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Protein

F-box only protein 15

Gene

FBXO15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 15
Gene namesi
Name:FBXO15
Synonyms:FBX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141665.11
HGNCiHGNC:13617 FBXO15
MIMi609093 gene
neXtProtiNX_Q8NCQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi201456
OpenTargetsiENSG00000141665
PharmGKBiPA134894755

Polymorphism and mutation databases

BioMutaiFBXO15
DMDMi384872371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198931 – 510F-box only protein 15Add BLAST510

Proteomic databases

PaxDbiQ8NCQ5
PeptideAtlasiQ8NCQ5
PRIDEiQ8NCQ5
ProteomicsDBi72921
72922 [Q8NCQ5-2]

PTM databases

iPTMnetiQ8NCQ5
PhosphoSitePlusiQ8NCQ5

Expressioni

Gene expression databases

BgeeiENSG00000141665
CleanExiHS_FBXO15
ExpressionAtlasiQ8NCQ5 baseline and differential
GenevisibleiQ8NCQ5 HS

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi128386, 7 interactors
IntActiQ8NCQ5, 1 interactor
STRINGi9606.ENSP00000393154

Structurei

3D structure databases

ProteinModelPortaliQ8NCQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 117F-boxPROSITE-ProRule annotationAdd BLAST41

Phylogenomic databases

eggNOGiENOG410IERD Eukaryota
ENOG410YHRX LUCA
GeneTreeiENSGT00390000017498
HOGENOMiHOG000247014
HOVERGENiHBG051566
InParanoidiQ8NCQ5
KOiK10298
OMAiYWKKEYI
OrthoDBiEOG091G0ISW
PhylomeDBiQ8NCQ5
TreeFamiTF332483

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS
60 70 80 90 100
AALRCHAGGG QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV
110 120 130 140 150
SRRFYHLAND NFIWIGIYST AFSPARSNWK FNSVEKIAMS MSFLSVQDKE
160 170 180 190 200
AGYWKKEYIT KQIASVKAAL ADILKPVNPY TGLPVKTKEA LRIFGLGWAI
210 220 230 240 250
ILKEKGGKEY IMEHVDLSIN DTSVTVIWYG KKWPCLASLS TLDLCGMTPV
260 270 280 290 300
FTDWYKTPTK HRLRWHSLIA KYNLSHLTIS TMIGCDRLIR IFCLHPGLLV
310 320 330 340 350
GVWKKEEELA FVMANLHFHH LVERSTLGSA TIPYELPPHS PFLDDSPEYG
360 370 380 390 400
LHGYQLHVDL HSGGVFYLCG TFRNLFTKRG NIENGHVKLI VIHLKNNREH
410 420 430 440 450
LPLIGKVGLS WKTDIFDGCI KSCSMMDVTL LDEHGKPFWC FSSPVCLRSP
460 470 480 490 500
ATPSDSSSFL GQTYNVDYVD AEGRVHVELV WIRETEEYLI VNLVLYLSIA
510
KINHWFGTEY
Length:510
Mass (Da):57,258
Last modified:April 18, 2012 - v2
Checksum:i99760CBB50B9DC8E
GO
Isoform 2 (identifier: Q8NCQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):49,450
Checksum:i745237A3B2D44598
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049040496Y → H. Corresponds to variant dbSNP:rs35815390Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430331 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094215 mRNA Translation: BAG52845.1
CH471117 Genomic DNA Translation: EAW66537.1
BC029579 mRNA Translation: AAH29579.1
CCDSiCCDS45884.1 [Q8NCQ5-1]
RefSeqiNP_001136430.1, NM_001142958.1 [Q8NCQ5-1]
NP_689889.1, NM_152676.2 [Q8NCQ5-2]
XP_016881092.1, XM_017025603.1 [Q8NCQ5-2]
XP_016881093.1, XM_017025604.1 [Q8NCQ5-2]
UniGeneiHs.664011

Genome annotation databases

EnsembliENST00000419743; ENSP00000393154; ENSG00000141665 [Q8NCQ5-1]
GeneIDi201456
KEGGihsa:201456
UCSCiuc002llf.3 human [Q8NCQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX15_HUMAN
AccessioniPrimary (citable) accession number: Q8NCQ5
Secondary accession number(s): B3KST3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 18, 2012
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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