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UniProtKB - Q8NCM2 (KCNH5_HUMAN)

Entry version 179 (25 May 2022)
Sequence version 3 (31 May 2011)
Previous versions | rss
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Protein

Potassium voltage-gated channel subfamily H member 5

Gene

KCNH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi550 – 667cNMPAdd BLAST118

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NCM2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072, Voltage gated Potassium channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8NCM2

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.20.9, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 5
Alternative name(s):
Ether-a-go-go potassium channel 2
Short name:
hEAG2
Voltage-gated potassium channel subunit Kv10.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNH5
Synonyms:EAG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6254, KCNH5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605716, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NCM2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140015

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 217CytoplasmicSequence analysisAdd BLAST217
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei218 – 238Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini239 – 243ExtracellularSequence analysis5
Transmembranei244 – 264Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini265 – 291CytoplasmicSequence analysisAdd BLAST27
Transmembranei292 – 312Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini313 – 319ExtracellularSequence analysis7
Transmembranei320 – 340Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini341 – 346CytoplasmicSequence analysis6
Transmembranei347 – 367Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini368 – 419ExtracellularSequence analysisAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei420 – 440Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini441 – 446ExtracellularSequence analysis6
Transmembranei447 – 467Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini468 – 988CytoplasmicSequence analysisAdd BLAST521

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27133

MalaCards human disease database

More...MalaCardsi		KCNH5

Open Targets

More...OpenTargetsi		ENSG00000140015

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30040

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NCM2, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2362996

Drug and drug target database

More...DrugBanki		DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

DrugCentral

More...DrugCentrali		Q8NCM2

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		571

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNH5

Domain mapping of disease mutations (DMDM)

More...DMDMi		334302891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540101 – 988Potassium voltage-gated channel subfamily H member 5Add BLAST988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei883PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NCM2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NCM2

PeptideAtlas

More...PeptideAtlasi		Q8NCM2

PRoteomics IDEntifications database

More...PRIDEi		Q8NCM2

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NCM2, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NCM2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NCM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140015, Expressed in buccal mucosa cell and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NCM2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140015, Group enriched (brain, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable).

Curated

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118024, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8NCM2, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000321427

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NCM2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8NCM2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NCM2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 90PASAdd BLAST79
Domaini91 – 143PACPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni704 – 715Calmodulin-bindingSequence analysisAdd BLAST12
Regioni717 – 742DisorderedSequence analysisAdd BLAST26
Regioni838 – 890DisorderedSequence analysisAdd BLAST53
Regioni909 – 948CAD (involved in subunit assembly)By similarityAdd BLAST40
Regioni969 – 988DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi432 – 437Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi842 – 864Polar residuesSequence analysisAdd BLAST23
Compositional biasi865 – 883Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0501, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005746_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NCM2

Identification of Orthologs from Complete Genome Data

More...OMAi		EKKEEWN

Database of Orthologous Groups

More...OrthoDBi		464006at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NCM2

TreeFam database of animal gene trees

More...TreeFami		TF313130

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 1 hit
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR030171, EAG2
IPR005821, Ion_trans_dom
IPR003949, K_chnl_volt-dep_EAG
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR014710, RmlC-like_jellyroll

