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UniProtKB - Q8NCP5 (ZBT44_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 44
Gene
ZBTB44
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 399 – 421 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 479 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 487 – 511 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NCP5 |
SignaLinki | Q8NCP5 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 44Alternative name(s): BTB/POZ domain-containing protein 15 Zinc finger protein 851 |
Gene namesi | Name:ZBTB44 Synonyms:BTBD15, ZNF851 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25001, ZBTB44 |
neXtProti | NX_Q8NCP5 |
VEuPathDBi | HostDB:ENSG00000196323 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 29068 |
OpenTargetsi | ENSG00000196323 |
PharmGKBi | PA162409447 |
Miscellaneous databases
Pharosi | Q8NCP5, Tdark |
Genetic variation databases
BioMutai | ZBTB44 |
DMDMi | 74760158 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274608 | 1 – 570 | Zinc finger and BTB domain-containing protein 44Add BLAST | 570 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 135 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 200 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 290 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q8NCP5 |
MassIVEi | Q8NCP5 |
MaxQBi | Q8NCP5 |
PaxDbi | Q8NCP5 |
PeptideAtlasi | Q8NCP5 |
PRIDEi | Q8NCP5 |
ProteomicsDBi | 72915 [Q8NCP5-1] 72916 [Q8NCP5-2] 72917 [Q8NCP5-3] 72918 [Q8NCP5-4] |
PTM databases
iPTMneti | Q8NCP5 |
PhosphoSitePlusi | Q8NCP5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196323, Expressed in quadriceps femoris and 230 other tissues |
ExpressionAtlasi | Q8NCP5, baseline and differential |
Genevisiblei | Q8NCP5, HS |
Organism-specific databases
HPAi | ENSG00000196323, Low tissue specificity |
Interactioni
Binary interactionsi
Q8NCP5
Isoform 3 [Q8NCP5-3]
With | #Exp. | IntAct |
---|---|---|
VHL - isoform 2 [P40337-2] | 3 | EBI-25895743,EBI-12157263 |
Protein-protein interaction databases
BioGRIDi | 118842, 62 interactors |
IntActi | Q8NCP5, 24 interactors |
MINTi | Q8NCP5 |
STRINGi | 9606.ENSP00000380861 |
Miscellaneous databases
RNActi | Q8NCP5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 98 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 220 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 243 – 267 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 295 – 369 | DisorderedSequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 220 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 304 – 362 | Polar residuesSequence analysisAdd BLAST | 59 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 399 – 421 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 479 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 487 – 511 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153306 |
HOGENOMi | CLU_034849_1_0_1 |
InParanoidi | Q8NCP5 |
PhylomeDBi | Q8NCP5 |
TreeFami | TF332673 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NCP5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA
60 70 80 90 100
ACSDFFRTKL VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN
110 120 130 140 150
IIDVLAAASY MQMFSVASTC SEFMKSSILW NTPNSQPEKG LDAGQENNSN
160 170 180 190 200
CNFTSRDGSI SPVSSECSVV ERTIPVCRES RRKRKSYIVM SPESPVKCGT
210 220 230 240 250
QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI QPEKVKQAEN
260 270 280 290 300
TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH
310 320 330 340 350
EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL
360 370 380 390 400
PTLQSTSSTN APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ
410 420 430 440 450
CPTCGVRFTR IQNLKQHMLI HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE
460 470 480 490 500
GKRCFRCQIC SATFTSFGEY KHHMRVSRHI IRKPRIYECK TCGAMLTNSG
510 520 530 540 550
NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV QYDLGEHGFE
560 570
SNSSVQMPVI SQYHSKGKEP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BY22 | H7BY22_HUMAN | Zinc finger and BTB domain-containi... | ZBTB44 | 570 | Annotation score: | ||
