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Entry version 115 (18 Sep 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Keratinocyte-associated transmembrane protein 2

Gene

KCT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratinocyte-associated transmembrane protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCT2
Synonyms:C5orf15
ORF Names:HTGN29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20656 C5orf15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NC54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini50 – 196ExtracellularSequence analysisAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 265CytoplasmicSequence analysisAdd BLAST48

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000113583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134898147

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C5orf15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 49Sequence analysisAdd BLAST49
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001957950 – 265Keratinocyte-associated transmembrane protein 2Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei229PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NC54

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NC54

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NC54

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NC54

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NC54

PeptideAtlas

More...
PeptideAtlasi
Q8NC54

PRoteomics IDEntifications database

More...
PRIDEi
Q8NC54

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NC54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NC54

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NC54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113583 Expressed in 238 organ(s), highest expression level in tibia

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NC54 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011951
HPA039165

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121275, 5 interactors

Protein interaction database and analysis system

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IntActi
Q8NC54, 5 interactors

Molecular INTeraction database

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MINTi
Q8NC54

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231512

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ0E Eukaryota
ENOG410XUUR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037499

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059651

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NC54

Identification of Orthologs from Complete Genome Data

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OMAi
THENQTK

Database of Orthologous Groups

More...
OrthoDBi
1167989at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NC54

TreeFam database of animal gene trees

More...
TreeFami
TF332514

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037645 KCT2

The PANTHER Classification System

More...
PANTHERi
PTHR16502 PTHR16502, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NC54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR
60 70 80 90 100
TDSPSPTVLN SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA
110 120 130 140 150
SVVPHPSPTP LSQEEADNNE DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE
160 170 180 190 200
PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ SVKSFKMPSS NIEEEDSHFF
210 220 230 240 250
FHLIIFAFCI AVVYITYHNK RKIFLLVQSR KWRDGLCSKT VEYHRLDQNV
260
NEAMPSLKIT NDYIF
Length:265
Mass (Da):29,235
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5852136988E6D885
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119N → S in BAC11319 (PubMed:14702039).Curated1
Sequence conflicti176M → V in BAC11319 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY157581 mRNA Translation: AAO13165.1
AF226055 mRNA Translation: AAF86955.1
AK074963 mRNA Translation: BAC11319.1
AK315362 mRNA Translation: BAG37757.1
CH471062 Genomic DNA Translation: EAW62287.1
CH471062 Genomic DNA Translation: EAW62288.1
BC020875 mRNA Translation: AAH20875.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4167.1

NCBI Reference Sequences

More...
RefSeqi
NP_064584.1, NM_020199.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231512; ENSP00000231512; ENSG00000113583

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56951

UCSC genome browser

More...
UCSCi
uc003kyo.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157581 mRNA Translation: AAO13165.1
AF226055 mRNA Translation: AAF86955.1
AK074963 mRNA Translation: BAC11319.1
AK315362 mRNA Translation: BAG37757.1
CH471062 Genomic DNA Translation: EAW62287.1
CH471062 Genomic DNA Translation: EAW62288.1
BC020875 mRNA Translation: AAH20875.1
CCDSiCCDS4167.1
RefSeqiNP_064584.1, NM_020199.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121275, 5 interactors
IntActiQ8NC54, 5 interactors
MINTiQ8NC54
STRINGi9606.ENSP00000231512

PTM databases

iPTMnetiQ8NC54
PhosphoSitePlusiQ8NC54
SwissPalmiQ8NC54

Polymorphism and mutation databases

BioMutaiC5orf15
DMDMi68565518

Proteomic databases

EPDiQ8NC54
jPOSTiQ8NC54
MassIVEiQ8NC54
MaxQBiQ8NC54
PaxDbiQ8NC54
PeptideAtlasiQ8NC54
PRIDEiQ8NC54
ProteomicsDBi72854

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
56951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231512; ENSP00000231512; ENSG00000113583
GeneIDi56951
KEGGihsa:56951
UCSCiuc003kyo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56951

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C5orf15
HGNCiHGNC:20656 C5orf15
HPAiHPA011951
HPA039165
neXtProtiNX_Q8NC54
OpenTargetsiENSG00000113583
PharmGKBiPA134898147

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ0E Eukaryota
ENOG410XUUR LUCA
GeneTreeiENSGT00440000037499
HOGENOMiHOG000059651
InParanoidiQ8NC54
OMAiTHENQTK
OrthoDBi1167989at2759
PhylomeDBiQ8NC54
TreeFamiTF332514

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C5orf15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56951

Pharos

More...
Pharosi
Q8NC54

Protein Ontology

More...
PROi
PR:Q8NC54

Gene expression databases

BgeeiENSG00000113583 Expressed in 238 organ(s), highest expression level in tibia
GenevisibleiQ8NC54 HS

Family and domain databases

InterProiView protein in InterPro
IPR037645 KCT2
PANTHERiPTHR16502 PTHR16502, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NC54
Secondary accession number(s): B2RD10, D3DQ92, Q9NRG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 18, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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