The PANTHER Classification System

More...PANTHERi		PTHR10217:SF533, PTHR10217:SF533, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF13426, PAS_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01463, EAGCHANLFMLY
PR01464, EAGCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 1 hit
SM00086, PAC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 1 hit
SSF55785, SSF55785, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50113, PAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q8NCM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGKRGLVA PQNTFLENIV RRSSESSFLL GNAQIVDWPV VYSNDGFCKL 
        60         70         80         90        100
SGYHRADVMQ KSSTCSFMYG ELTDKKTIEK VRQTFDNYES NCFEVLLYKK 
       110        120        130        140        150
NRTPVWFYMQ IAPIRNEHEK VVLFLCTFKD ITLFKQPIED DSTKGWTKFA 
       160        170        180        190        200
RLTRALTNSR SVLQQLTPMN KTEVVHKHSR LAEVLQLGSD ILPQYKQEAP 
       210        220        230        240        250
KTPPHIILHY CAFKTTWDWV ILILTFYTAI MVPYNVSFKT KQNNIAWLVL 
       260        270        280        290        300
DSVVDVIFLV DIVLNFHTTF VGPGGEVISD PKLIRMNYLK TWFVIDLLSC 
       310        320        330        340        350
LPYDIINAFE NVDEGISSLF SSLKVVRLLR LGRVARKLDH YLEYGAAVLV 
       360        370        380        390        400
LLVCVFGLVA HWLACIWYSI GDYEVIDEVT NTIQIDSWLY QLALSIGTPY 
       410        420        430        440        450
RYNTSAGIWE GGPSKDSLYV SSLYFTMTSL TTIGFGNIAP TTDVEKMFSV 
       460        470        480        490        500
AMMMVGSLLY ATIFGNVTTI FQQMYANTNR YHEMLNNVRD FLKLYQVPKG 
       510        520        530        540        550
LSERVMDYIV STWSMSKGID TEKVLSICPK DMRADICVHL NRKVFNEHPA 
       560        570        580        590        600
FRLASDGCLR ALAVEFQTIH CAPGDLIYHA GESVDALCFV VSGSLEVIQD 
       610        620        630        640        650
DEVVAILGKG DVFGDIFWKE TTLAHACANV RALTYCDLHI IKREALLKVL 
       660        670        680        690        700
DFYTAFANSF SRNLTLTCNL RKRIIFRKIS DVKKEEEERL RQKNEVTLSI 
       710        720        730        740        750
PVDHPVRKLF QKFKQQKELR NQGSTQGDPE RNQLQVESRS LQNGASITGT 
       760        770        780        790        800
SVVTVSQITP IQTSLAYVKT SESLKQNNRD AMELKPNGGA DQKCLKVNSP 
       810        820        830        840        850
IRMKNGNGKG WLRLKNNMGA HEEKKEDWNN VTKAESMGLL SEDPKSSDSE 
       860        870        880        890        900
NSVTKNPLRK TDSCDSGITK SDLRLDKAGE ARSPLEHSPI QADAKHPFYP 
       910        920        930        940        950
IPEQALQTTL QEVKHELKED IQLLSCRMTA LEKQVAEILK ILSEKSVPQA 
       960        970        980 
SSPKSQMPLQ VPPQIPCQDI FSVSRPESPE SDKDEIHF
Length:988
Mass (Da):111,877
Last modified:May 31, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA58E4CE0A32C83BC
GO
Isoform 2 (identifier: Q8NCM2-2) [UniParc]FASTAAdd to basket
Also known as: 2b

The sequence of this isoform differs from the canonical sequence as follows:
     608-611: GKGD → DHLS
     612-988: Missing.

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Length:611
Mass (Da):69,443
Checksum:i7BFDAE4B26410886
GO
Isoform 3 (identifier: Q8NCM2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     674-682: IIFRKISDV → GWFSMANAL
     683-988: Missing.

Show »
Length:624
Mass (Da):71,123
Checksum:iD6D18C16D9CAA93F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11016 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077834327R → H Found in a child with sporadic epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777164EnsemblClinVar.1
Natural variantiVAR_065162745A → T3 PublicationsCorresponds to variant dbSNP:rs4902176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0009721 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_000973608 – 611GKGD → DHLS in isoform 2. 1 Publication4
Alternative sequenceiVSP_000974612 – 988Missing in isoform 2. 1 PublicationAdd BLAST377
Alternative sequenceiVSP_000975674 – 682IIFRKISDV → GWFSMANAL in isoform 3. 1 Publication9
Alternative sequenceiVSP_000976683 – 988Missing in isoform 3. 1 PublicationAdd BLAST306

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF418206 mRNA Translation: AAM28435.1
AF472412 mRNA Translation: AAM49565.1
AF493798 mRNA Translation: AAM49574.1
AK074484 mRNA Translation: BAC11016.1 Sequence problems.
AL109985 Genomic DNA No translation available.
AL132666 Genomic DNA No translation available.
AL137191 Genomic DNA No translation available.
AL355101 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80819.1
BC073979 mRNA Translation: AAH73979.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45122.1 [Q8NCM2-2]
CCDS9756.1 [Q8NCM2-1]

NCBI Reference Sequences

More...RefSeqi		NP_647479.2, NM_139318.4 [Q8NCM2-1]
NP_758963.1, NM_172375.2 [Q8NCM2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322893.12; ENSP00000321427.7; ENSG00000140015.20
ENST00000394968.2; ENSP00000378419.1; ENSG00000140015.20 [Q8NCM2-3]
ENST00000420622.6; ENSP00000395439.2; ENSG00000140015.20 [Q8NCM2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27133

