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UniProtKB - Q8NCD3 (HJURP_HUMAN)

Entry version 143 (07 Apr 2021)
Sequence version 2 (16 Jun 2009)
Previous versions | rss
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Protein

Holliday junction recognition protein

Gene

HJURP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, DNA-binding
Biological processCell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NCD3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8NCD3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Holliday junction recognition protein
Alternative name(s):
14-3-3-associated AKT substrate
Fetal liver-expressing gene 1 protein
Up-regulated in lung cancer 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HJURP
Synonyms:FAKTS, FLEG1Imported, URLC9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25444, HJURP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612667, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NCD3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123485.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi486S → A: Loss of phosphorylation by AKT1 and binding to YWHAG. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55355

Open Targets

More...OpenTargetsi		ENSG00000123485

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162390937

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NCD3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HJURP

Domain mapping of disease mutations (DMDM)

More...DMDMi		239938642

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874331 – 748Holliday junction recognition proteinAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei123PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei412PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei486Phosphoserine; by PKB/AKT1Combined sources1 Publication1
Modified residuei496PhosphoserineCombined sources1
Cross-linki581Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei595PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NCD3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NCD3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NCD3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NCD3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NCD3

PeptideAtlas

More...PeptideAtlasi		Q8NCD3

PRoteomics IDEntifications database

More...PRIDEi		Q8NCD3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72875 [Q8NCD3-1]
72876 [Q8NCD3-2]
72877 [Q8NCD3-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2048, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NCD3, 1 site, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NCD3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q8NCD3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NCD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123485, Expressed in ventricular zone and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NCD3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NCD3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123485, Group enriched (bone marrow, lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes (PubMed:16622419, PubMed:19410544, PubMed:19410545). Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4 (PubMed:21478274).

Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292).

Interacts with 14-3-3 family members in a phosphorylation-dependent manner (PubMed:17256767).

Interacts with MSH5 and NBN (PubMed:17823411).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120635, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8NCD3

Database of interacting proteins

More...DIPi		DIP-53282N

Protein interaction database and analysis system

More...IntActi		Q8NCD3, 19 interactors

Molecular INTeraction database

More...MINTi		Q8NCD3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414109

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NCD3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1748
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NCD3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SJZT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005575

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NCD3

Identification of Orthologs from Complete Genome Data

More...OMAi		YGQWASS

Database of Orthologous Groups

More...OrthoDBi		426984at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NCD3

TreeFam database of animal gene trees

More...TreeFami		TF336293

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00283

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021052, HJURP
IPR022102, HJURP_C
IPR018465, Scm3/HJURP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12347, HJURP_C, 2 hits
PF12346, HJURP_mid, 1 hit
PF10384, Scm3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGTLRAMEG EDVEDDQLLQ KLRASRRRFQ RRMQRLIEKY NQPFEDTPVV 
        60         70         80         90        100
QMATLTYETP QGLRIWGGRL IKERNEGEIQ DSSMKPADRT DGSVQAAAWG 
       110        120        130        140        150
PELPSHRTVL GADSKSGEVD ATSDQEESVA WALAPAVPQS PLKNELRRKY 
       160        170        180        190        200
LTQVDILLQG AEYFECAGNR AGRDVRVTPL PSLASPAVPA PGYCSRISRK 
       210        220        230        240        250
SPGDPAKPAS SPREWDPLHP SSTDMALVPR NDSLSLQETS SSSFLSSQPF 
       260        270        280        290        300
EDDDICNVTI SDLYAGMLHS MSRLLSTKPS SIISTKTFIM QNWNSRRRHR 
       310        320        330        340        350
YKSRMNKTYC KGARRSQRSS KENFIPCSEP VKGTGALRDC KNVLDVSCRK 
       360        370        380        390        400
TGLKLEKAFL EVNRPQIHKL DPSWKERKVT PSKYSSLIYF DSSATYNLDE 
       410        420        430        440        450
ENRFRTLKWL ISPVKIVSRP TIRQGHGENR QREIEIRFDQ LHREYCLSPR 
       460        470        480        490        500
NQPRRMCLPD SWAMNMYRGG PASPGGLQGL ETRRLSLPSS KAKAKSLSEA 
       510        520        530        540        550
FENLGKRSLE AGRCLPKSDS SSSLPKTNPT HSATRPQQTS DLHVQGNSSG 
       560        570        580        590        600
IFRKSVSPSK TLSVPDKEVP GHGRNRYDEI KEEFDKLHQK YCLKSPGQMT 
       610        620        630        640        650
VPLCIGVSTD KASMEVRYQT EGFLGKLNPD PHFQGFQKLP SSPLGCRKSL 
       660        670        680        690        700
LGSTAIEAPS STCVARAITR DGTRDHQFPA KRPRLSEPQG SGRQGNSLGA 
       710        720        730        740 
SDGVDNTVRP GDQGSSSQPN SEERGENTSY RMEEKSDFML EKLETKSV
Length:748
Mass (Da):83,539
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE7F1410F9A748D5
GO
Isoform 2 (identifier: Q8NCD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-134: Missing.

