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Protein

Zinc finger protein 485

Gene

ZNF485

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 485
Gene namesi
Name:ZNF485
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000198298.12
HGNCiHGNC:23440 ZNF485
neXtProtiNX_Q8NCK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198298
PharmGKBiPA134887005

Polymorphism and mutation databases

BioMutaiZNF485
DMDMi74762554

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239531 – 441Zinc finger protein 485Add BLAST441

Proteomic databases

EPDiQ8NCK3
MaxQBiQ8NCK3
PaxDbiQ8NCK3
PeptideAtlasiQ8NCK3
PRIDEiQ8NCK3
ProteomicsDBi72901

PTM databases

iPTMnetiQ8NCK3
PhosphoSitePlusiQ8NCK3

Expressioni

Gene expression databases

BgeeiENSG00000198298 Expressed in 145 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_ZNF485
ExpressionAtlasiQ8NCK3 baseline and differential
GenevisibleiQ8NCK3 HS

Organism-specific databases

HPAiHPA059356

Interactioni

Protein-protein interaction databases

BioGridi128671, 26 interactors
IntActiQ8NCK3, 2 interactors
STRINGi9606.ENSP00000354694

Structurei

3D structure databases

ProteinModelPortaliQ8NCK3
SMRiQ8NCK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 82KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150958
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NCK3
OMAiTEKNYKC
OrthoDBiEOG091G02KC
PhylomeDBiQ8NCK3
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRAQIQGP LTFGDVAVAF TRIEWRHLDA AQRALYRDVM LENYGNLVSV
60 70 80 90 100
GLLSSKPKLI TQLEQGAEPW TEVREAPSGT HAVEDYWFET KMSALKQSTS
110 120 130 140 150
EASVLGERTK SVMMEKGLDW EGRSSTEKNY KCKECGKVFK YNSSFISHQR
160 170 180 190 200
NHTSEKPHKC KECGIAFMNS SSLLNHHKVH AGKQPYRCIE CGKFLKKHST
210 220 230 240 250
FINHQRIHSR EKPHKCIECG KTFRKNSILL SHQRIHTGQK PYKCNDCGKA
260 270 280 290 300
FAQNAALTRH ERIHSGEKPF KCNKCGRAFR DNSTVLEHQK IHTGEKPYQC
310 320 330 340 350
NECGKAFRKS STLISHQRMH TGEKPYHCSK CGKSFRYSSS FAGHQKTHSG
360 370 380 390 400
NKPYQCRDCG KAFTKSSTLT GHQRIHTGEK PYHCKKCGKA FRHSSGLVEH
410 420 430 440
QRLHTGEKPY KCNECGKAFP RSSALKQHKK IHNKERAMKC S
Length:441
Mass (Da):50,280
Last modified:October 1, 2002 - v1
Checksum:i34AAEC75A350EFE6
GO
Isoform 2 (identifier: Q8NCK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,025
Checksum:iF3E94A78DBA27879
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JV60C9JV60_HUMAN
Zinc finger protein 485
ZNF485
117Annotation score:

Sequence cautioni

The sequence AAH14161 differs from that shown. Reason: Frameshift at position 3.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059920252A → T. Corresponds to variant dbSNP:rs12354886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559571 – 91Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074679 mRNA Translation: BAC11133.1
AK299707 mRNA Translation: BAG61608.1
AL645634 Genomic DNA No translation available.
BC014161 mRNA Translation: AAH14161.1 Frameshift.
CCDSiCCDS7205.2 [Q8NCK3-1]
RefSeqiNP_001305069.1, NM_001318140.1 [Q8NCK3-1]
NP_001305070.1, NM_001318141.1 [Q8NCK3-1]
NP_001305071.1, NM_001318142.1 [Q8NCK3-2]
NP_001305072.1, NM_001318143.1 [Q8NCK3-2]
NP_660355.2, NM_145312.3 [Q8NCK3-1]
XP_011537800.1, XM_011539498.2 [Q8NCK3-2]
UniGeneiHs.147440

Genome annotation databases

EnsembliENST00000361807; ENSP00000354694; ENSG00000198298 [Q8NCK3-1]
ENST00000374435; ENSP00000363558; ENSG00000198298 [Q8NCK3-1]
GeneIDi220992
KEGGihsa:220992
UCSCiuc010qfc.3 human [Q8NCK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074679 mRNA Translation: BAC11133.1
AK299707 mRNA Translation: BAG61608.1
AL645634 Genomic DNA No translation available.
BC014161 mRNA Translation: AAH14161.1 Frameshift.
CCDSiCCDS7205.2 [Q8NCK3-1]
RefSeqiNP_001305069.1, NM_001318140.1 [Q8NCK3-1]
NP_001305070.1, NM_001318141.1 [Q8NCK3-1]
NP_001305071.1, NM_001318142.1 [Q8NCK3-2]
NP_001305072.1, NM_001318143.1 [Q8NCK3-2]
NP_660355.2, NM_145312.3 [Q8NCK3-1]
XP_011537800.1, XM_011539498.2 [Q8NCK3-2]
UniGeneiHs.147440

3D structure databases

ProteinModelPortaliQ8NCK3
SMRiQ8NCK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128671, 26 interactors
IntActiQ8NCK3, 2 interactors
STRINGi9606.ENSP00000354694

PTM databases

iPTMnetiQ8NCK3
PhosphoSitePlusiQ8NCK3

Polymorphism and mutation databases

BioMutaiZNF485
DMDMi74762554

Proteomic databases

EPDiQ8NCK3
MaxQBiQ8NCK3
PaxDbiQ8NCK3
PeptideAtlasiQ8NCK3
PRIDEiQ8NCK3
ProteomicsDBi72901

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361807; ENSP00000354694; ENSG00000198298 [Q8NCK3-1]
ENST00000374435; ENSP00000363558; ENSG00000198298 [Q8NCK3-1]
GeneIDi220992
KEGGihsa:220992
UCSCiuc010qfc.3 human [Q8NCK3-1]

Organism-specific databases

CTDi220992
EuPathDBiHostDB:ENSG00000198298.12
GeneCardsiZNF485
HGNCiHGNC:23440 ZNF485
HPAiHPA059356
neXtProtiNX_Q8NCK3
OpenTargetsiENSG00000198298
PharmGKBiPA134887005
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150958
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NCK3
OMAiTEKNYKC
OrthoDBiEOG091G02KC
PhylomeDBiQ8NCK3
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii220992
PROiPR:Q8NCK3

Gene expression databases

BgeeiENSG00000198298 Expressed in 145 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_ZNF485
ExpressionAtlasiQ8NCK3 baseline and differential
GenevisibleiQ8NCK3 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN485_HUMAN
AccessioniPrimary (citable) accession number: Q8NCK3
Secondary accession number(s): B4DSE6, Q96CL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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