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Entry version 122 (18 Sep 2019)
Sequence version 2 (17 Oct 2006)
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Protein

SPRY domain-containing protein 3

Gene

SPRYD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPRY domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRYD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25920 SPRYD3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NCJ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000167778

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NCJ5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPRYD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242798

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408541 – 442SPRY domain-containing protein 3Add BLAST442

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NCJ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NCJ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NCJ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NCJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NCJ5

PeptideAtlas

More...
PeptideAtlasi
Q8NCJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q8NCJ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72900

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NCJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NCJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167778 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NCJ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NCJ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039426
HPA039685

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124361, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NCJ5, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301463

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1442
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NCJ5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NCJ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 204B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi371 – 393Glu-richAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1477 Eukaryota
ENOG410XPCC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004843

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NCJ5

Database of Orthologous Groups

More...
OrthoDBi
1106989at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NCJ5

TreeFam database of animal gene trees

More...
TreeFami
TF331658

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12908 SPRYD3, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035783 SPRYD3_SPRY

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00622 SPRY, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00449 SPRY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8NCJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL
60 70 80 90 100
VDGDTLSYHG NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP
110 120 130 140 150
QYYSLDHQPG WLPDSVAYHA DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE
160 170 180 190 200
PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD GLFPAVGMHS LGEEVRLHLN
210 220 230 240 250
AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK SIVDVGLAQA
260 270 280 290 300
RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
310 320 330 340 350
DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV
360 370 380 390 400
ILSPTARAVR NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF
410 420 430 440
FTRNGKIIGK KDAVVPSGGF FPTIGMLSCG EKVKVDLHPL SG
Length:442
Mass (Da):49,694
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB868EF60894E66D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWW7F8VWW7_HUMAN
SPRY domain-containing protein 3
SPRYD3
479Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z1Y3B7Z1Y3_HUMAN
SPRY domain-containing protein 3
SPRYD3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI85H0YI85_HUMAN
SPRY domain-containing protein 3
SPRYD3
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti359V → I in BAC11144 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027706 mRNA Translation: BAB55311.1
AK074694 mRNA Translation: BAC11144.1
CH471054 Genomic DNA Translation: EAW96662.1
BC136312 mRNA Translation: AAI36313.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8845.1

NCBI Reference Sequences

More...
RefSeqi
NP_116229.1, NM_032840.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301463; ENSP00000301463; ENSG00000167778

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84926

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84926

UCSC genome browser

More...
UCSCi
uc001sbt.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027706 mRNA Translation: BAB55311.1
AK074694 mRNA Translation: BAC11144.1
CH471054 Genomic DNA Translation: EAW96662.1
BC136312 mRNA Translation: AAI36313.1
CCDSiCCDS8845.1
RefSeqiNP_116229.1, NM_032840.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YYOX-ray2.00A46-203[»]
SMRiQ8NCJ5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124361, 12 interactors
IntActiQ8NCJ5, 9 interactors
STRINGi9606.ENSP00000301463

PTM databases

iPTMnetiQ8NCJ5
PhosphoSitePlusiQ8NCJ5

Polymorphism and mutation databases

BioMutaiSPRYD3
DMDMi116242798

Proteomic databases

EPDiQ8NCJ5
jPOSTiQ8NCJ5
MassIVEiQ8NCJ5
MaxQBiQ8NCJ5
PaxDbiQ8NCJ5
PeptideAtlasiQ8NCJ5
PRIDEiQ8NCJ5
ProteomicsDBi72900

Genome annotation databases

EnsembliENST00000301463; ENSP00000301463; ENSG00000167778
GeneIDi84926
KEGGihsa:84926
UCSCiuc001sbt.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84926

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPRYD3
HGNCiHGNC:25920 SPRYD3
HPAiHPA039426
HPA039685
neXtProtiNX_Q8NCJ5
OpenTargetsiENSG00000167778
PharmGKBiPA143485621

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00940000158675
HOGENOMiHOG000004843
InParanoidiQ8NCJ5
OrthoDBi1106989at2759
PhylomeDBiQ8NCJ5
TreeFamiTF331658

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPRYD3 human
EvolutionaryTraceiQ8NCJ5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84926
PharosiQ8NCJ5

Protein Ontology

More...
PROi
PR:Q8NCJ5

Gene expression databases

BgeeiENSG00000167778 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasiQ8NCJ5 baseline and differential
GenevisibleiQ8NCJ5 HS

Family and domain databases

CDDicd12908 SPRYD3, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035783 SPRYD3_SPRY
PfamiView protein in Pfam
PF00622 SPRY, 2 hits
SMARTiView protein in SMART
SM00449 SPRY, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRY3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCJ5
Secondary accession number(s): B9EG99, Q96SK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: September 18, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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