668 |
Pharosi | Q8ND23, Tdark |
PROi | PR:Q8ND23 |
RNActi | Q8ND23, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186648, Expressed in right hemisphere of cerebellum and 197 other tissues |
Genevisiblei | Q8ND23, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR029766, CARMIL3 IPR031943, CARMIL_C IPR041245, CARMIL_PH IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR24112:SF43, PTHR24112:SF43, 1 hit |
Pfami | View protein in Pfam PF17888, Carm_PH, 1 hit PF16000, CARMIL_C, 1 hit PF13516, LRR_6, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CARL3_HUMAN | |
Accessioni | Q8ND23Primary (citable) accession number: Q8ND23 Secondary accession number(s): Q8TEF7, Q96HS9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | February 10, 2021 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants