Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 119 (13 Feb 2019)
Sequence version 3 (01 Mar 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

RBBP8 N-terminal-like protein

Gene

RBBP8NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RBBP8 N-terminal-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBBP8NL
Synonyms:C20orf151
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130701.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16144 RBBP8NL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NC74

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000130701

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25693

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBBP8NL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60416376

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794701 – 664RBBP8 N-terminal-like proteinAdd BLAST664

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NC74

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NC74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NC74

PeptideAtlas

More...
PeptideAtlasi
Q8NC74

PRoteomics IDEntifications database

More...
PRIDEi
Q8NC74

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72860

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NC74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NC74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130701 Expressed in 119 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NC74 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042627

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126756, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8NC74, 10 interactors

Molecular INTeraction database

More...
MINTi
Q8NC74

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252998

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NC74

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NC74

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi475 – 560Pro-richAdd BLAST86

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKHR Eukaryota
ENOG410YF09 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231237

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051201

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NC74

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELCAKNH

Database of Orthologous Groups

More...
OrthoDBi
567214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NC74

TreeFam database of animal gene trees

More...
TreeFami
TF336239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019518 CtIP_N
IPR033316 RBBP8-like

The PANTHER Classification System

More...
PANTHERi
PTHR15107 PTHR15107, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10482 CtIP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NC74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL
60 70 80 90 100
REQQKTLKEN LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR
110 120 130 140 150
IFILTNEMNG LKEENETLKE EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP
160 170 180 190 200
SPGGWKAITE KPPGGHEEAE EDHQGVGLRG EEKPAGHRTS PVAKISPGAT
210 220 230 240 250
LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN GTPPPLPARS
260 270 280 290 300
SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL
310 320 330 340 350
QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR
360 370 380 390 400
LEGALHLLLA QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE
410 420 430 440 450
GTRAALAAAG LSGGRHTQPA GPGRAQRTEA AATQDCALDK PLDLSEWGRA
460 470 480 490 500
RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ SGPLTRSPQA LSNGTKGTRV
510 520 530 540 550
PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP PHPQPPPHPQ
560 570 580 590 600
PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP
610 620 630 640 650
ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE
660
DHSPSPNSSP WEET
Length:664
Mass (Da):71,432
Last modified:March 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF74AE9E54CE88F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127G → V in BAC11293 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056849348D → N1 PublicationCorresponds to variant dbSNP:rs3810553Ensembl.1
Natural variantiVAR_056850408A → T. Corresponds to variant dbSNP:rs10888228Ensembl.1
Natural variantiVAR_056851607E → K. Corresponds to variant dbSNP:rs6089366Ensembl.1
Natural variantiVAR_056852637L → R1 PublicationCorresponds to variant dbSNP:rs2236200Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074919 mRNA Translation: BAC11293.1
AL121832 Genomic DNA No translation available.
BC006450 mRNA Translation: AAH06450.1
BC033142 mRNA Translation: AAH33142.2
BC137326 mRNA Translation: AAI37327.1
BC137327 mRNA Translation: AAI37328.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13498.1

NCBI Reference Sequences

More...
RefSeqi
NP_543023.2, NM_080833.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.180374

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252998; ENSP00000252998; ENSG00000130701

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140893

UCSC genome browser

More...
UCSCi
uc002ycw.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074919 mRNA Translation: BAC11293.1
AL121832 Genomic DNA No translation available.
BC006450 mRNA Translation: AAH06450.1
BC033142 mRNA Translation: AAH33142.2
BC137326 mRNA Translation: AAI37327.1
BC137327 mRNA Translation: AAI37328.1
CCDSiCCDS13498.1
RefSeqiNP_543023.2, NM_080833.2
UniGeneiHs.180374

3D structure databases

ProteinModelPortaliQ8NC74
SMRiQ8NC74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126756, 1 interactor
IntActiQ8NC74, 10 interactors
MINTiQ8NC74
STRINGi9606.ENSP00000252998

PTM databases

iPTMnetiQ8NC74
PhosphoSitePlusiQ8NC74

Polymorphism and mutation databases

BioMutaiRBBP8NL
DMDMi60416376

Proteomic databases

jPOSTiQ8NC74
MaxQBiQ8NC74
PaxDbiQ8NC74
PeptideAtlasiQ8NC74
PRIDEiQ8NC74
ProteomicsDBi72860

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252998; ENSP00000252998; ENSG00000130701
GeneIDi140893
KEGGihsa:140893
UCSCiuc002ycw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140893
EuPathDBiHostDB:ENSG00000130701.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RBBP8NL
HGNCiHGNC:16144 RBBP8NL
HPAiHPA042627
neXtProtiNX_Q8NC74
OpenTargetsiENSG00000130701
PharmGKBiPA25693

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKHR Eukaryota
ENOG410YF09 LUCA
GeneTreeiENSGT00530000063835
HOGENOMiHOG000231237
HOVERGENiHBG051201
InParanoidiQ8NC74
OMAiELCAKNH
OrthoDBi567214at2759
PhylomeDBiQ8NC74
TreeFamiTF336239

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RBBP8NL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140893

Protein Ontology

More...
PROi
PR:Q8NC74

Gene expression databases

BgeeiENSG00000130701 Expressed in 119 organ(s), highest expression level in heart
GenevisibleiQ8NC74 HS

Family and domain databases

InterProiView protein in InterPro
IPR019518 CtIP_N
IPR033316 RBBP8-like
PANTHERiPTHR15107 PTHR15107, 1 hit
PfamiView protein in Pfam
PF10482 CtIP_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRB8NL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NC74
Secondary accession number(s): B2RP98
, Q8N4Z9, Q9BR75, Q9H0Y9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2005
Last modified: February 13, 2019
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again