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Entry version 150 (08 May 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Group XV phospholipase A2

Gene

PLA2G15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).By similarity5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46Substrate; via amide nitrogenCombined sources1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei198Acyl-ester intermediateSequence analysisCombined sources1 Publication1
Binding sitei199Substrate; via amide nitrogenCombined sources1 Publication1
Active sitei360Charge relay system1 Publication1
Active sitei392Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483115 Hydrolysis of LPC

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-PLA2G15 PC-sterol_acyltransferase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001924

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Group XV phospholipase A2 (EC:2.3.1.-4 Publications)
Alternative name(s):
1-O-acylceramide synthase1 Publication
Short name:
ACS
LCAT-like lysophospholipase1 Publication
Short name:
LLPL1 Publication
Lysophospholipase 3
Lysosomal phospholipase A22 Publications
Short name:
LPLA22 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G15
Synonyms:LYPLA3
ORF Names:UNQ341/PRO540
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17163 PLA2G15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609362 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NCC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi46D → A: Decreases phospholipase and transacetylase activity. Has no effect on association with membranes. 1 Publication1
Mutagenesisi83L → S: No effect on phospholipase activity. Strongly decreases transacetylase activity and association with membranes. 1 Publication1
Mutagenesisi85V → S: No effect on phospholipase activity. Strongly decreases transacetylase activity and association with membranes. 1 Publication1
Mutagenesisi99N → A: Loss of glycosylation site. Leads to retention in the endoplasmic reticulum and nearly abolishes the production of the mature, active enzyme. 1 Publication1
Mutagenesisi198S → A: Abolishes phospholipase and transacetylase activity. Abolishes association with membranes. 1 Publication1
Mutagenesisi235K → A: No effect on phospholipase activity. Abolishes transacetylase activity. Has no effect on association with membranes. 1 Publication1
Mutagenesisi273N → A: Loss of glycosylation site. Mildly reduces production of the mature, active enzyme. 1 Publication1
Mutagenesisi289N → A: Loss of glycosylation site. Mildly reduces production of the mature, active enzyme. 1 Publication1
Mutagenesisi362T → A: No effect on phospholipase activity. Strongly decreases transacetylase activity and abolishes association with membranes. 1 Publication1
Mutagenesisi398N → A: Loss of glycosylation site. Slightly reduces production of the mature, active enzyme. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23659

Open Targets

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OpenTargetsi
ENSG00000103066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724567

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4986

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLA2G15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44888104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 332 PublicationsAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001780834 – 412Group XV phospholipase A2Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 89Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:11790796, PubMed:23958596). N-glycosylation is important for maturation of the enzyme and normal subcellular location (PubMed:23958596).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NCC3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NCC3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NCC3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NCC3

PeptideAtlas

More...
PeptideAtlasi
Q8NCC3

PRoteomics IDEntifications database

More...
PRIDEi
Q8NCC3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72871

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1292

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NCC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NCC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103066 Expressed in 166 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NCC3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NCC3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041702
HPA041727

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117181, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NCC3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000219345

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8NCC3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X90X-ray1.84A/B/C/D34-412[»]
4X91X-ray2.30A/B/C/D34-412[»]
4X92X-ray3.00A34-412[»]
4X93X-ray2.60A/B34-412[»]
4X94X-ray2.70A34-412[»]
4X95X-ray3.08A/B34-412[»]
4X97X-ray2.65A/B/C/D34-412[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NCC3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2369 Eukaryota
ENOG410Y9CF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157499

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000238654

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NCC3

KEGG Orthology (KO)

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KOi
K06129

Identification of Orthologs from Complete Genome Data

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OMAi
PGVPLHC

Database of Orthologous Groups

More...
OrthoDBi
828056at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NCC3

TreeFam database of animal gene trees

More...
TreeFami
TF313258

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR003386 LACT/PDAT_acylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02450 LCAT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLHLRPYRV GLLPDGLLFL LLLLMLLADP ALPAGRHPPV VLVPGDLGNQ
60 70 80 90 100
LEAKLDKPTV VHYLCSKKTE SYFTIWLNLE LLLPVIIDCW IDNIRLVYNK
110 120 130 140 150
TSRATQFPDG VDVRVPGFGK TFSLEFLDPS KSSVGSYFHT MVESLVGWGY
160 170 180 190 200
TRGEDVRGAP YDWRRAPNEN GPYFLALREM IEEMYQLYGG PVVLVAHSMG
210 220 230 240 250
NMYTLYFLQR QPQAWKDKYI RAFVSLGAPW GGVAKTLRVL ASGDNNRIPV
260 270 280 290 300
IGPLKIREQQ RSAVSTSWLL PYNYTWSPEK VFVQTPTINY TLRDYRKFFQ
310 320 330 340 350
DIGFEDGWLM RQDTEGLVEA TMPPGVQLHC LYGTGVPTPD SFYYESFPDR
360 370 380 390 400
DPKICFGDGD GTVNLKSALQ CQAWQSRQEH QVLLQELPGS EHIEMLANAT
410
TLAYLKRVLL GP
Length:412
Mass (Da):46,658
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FEA8A5783AF050A
GO
Isoform 2 (identifier: Q8NCC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-114: VPGDLGNQLE...TQFPDGVDVR → GWFTTKHPGP...EGLPMTGAEP
     115-208: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):35,717
Checksum:i9E52C12B51F5D3C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DPU0B4DPU0_HUMAN
Group XV phospholipase A2
PLA2G15
212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DJW4B4DJW4_HUMAN
Group XV phospholipase A2
PLA2G15
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMU8H3BMU8_HUMAN
Group XV phospholipase A2
PLA2G15
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM47H3BM47_HUMAN
Group XV phospholipase A2
PLA2G15
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPT3H3BPT3_HUMAN
Group XV phospholipase A2
PLA2G15
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT70H3BT70_HUMAN
Group XV phospholipase A2
PLA2G15
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB53675 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94I → T in BAD96510 (Ref. 4) Curated1
Sequence conflicti370Q → R in BAC11233 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05668943 – 114VPGDL…GVDVR → GWFTTKHPGPPSFLMVWMYV SLALGRPSHWSSWTPAKAAW VPISTPWWRALWAGATHGVR MSEGLPMTGAEP in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_056690115 – 208Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB017494 mRNA Translation: BAA76877.1
AY358425 mRNA Translation: AAQ88791.1
AK001705 mRNA Translation: BAG50965.1
AK074828 mRNA Translation: BAC11233.1
AK300596 mRNA Translation: BAG62293.1
AK222790 mRNA Translation: BAD96510.1
AL110209 mRNA Translation: CAB53675.1 Different initiation.
AC020978 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83217.1
BC011640 mRNA Translation: AAH11640.2
BC062605 mRNA Translation: AAH62605.1
AL389957 mRNA Translation: CAB97531.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10864.1 [Q8NCC3-1]

