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Entry version 161 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Neuropilin and tolloid-like protein 2

Gene

NETO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NC67

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NC67

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.47.1.2, the neuropilin and tolloid-like (neto) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin and tolloid-like protein 2
Alternative name(s):
Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NETO2
Synonyms:BTCL2
ORF Names:UNQ1926/PRO4401
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14644, NETO2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607974, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NC67

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171208.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 347ExtracellularSequence analysisAdd BLAST325
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 525CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81831

Open Targets

More...
OpenTargetsi
ENSG00000171208

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31559

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NC67, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NETO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59798464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002180123 – 525Neuropilin and tolloid-like protein 2Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 72By similarity
Disulfide bondi100 ↔ 122By similarity
Disulfide bondi177 ↔ 207By similarity
Disulfide bondi234 ↔ 256By similarity
Disulfide bondi297 ↔ 309By similarity
Disulfide bondi304 ↔ 322By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi316 ↔ 331By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei409PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NC67

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NC67

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NC67

PeptideAtlas

More...
PeptideAtlasi
Q8NC67

PRoteomics IDEntifications database

More...
PRIDEi
Q8NC67

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72857 [Q8NC67-1]
72858 [Q8NC67-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8NC67, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NC67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NC67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171208, Expressed in neocortex and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NC67, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NC67, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171208, Tissue enhanced (brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123589, 56 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NC67, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000455169

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NC67, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NC67

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 159CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini177 – 292CUB 2PROSITE-ProRule annotationAdd BLAST116
Domaini296 – 332LDL-receptor class APROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW0Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015228_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NC67

Identification of Orthologs from Complete Genome Data

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OMAi
KECIYVL

Database of Orthologous Groups

More...
OrthoDBi
477476at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NC67

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR028868, NETO2
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45645:SF22, PTHR45645:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NC67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR
60 70 80 90 100
TSNGGHFASP NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC
110 120 130 140 150
RFDHLEVRDG PFGFSPLIDR YCGVKSPPLI RSTGRFMWIK FSSDEELEGL
160 170 180 190 200
GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE LSGADGIVRS SQVEQEEKTK
210 220 230 240 250
PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA VYDGSSSIEN
260 270 280 290 300
LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS
310 320 330 340 350
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI
360 370 380 390 400
IGITSGIVLV LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL
410 420 430 440 450
FSLRDKEISA DLADLSEELD NYQKMRRSST ASRCIHDHHC GSQASSVKQS
460 470 480 490 500
RTNLSSMELP FRNDFAQPQP MKTFNSTFKK SSYTFKQGHE CPEQALEDRV
510 520
MEEIPCEIYV RGREDSAQAS ISIDF
Length:525
Mass (Da):59,393
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA6F98C3A88220EA
GO
Isoform 2 (identifier: Q8NC67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.
     325-333: PWDENHCKE → MLFTSFVEQ

Show »
Length:201
Mass (Da):22,849
Checksum:iBC01389AE0203E84
GO
Isoform 3 (identifier: Q8NC67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-175: Missing.

Show »
Length:518
Mass (Da):58,688
Checksum:iF360FA90C0A96056
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM37H3BM37_HUMAN
Neuropilin and tolloid-like protein...
NETO2
365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSR0H3BSR0_HUMAN
Neuropilin and tolloid-like protein...
NETO2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTE1H3BTE1_HUMAN
Neuropilin and tolloid-like protein...
NETO2
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti211I → V in CAD97994 (PubMed:17974005).Curated1
Sequence conflicti278E → G in CAD97994 (PubMed:17974005).Curated1
Sequence conflicti424K → R in BAB55247 (PubMed:14702039).Curated1
Sequence conflicti461F → L in BAB55247 (PubMed:14702039).Curated1
Sequence conflicti482S → G in CAD97994 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051232456S → T. Corresponds to variant dbSNP:rs2231983EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128561 – 324Missing in isoform 2. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_053795169 – 175Missing in isoform 3. Curated7
Alternative sequenceiVSP_012857325 – 333PWDENHCKE → MLFTSFVEQ in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358718 mRNA Translation: AAQ89080.1
AK001292 mRNA Translation: BAA91604.1
AK027478 mRNA Translation: BAB55141.1
AK027630 mRNA Translation: BAB55247.1
AK074937 mRNA Translation: BAC11303.1
AL834404 mRNA Translation: CAD39066.1
BX538063 mRNA Translation: CAD97994.1
CR457255 mRNA Translation: CAG33536.1
AC007338 Genomic DNA No translation available.
AC007494 Genomic DNA No translation available.
BC012381 mRNA Translation: AAH12381.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10727.1 [Q8NC67-1]
CCDS58460.1 [Q8NC67-3]

NCBI Reference Sequences

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RefSeqi
NP_001188406.1, NM_001201477.1 [Q8NC67-3]
NP_060562.3, NM_018092.4 [Q8NC67-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000303155; ENSP00000306726; ENSG00000171208 [Q8NC67-3]
ENST00000562435; ENSP00000455169; ENSG00000171208 [Q8NC67-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81831

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81831

UCSC genome browser

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UCSCi
uc002eer.3, human [Q8NC67-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358718 mRNA Translation: AAQ89080.1
AK001292 mRNA Translation: BAA91604.1
AK027478 mRNA Translation: BAB55141.1
AK027630 mRNA Translation: BAB55247.1
AK074937 mRNA Translation: BAC11303.1
AL834404 mRNA Translation: CAD39066.1
BX538063 mRNA Translation: CAD97994.1
CR457255 mRNA Translation: CAG33536.1
AC007338 Genomic DNA No translation available.
AC007494 Genomic DNA No translation available.
BC012381 mRNA Translation: AAH12381.1
CCDSiCCDS10727.1 [Q8NC67-1]
CCDS58460.1 [Q8NC67-3]
RefSeqiNP_001188406.1, NM_001201477.1 [Q8NC67-3]
NP_060562.3, NM_018092.4 [Q8NC67-1]

3D structure databases

SMRiQ8NC67
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123589, 56 interactors
IntActiQ8NC67, 36 interactors
STRINGi9606.ENSP00000455169

Protein family/group databases

TCDBi8.A.47.1.2, the neuropilin and tolloid-like (neto) family

PTM databases

GlyGeniQ8NC67, 1 site
iPTMnetiQ8NC67
PhosphoSitePlusiQ8NC67

Genetic variation databases

BioMutaiNETO2
DMDMi59798464

Proteomic databases

MassIVEiQ8NC67
MaxQBiQ8NC67
PaxDbiQ8NC67
PeptideAtlasiQ8NC67
PRIDEiQ8NC67
ProteomicsDBi72857 [Q8NC67-1]
72858 [Q8NC67-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2630, 190 antibodies

The DNASU plasmid repository

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DNASUi
81831

Genome annotation databases

EnsembliENST00000303155; ENSP00000306726; ENSG00000171208 [Q8NC67-3]
ENST00000562435; ENSP00000455169; ENSG00000171208 [Q8NC67-1]
GeneIDi81831
KEGGihsa:81831
UCSCiuc002eer.3, human [Q8NC67-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81831
DisGeNETi81831

GeneCards: human genes, protein and diseases

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GeneCardsi
NETO2
HGNCiHGNC:14644, NETO2
HPAiENSG00000171208, Tissue enhanced (brain, lymphoid tissue)
MIMi607974, gene
neXtProtiNX_Q8NC67
OpenTargetsiENSG00000171208
PharmGKBiPA31559
VEuPathDBiHostDB:ENSG00000171208.9

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QW0Z, Eukaryota
GeneTreeiENSGT00940000156041
HOGENOMiCLU_015228_0_1_1
InParanoidiQ8NC67
OMAiKECIYVL
OrthoDBi477476at2759
PhylomeDBiQ8NC67

Enzyme and pathway databases

PathwayCommonsiQ8NC67
SIGNORiQ8NC67

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81831, 16 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NETO2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81831
PharosiQ8NC67, Tbio

Protein Ontology

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PROi
PR:Q8NC67
RNActiQ8NC67, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171208, Expressed in neocortex and 190 other tissues
ExpressionAtlasiQ8NC67, baseline and differential
GenevisibleiQ8NC67, HS

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.60.120.290, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR028868, NETO2
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR45645:SF22, PTHR45645:SF22, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNETO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NC67
Secondary accession number(s): J3KNF1
, Q7Z381, Q8ND51, Q96SP4, Q9NVY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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