H0YEM9 | H0YEM9_HUMAN | Zinc finger and BTB domain-containi... | ZBTB44 | 616 | Annotation score: | ||
H0YCZ0 | H0YCZ0_HUMAN | Zinc finger and BTB domain-containi... | ZBTB44 | 328 | Annotation score: | ||
A0A0A0MTE9 | A0A0A0MTE9_HUMAN | Zinc finger and BTB domain-containi... | ZBTB44 | 180 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030336 | 185 | K → E1 PublicationCorresponds to variant dbSNP:rs17857365Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022834 | 451 – 570 | GKRCF…KGKEP → VPLQRQGTMIDNSQAVDEMT RNGE in isoform 2. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_022835 | 451 – 570 | GKRCF…KGKEP → GHPRKSASRSSSATNCC in isoform 4. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_022836 | 451 – 558 | Missing in isoform 3. 1 PublicationAdd BLAST | 108 | |
Alternative sequenceiVSP_022837 | 562 – 570 | Missing in isoform 3. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC030580 mRNA Translation: AAH30580.1 BC049375 mRNA Translation: AAH49375.1 BC050723 mRNA Translation: AAH50723.1 BC071729 mRNA Translation: AAH71729.1 |
CCDSi | CCDS44776.1 [Q8NCP5-3] CCDS73414.1 [Q8NCP5-1] CCDS73415.1 [Q8NCP5-2] |
RefSeqi | NP_001288027.1, NM_001301098.1 NP_001288028.1, NM_001301099.1 [Q8NCP5-2] NP_054874.3, NM_014155.4 [Q8NCP5-3] XP_016873112.1, XM_017017623.1 |
Genome annotation databases
Ensembli | ENST00000445008; ENSP00000408079; ENSG00000196323 [Q8NCP5-4] ENST00000525842; ENSP00000433457; ENSG00000196323 [Q8NCP5-3] ENST00000530205; ENSP00000434177; ENSG00000196323 [Q8NCP5-2] |
GeneIDi | 29068 |
KEGGi | hsa:29068 |
UCSCi | uc001qfz.4, human [Q8NCP5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC030580 mRNA Translation: AAH30580.1 BC049375 mRNA Translation: AAH49375.1 BC050723 mRNA Translation: AAH50723.1 BC071729 mRNA Translation: AAH71729.1 |
CCDSi | CCDS44776.1 [Q8NCP5-3] CCDS73414.1 [Q8NCP5-1] CCDS73415.1 [Q8NCP5-2] |
RefSeqi | NP_001288027.1, NM_001301098.1 NP_001288028.1, NM_001301099.1 [Q8NCP5-2] NP_054874.3, NM_014155.4 [Q8NCP5-3] XP_016873112.1, XM_017017623.1 |
3D structure databases
SMRi | Q8NCP5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118842, 62 interactors |
IntActi | Q8NCP5, 24 interactors |
MINTi | Q8NCP5 |
STRINGi | 9606.ENSP00000380861 |
PTM databases
iPTMneti | Q8NCP5 |
PhosphoSitePlusi | Q8NCP5 |
Genetic variation databases
BioMutai | ZBTB44 |
DMDMi | 74760158 |
Proteomic databases
jPOSTi | Q8NCP5 |
MassIVEi | Q8NCP5 |
MaxQBi | Q8NCP5 |
PaxDbi | Q8NCP5 |
PeptideAtlasi | Q8NCP5 |
PRIDEi | Q8NCP5 |
ProteomicsDBi | 72915 [Q8NCP5-1] 72916 [Q8NCP5-2] 72917 [Q8NCP5-3] 72918 [Q8NCP5-4] |
Protocols and materials databases
Antibodypediai | 33097, 160 antibodies from 24 providers |
DNASUi | 29068 |
Genome annotation databases
Ensembli | ENST00000445008; ENSP00000408079; ENSG00000196323 [Q8NCP5-4] ENST00000525842; ENSP00000433457; ENSG00000196323 [Q8NCP5-3] ENST00000530205; ENSP00000434177; ENSG00000196323 [Q8NCP5-2] |
GeneIDi | 29068 |
KEGGi | hsa:29068 |
UCSCi | uc001qfz.4, human [Q8NCP5-1] |
Organism-specific databases
CTDi | 29068 |
DisGeNETi | 29068 |
GeneCardsi | ZBTB44 |
HGNCi | HGNC:25001, ZBTB44 |
HPAi | ENSG00000196323, Low tissue specificity |
neXtProti | NX_Q8NCP5 |
OpenTargetsi | ENSG00000196323 |
PharmGKBi | PA162409447 |
VEuPathDBi | HostDB:ENSG00000196323 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153306 |
HOGENOMi | CLU_034849_1_0_1 |
InParanoidi | Q8NCP5 |
PhylomeDBi | Q8NCP5 |
TreeFami | TF332673 |
Enzyme and pathway databases
PathwayCommonsi | Q8NCP5 |
SignaLinki | Q8NCP5 |
Miscellaneous databases
BioGRID-ORCSi | 29068, 10 hits in 1105 CRISPR screens |
ChiTaRSi | ZBTB44, human |
GenomeRNAii | 29068 |
Pharosi | Q8NCP5, Tdark |
PROi | PR:Q8NCP5 |
RNActi | Q8NCP5, protein |
Gene expression databases
Bgeei | ENSG00000196323, Expressed in quadriceps femoris and 230 other tissues |
ExpressionAtlasi | Q8NCP5, baseline and differential |
Genevisiblei | Q8NCP5, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT44_HUMAN | |
Accessioni | Q8NCP5Primary (citable) accession number: Q8NCP5 Secondary accession number(s): Q6IPT8, Q86VJ7, Q86XX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports