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Protein

Beta-galactosidase-1-like protein 3

Gene

GLB1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Proton donorBy similarity1
Active sitei301NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase-1-like protein 3 (EC:3.2.1.-)
Gene namesi
Name:GLB1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166105.15
HGNCiHGNC:25147 GLB1L3
neXtProtiNX_Q8NCI6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi112937
OpenTargetsiENSG00000166105
PharmGKBiPA145148764

Polymorphism and mutation databases

BioMutaiGLB1L3
DMDMi269849685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830281 – 653Beta-galactosidase-1-like protein 3Add BLAST653

Proteomic databases

EPDiQ8NCI6
MaxQBiQ8NCI6
PaxDbiQ8NCI6
PeptideAtlasiQ8NCI6
PRIDEiQ8NCI6
ProteomicsDBi72897
72898 [Q8NCI6-2]
72899 [Q8NCI6-4]

PTM databases

iPTMnetiQ8NCI6
PhosphoSitePlusiQ8NCI6

Expressioni

Gene expression databases

BgeeiENSG00000166105 Expressed in 92 organ(s), highest expression level in myometrium
ExpressionAtlasiQ8NCI6 baseline and differential
GenevisibleiQ8NCI6 HS

Organism-specific databases

HPAiHPA039916

Interactioni

Protein-protein interaction databases

BioGridi125216, 5 interactors
STRINGi9606.ENSP00000396615

Structurei

3D structure databases

ProteinModelPortaliQ8NCI6
SMRiQ8NCI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Phylogenomic databases

eggNOGiKOG0496 Eukaryota
COG1874 LUCA
GeneTreeiENSGT00390000006586
HOGENOMiHOG000221607
HOVERGENiHBG004841
InParanoidiQ8NCI6
OMAiECQLLRI
OrthoDBiEOG091G006X
PhylomeDBiQ8NCI6
TreeFamiTF354299

Family and domain databases

Gene3Di2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR026283 B-gal_1-like
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF01301 Glyco_hydro_35, 1 hit
PIRSFiPIRSF006336 B-gal, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSPPLLSPC LSWKRMAGIF FLPFISSGFA PRFKQEENFM LGRAHPSQPR
60 70 80 90 100
FNWSHLTPLE LKNRSVGLGT ESTGRGKPHF TLEGHKFLIF GGSIHYFRVP
110 120 130 140 150
REYWRDRLLK LKACGFNTVT TYVPWNLHEP ERGKFDFSGN LDLEAFVLMA
160 170 180 190 200
AEIGLWVILR PGRYICSEMD LGGLPSWLLQ DPRLLLRTTN KSFIEAVEKY
210 220 230 240 250
FDHLIPRVIP LQYRQAGPVI AVQVENEYGS FNKDKTYMPY LHKALLRRGI
260 270 280 290 300
VELLLTSDGE KHVLSGHTKG VLAAINLQKL HQDTFNQLHK VQRDKPLLIM
310 320 330 340 350
EYWVGWFDRW GDKHHVKDAK EVEHAVSEFI KYEISFNVYM FHGGTNFGFM
360 370 380 390 400
NGATYFGKHS GIVTSYDYDA VLTEAGDYTE KYLKLQKLFQ SVSATPLPRV
410 420 430 440 450
PKLPPKAVYP PVRPSLYLPL WDALSYLNEP VRSRQPVNME NLPINNGSGQ
460 470 480 490 500
SYGLVLYEKS ICSGGRLRAH AHDVAQVFLD ETMIGILNEN NKDLHIPELR
510 520 530 540 550
DCRYLRILVE NQGRVNFSWQ IQNEQKGITG SVSINNSSLE GFTIYSLEMK
560 570 580 590 600
MSFFERLRSA TWKPVPDSHQ GPAFYCGTLK AGPSPKDTFL SLLNWNYGFV
610 620 630 640 650
FINGRNLGRY WNIGPQKTLY LPGVWLHPED NEVILFEKMM SGSDIKSTDK

PTL
Length:653
Mass (Da):74,823
Last modified:November 24, 2009 - v3
Checksum:i997972E36F2ECF16
GO
Isoform 2 (identifier: Q8NCI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Show »
Length:314
Mass (Da):35,501
Checksum:i40AA41A184F473DE
GO
Isoform 4 (identifier: Q8NCI6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: RDKPLLIMEYWVGWFDRWGDK → GASIDAGLLSDASQAATSSSL
     314-653: Missing.

