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Protein

Myb/SANT-like DNA-binding domain-containing protein 4

Gene

MSANTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 4
Alternative name(s):
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Gene namesi
Name:MSANTD4
Synonyms:KIAA1826
ORF Names:DC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170903.10
HGNCiHGNC:29383 MSANTD4
neXtProtiNX_Q8NCY6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi84437
OpenTargetsiENSG00000170903
PharmGKBiPA143485519

Polymorphism and mutation databases

BioMutaiMSANTD4
DMDMi74760164

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118301 – 345Myb/SANT-like DNA-binding domain-containing protein 4Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei106PhosphoserineBy similarity1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei188PhosphothreonineCombined sources1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCY6
MaxQBiQ8NCY6
PaxDbiQ8NCY6
PeptideAtlasiQ8NCY6
PRIDEiQ8NCY6
ProteomicsDBi72967

PTM databases

iPTMnetiQ8NCY6
PhosphoSitePlusiQ8NCY6

Expressioni

Gene expression databases

BgeeiENSG00000170903 Expressed in 199 organ(s), highest expression level in medial globus pallidus
CleanExiHS_KIAA1826
ExpressionAtlasiQ8NCY6 baseline and differential
GenevisibleiQ8NCY6 HS

Organism-specific databases

HPAiHPA014411

Interactioni

Protein-protein interaction databases

BioGridi124077, 2 interactors
IntActiQ8NCY6, 11 interactors
MINTiQ8NCY6

Structurei

3D structure databases

ProteinModelPortaliQ8NCY6
SMRiQ8NCY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 77Myb-likeAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili203 – 345Sequence analysisAdd BLAST143

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJBK Eukaryota
ENOG4111EBJ LUCA
GeneTreeiENSGT00440000039469
HOGENOMiHOG000113179
HOVERGENiHBG059495
InParanoidiQ8NCY6
OMAiDTNFDWQ
OrthoDBiEOG091G1BN9
PhylomeDBiQ8NCY6
TreeFamiTF330965

Family and domain databases

InterProiView protein in InterPro
IPR026162 MSANTD4
IPR028002 Myb_DNA-bind_5
PANTHERiPTHR21732 PTHR21732, 1 hit
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8NCY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLKRKRKS NFSVQETQTL LKEITKRKEV IFSKQLNTTI NVMKRMAWEE
60 70 80 90 100
IAQCVNAVGE GEQRTGTEVK RRYLDWRALM KRKRMKANIK LVGSGFPLPS
110 120 130 140 150
SDLDDSLTEE IDEKIGFRND ANFDWQNVAD FRDAGGSLTE VKVEEEERDP
160 170 180 190 200
QSPEFEIEEE EEMLSSVIPD SRRENELPDF PHIDEFFTLN STPSRSAYDE
210 220 230 240 250
PHLLVNIEKQ KLELEKRRLD IEAERLQVEK ERLQIEKERL RHLDMEHERL
260 270 280 290 300
QLEKERLQIE REKLRLQIVN SEKPSLENEL GQGEKSMLQP QDIETEKLKL
310 320 330 340
ERERLQLEKD RLQFLKFESE KLQIEKERLQ VEKDRLRIQK EGHLQ
Length:345
Mass (Da):41,150
Last modified:October 1, 2002 - v1
Checksum:iF60EA447B282F812
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZP0A0A087WZP0_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD4
134Annotation score:
E9PKC8E9PKC8_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD4
71Annotation score:
E9PLV2E9PLV2_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD4
196Annotation score:
E9PRK0E9PRK0_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD4
111Annotation score:

Sequence cautioni

The sequence AAG44625 differs from that shown. Reason: Frameshift at positions 122 and 225.Curated
The sequence BAB47455 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55371 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058729 mRNA Translation: BAB47455.1 Different initiation.
AK293050 mRNA Translation: BAF85739.1
AL834523 mRNA Translation: CAD39179.1
CH471065 Genomic DNA Translation: EAW67071.1
BC041118 mRNA Translation: AAH41118.1
AF253976 mRNA Translation: AAG44625.1 Frameshift.
AK027790 mRNA Translation: BAB55371.1 Different initiation.
CCDSiCCDS31663.1
RefSeqiNP_001305676.1, NM_001318747.1
NP_001305677.1, NM_001318748.1
NP_001305678.1, NM_001318749.1
NP_001305679.1, NM_001318750.1
NP_115800.1, NM_032424.2
XP_011541324.1, XM_011543022.2
XP_016873905.1, XM_017018416.1
XP_016873906.1, XM_017018417.1
UniGeneiHs.266782

Genome annotation databases

EnsembliENST00000301919; ENSP00000304713; ENSG00000170903
GeneIDi84437
KEGGihsa:84437
UCSCiuc001piz.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058729 mRNA Translation: BAB47455.1 Different initiation.
AK293050 mRNA Translation: BAF85739.1
AL834523 mRNA Translation: CAD39179.1
CH471065 Genomic DNA Translation: EAW67071.1
BC041118 mRNA Translation: AAH41118.1
AF253976 mRNA Translation: AAG44625.1 Frameshift.
AK027790 mRNA Translation: BAB55371.1 Different initiation.
CCDSiCCDS31663.1
RefSeqiNP_001305676.1, NM_001318747.1
NP_001305677.1, NM_001318748.1
NP_001305678.1, NM_001318749.1
NP_001305679.1, NM_001318750.1
NP_115800.1, NM_032424.2
XP_011541324.1, XM_011543022.2
XP_016873905.1, XM_017018416.1
XP_016873906.1, XM_017018417.1
UniGeneiHs.266782

3D structure databases

ProteinModelPortaliQ8NCY6
SMRiQ8NCY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124077, 2 interactors
IntActiQ8NCY6, 11 interactors
MINTiQ8NCY6

PTM databases

iPTMnetiQ8NCY6
PhosphoSitePlusiQ8NCY6

Polymorphism and mutation databases

BioMutaiMSANTD4
DMDMi74760164

Proteomic databases

EPDiQ8NCY6
MaxQBiQ8NCY6
PaxDbiQ8NCY6
PeptideAtlasiQ8NCY6
PRIDEiQ8NCY6
ProteomicsDBi72967

Protocols and materials databases

DNASUi84437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301919; ENSP00000304713; ENSG00000170903
GeneIDi84437
KEGGihsa:84437
UCSCiuc001piz.3 human

Organism-specific databases

CTDi84437
DisGeNETi84437
EuPathDBiHostDB:ENSG00000170903.10
GeneCardsiMSANTD4
HGNCiHGNC:29383 MSANTD4
HPAiHPA014411
neXtProtiNX_Q8NCY6
OpenTargetsiENSG00000170903
PharmGKBiPA143485519
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBK Eukaryota
ENOG4111EBJ LUCA
GeneTreeiENSGT00440000039469
HOGENOMiHOG000113179
HOVERGENiHBG059495
InParanoidiQ8NCY6
OMAiDTNFDWQ
OrthoDBiEOG091G1BN9
PhylomeDBiQ8NCY6
TreeFamiTF330965

Miscellaneous databases

ChiTaRSiMSANTD4 human
GeneWikiiKIAA1826
GenomeRNAii84437
PROiPR:Q8NCY6

Gene expression databases

BgeeiENSG00000170903 Expressed in 199 organ(s), highest expression level in medial globus pallidus
CleanExiHS_KIAA1826
ExpressionAtlasiQ8NCY6 baseline and differential
GenevisibleiQ8NCY6 HS

Family and domain databases

InterProiView protein in InterPro
IPR026162 MSANTD4
IPR028002 Myb_DNA-bind_5
PANTHERiPTHR21732 PTHR21732, 1 hit
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSD4_HUMAN
AccessioniPrimary (citable) accession number: Q8NCY6
Secondary accession number(s): Q96JK1, Q96JZ3, Q9H2N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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