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Protein

Zinc finger and BTB domain-containing protein 44

Gene

ZBTB44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri399 – 421C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 479C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri487 – 511C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 44
Alternative name(s):
BTB/POZ domain-containing protein 15
Zinc finger protein 851
Gene namesi
Name:ZBTB44
Synonyms:BTBD15, ZNF851
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196323.11
HGNCiHGNC:25001 ZBTB44
neXtProtiNX_Q8NCP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196323
PharmGKBiPA162409447

Polymorphism and mutation databases

BioMutaiZBTB44
DMDMi74760158

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746081 – 570Zinc finger and BTB domain-containing protein 44Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei135PhosphoserineCombined sources1
Modified residuei159PhosphoserineBy similarity1
Modified residuei161PhosphoserineCombined sources1
Modified residuei165PhosphoserineBy similarity1
Modified residuei191PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei200PhosphothreonineBy similarity1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8NCP5
PaxDbiQ8NCP5
PeptideAtlasiQ8NCP5
PRIDEiQ8NCP5
ProteomicsDBi72915
72916 [Q8NCP5-2]
72917 [Q8NCP5-3]
72918 [Q8NCP5-4]

PTM databases

iPTMnetiQ8NCP5
PhosphoSitePlusiQ8NCP5

Expressioni

Gene expression databases

BgeeiENSG00000196323 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZBTB44
ExpressionAtlasiQ8NCP5 baseline and differential
GenevisibleiQ8NCP5 HS

Organism-specific databases

HPAiHPA052589

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi118842, 23 interactors
IntActiQ8NCP5, 11 interactors
STRINGi9606.ENSP00000433457

Structurei

3D structure databases

ProteinModelPortaliQ8NCP5
SMRiQ8NCP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 98BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 14Poly-Ser6
Compositional biasi364 – 367Poly-Asp4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri399 – 421C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 479C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri487 – 511C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000155763
HOVERGENiHBG061797
InParanoidiQ8NCP5
KOiK10515
PhylomeDBiQ8NCP5
TreeFamiTF332673

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA
60 70 80 90 100
ACSDFFRTKL VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN
110 120 130 140 150
IIDVLAAASY MQMFSVASTC SEFMKSSILW NTPNSQPEKG LDAGQENNSN
160 170 180 190 200
CNFTSRDGSI SPVSSECSVV ERTIPVCRES RRKRKSYIVM SPESPVKCGT
210 220 230 240 250
QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI QPEKVKQAEN
260 270 280 290 300
TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH
310 320 330 340 350
EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL
360 370 380 390 400
PTLQSTSSTN APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ
410 420 430 440 450
CPTCGVRFTR IQNLKQHMLI HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE
460 470 480 490 500
GKRCFRCQIC SATFTSFGEY KHHMRVSRHI IRKPRIYECK TCGAMLTNSG
510 520 530 540 550
NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV QYDLGEHGFE
560 570
SNSSVQMPVI SQYHSKGKEP
Length:570
Mass (Da):63,848
Last modified:October 1, 2002 - v1
Checksum:i9C0E64DB7D0343DF
GO
Isoform 2 (identifier: Q8NCP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-570: GKRCFRCQIC...SQYHSKGKEP → VPLQRQGTMIDNSQAVDEMTRNGE

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):52,706
Checksum:i81480A579D6847EB
GO
Isoform 3 (identifier: Q8NCP5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-558: Missing.
     562-570: Missing.

Show »
Length:453
Mass (Da):50,333
Checksum:i7EE1FDEDC4452CE0
GO
Isoform 4 (identifier: Q8NCP5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-570: GKRCFRCQIC...SQYHSKGKEP → GHPRKSASRSSSATNCC

