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UniProtKB - Q8NCF5 (NF2IP_HUMAN)

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Protein

NFATC2-interacting protein

Gene

NFATC2IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
NFATC2-interacting protein
Alternative name(s):
45 kDa NF-AT-interacting protein
Short name:
45 kDa NFAT-interacting protein
Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
Gene namesi
Name:NFATC2IP
Synonyms:NIP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000176953.10
HGNCiHGNC:25906 NFATC2IP
MIMi614525 gene
neXtProtiNX_Q8NCF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176953
PharmGKBiPA134887712

Polymorphism and mutation databases

BioMutaiNFATC2IP
DMDMi74751188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810081 – 419NFATC2-interacting proteinAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei84PhosphoserineCombined sources1
Modified residuei88PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei198PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei316PhosphothreonineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1

Post-translational modificationi

Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NCF5
MaxQBiQ8NCF5
PaxDbiQ8NCF5
PeptideAtlasiQ8NCF5
PRIDEiQ8NCF5
ProteomicsDBi72887
72888 [Q8NCF5-2]
72889 [Q8NCF5-3]
TopDownProteomicsiQ8NCF5-2 [Q8NCF5-2]

PTM databases

iPTMnetiQ8NCF5
PhosphoSitePlusiQ8NCF5

Expressioni

Gene expression databases

BgeeiENSG00000176953
CleanExiHS_NFATC2IP
ExpressionAtlasiQ8NCF5 baseline and differential
GenevisibleiQ8NCF5 HS

Organism-specific databases

HPAiHPA053587

Interactioni

Subunit structurei

Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi124341, 32 interactors
IntActiQ8NCF5, 7 interactors
MINTiQ8NCF5
STRINGi9606.ENSP00000324792

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi252 – 254Combined sources3
Beta strandi265 – 270Combined sources6
Beta strandi272 – 280Combined sources9
Beta strandi282 – 284Combined sources3
Helixi287 – 297Combined sources11
Helixi301 – 303Combined sources3
Beta strandi304 – 308Combined sources5
Helixi319 – 322Combined sources4
Beta strandi329 – 334Combined sources6
Beta strandi347 – 353Combined sources7
Beta strandi359 – 366Combined sources8
Helixi371 – 382Combined sources12
Beta strandi385 – 387Combined sources3
Beta strandi390 – 393Combined sources4
Helixi404 – 407Combined sources4
Beta strandi414 – 418Combined sources5

3D structure databases

ProteinModelPortaliQ8NCF5
SMRiQ8NCF5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NCF5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini348 – 419Ubiquitin-likePROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 231Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 112Poly-Arg5

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
GeneTreeiENSGT00390000007119
HOGENOMiHOG000285948
HOVERGENiHBG082020
InParanoidiQ8NCF5
OMAiKEKHQML
OrthoDBiEOG091G0KS7
PhylomeDBiQ8NCF5
TreeFamiTF328600

Family and domain databases

InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 2 hits
SUPFAMiSSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NCF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL 
        60         70         80         90        100
VTDSDEEILE VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA 
       110        120        130        140        150
GPPREPVRRR RRLVLDPGEA PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG 
       160        170        180        190        200
DEEEAELADS SGLYHEGSPS PGSPWKTKLR TKDKEEKKKT EFLDLDNSPL 
       210        220        230        240        250
SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG QEQQGQEDEV 
       260        270        280        290        300
VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS 
       310        320        330        340        350
PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL 
       360        370        380        390        400
RVQGKEKHQT LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG 
       410 
RELPADLGME SGDLIEVWG
Length:419
Mass (Da):45,817
Last modified:October 1, 2002 - v1
Checksum:iCA04220B4BF0B245
GO
Isoform 2 (identifier: Q8NCF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,054
Checksum:i88093D025BC0865D
GO
Isoform 3 (identifier: Q8NCF5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.

Show »
Length:127
Mass (Da):13,831
Checksum:iBE391D16B4ED93BF
GO

Sequence cautioni

The sequence AAM49721 differs from that shown. Reason: Frameshift at positions 107 and 114.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03120833R → W. Corresponds to variant dbSNP:rs7201257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0239311 – 292Missing in isoform 3. 2 PublicationsAdd BLAST292
Alternative sequenceiVSP_0239321 – 281Missing in isoform 2. 1 PublicationAdd BLAST281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027545 mRNA Translation: BAB55189.1
AK074761 mRNA Translation: BAC11189.1
AK297333 mRNA Translation: BAH12551.1
AK316535 mRNA Translation: BAH14906.1
AF458593 mRNA Translation: AAM49721.1 Frameshift.
BC018311 mRNA Translation: AAH18311.2
BC021551 mRNA Translation: AAH21551.2
BC068007 mRNA Translation: AAH68007.1
BC080628 mRNA Translation: AAH80628.1
BC101741 mRNA Translation: AAI01742.1
BC112182 mRNA Translation: AAI12183.1
CCDSiCCDS10645.1 [Q8NCF5-1]
RefSeqiNP_116204.3, NM_032815.3 [Q8NCF5-1]
UniGeneiHs.513470

Genome annotation databases

EnsembliENST00000320805; ENSP00000324792; ENSG00000176953 [Q8NCF5-1]
ENST00000568148; ENSP00000454958; ENSG00000176953 [Q8NCF5-3]
GeneIDi84901
KEGGihsa:84901
UCSCiuc002dru.4 human [Q8NCF5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNF2IP_HUMAN
AccessioniPrimary (citable) accession number: Q8NCF5
Secondary accession number(s): B7Z4G5
, Q66K34, Q6NVK1, Q8NFR2, Q96ST9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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