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Protein

Carbohydrate sulfotransferase 14

Gene

CHST14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi155 – 161PAPSBy similarity7
Nucleotide bindingi213 – 221PAPSBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • N-acetylgalactosamine 4-O-sulfotransferase activity Source: UniProtKB
  • phosphate ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000169105-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.8.2.35 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbohydrate sulfotransferase 14 (EC:2.8.2.35)
Alternative name(s):
Dermatan 4-sulfotransferase 1
Short name:
D4ST-1
Short name:
hD4ST1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHST14
Synonyms:D4ST1
ORF Names:UNQ1925/PRO4400
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169105.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24464 CHST14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608429 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NCH0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 376LumenalSequence analysisAdd BLAST316

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ehlers-Danlos syndrome, musculocontractural type 1 (EDSMC1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement.
See also OMIM:601776
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063754135R → G in EDSMC1; associated in a complex allele with Q-137; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs267606727EnsemblClinVar.1
Natural variantiVAR_063755137L → Q in EDSMC1; associated in a complex allele with G-135; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs267606728EnsemblClinVar.1
Natural variantiVAR_063756213R → P in EDSMC1; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs121908257EnsemblClinVar.1
Natural variantiVAR_064555281P → L in EDSMC1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606729EnsemblClinVar.1
Natural variantiVAR_064556289C → S in EDSMC1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606731EnsemblClinVar.1
Natural variantiVAR_063757293Y → C in EDSMC1; results in altered intracellular processing; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121908258EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
113189

MalaCards human disease database

More...
MalaCardsi
CHST14
MIMi601776 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169105

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2953 Ehlers-Danlos syndrome, musculocontractural type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHST14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61211839

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001896721 – 376Carbohydrate sulfotransferase 14Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NCH0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NCH0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NCH0

PeptideAtlas

More...
PeptideAtlasi
Q8NCH0

PRoteomics IDEntifications database

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PRIDEi
Q8NCH0

ProteomicsDB human proteome resource

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ProteomicsDBi
72895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NCH0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NCH0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000169105 Expressed in 170 organ(s), highest expression level in layer of synovial tissue

CleanEx database of gene expression profiles

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CleanExi
HS_CHST14

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NCH0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NCH0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057697
HPA071601

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125232, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307297

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NCH0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfotransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4651 Eukaryota
ENOG4111GJR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162640

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231801

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050954

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NCH0

KEGG Orthology (KO)

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KOi
K08105

Identification of Orthologs from Complete Genome Data

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OMAi
YNLCQPC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0FZO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NCH0

TreeFam database of animal gene trees

More...
TreeFami
TF325581

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018011 Carb_sulfotrans_8-10
IPR005331 Sulfotransferase

The PANTHER Classification System

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PANTHERi
PTHR12137 PTHR12137, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03567 Sulfotransfer_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NCH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPRPLTPLA APNGAEPLGR ALRRAPLGRA RAGLGGPPLL LPSMLMFAVI
60 70 80 90 100
VASSGLLLMI ERGILAEMKP LPLHPPGREG TAWRGKAPKP GGLSLRAGDA
110 120 130 140 150
DLQVRQDVRN RTLRAVCGQP GMPRDPWDLP VGQRRTLLRH ILVSDRYRFL
160 170 180 190 200
YCYVPKVACS NWKRVMKVLA GVLDSVDVRL KMDHRSDLVF LADLRPEEIR
210 220 230 240 250
YRLQHYFKFL FVREPLERLL SAYRNKFGEI REYQQRYGAE IVRRYRAGAG
260 270 280 290 300
PSPAGDDVTF PEFLRYLVDE DPERMNEHWM PVYHLCQPCA VHYDFVGSYE
310 320 330 340 350
RLEADANQVL EWVRAPPHVR FPARQAWYRP ASPESLHYHL CSAPRALLQD
360 370
VLPKYILDFS LFAYPLPNVT KEACQQ
Length:376
Mass (Da):42,997
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53BF537979260188
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN65H0YN65_HUMAN
Carbohydrate sulfotransferase
CHST14
351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195R → L in BAC11172 (PubMed:14702039).Curated1
Sequence conflicti214E → D in BAC11172 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063754135R → G in EDSMC1; associated in a complex allele with Q-137; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs267606727EnsemblClinVar.1
Natural variantiVAR_063755137L → Q in EDSMC1; associated in a complex allele with G-135; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs267606728EnsemblClinVar.1
Natural variantiVAR_063756213R → P in EDSMC1; results in altered intracellular processing. 1 PublicationCorresponds to variant dbSNP:rs121908257EnsemblClinVar.1
Natural variantiVAR_064555281P → L in EDSMC1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606729EnsemblClinVar.1
Natural variantiVAR_064556289C → S in EDSMC1; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606731EnsemblClinVar.1
Natural variantiVAR_063757293Y → C in EDSMC1; results in altered intracellular processing; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs121908258EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF401222 mRNA Translation: AAK92532.1
AB066595 mRNA Translation: BAB84097.1
AF282905 mRNA Translation: AAK69530.1
AK074739 mRNA Translation: BAC11172.1
BC023653 mRNA Translation: AAH23653.1
BC049214 mRNA Translation: AAH49214.1
BC053633 mRNA Translation: AAH53633.1
AY358446 mRNA Translation: AAQ88811.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10059.1

