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Protein

C-type lectin domain family 18 member C

Gene

CLEC18C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds polysaccharidesin a Ca2+-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.1 Publication

GO - Molecular functioni

  • polysaccharide binding Source: UniProtKB

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 18 member C
Alternative name(s):
Mannose receptor-like protein 3
Gene namesi
Name:CLEC18C
Synonyms:MRLP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000157335.19
HGNCiHGNC:28538 CLEC18C
MIMi616573 gene
neXtProtiNX_Q8NCF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718038

Polymorphism and mutation databases

BioMutaiCLEC18C
DMDMi172045775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000032431727 – 446C-type lectin domain family 18 member CAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi236 ↔ 249By similarity
Disulfide bondi251 ↔ 260By similarity
Disulfide bondi327 ↔ 432By similarity
Disulfide bondi408 ↔ 424By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NCF0
PeptideAtlasiQ8NCF0
PRIDEiQ8NCF0
ProteomicsDBi72885
72886 [Q8NCF0-2]

PTM databases

iPTMnetiQ8NCF0
PhosphoSitePlusiQ8NCF0

Expressioni

Tissue specificityi

Detected in peripheral blood cells.1 Publication

Gene expression databases

BgeeiENSG00000157335 Expressed in 72 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ8NCF0 baseline and differential
GenevisibleiQ8NCF0 HS

Organism-specific databases

HPAiHPA048976

Interactioni

Protein-protein interaction databases

BioGridi129716, 1 interactor
IntActiQ8NCF0, 1 interactor
STRINGi9606.ENSP00000326538

Structurei

3D structure databases

ProteinModelPortaliQ8NCF0
SMRiQ8NCF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 182SCPAdd BLAST131
Domaini228 – 261EGF-likePROSITE-ProRule annotationAdd BLAST34
Domaini306 – 433C-type lectinPROSITE-ProRule annotationAdd BLAST128

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
KOG4297 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00900000141128
HOGENOMiHOG000111780
InParanoidiQ8NCF0
KOiK22682
PhylomeDBiQ8NCF0
TreeFamiTF350472

Family and domain databases

Gene3Di3.10.100.10, 1 hit
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF00059 Lectin_C, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLHPETSPGR GHLLAVLLAL LGTAWAEVWP PQLQEQAPMA GALNRKESFL
60 70 80 90 100
LLSLHNRLRS WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL
110 120 130 140 150
WRTLQVGWNM QLLPAGLASF VEVVSLWFAE GQRYSHAAGE CARNATCTHY
160 170 180 190 200
TQLVWATSSQ LGCGRHLCSA GQAAIEAFVC AYSPRGNWEV NGKTIVPYKK
210 220 230 240 250
GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG RLNISTCHCH
260 270 280 290 300
CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
310 320 330 340 350
TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL
360 370 380 390 400
GRLETTNEVI DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP
410 420 430 440
DNHGFGNCVE LQASAAFNWN NQRCKTRNRY ICQFAQEHIS RWGPGS
Length:446
Mass (Da):49,585
Last modified:March 18, 2008 - v2
Checksum:i6E4D566B5A62782F
GO
Isoform 2 (identifier: Q8NCF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-339: RKGGVLAQIKS → VTVTPSFLGTP
     340-446: Missing.

Show »
Length:339
Mass (Da):37,176
Checksum:i84F1BBA375179069
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H550F5H550_HUMAN
C-type lectin domain family 18 memb...
CLEC18C
455Annotation score:
H3BUD1H3BUD1_HUMAN
C-type lectin domain family 18 memb...
CLEC18C
119Annotation score:
H3BSF2H3BSF2_HUMAN
C-type lectin domain family 18 memb...
CLEC18C
134Annotation score:

Sequence cautioni

The sequence AAH39068 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69M → R in AAH39068 (PubMed:15489334).Curated1
Sequence conflicti91I → T in BAC11199 (PubMed:14702039).Curated1
Sequence conflicti100L → P in BAC11199 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032206329 – 339RKGGVLAQIKS → VTVTPSFLGTP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_032207340 – 446Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074773 mRNA Translation: BAC11199.1
BC039068 mRNA Translation: AAH39068.1 Different initiation.
CCDSiCCDS32473.1 [Q8NCF0-1]
RefSeqiNP_775890.2, NM_173619.3 [Q8NCF0-1]
UniGeneiHs.556045
Hs.592064

Genome annotation databases

EnsembliENST00000314151; ENSP00000326538; ENSG00000157335 [Q8NCF0-1]
ENST00000541793; ENSP00000444875; ENSG00000157335 [Q8NCF0-1]
ENST00000569347; ENSP00000455920; ENSG00000157335 [Q8NCF0-1]
ENST00000618957; ENSP00000477846; ENSG00000157335 [Q8NCF0-1]
GeneIDi283971
KEGGihsa:283971
UCSCiuc002eyk.3 human [Q8NCF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074773 mRNA Translation: BAC11199.1
BC039068 mRNA Translation: AAH39068.1 Different initiation.
CCDSiCCDS32473.1 [Q8NCF0-1]
RefSeqiNP_775890.2, NM_173619.3 [Q8NCF0-1]
UniGeneiHs.556045
Hs.592064

3D structure databases

ProteinModelPortaliQ8NCF0
SMRiQ8NCF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129716, 1 interactor
IntActiQ8NCF0, 1 interactor
STRINGi9606.ENSP00000326538

PTM databases

iPTMnetiQ8NCF0
PhosphoSitePlusiQ8NCF0

Polymorphism and mutation databases

BioMutaiCLEC18C
DMDMi172045775

Proteomic databases

PaxDbiQ8NCF0
PeptideAtlasiQ8NCF0
PRIDEiQ8NCF0
ProteomicsDBi72885
72886 [Q8NCF0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314151; ENSP00000326538; ENSG00000157335 [Q8NCF0-1]
ENST00000541793; ENSP00000444875; ENSG00000157335 [Q8NCF0-1]
ENST00000569347; ENSP00000455920; ENSG00000157335 [Q8NCF0-1]
ENST00000618957; ENSP00000477846; ENSG00000157335 [Q8NCF0-1]
GeneIDi283971
KEGGihsa:283971
UCSCiuc002eyk.3 human [Q8NCF0-1]

Organism-specific databases

CTDi283971
EuPathDBiHostDB:ENSG00000157335.19
GeneCardsiCLEC18C
HGNCiHGNC:28538 CLEC18C
HPAiHPA048976
MIMi616573 gene
neXtProtiNX_Q8NCF0
PharmGKBiPA164718038
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
KOG4297 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00900000141128
HOGENOMiHOG000111780
InParanoidiQ8NCF0
KOiK22682
PhylomeDBiQ8NCF0
TreeFamiTF350472

Miscellaneous databases

GenomeRNAii283971
PROiPR:Q8NCF0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157335 Expressed in 72 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ8NCF0 baseline and differential
GenevisibleiQ8NCF0 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF00059 Lectin_C, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCL18C_HUMAN
AccessioniPrimary (citable) accession number: Q8NCF0
Secondary accession number(s): Q8IUW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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