Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8NCR6 (SMRP1_HUMAN)

Entry version 118 (16 Oct 2019)
Sequence version 2 (24 Jul 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Spermatid-specific manchette-related protein 1

Gene

SMRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatid-specific manchette-related protein 1
Alternative name(s):
Ciliated bronchial epithelial protein 1
Testis development protein NYD-SP22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMRP1
Synonyms:C9orf24, CBE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19919 C9orf24

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NCR6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi223 – 224RR → AA: Predominantly cytoplasmic rather than nuclear localization. 1 Publication2

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000164972

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134950467

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NCR6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C9orf24

Domain mapping of disease mutations (DMDM)

More...DMDMi		156630925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002962581 – 262Spermatid-specific manchette-related protein 1Add BLAST262

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NCR6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NCR6

PeptideAtlas

More...PeptideAtlasi		Q8NCR6

PRoteomics IDEntifications database

More...PRIDEi		Q8NCR6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72928 [Q8NCR6-1]
72929 [Q8NCR6-2]
72930 [Q8NCR6-3]
72931 [Q8NCR6-4]
72932 [Q8NCR6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NCR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NCR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells of nasal polyps and in intact epithelium of bronchial biopsies from subjects with and without asthma. Strong expression in columnar cells with little or no expression in basal epithelial cells along the basement membrane. Strongly expressed in ciliated epithelial cells with lower levels in goblet cells (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during in vitro differentiation of bronchial epithelial cells. In fetal lung, expression is barely detectable at 10 weeks post-conception but is strong in airway epithelium at 12.3 weeks post-conception.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by IL13.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164972 Expressed in 133 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NCR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NCR6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA053008

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with alpha-tubulin.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q930623EBI-10269322,EBI-740322

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124203, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q8NCR6, 31 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297623

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMRP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJMT Eukaryota
ENOG41119UP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000945

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000111634

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NCR6

KEGG Orthology (KO)

More...KOi		K18634

Identification of Orthologs from Complete Genome Data

More...OMAi		GHPYFPE

Database of Orthologous Groups

More...OrthoDBi		942401at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NCR6

TreeFam database of animal gene trees

More...TreeFami		TF335656

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028195 SMRP1

The PANTHER Classification System

More...PANTHERi		PTHR35664 PTHR35664, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15181 SMRP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCR6-1) [UniParc]FASTAAdd to basket
Also known as: NYD-SP22 v1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLFSRKTRT PISTYSDSYR APTSIKEVYK DPPLCAWEAN KFLTPGLTHT 
        60         70         80         90        100
MERHVDPEAL QKMAKCAVQD YTYRGSISGH PYLPEKYWLS QEEADKCSPN 
       110        120        130        140        150
YLGSDWYNTW RMEPYNSSCC NKYTTYLPRL PKEARMETAV RGMPLECPPR 
       160        170        180        190        200
PERLNAYERE VMVNMLNSLS RNQQLPRITP RCGCVDPLPG RLPFHGYESA 
       210        220        230        240        250
CSGRHYCLRG MDYYASGAPC TDRRLRPWCR EQPTMCTSLR APARNAVCCY 
       260 
NSPAVILPIS EP
Length:262
Mass (Da):30,167
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F1FA3A06401BFEB
GO
Isoform 2 (identifier: Q8NCR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     235-262: MCTSLRAPARNAVCCYNSPAVILPISEP → VRFAGLRPPQ...CRVPPSGSKA

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,443
Checksum:i01256E368A91D5C3
GO
Isoform 3 (identifier: Q8NCR6-3) [UniParc]FASTAAdd to basket
Also known as: NYD-SP22 v3

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     186-262: DPLPGRLPFH...PAVILPISEP → PPYEHRPGMQ...SETYPDYRCW

Note: No experimental confirmation available.Curated
Show »
Length:111
Mass (Da):13,000
Checksum:i875663781A719057
GO
Isoform 4 (identifier: Q8NCR6-4) [UniParc]FASTAAdd to basket
Also known as: CBE1 ORF2

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     235-262: MCTSLRAPARNAVCCYNSPAVILPISEP → VRCVPPYEHR...SETYPDYRCW

Show »
Length:164
Mass (Da):19,084
Checksum:i0F82B309386160F9
GO
Isoform 5 (identifier: Q8NCR6-5) [UniParc]FASTAAdd to basket
Also known as: CBE1 ORF1, NYD-SP22 v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:127
Mass (Da):14,344
Checksum:i993040B6142E6B41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y454H0Y454_HUMAN
Chromosome 9 open reading frame 24
C9orf24
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q8NCR6-3)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61C → Y in AAK53410 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034626233P → Q1 PublicationCorresponds to variant dbSNP:rs17852663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0271691 – 135Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST135
Alternative sequenceiVSP_027170186 – 262DPLPG…PISEP → PPYEHRPGMQCAVTTPPPSY YPYPNLRWDTSHFKKSGGPQ RNNYVIHPEFVSETYPDYRC W in isoform 3. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_027171235 – 262MCTSL…PISEP → VRFAGLRPPQPGSTPHKPRP RTPPPSSPASFRAGPQPALA PRCTLSRPCRVPPSGSKA in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_042861235 – 262MCTSL…PISEP → VRCVPPYEHRPGMQCAVTTP PPSYYPYPNLRWDTSHFKKS GGPQRNNYVIHPEFVSETYP DYRCW in isoform 4. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF367474 mRNA Translation: AAK53410.1
AK058087 mRNA Translation: BAB71657.1
AK094751 mRNA Translation: BAC04412.1
AL356494 Genomic DNA No translation available.
BC022084 mRNA Translation: AAH22084.1
BC029484 mRNA Translation: AAH29484.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59121.1 [Q8NCR6-4]
CCDS6553.1 [Q8NCR6-3]
CCDS6554.1 [Q8NCR6-1]
CCDS6555.1 [Q8NCR6-5]