Protein sequence database of the Protein Information Resource

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PIRi
T14755

NCBI Reference Sequences

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RefSeqi
NP_036452.1, NM_012320.3 [Q8NCC3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000219345; ENSP00000219345; ENSG00000103066 [Q8NCC3-1]
ENST00000413021; ENSP00000394197; ENSG00000103066 [Q8NCC3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23659

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23659

UCSC genome browser

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UCSCi
uc002evr.4 human [Q8NCC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017494 mRNA Translation: BAA76877.1
AY358425 mRNA Translation: AAQ88791.1
AK001705 mRNA Translation: BAG50965.1
AK074828 mRNA Translation: BAC11233.1
AK300596 mRNA Translation: BAG62293.1
AK222790 mRNA Translation: BAD96510.1
AL110209 mRNA Translation: CAB53675.1 Different initiation.
AC020978 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83217.1
BC011640 mRNA Translation: AAH11640.2
BC062605 mRNA Translation: AAH62605.1
AL389957 mRNA Translation: CAB97531.1
CCDSiCCDS10864.1 [Q8NCC3-1]
PIRiT14755
RefSeqiNP_036452.1, NM_012320.3 [Q8NCC3-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X90X-ray1.84A/B/C/D34-412[»]
4X91X-ray2.30A/B/C/D34-412[»]
4X92X-ray3.00A34-412[»]
4X93X-ray2.60A/B34-412[»]
4X94X-ray2.70A34-412[»]
4X95X-ray3.08A/B34-412[»]
4X97X-ray2.65A/B/C/D34-412[»]
SMRiQ8NCC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117181, 5 interactors
IntActiQ8NCC3, 2 interactors
STRINGi9606.ENSP00000219345

Chemistry databases

BindingDBiQ8NCC3
ChEMBLiCHEMBL4986
SwissLipidsiSLP:000001924

Protein family/group databases

ESTHERihuman-PLA2G15 PC-sterol_acyltransferase

PTM databases

GlyConnecti1292
iPTMnetiQ8NCC3
PhosphoSitePlusiQ8NCC3

Polymorphism and mutation databases

BioMutaiPLA2G15
DMDMi44888104

Proteomic databases

EPDiQ8NCC3
jPOSTiQ8NCC3
MaxQBiQ8NCC3
PaxDbiQ8NCC3
PeptideAtlasiQ8NCC3
PRIDEiQ8NCC3
ProteomicsDBi72871

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219345; ENSP00000219345; ENSG00000103066 [Q8NCC3-1]
ENST00000413021; ENSP00000394197; ENSG00000103066 [Q8NCC3-2]
GeneIDi23659
KEGGihsa:23659
UCSCiuc002evr.4 human [Q8NCC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23659
DisGeNETi23659

GeneCards: human genes, protein and diseases

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GeneCardsi
PLA2G15
HGNCiHGNC:17163 PLA2G15
HPAiHPA041702
HPA041727
MIMi609362 gene
neXtProtiNX_Q8NCC3
OpenTargetsiENSG00000103066
PharmGKBiPA164724567

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2369 Eukaryota
ENOG410Y9CF LUCA
GeneTreeiENSGT00940000157499
HOGENOMiHOG000238654
InParanoidiQ8NCC3
KOiK06129
OMAiPGVPLHC
OrthoDBi828056at2759
PhylomeDBiQ8NCC3
TreeFamiTF313258

Enzyme and pathway databases

ReactomeiR-HSA-1483115 Hydrolysis of LPC

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLA2G15 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LYPLA3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23659

Protein Ontology

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PROi
PR:Q8NCC3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103066 Expressed in 166 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ8NCC3 baseline and differential
GenevisibleiQ8NCC3 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR003386 LACT/PDAT_acylTrfase
PfamiView protein in Pfam
PF02450 LCAT, 2 hits
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAG15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCC3
Secondary accession number(s): B3KMF3
, B4DUD1, Q53GZ1, Q9NPQ6, Q9UG04, Q9Y2B3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: May 8, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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