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000322893.12; ENSP00000321427.7; NM_139318.5; NP_647479.2

UCSC genome browser

More...UCSCi		uc001xfx.5, human [Q8NCM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418206 mRNA Translation: AAM28435.1
AF472412 mRNA Translation: AAM49565.1
AF493798 mRNA Translation: AAM49574.1
AK074484 mRNA Translation: BAC11016.1 Sequence problems.
AL109985 Genomic DNA No translation available.
AL132666 Genomic DNA No translation available.
AL137191 Genomic DNA No translation available.
AL355101 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80819.1
BC073979 mRNA Translation: AAH73979.1
CCDSiCCDS45122.1 [Q8NCM2-2]
CCDS9756.1 [Q8NCM2-1]
RefSeqiNP_647479.2, NM_139318.4 [Q8NCM2-1]
NP_758963.1, NM_172375.2 [Q8NCM2-2]

3D structure databases

AlphaFoldDBiQ8NCM2
SMRiQ8NCM2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118024, 7 interactors
IntActiQ8NCM2, 2 interactors
STRINGi9606.ENSP00000321427

Chemistry databases

ChEMBLiCHEMBL2362996
DrugBankiDB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine
DrugCentraliQ8NCM2
GuidetoPHARMACOLOGYi571

Protein family/group databases

TCDBi1.A.1.20.9, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ8NCM2, 1 site
iPTMnetiQ8NCM2
PhosphoSitePlusiQ8NCM2

Genetic variation databases

BioMutaiKCNH5
DMDMi334302891

Proteomic databases

MassIVEiQ8NCM2
PaxDbiQ8NCM2
PeptideAtlasiQ8NCM2
PRIDEiQ8NCM2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11594, 59 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		27133

Genome annotation databases

EnsembliENST00000322893.12; ENSP00000321427.7; ENSG00000140015.20
ENST00000394968.2; ENSP00000378419.1; ENSG00000140015.20 [Q8NCM2-3]
ENST00000420622.6; ENSP00000395439.2; ENSG00000140015.20 [Q8NCM2-2]
GeneIDi27133
KEGGihsa:27133
MANE-SelectiENST00000322893.12; ENSP00000321427.7; NM_139318.5; NP_647479.2
UCSCiuc001xfx.5, human [Q8NCM2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27133
DisGeNETi27133

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNH5
HGNCiHGNC:6254, KCNH5
HPAiENSG00000140015, Group enriched (brain, retina)
MalaCardsiKCNH5
MIMi605716, gene
neXtProtiNX_Q8NCM2
OpenTargetsiENSG00000140015
PharmGKBiPA30040
VEuPathDBiHostDB:ENSG00000140015

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0501, Eukaryota
GeneTreeiENSGT00940000156540
HOGENOMiCLU_005746_3_1_1
InParanoidiQ8NCM2
OMAiEKKEEWN
OrthoDBi464006at2759
PhylomeDBiQ8NCM2
TreeFamiTF313130

Enzyme and pathway databases

PathwayCommonsiQ8NCM2
ReactomeiR-HSA-1296072, Voltage gated Potassium channels
SignaLinkiQ8NCM2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27133, 21 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNH5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNH5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27133
PharosiQ8NCM2, Tclin

Protein Ontology

More...PROi		PR:Q8NCM2
RNActiQ8NCM2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140015, Expressed in buccal mucosa cell and 71 other tissues
GenevisibleiQ8NCM2, HS

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
cd00130, PAS, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR030171, EAG2
IPR005821, Ion_trans_dom
IPR003949, K_chnl_volt-dep_EAG
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR014710, RmlC-like_jellyroll
PANTHERiPTHR10217:SF533, PTHR10217:SF533, 1 hit
PfamiView protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF13426, PAS_9, 1 hit
PRINTSiPR01463, EAGCHANLFMLY
PR01464, EAGCHANNEL
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SM00086, PAC, 1 hit
SUPFAMiSSF51206, SSF51206, 1 hit
SSF55785, SSF55785, 1 hit
TIGRFAMsiTIGR00229, sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50113, PAC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNH5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCM2
Secondary accession number(s): C9JP98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 31, 2011
Last modified: May 25, 2022
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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