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Entry version 122 (17 Jun 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Capping protein, Arp2/3 and myosin-I linker protein 3

Gene

CARMIL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Capping protein, Arp2/3 and myosin-I linker protein 31 Publication
Alternative name(s):
Capping protein regulator and myosin 1 linker protein 3
Leucine-rich repeat-containing protein 16B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARMIL3Imported
Synonyms:C14orf121, LRRC16B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186648.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20272 CARMIL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614716 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8ND23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
90668

Open Targets

More...
OpenTargetsi
ENSG00000186648

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8ND23 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARMIL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172045774

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246081 – 1372Capping protein, Arp2/3 and myosin-I linker protein 3Add BLAST1372

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8ND23

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8ND23

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8ND23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8ND23

PeptideAtlas

More...
PeptideAtlasi
Q8ND23

PRoteomics IDEntifications database

More...
PRIDEi
Q8ND23

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72972 [Q8ND23-1]
72973 [Q8ND23-2]
72974 [Q8ND23-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8ND23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8ND23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with much higher levels in fetal tissues than in adult ones. Up-regulated in certain cancer tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186648 Expressed in right hemisphere of cerebellum and 184 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8ND23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186648 Group enriched (brain, pituitary gland, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124752, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8ND23, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8ND23

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340467

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8ND23 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8ND23

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati244 – 264LRR 1Add BLAST21
Repeati274 – 295LRR 2Add BLAST22
Repeati303 – 323LRR 3Add BLAST21
Repeati335 – 357LRR 4Add BLAST23
Repeati365 – 385LRR 5Add BLAST21
Repeati392 – 413LRR 6Add BLAST22
Repeati424 – 444LRR 7Add BLAST21
Repeati455 – 475LRR 8Add BLAST21
Repeati482 – 501LRR 9Add BLAST20
Repeati509 – 530LRR 10Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1040 – 1073Necessary for localization at the cell membrane1 PublicationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1070 – 1098Pro-richAdd BLAST29
Compositional biasi1204 – 1208Poly-Pro5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus is necessary for localization to the cell membrane (PubMed:26578515).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CARMIL family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPN8 Eukaryota
ENOG410XPZM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003119_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8ND23

KEGG Orthology (KO)

More...
KOi
K20493

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHEHEET

Database of Orthologous Groups

More...
OrthoDBi
208951at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8ND23

TreeFam database of animal gene trees

More...
TreeFami
TF316381

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029766 CARMIL3
IPR031943 CARMIL_C
IPR041245 CARMIL_PH
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR011993 PH-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24112:SF43 PTHR24112:SF43, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17888 Carm_PH, 1 hit
PF16000 CARMIL_C, 1 hit
PF13516 LRR_6, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8ND23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKPSVELTR ELQDSIRRCL SQGAVLQQHH VKLETKPKKF EDRVLALTSW
60 70 80 90 100
RLHLFLLKVP AKVESSFNVL EIRAFNTLSQ NQILVETERG MVSMRLPSAE
110 120 130 140 150
SVDQVTRHVS SALSKVCPGP GCLIRRGNAD TPEGPRDTSP NSETSTSTTH
160 170 180 190 200
SVCGGFSETY AALCDYNGLH CREEVQWDVD TIYHAEDNRE FNLLDFSHLE
210 220 230 240 250
SRDLALMVAA LAYNQWFTKL YCKDLRLGSE VLEQVLHTLS KSGSLEELVL
260 270 280 290 300
DNAGLKTDFV QKLAGVFGEN GSCVLHALTL SHNPIEDKGF LSLSQQLLCF
310 320 330 340 350
PSGLTKLCLA KTAISPRGLQ ALGQTFGANP AFASSLRYLD LSKNPGLLAT
360 370 380 390 400
DEANALYSFL AQPNALVHLD LSGTDCVIDL LLGALLHGCC SHLTYLNLAR
410 420 430 440 450
NSCSHRKGRE APPAFKQFFS SAYTLSHVNL SATKLPLEAL RALLQGLSLN
460 470 480 490 500
SHLSDLHLDL SSCELRSAGA QALQEQLGAV TCVGSLDLSD NGFDSDLLTL
510 520 530 540 550
VPALGKNKSL KHLFLGKNFN VKAKTLEEIL HKLVQLIQEE DCSLQSLSVA
560 570 580 590 600
DSRLKLRTSI LINALGSNTC LAKVDLSGNG MEDIGAKMLS KALQINSSLR
610 620 630 640 650
TILWDRNNTS ALGFLDIARA LESNHTLRFM SFPVSDISQA YRSAPERTED
660 670 680 690 700
VWQKIQWCLV RNNHSQTCPQ EQAFRLQQGL VTSSAEQMLQ RLCGRVQEEV
710 720 730 740 750
RALRLCPLEP VQDELLYARD LIKDAKNSRA LFPSLYELGH VLANDGPVRQ
760 770 780 790 800
RLESVASEVS KAVDKELQVI LESMVSLTQE LCPVAMRVAE GHNKMLSNVA
810 820 830 840 850
ERVTVPRNFI RGALLEQAGQ DIQNKLDEVK LSVVTYLTSS IVDEILQELY
860 870 880 890 900
HSHKSLARHL TQLRTLSDPP GCPGQGQDLS SRGRGRNHDH EETTDDELGT
910 920 930 940 950
NIDTMAIKKQ KRCRKIRPVS AFISGSPQDM ESQLGNLGIP PGWFSGLGGS
960 970 980 990 1000
QPTASGSWEG LSELPTHGYK LRHQTQGRPR PPRTTPPGPG RPSMPAPGTR
1010 1020 1030 1040 1050
QENGMATRLD EGLEDFFSRR VLEESSSYPR TLRTVRPGLS EAPLPPLQKK
1060 1070 1080 1090 1100
RRRGLFHFRR PRSFKGDRGP GSPTTGLLLP PPPPPPPTQE SPPSPDPPSL
1110 1120 1130 1140 1150
GNNSSPCWSP EEESSLLPGF GGGRGPSFRR KMGTEGSEPG EGGPAPGTAQ
1160 1170 1180 1190 1200
QPRVHGVALP GLERAKGWSF DGKREGPGPD QEGSTQAWQK RRSSDDAGPG
1210 1220 1230 1240 1250
SWKPPPPPQS TKPSFSAMRR AEATWHIAEE SAPNHSCQSP SPASQDGEEE
1260 1270 1280 1290 1300
KEGTLFPERT LPARNAKLQD PALAPWPPKP VAVPRGRQPP QEPGVREEAE
1310 1320 1330 1340 1350
AGDAAPGVNK PRLRLSSQQD QEEPEVQGPP DPGRRTAPLK PKRTRRAQSC
1360 1370
DKLEPDRRRP PDPTGTSEPG TD
Length:1,372
Mass (Da):150,230
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i005B21A69E88ADAB
GO
Isoform 2 (identifier: Q8ND23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-904: Missing.
     1133-1175: Missing.