Show »
Length:694
Mass (Da):77,971
Checksum:iCF6B285E45EDACC0
GO
Isoform 3 (identifier: Q8NCD3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-165: Missing.

Show »
Length:663
Mass (Da):74,372
Checksum:i714B1621C5107AC6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWC4C9JWC4_HUMAN
Holliday junction recognition prote...
HJURP
570Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCV1F8WCV1_HUMAN
Holliday junction recognition prote...
HJURP
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3V8H7C3V8_HUMAN
Holliday junction recognition prote...
HJURP
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0I6H7C0I6_HUMAN
Holliday junction recognition prote...
HJURP
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB82391 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti613S → C in BAG63122 (PubMed:14702039).Curated1
Sequence conflicti733E → G in BAG63122 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0569124T → A. Corresponds to variant dbSNP:rs2302154Ensembl.1
Natural variantiVAR_05794676E → K4 PublicationsCorresponds to variant dbSNP:rs2286430Ensembl.1
Natural variantiVAR_057947199R → GCombined sources3 PublicationsCorresponds to variant dbSNP:rs3806589Ensembl.1
Natural variantiVAR_057948295S → C4 PublicationsCorresponds to variant dbSNP:rs3732215Ensembl.1
Natural variantiVAR_056913548S → T. Corresponds to variant dbSNP:rs17863822Ensembl.1
Natural variantiVAR_056914549S → C1 PublicationCorresponds to variant dbSNP:rs3821238Ensembl.1
Natural variantiVAR_056915568E → D. Corresponds to variant dbSNP:rs3771333Ensembl.1
Natural variantiVAR_056916691S → F1 PublicationCorresponds to variant dbSNP:rs12582Ensembl.1
Natural variantiVAR_057949723E → G1 PublicationCorresponds to variant dbSNP:rs10511Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03746781 – 165Missing in isoform 3. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_03746881 – 134Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB101211 mRNA Translation: BAF82039.1
AB162218 mRNA Translation: BAD36741.1
AK301643 mRNA Translation: BAG63122.1
AK303109 mRNA Translation: BAG64216.1
AK074809 mRNA Translation: BAC11221.1
AC005538 Genomic DNA No translation available.
BC001940 mRNA Translation: AAH01940.2
AL162048 mRNA Translation: CAB82391.2 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33406.1 [Q8NCD3-1]
CCDS63166.1 [Q8NCD3-3]
CCDS63167.1 [Q8NCD3-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T47163

NCBI Reference Sequences

More...RefSeqi		NP_001269891.1, NM_001282962.1 [Q8NCD3-2]
NP_001269892.1, NM_001282963.1 [Q8NCD3-3]
NP_060880.3, NM_018410.4 [Q8NCD3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000411486; ENSP00000414109; ENSG00000123485 [Q8NCD3-1]
ENST00000432087; ENSP00000407208; ENSG00000123485 [Q8NCD3-2]
ENST00000441687; ENSP00000401944; ENSG00000123485 [Q8NCD3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55355