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):51,765
Checksum:iC5E2A4931C6215C8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY22H7BY22_HUMAN
Zinc finger and BTB domain-containi...
ZBTB44
570Annotation score:
H0YEM9H0YEM9_HUMAN
Zinc finger and BTB domain-containi...
ZBTB44
595Annotation score:
H0YCZ0H0YCZ0_HUMAN
Zinc finger and BTB domain-containi...
ZBTB44
328Annotation score:
A0A0A0MTE9A0A0A0MTE9_HUMAN
Zinc finger and BTB domain-containi...
ZBTB44
180Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030336185K → E1 PublicationCorresponds to variant dbSNP:rs17857365Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022834451 – 570GKRCF…KGKEP → VPLQRQGTMIDNSQAVDEMT RNGE in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_022835451 – 570GKRCF…KGKEP → GHPRKSASRSSSATNCC in isoform 4. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_022836451 – 558Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_022837562 – 570Missing in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030580 mRNA Translation: AAH30580.1
BC049375 mRNA Translation: AAH49375.1
BC050723 mRNA Translation: AAH50723.1
BC071729 mRNA Translation: AAH71729.1
CCDSiCCDS44776.1 [Q8NCP5-3]
CCDS73414.1 [Q8NCP5-1]
CCDS73415.1 [Q8NCP5-2]
RefSeqiNP_001288027.1, NM_001301098.1
NP_001288028.1, NM_001301099.1 [Q8NCP5-2]
NP_054874.3, NM_014155.4 [Q8NCP5-3]
XP_016873112.1, XM_017017623.1 [Q8NCP5-2]
UniGeneiHs.721470

Genome annotation databases

EnsembliENST00000445008; ENSP00000408079; ENSG00000196323 [Q8NCP5-4]
ENST00000525842; ENSP00000433457; ENSG00000196323 [Q8NCP5-3]
ENST00000530205; ENSP00000434177; ENSG00000196323 [Q8NCP5-2]
GeneIDi29068
KEGGihsa:29068
UCSCiuc001qfz.4 human [Q8NCP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030580 mRNA Translation: AAH30580.1
BC049375 mRNA Translation: AAH49375.1
BC050723 mRNA Translation: AAH50723.1
BC071729 mRNA Translation: AAH71729.1
CCDSiCCDS44776.1 [Q8NCP5-3]
CCDS73414.1 [Q8NCP5-1]
CCDS73415.1 [Q8NCP5-2]
RefSeqiNP_001288027.1, NM_001301098.1
NP_001288028.1, NM_001301099.1 [Q8NCP5-2]
NP_054874.3, NM_014155.4 [Q8NCP5-3]
XP_016873112.1, XM_017017623.1 [Q8NCP5-2]
UniGeneiHs.721470

3D structure databases

ProteinModelPortaliQ8NCP5
SMRiQ8NCP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118842, 23 interactors
IntActiQ8NCP5, 11 interactors
STRINGi9606.ENSP00000433457

PTM databases

iPTMnetiQ8NCP5
PhosphoSitePlusiQ8NCP5

Polymorphism and mutation databases

BioMutaiZBTB44
DMDMi74760158

Proteomic databases

MaxQBiQ8NCP5
PaxDbiQ8NCP5
PeptideAtlasiQ8NCP5
PRIDEiQ8NCP5
ProteomicsDBi72915
72916 [Q8NCP5-2]
72917 [Q8NCP5-3]
72918 [Q8NCP5-4]

Protocols and materials databases

DNASUi29068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445008; ENSP00000408079; ENSG00000196323 [Q8NCP5-4]
ENST00000525842; ENSP00000433457; ENSG00000196323 [Q8NCP5-3]
ENST00000530205; ENSP00000434177; ENSG00000196323 [Q8NCP5-2]
GeneIDi29068
KEGGihsa:29068
UCSCiuc001qfz.4 human [Q8NCP5-1]

Organism-specific databases

CTDi29068
EuPathDBiHostDB:ENSG00000196323.11
GeneCardsiZBTB44
HGNCiHGNC:25001 ZBTB44
HPAiHPA052589
neXtProtiNX_Q8NCP5
OpenTargetsiENSG00000196323
PharmGKBiPA162409447
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000155763
HOVERGENiHBG061797
InParanoidiQ8NCP5
KOiK10515
PhylomeDBiQ8NCP5
TreeFamiTF332673

Miscellaneous databases

ChiTaRSiZBTB44 human
GenomeRNAii29068
PROiPR:Q8NCP5

Gene expression databases

BgeeiENSG00000196323 Expressed in 217 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZBTB44
ExpressionAtlasiQ8NCP5 baseline and differential
GenevisibleiQ8NCP5 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT44_HUMAN
AccessioniPrimary (citable) accession number: Q8NCP5
Secondary accession number(s): Q6IPT8, Q86VJ7, Q86XX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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