Show »
Length:425
Mass (Da):46,185
Checksum:iA7131B0A3B5E9B14
GO
Isoform 3 (identifier: Q8ND23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-580: Missing.
     731-753: LFPSLYELGHVLANDGPVRQRLE → VSPPQATLPLKSGEPKKADHAKP
     754-1372: Missing.

Show »
Length:173
Mass (Da):19,598
Checksum:i09F7E8CC3102E462
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84993 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1062R → W in CAD38886 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0398451022L → M. Corresponds to variant dbSNP:rs10146906Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0323051 – 904Missing in isoform 2. 1 PublicationAdd BLAST904
Alternative sequenceiVSP_0323061 – 580Missing in isoform 3. 1 PublicationAdd BLAST580
Alternative sequenceiVSP_032307731 – 753LFPSL…RQRLE → VSPPQATLPLKSGEPKKADH AKP in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_032308754 – 1372Missing in isoform 3. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_0323091133 – 1175Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074167 mRNA Translation: BAB84993.1 Different initiation.
AL834197 mRNA Translation: CAD38886.1
AL136295 Genomic DNA No translation available.
BC008134 mRNA Translation: AAH08134.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32054.1 [Q8ND23-1]

NCBI Reference Sequences

More...
RefSeqi
NP_612369.3, NM_138360.3 [Q8ND23-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342740; ENSP00000340467; ENSG00000186648 [Q8ND23-1]
ENST00000646442; ENSP00000493710; ENSG00000284765 [Q8ND23-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90668

UCSC genome browser

More...
UCSCi
uc001wlj.3 human [Q8ND23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074167 mRNA Translation: BAB84993.1 Different initiation.
AL834197 mRNA Translation: CAD38886.1
AL136295 Genomic DNA No translation available.
BC008134 mRNA Translation: AAH08134.2
CCDSiCCDS32054.1 [Q8ND23-1]
RefSeqiNP_612369.3, NM_138360.3 [Q8ND23-1]

3D structure databases

SMRiQ8ND23
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124752, 1 interactor
IntActiQ8ND23, 1 interactor
MINTiQ8ND23
STRINGi9606.ENSP00000340467

PTM databases

iPTMnetiQ8ND23
PhosphoSitePlusiQ8ND23

Polymorphism and mutation databases

BioMutaiCARMIL3
DMDMi172045774

Proteomic databases

EPDiQ8ND23
jPOSTiQ8ND23
MassIVEiQ8ND23
PaxDbiQ8ND23
PeptideAtlasiQ8ND23
PRIDEiQ8ND23
ProteomicsDBi72972 [Q8ND23-1]
72973 [Q8ND23-2]
72974 [Q8ND23-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22575 39 antibodies

Genome annotation databases

EnsembliENST00000342740; ENSP00000340467; ENSG00000186648 [Q8ND23-1]
ENST00000646442; ENSP00000493710; ENSG00000284765 [Q8ND23-1]
GeneIDi90668
KEGGihsa:90668
UCSCiuc001wlj.3 human [Q8ND23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90668
DisGeNETi90668
EuPathDBiHostDB:ENSG00000186648.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CARMIL3
HGNCiHGNC:20272 CARMIL3
HPAiENSG00000186648 Group enriched (brain, pituitary gland, skin)
MIMi614716 gene
neXtProtiNX_Q8ND23
OpenTargetsiENSG00000186648
PharmGKBiPA162394445

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPN8 Eukaryota
ENOG410XPZM LUCA
GeneTreeiENSGT00940000157990
HOGENOMiCLU_003119_3_2_1
InParanoidiQ8ND23
KOiK20493
OMAiNHEHEET
OrthoDBi208951at2759
PhylomeDBiQ8ND23
TreeFamiTF316381

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
90668 2 hits in 785 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90668
PharosiQ8ND23 Tdark

Protein Ontology

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PROi
PR:Q8ND23
RNActiQ8ND23 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186648 Expressed in right hemisphere of cerebellum and 184 other tissues
GenevisibleiQ8ND23 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR029766 CARMIL3
IPR031943 CARMIL_C
IPR041245 CARMIL_PH
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR011993 PH-like_dom_sf
PANTHERiPTHR24112:SF43 PTHR24112:SF43, 1 hit
PfamiView protein in Pfam
PF17888 Carm_PH, 1 hit
PF16000 CARMIL_C, 1 hit
PF13516 LRR_6, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCARL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8ND23
Secondary accession number(s): Q8TEF7, Q96HS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 17, 2020
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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