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Protein

CaM kinase-like vesicle-associated protein

Gene

CAMKV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not appear to have detectable kinase activity.

Cofactori

Ca2+By similarity

GO - Molecular functioni

  • ATP binding Source: InterPro
  • calmodulin binding Source: GO_Central
  • calmodulin-dependent protein kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

SignaLinkiQ8NCB2

Names & Taxonomyi

Protein namesi
Recommended name:
CaM kinase-like vesicle-associated protein
Gene namesi
Name:CAMKV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164076.16
HGNCiHGNC:28788 CAMKV
MIMi614993 gene
neXtProtiNX_Q8NCB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79012
OpenTargetsiENSG00000164076
PharmGKBiPA142672205

Polymorphism and mutation databases

BioMutaiCAMKV
DMDMi115311319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002500941 – 501CaM kinase-like vesicle-associated proteinAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphothreonineBy similarity1
Modified residuei459PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NCB2
MaxQBiQ8NCB2
PaxDbiQ8NCB2
PeptideAtlasiQ8NCB2
PRIDEiQ8NCB2
ProteomicsDBi72868
72869 [Q8NCB2-2]
72870 [Q8NCB2-3]

PTM databases

iPTMnetiQ8NCB2
PhosphoSitePlusiQ8NCB2

Expressioni

Gene expression databases

BgeeiENSG00000164076 Expressed in 93 organ(s), highest expression level in frontal cortex
CleanExiHS_CAMKV
ExpressionAtlasiQ8NCB2 baseline and differential
GenevisibleiQ8NCB2 HS

Organism-specific databases

HPAiCAB034931
HPA007656

Interactioni

Subunit structurei

Interacts with calmodulin, in the presence of calcium.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122482, 63 interactors
IntActiQ8NCB2, 2 interactors
STRINGi9606.ENSP00000419195

Structurei

3D structure databases

ProteinModelPortaliQ8NCB2
SMRiQ8NCB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 492Ala-richAdd BLAST158

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOVERGENiHBG108055
InParanoidiQ8NCB2
KOiK08812
OMAiHEWISGG
OrthoDBiEOG091G097B
PhylomeDBiQ8NCB2
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NCB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVI KTEEFCEIFR AKDKTTGKLH
60 70 80 90 100
TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE
110 120 130 140 150
LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN
160 170 180 190 200
LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP
210 220 230 240 250
VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP
260 270 280 290 300
YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
310 320 330 340 350
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSSTAAAQSA SATDTATPGA
360 370 380 390 400
AGGATAAAAS GATSAPEGDA ARAAKSDNVA PADRSATPAT DGSATPATDG
410 420 430 440 450
SVTPATDGSI TPATDGSVTP ATDRSATPAT DGRATPATEE STVPTTQSSA
460 470 480 490 500
MLATKAAATP EPAMAQPDST APEGATGQAP PSSKGEEAAG YAQESQREEA

S
Length:501
Mass (Da):54,354
Last modified:September 19, 2006 - v2
Checksum:i1D6DBF8ABA0D1D70
GO
Isoform 2 (identifier: Q8NCB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-215: Missing.

Show »
Length:473
Mass (Da):51,209
Checksum:i8DF2CEE6C4F43262
GO
Isoform 3 (identifier: Q8NCB2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-382: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):51,687
Checksum:i16CC94CED91EE893
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9E2C9J9E2_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
434Annotation score:
B4DM24B4DM24_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
426Annotation score:
C9JSB2C9JSB2_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
123Annotation score:
E7ETR1E7ETR1_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
427Annotation score:
B4DSW8B4DSW8_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
143Annotation score:
F8WDJ4F8WDJ4_HUMAN
CaM kinase-like vesicle-associated ...
CAMKV
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22D → G in CAG38539 (Ref. 3) Curated1
Sequence conflicti64R → Q in BAC11528 (PubMed:14702039).Curated1
Sequence conflicti285W → S in BAC11248 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04133740R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04133860G → S in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041339274R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041340279E → D1 PublicationCorresponds to variant dbSNP:rs56071455Ensembl.1
Natural variantiVAR_041341472P → L1 PublicationCorresponds to variant dbSNP:rs56307047Ensembl.1
Natural variantiVAR_027539491Y → C1 PublicationCorresponds to variant dbSNP:rs17849325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020600188 – 215Missing in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_020601352 – 382Missing in isoform 3. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA Translation: BAC11248.1
AK074899 mRNA Translation: BAC11278.1
AK075294 mRNA Translation: BAC11528.1
AL136697 mRNA Translation: CAB66632.1
CR533508 mRNA Translation: CAG38539.1
AL833943 Transcribed RNA Translation: CAD38798.2
AC105935 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65027.1
BC000497 mRNA Translation: AAH00497.1
BC001921 mRNA Translation: AAH01921.1
BC005828 mRNA Translation: AAH05828.1
BC017363 mRNA Translation: AAH17363.1
BC019256 mRNA Translation: AAH19256.1
CCDSiCCDS33762.1 [Q8NCB2-1]
CCDS82776.1 [Q8NCB2-3]
RefSeqiNP_001307076.1, NM_001320147.1 [Q8NCB2-3]
NP_076951.2, NM_024046.4 [Q8NCB2-1]
UniGeneiHs.145156