NCBI Reference Sequences

More...
RefSeqi
NP_569735.1, NM_130468.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.442449

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306243; ENSP00000307297; ENSG00000169105

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113189

UCSC genome browser

More...
UCSCi
uc001zlw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401222 mRNA Translation: AAK92532.1
AB066595 mRNA Translation: BAB84097.1
AF282905 mRNA Translation: AAK69530.1
AK074739 mRNA Translation: BAC11172.1
BC023653 mRNA Translation: AAH23653.1
BC049214 mRNA Translation: AAH49214.1
BC053633 mRNA Translation: AAH53633.1
AY358446 mRNA Translation: AAQ88811.1 Different initiation.
CCDSiCCDS10059.1
RefSeqiNP_569735.1, NM_130468.3
UniGeneiHs.442449

3D structure databases

ProteinModelPortaliQ8NCH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125232, 6 interactors
STRINGi9606.ENSP00000307297

PTM databases

iPTMnetiQ8NCH0
PhosphoSitePlusiQ8NCH0

Polymorphism and mutation databases

BioMutaiCHST14
DMDMi61211839

Proteomic databases

EPDiQ8NCH0
MaxQBiQ8NCH0
PaxDbiQ8NCH0
PeptideAtlasiQ8NCH0
PRIDEiQ8NCH0
ProteomicsDBi72895

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
113189
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306243; ENSP00000307297; ENSG00000169105
GeneIDi113189
KEGGihsa:113189
UCSCiuc001zlw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113189
DisGeNETi113189
EuPathDBiHostDB:ENSG00000169105.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHST14
HGNCiHGNC:24464 CHST14
HPAiHPA057697
HPA071601
MalaCardsiCHST14
MIMi601776 phenotype
608429 gene
neXtProtiNX_Q8NCH0
OpenTargetsiENSG00000169105
Orphaneti2953 Ehlers-Danlos syndrome, musculocontractural type
PharmGKBiPA162382258

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4651 Eukaryota
ENOG4111GJR LUCA
GeneTreeiENSGT00940000162640
HOGENOMiHOG000231801
HOVERGENiHBG050954
InParanoidiQ8NCH0
KOiK08105
OMAiYNLCQPC
OrthoDBiEOG091G0FZO
PhylomeDBiQ8NCH0
TreeFamiTF325581

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000169105-MONOMER
BRENDAi2.8.2.35 2681
ReactomeiR-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHST14 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CHST14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
113189

Protein Ontology

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PROi
PR:Q8NCH0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169105 Expressed in 170 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_CHST14
ExpressionAtlasiQ8NCH0 baseline and differential
GenevisibleiQ8NCH0 HS

Family and domain databases

InterProiView protein in InterPro
IPR018011 Carb_sulfotrans_8-10
IPR005331 Sulfotransferase
PANTHERiPTHR12137 PTHR12137, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHSTE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCH0
Secondary accession number(s): Q6PJ31, Q6UXA0, Q96P94
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: December 5, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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