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Entry version 138 (13 Feb 2019)
Sequence version 2 (08 Apr 2008)
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Protein

Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Gene

PDPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Short name:
PDPr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDPR
Synonyms:KIAA1990
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090857.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30264 PDPR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617835 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NCN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000090857

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDPR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182668644

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032874028 – 879Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialAdd BLAST852

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NCN5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NCN5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NCN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NCN5

PeptideAtlas

More...
PeptideAtlasi
Q8NCN5

PRoteomics IDEntifications database

More...
PRIDEi
Q8NCN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72914

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NCN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NCN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090857 Expressed in 202 organ(s), highest expression level in parietal pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NCN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NCN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048092
HPA070386

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120384, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NCN5, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8NCN5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NCN5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NCN5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2844 Eukaryota
COG0404 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251716

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103854

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NCN5

KEGG Orthology (KO)

More...
KOi
K17509

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMYTAIC

Database of Orthologous Groups

More...
OrthoDBi
137947at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NCN5

TreeFam database of animal gene trees

More...
TreeFami
TF314735

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1360.120, 1 hit
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR032503 FAO_M
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01266 DAO, 1 hit
PF16350 FAO_M, 1 hit
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101790 SSF101790, 1 hit
SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFYRLLSIV GRQRASPGWQ NWSSARNSTS AAEARSMALP TQAQVVICGG
60 70 80 90 100
GITGTSVAYH LSKMGWKDIV LLEQGRLAAG STRFCAGILS TARHLTIEQK
110 120 130 140 150
MADYSNKLYY QLEQETGIQT GYTRTGSIFL AQTQDRLISL KRINAGLNVI
160 170 180 190 200
GIPSEIISPK KVAELHHLLN VHDLVGAMHV PEDAVVSSAD VALALASAAS
210 220 230 240 250
QNGVQIYDRT SVLHVMVKKG QVTGVETDKG QIECQYFVNC AGQWAYELGL
260 270 280 290 300
SNEEPVSIPL HACEHFYLLT RPLETPLQSS TPTIVDADGR IYIRNWQGGI
310 320 330 340 350
LSGGFEKNPK PIFTEGKNQL EIQNLQEDWD HFEPLLSSLL RRMPELETLE
360 370 380 390 400
IMKLVNCPET FTPDMRCIMG ESPAVQGYFV LAGMNSAGLS FGGGAGKYLA
410 420 430 440 450
EWMVHGYPSE NVWELDLKRF GALQSSRTFL RHRVMEVMPL MYDLKVPRWD
460 470 480 490 500
FQTGRQLRTS PLYDRLDAQG ARWMEKHGFE RPKYFVPPDK DLLALEQSKT
510 520 530 540 550
FYKPDWFDIV ESEVKCCKEA VCVIDMSSFT KFEITSTGDQ ALEVLQYLFS
560 570 580 590 600
NDLDVPVGHI VHTGMLNEGG GYENDCSIAR LNKRSFFMIS PTDQQVHCWA
610 620 630 640 650
WLKKHMPKDS NLLLEDVTWK YTALNLIGPR AVDVLSELSY APMTPDHFPS
660 670 680 690 700
LFCKEMSVGY ANGIRVMSMT HTGEPGFMLY IPIEYALHVY NEVMSVGQKY
710 720 730 740 750
GIRNAGYYAL RSLRIEKFFA FWGQDINNLT TPLECGRESR VKLEKGMDFI
760 770 780 790 800
GRDALLQQKQ NGVYKRLTMF ILDDHDSDLD LWPWWGEPIY RNGQYVGKTT
810 820 830 840 850
SSAYSYSLER HVCLGFVHNF SEDTGEEQVV TADFINRGEY EIDIAGYRFQ
860 870
AKAKLYPVAS LFTQKRRKDD MELSDLHGK
Length:879
Mass (Da):99,364
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD555CDE2A289753F
GO
Isoform 2 (identifier: Q8NCN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-655: Missing.

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):25,877
Checksum:iBDC4BBA660C3D86A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MT40A8MT40_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
779Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQG3H3BQG3_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
491Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZAR9B7ZAR9_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUH3H3BUH3_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV59H3BV59_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU60H3BU60_HUMAN
Pyruvate dehydrogenase phosphatase ...
PDPR
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRS5H3BRS5_HUMAN
HCG201155, isoform CRA_d
PDPR hCG_201155
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC02699 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF85191 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29T → A in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti47I → V in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti59 – 61YHL → HHQ in CAH10555 (PubMed:17974005).Curated3
Sequence conflicti110Y → H in BAF85191 (PubMed:14702039).Curated1
Sequence conflicti110Y → H in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti171V → A in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti206I → V in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti210T → A in BAF85191 (PubMed:14702039).Curated1
Sequence conflicti284I → T in CAH10494 (PubMed:17974005).Curated1
Sequence conflicti355V → A in CAH10494 (PubMed:17974005).Curated1
Sequence conflicti363P → S in CAH10555 (PubMed:17974005).Curated1
Sequence conflicti497Q → R in CAH10494 (PubMed:17974005).Curated1
Sequence conflicti597H → D in BAF85191 (PubMed:14702039).Curated1
Sequence conflicti662N → K in CAH10555 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042504109Y → H. Corresponds to variant dbSNP:rs2549532Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0560771 – 655Missing in isoform 2. 1 PublicationAdd BLAST655

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB082521 mRNA Translation: BAC02699.1 Different initiation.
AK093391 mRNA Translation: BAG52703.1
AK292502 mRNA Translation: BAF85191.1 Different initiation.
BX538153 mRNA Translation: CAH10555.1
CR627404 mRNA Translation: CAH10494.1
AC009022 Genomic DNA No translation available.
AC009060 Genomic DNA No translation available.
BC150251 mRNA Translation: AAI50252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45520.1 [Q8NCN5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001309046.1, NM_001322117.1 [Q8NCN5-1]
NP_060460.4, NM_017990.4 [Q8NCN5-1]
XP_005256072.1, XM_005256015.2 [Q8NCN5-1]
XP_005256073.1, XM_005256016.3 [Q8NCN5-1]
XP_016878876.1, XM_017023387.1 [Q8NCN5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.744043

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288050; ENSP00000288050; ENSG00000090857 [Q8NCN5-1]
ENST00000568530; ENSP00000457916; ENSG00000090857 [Q8NCN5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55066

UCSC genome browser

More...
UCSCi
uc002eyf.2 human [Q8NCN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082521 mRNA Translation: BAC02699.1 Different initiation.
AK093391 mRNA Translation: BAG52703.1
AK292502 mRNA Translation: BAF85191.1 Different initiation.
BX538153 mRNA Translation: CAH10555.1
CR627404 mRNA Translation: CAH10494.1
AC009022 Genomic DNA No translation available.
AC009060 Genomic DNA No translation available.
BC150251 mRNA Translation: AAI50252.1
CCDSiCCDS45520.1 [Q8NCN5-1]
RefSeqiNP_001309046.1, NM_001322117.1 [Q8NCN5-1]
NP_060460.4, NM_017990.4 [Q8NCN5-1]
XP_005256072.1, XM_005256015.2 [Q8NCN5-1]
XP_005256073.1, XM_005256016.3 [Q8NCN5-1]
XP_016878876.1, XM_017023387.1 [Q8NCN5-1]
UniGeneiHs.744043

3D structure databases

ProteinModelPortaliQ8NCN5
SMRiQ8NCN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120384, 31 interactors
IntActiQ8NCN5, 5 interactors
MINTiQ8NCN5
STRINGi9606.ENSP00000288050

PTM databases

iPTMnetiQ8NCN5
PhosphoSitePlusiQ8NCN5

Polymorphism and mutation databases

BioMutaiPDPR
DMDMi182668644

Proteomic databases

EPDiQ8NCN5
jPOSTiQ8NCN5
MaxQBiQ8NCN5
PaxDbiQ8NCN5
PeptideAtlasiQ8NCN5
PRIDEiQ8NCN5
ProteomicsDBi72914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288050; ENSP00000288050; ENSG00000090857 [Q8NCN5-1]
ENST00000568530; ENSP00000457916; ENSG00000090857 [Q8NCN5-1]
GeneIDi55066
KEGGihsa:55066
UCSCiuc002eyf.2 human [Q8NCN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55066
EuPathDBiHostDB:ENSG00000090857.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PDPR
HGNCiHGNC:30264 PDPR
HPAiHPA048092
HPA070386
MIMi617835 gene
neXtProtiNX_Q8NCN5
OpenTargetsiENSG00000090857

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2844 Eukaryota
COG0404 LUCA
GeneTreeiENSGT00940000159082
HOGENOMiHOG000251716
HOVERGENiHBG103854
InParanoidiQ8NCN5
KOiK17509
OMAiSMYTAIC
OrthoDBi137947at2759
PhylomeDBiQ8NCN5
TreeFamiTF314735

Enzyme and pathway databases

ReactomeiR-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDPR human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55066

Protein Ontology

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PROi
PR:Q8NCN5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090857 Expressed in 202 organ(s), highest expression level in parietal pleura
ExpressionAtlasiQ8NCN5 baseline and differential
GenevisibleiQ8NCN5 HS

Family and domain databases

Gene3Di3.30.1360.120, 1 hit
3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR032503 FAO_M
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16350 FAO_M, 1 hit
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
SSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCN5
Secondary accession number(s): A7E298
, A8K8Y7, B3KSE1, Q6AI20, Q6AWC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 13, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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