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076 [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076 [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076 [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076 [Q8NCB2-2]
GeneIDi79012
KEGGihsa:79012
UCSCiuc003cxt.2 human [Q8NCB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074856 mRNA Translation: BAC11248.1
AK074899 mRNA Translation: BAC11278.1
AK075294 mRNA Translation: BAC11528.1
AL136697 mRNA Translation: CAB66632.1
CR533508 mRNA Translation: CAG38539.1
AL833943 Transcribed RNA Translation: CAD38798.2
AC105935 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65027.1
BC000497 mRNA Translation: AAH00497.1
BC001921 mRNA Translation: AAH01921.1
BC005828 mRNA Translation: AAH05828.1
BC017363 mRNA Translation: AAH17363.1
BC019256 mRNA Translation: AAH19256.1
CCDSiCCDS33762.1 [Q8NCB2-1]
CCDS82776.1 [Q8NCB2-3]
RefSeqiNP_001307076.1, NM_001320147.1 [Q8NCB2-3]
NP_076951.2, NM_024046.4 [Q8NCB2-1]
UniGeneiHs.145156

3D structure databases

ProteinModelPortaliQ8NCB2
SMRiQ8NCB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122482, 63 interactors
IntActiQ8NCB2, 2 interactors
STRINGi9606.ENSP00000419195

PTM databases

iPTMnetiQ8NCB2
PhosphoSitePlusiQ8NCB2

Polymorphism and mutation databases

BioMutaiCAMKV
DMDMi115311319

Proteomic databases

EPDiQ8NCB2
MaxQBiQ8NCB2
PaxDbiQ8NCB2
PeptideAtlasiQ8NCB2
PRIDEiQ8NCB2
ProteomicsDBi72868
72869 [Q8NCB2-2]
72870 [Q8NCB2-3]

Protocols and materials databases

DNASUi79012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296471; ENSP00000296471; ENSG00000164076 [Q8NCB2-2]
ENST00000477224; ENSP00000419195; ENSG00000164076 [Q8NCB2-1]
ENST00000488336; ENSP00000418809; ENSG00000164076 [Q8NCB2-3]
ENST00000620470; ENSP00000484045; ENSG00000164076 [Q8NCB2-2]
GeneIDi79012
KEGGihsa:79012
UCSCiuc003cxt.2 human [Q8NCB2-1]

Organism-specific databases

CTDi79012
DisGeNETi79012
EuPathDBiHostDB:ENSG00000164076.16
GeneCardsiCAMKV
H-InvDBiHIX0003323
HGNCiHGNC:28788 CAMKV
HPAiCAB034931
HPA007656
MIMi614993 gene
neXtProtiNX_Q8NCB2
OpenTargetsiENSG00000164076
PharmGKBiPA142672205
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOVERGENiHBG108055
InParanoidiQ8NCB2
KOiK08812
OMAiHEWISGG
OrthoDBiEOG091G097B
PhylomeDBiQ8NCB2
TreeFamiTF314166

Enzyme and pathway databases

SignaLinkiQ8NCB2

Miscellaneous databases

ChiTaRSiCAMKV human
GenomeRNAii79012
PROiPR:Q8NCB2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164076 Expressed in 93 organ(s), highest expression level in frontal cortex
CleanExiHS_CAMKV
ExpressionAtlasiQ8NCB2 baseline and differential
GenevisibleiQ8NCB2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAMKV_HUMAN
AccessioniPrimary (citable) accession number: Q8NCB2
Secondary accession number(s): A6NFD4
, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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