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Protein

SPRY domain-containing protein 3

Gene

SPRYD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 3
Gene namesi
Name:SPRYD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167778.8
HGNCiHGNC:25920 SPRYD3
neXtProtiNX_Q8NCJ5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167778
PharmGKBiPA143485621

Polymorphism and mutation databases

BioMutaiSPRYD3
DMDMi116242798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408541 – 442SPRY domain-containing protein 3Add BLAST442

Proteomic databases

EPDiQ8NCJ5
MaxQBiQ8NCJ5
PaxDbiQ8NCJ5
PeptideAtlasiQ8NCJ5
PRIDEiQ8NCJ5
ProteomicsDBi72900

PTM databases

iPTMnetiQ8NCJ5
PhosphoSitePlusiQ8NCJ5

Expressioni

Gene expression databases

BgeeiENSG00000167778 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SPRYD3
ExpressionAtlasiQ8NCJ5 baseline and differential
GenevisibleiQ8NCJ5 HS

Organism-specific databases

HPAiHPA039426
HPA039685

Interactioni

Protein-protein interaction databases

BioGridi124361, 11 interactors
IntActiQ8NCJ5, 7 interactors
STRINGi9606.ENSP00000301463

Structurei

Secondary structure

1442
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8NCJ5
SMRiQ8NCJ5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NCJ5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 204B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 393Glu-richAdd BLAST23

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000004843
HOVERGENiHBG079840
InParanoidiQ8NCJ5
PhylomeDBiQ8NCJ5
TreeFamiTF331658

Family and domain databases

CDDicd12908 SPRYD3, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035783 SPRYD3_SPRY
PfamiView protein in Pfam
PF00622 SPRY, 2 hits
SMARTiView protein in SMART
SM00449 SPRY, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8NCJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL
60 70 80 90 100
VDGDTLSYHG NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP
110 120 130 140 150
QYYSLDHQPG WLPDSVAYHA DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE
160 170 180 190 200
PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD GLFPAVGMHS LGEEVRLHLN
210 220 230 240 250
AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK SIVDVGLAQA
260 270 280 290 300
RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
310 320 330 340 350
DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV
360 370 380 390 400
ILSPTARAVR NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF
410 420 430 440
FTRNGKIIGK KDAVVPSGGF FPTIGMLSCG EKVKVDLHPL SG
Length:442
Mass (Da):49,694
Last modified:October 17, 2006 - v2
Checksum:iBB868EF60894E66D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWW7F8VWW7_HUMAN
SPRY domain-containing protein 3
SPRYD3
479Annotation score:
B7Z1Y3B7Z1Y3_HUMAN
cDNA FLJ53727, highly similar to SP...
SPRYD3
165Annotation score:
H0YI85H0YI85_HUMAN
SPRY domain-containing protein 3
SPRYD3
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359V → I in BAC11144 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027706 mRNA Translation: BAB55311.1
AK074694 mRNA Translation: BAC11144.1
CH471054 Genomic DNA Translation: EAW96662.1
BC136312 mRNA Translation: AAI36313.1
CCDSiCCDS8845.1
RefSeqiNP_116229.1, NM_032840.2
UniGeneiHs.343334

Genome annotation databases

EnsembliENST00000301463; ENSP00000301463; ENSG00000167778
GeneIDi84926
KEGGihsa:84926
UCSCiuc001sbt.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027706 mRNA Translation: BAB55311.1
AK074694 mRNA Translation: BAC11144.1
CH471054 Genomic DNA Translation: EAW96662.1
BC136312 mRNA Translation: AAI36313.1
CCDSiCCDS8845.1
RefSeqiNP_116229.1, NM_032840.2
UniGeneiHs.343334

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YYOX-ray2.00A46-203[»]
ProteinModelPortaliQ8NCJ5
SMRiQ8NCJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124361, 11 interactors
IntActiQ8NCJ5, 7 interactors
STRINGi9606.ENSP00000301463

PTM databases

iPTMnetiQ8NCJ5
PhosphoSitePlusiQ8NCJ5

Polymorphism and mutation databases

BioMutaiSPRYD3
DMDMi116242798

Proteomic databases

EPDiQ8NCJ5
MaxQBiQ8NCJ5
PaxDbiQ8NCJ5
PeptideAtlasiQ8NCJ5
PRIDEiQ8NCJ5
ProteomicsDBi72900

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301463; ENSP00000301463; ENSG00000167778
GeneIDi84926
KEGGihsa:84926
UCSCiuc001sbt.2 human

Organism-specific databases

CTDi84926
EuPathDBiHostDB:ENSG00000167778.8
GeneCardsiSPRYD3
HGNCiHGNC:25920 SPRYD3
HPAiHPA039426
HPA039685
neXtProtiNX_Q8NCJ5
OpenTargetsiENSG00000167778
PharmGKBiPA143485621
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000004843
HOVERGENiHBG079840
InParanoidiQ8NCJ5
PhylomeDBiQ8NCJ5
TreeFamiTF331658

Miscellaneous databases

ChiTaRSiSPRYD3 human
EvolutionaryTraceiQ8NCJ5
GenomeRNAii84926
PROiPR:Q8NCJ5

Gene expression databases

BgeeiENSG00000167778 Expressed in 201 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SPRYD3
ExpressionAtlasiQ8NCJ5 baseline and differential
GenevisibleiQ8NCJ5 HS

Family and domain databases

CDDicd12908 SPRYD3, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR035783 SPRYD3_SPRY
PfamiView protein in Pfam
PF00622 SPRY, 2 hits
SMARTiView protein in SMART
SM00449 SPRY, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPRY3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCJ5
Secondary accession number(s): B9EG99, Q96SK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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