NCBI Reference Sequences

More...RefSeqi		NP_001239124.1, NM_001252195.1 [Q8NCR6-4]
NP_115985.2, NM_032596.3 [Q8NCR6-1]
NP_671697.1, NM_147168.1 [Q8NCR6-5]
NP_671698.1, NM_147169.2 [Q8NCR6-3]
XP_005251675.1, XM_005251618.4 [Q8NCR6-4]
XP_011516357.1, XM_011518055.2 [Q8NCR6-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297623; ENSP00000297623; ENSG00000164972 [Q8NCR6-1]
ENST00000379124; ENSP00000368419; ENSG00000164972 [Q8NCR6-4]
ENST00000379126; ENSP00000368421; ENSG00000164972 [Q8NCR6-3]
ENST00000379127; ENSP00000368422; ENSG00000164972 [Q8NCR6-4]
ENST00000379133; ENSP00000368428; ENSG00000164972 [Q8NCR6-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84688

UCSC genome browser

More...UCSCi		uc003zuf.3 human [Q8NCR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367474 mRNA Translation: AAK53410.1
AK058087 mRNA Translation: BAB71657.1
AK094751 mRNA Translation: BAC04412.1
AL356494 Genomic DNA No translation available.
BC022084 mRNA Translation: AAH22084.1
BC029484 mRNA Translation: AAH29484.1
CCDSiCCDS59121.1 [Q8NCR6-4]
CCDS6553.1 [Q8NCR6-3]
CCDS6554.1 [Q8NCR6-1]
CCDS6555.1 [Q8NCR6-5]
RefSeqiNP_001239124.1, NM_001252195.1 [Q8NCR6-4]
NP_115985.2, NM_032596.3 [Q8NCR6-1]
NP_671697.1, NM_147168.1 [Q8NCR6-5]
NP_671698.1, NM_147169.2 [Q8NCR6-3]
XP_005251675.1, XM_005251618.4 [Q8NCR6-4]
XP_011516357.1, XM_011518055.2 [Q8NCR6-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi124203, 11 interactors
IntActiQ8NCR6, 31 interactors
STRINGi9606.ENSP00000297623

PTM databases

iPTMnetiQ8NCR6
PhosphoSitePlusiQ8NCR6

Polymorphism and mutation databases

BioMutaiC9orf24
DMDMi156630925

Proteomic databases

MassIVEiQ8NCR6
PaxDbiQ8NCR6
PeptideAtlasiQ8NCR6
PRIDEiQ8NCR6
ProteomicsDBi72928 [Q8NCR6-1]
72929 [Q8NCR6-2]
72930 [Q8NCR6-3]
72931 [Q8NCR6-4]
72932 [Q8NCR6-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		84688

Genome annotation databases

EnsembliENST00000297623; ENSP00000297623; ENSG00000164972 [Q8NCR6-1]
ENST00000379124; ENSP00000368419; ENSG00000164972 [Q8NCR6-4]
ENST00000379126; ENSP00000368421; ENSG00000164972 [Q8NCR6-3]
ENST00000379127; ENSP00000368422; ENSG00000164972 [Q8NCR6-4]
ENST00000379133; ENSP00000368428; ENSG00000164972 [Q8NCR6-5]
GeneIDi84688
KEGGihsa:84688
UCSCiuc003zuf.3 human [Q8NCR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84688

GeneCards: human genes, protein and diseases

More...GeneCardsi		C9orf24
HGNCiHGNC:19919 C9orf24
HPAiHPA053008
neXtProtiNX_Q8NCR6
OpenTargetsiENSG00000164972
PharmGKBiPA134950467

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJMT Eukaryota
ENOG41119UP LUCA
GeneTreeiENSGT00390000000945
HOGENOMiHOG000111634
InParanoidiQ8NCR6
KOiK18634
OMAiGHPYFPE
OrthoDBi942401at2759
PhylomeDBiQ8NCR6
TreeFamiTF335656

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C9orf24 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84688
PharosiQ8NCR6

Protein Ontology

More...PROi		PR:Q8NCR6

Gene expression databases

BgeeiENSG00000164972 Expressed in 133 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ8NCR6 baseline and differential
GenevisibleiQ8NCR6 HS

Family and domain databases

InterProiView protein in InterPro
IPR028195 SMRP1
PANTHERiPTHR35664 PTHR35664, 1 hit
PfamiView protein in Pfam
PF15181 SMRP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMRP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCR6
Secondary accession number(s): Q5T598
, Q5T599, Q5T5A0, Q8N9G4, Q96KD1, Q96LN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 16, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again