UCSC genome browser

More...UCSCi		uc002vvg.5, human [Q8NCD3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB101211 mRNA Translation: BAF82039.1
AB162218 mRNA Translation: BAD36741.1
AK301643 mRNA Translation: BAG63122.1
AK303109 mRNA Translation: BAG64216.1
AK074809 mRNA Translation: BAC11221.1
AC005538 Genomic DNA No translation available.
BC001940 mRNA Translation: AAH01940.2
AL162048 mRNA Translation: CAB82391.2 Sequence problems.
CCDSiCCDS33406.1 [Q8NCD3-1]
CCDS63166.1 [Q8NCD3-3]
CCDS63167.1 [Q8NCD3-2]
PIRiT47163
RefSeqiNP_001269891.1, NM_001282962.1 [Q8NCD3-2]
NP_001269892.1, NM_001282963.1 [Q8NCD3-3]
NP_060880.3, NM_018410.4 [Q8NCD3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R45X-ray2.60C1-80[»]
SMRiQ8NCD3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120635, 33 interactors
CORUMiQ8NCD3
DIPiDIP-53282N
IntActiQ8NCD3, 19 interactors
MINTiQ8NCD3
STRINGi9606.ENSP00000414109

PTM databases

GlyConnecti2048, 3 N-Linked glycans (1 site)
GlyGeniQ8NCD3, 1 site, 3 N-linked glycans (1 site)
iPTMnetiQ8NCD3
MetOSiteiQ8NCD3
PhosphoSitePlusiQ8NCD3

Genetic variation databases

BioMutaiHJURP
DMDMi239938642

Proteomic databases

EPDiQ8NCD3
jPOSTiQ8NCD3
MassIVEiQ8NCD3
MaxQBiQ8NCD3
PaxDbiQ8NCD3
PeptideAtlasiQ8NCD3
PRIDEiQ8NCD3
ProteomicsDBi72875 [Q8NCD3-1]
72876 [Q8NCD3-2]
72877 [Q8NCD3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2018, 139 antibodies

Genome annotation databases

EnsembliENST00000411486; ENSP00000414109; ENSG00000123485 [Q8NCD3-1]
ENST00000432087; ENSP00000407208; ENSG00000123485 [Q8NCD3-2]
ENST00000441687; ENSP00000401944; ENSG00000123485 [Q8NCD3-3]
GeneIDi55355
KEGGihsa:55355
UCSCiuc002vvg.5, human [Q8NCD3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55355
DisGeNETi55355

GeneCards: human genes, protein and diseases

More...GeneCardsi		HJURP
HGNCiHGNC:25444, HJURP
HPAiENSG00000123485, Group enriched (bone marrow, lymphoid tissue, testis)
MIMi612667, gene
neXtProtiNX_Q8NCD3
OpenTargetsiENSG00000123485
PharmGKBiPA162390937
VEuPathDBiHostDB:ENSG00000123485.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SJZT, Eukaryota
GeneTreeiENSGT00390000005575
InParanoidiQ8NCD3
OMAiYGQWASS
OrthoDBi426984at2759
PhylomeDBiQ8NCD3
TreeFamiTF336293

Enzyme and pathway databases

PathwayCommonsiQ8NCD3
ReactomeiR-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere
SIGNORiQ8NCD3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55355, 676 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HJURP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55355
PharosiQ8NCD3, Tbio

Protein Ontology

More...PROi		PR:Q8NCD3
RNActiQ8NCD3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123485, Expressed in ventricular zone and 139 other tissues
ExpressionAtlasiQ8NCD3, baseline and differential
GenevisibleiQ8NCD3, HS

Family and domain databases

IDEALiIID00283
InterProiView protein in InterPro
IPR021052, HJURP
IPR022102, HJURP_C
IPR018465, Scm3/HJURP
PfamiView protein in Pfam
PF12347, HJURP_C, 2 hits
PF12346, HJURP_mid, 1 hit
PF10384, Scm3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHJURP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCD3
Secondary accession number(s): A8IRH5
, B4DWR0, B4DZV4, Q9BUT2, Q9NSL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 16, 2009
Last modified: April 7, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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