Show »
Length:313
Mass (Da):35,449
Checksum:i7013E2F6E381EC78
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C115H7C115_HUMAN
Beta-galactosidase-1-like protein 3
GLB1L3
186Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031477163R → P1 PublicationCorresponds to variant dbSNP:rs472287Ensembl.1
Natural variantiVAR_031478474V → M1 PublicationCorresponds to variant dbSNP:rs2509062Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242801 – 339Missing in isoform 2. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_024283293 – 313RDKPL…RWGDK → GASIDAGLLSDASQAATSSS L in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_024284314 – 653Missing in isoform 4. 1 PublicationAdd BLAST340

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074712 mRNA Translation: BAC11155.1
AP000859 Genomic DNA No translation available.
BC011001 mRNA Translation: AAH11001.2
CCDSiCCDS44780.1 [Q8NCI6-1]
RefSeqiNP_001073876.2, NM_001080407.2 [Q8NCI6-1]
UniGeneiHs.721382

Genome annotation databases

EnsembliENST00000389887; ENSP00000374537; ENSG00000166105 [Q8NCI6-4]
ENST00000431683; ENSP00000396615; ENSG00000166105 [Q8NCI6-1]
GeneIDi112937
KEGGihsa:112937
UCSCiuc009zdf.4 human [Q8NCI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074712 mRNA Translation: BAC11155.1
AP000859 Genomic DNA No translation available.
BC011001 mRNA Translation: AAH11001.2
CCDSiCCDS44780.1 [Q8NCI6-1]
RefSeqiNP_001073876.2, NM_001080407.2 [Q8NCI6-1]
UniGeneiHs.721382

3D structure databases

ProteinModelPortaliQ8NCI6
SMRiQ8NCI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125216, 5 interactors
STRINGi9606.ENSP00000396615

Protein family/group databases

CAZyiGH35 Glycoside Hydrolase Family 35

PTM databases

iPTMnetiQ8NCI6
PhosphoSitePlusiQ8NCI6

Polymorphism and mutation databases

BioMutaiGLB1L3
DMDMi269849685

Proteomic databases

EPDiQ8NCI6
MaxQBiQ8NCI6
PaxDbiQ8NCI6
PeptideAtlasiQ8NCI6
PRIDEiQ8NCI6
ProteomicsDBi72897
72898 [Q8NCI6-2]
72899 [Q8NCI6-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389887; ENSP00000374537; ENSG00000166105 [Q8NCI6-4]
ENST00000431683; ENSP00000396615; ENSG00000166105 [Q8NCI6-1]
GeneIDi112937
KEGGihsa:112937
UCSCiuc009zdf.4 human [Q8NCI6-1]

Organism-specific databases

CTDi112937
DisGeNETi112937
EuPathDBiHostDB:ENSG00000166105.15
GeneCardsiGLB1L3
HGNCiHGNC:25147 GLB1L3
HPAiHPA039916
neXtProtiNX_Q8NCI6
OpenTargetsiENSG00000166105
PharmGKBiPA145148764
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0496 Eukaryota
COG1874 LUCA
GeneTreeiENSGT00390000006586
HOGENOMiHOG000221607
HOVERGENiHBG004841
InParanoidiQ8NCI6
OMAiECQLLRI
OrthoDBiEOG091G006X
PhylomeDBiQ8NCI6
TreeFamiTF354299

Miscellaneous databases

ChiTaRSiGLB1L3 human
GeneWikiiGLB1L3
GenomeRNAii112937
PROiPR:Q8NCI6

Gene expression databases

BgeeiENSG00000166105 Expressed in 92 organ(s), highest expression level in myometrium
ExpressionAtlasiQ8NCI6 baseline and differential
GenevisibleiQ8NCI6 HS

Family and domain databases

Gene3Di2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR026283 B-gal_1-like
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF01301 Glyco_hydro_35, 1 hit
PIRSFiPIRSF006336 B-gal, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLBL3_HUMAN
AccessioniPrimary (citable) accession number: Q8NCI6
Secondary accession number(s): A6NEM0
, A6NN15, Q6P3S3, Q96FF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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