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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

SERBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • mRNA 3'-UTR binding Source: HGNC
  • RNA binding Source: UniProtKB

GO - Biological processi

  • regulation of apoptotic process Source: Ensembl
  • regulation of mRNA stability Source: HGNC

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
SERPINE1 mRNA-binding protein 1
Gene namesi
Name:SERBP1
Synonyms:PAIRBP1
ORF Names:CGI-55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142864.14
HGNCiHGNC:17860 SERBP1
MIMi607378 gene
neXtProtiNX_Q8NC51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26135
OpenTargetsiENSG00000142864
PharmGKBiPA413

Polymorphism and mutation databases

BioMutaiSERBP1
DMDMi52783206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000581822 – 408Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei68N6-acetyllysineCombined sources1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei140N6-acetyllysineCombined sources1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei188Omega-N-methylarginineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211N6-acetyllysine; alternateCombined sources1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei216Omega-N-methylarginineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei234PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei329N6-acetyllysineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei364Omega-N-methylarginineCombined sources1
Modified residuei367Omega-N-methylarginineCombined sources1
Modified residuei370Omega-N-methylarginineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Isoform 4 (identifier: Q8NC51-4)
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Isoform 3 (identifier: Q8NC51-3)
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NC51
MaxQBiQ8NC51
PaxDbiQ8NC51
PeptideAtlasiQ8NC51
PRIDEiQ8NC51
ProteomicsDBi72850
72851 [Q8NC51-2]
72852 [Q8NC51-3]
72853 [Q8NC51-4]
TopDownProteomicsiQ8NC51-1 [Q8NC51-1]
Q8NC51-2 [Q8NC51-2]
Q8NC51-3 [Q8NC51-3]
Q8NC51-4 [Q8NC51-4]

PTM databases

CarbonylDBiQ8NC51
iPTMnetiQ8NC51
PhosphoSitePlusiQ8NC51
SwissPalmiQ8NC51

Expressioni

Tissue specificityi

Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.1 Publication

Gene expression databases

BgeeiENSG00000142864 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_SERBP1
ExpressionAtlasiQ8NC51 baseline and differential
GenevisibleiQ8NC51 HS

Organism-specific databases

HPAiCAB026297
HPA020559

Interactioni

Subunit structurei

Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3 (PubMed:12505151, PubMed:18632687). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CHD3Q128735EBI-523558,EBI-523590

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117571, 120 interactors
DIPiDIP-33819N
IntActiQ8NC51, 55 interactors
MINTiQ8NC51
STRINGi9606.ENSP00000360034

Structurei

3D structure databases

ProteinModelPortaliQ8NC51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOVERGENiHBG056357
InParanoidiQ8NC51
KOiK13199
OMAiQNRKREF
OrthoDBiEOG091G0UA9
PhylomeDBiQ8NC51
TreeFamiTF318374

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1
PANTHERiPTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NC51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD
260 270 280 290 300
QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD
310 320 330 340 350
RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND
360 370 380 390 400
ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD

PEAFPALA
Length:408
Mass (Da):44,965
Last modified:September 27, 2004 - v2
Checksum:i2289992374FA6A96
GO
Isoform 2 (identifier: Q8NC51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:402
Mass (Da):44,257
Checksum:iB5DBDE629FC4EC7A
GO
Isoform 3 (identifier: Q8NC51-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Note: May be due to a competing acceptor splice site.Combined sources
Show »
Length:393
Mass (Da):43,135
Checksum:iABE09AC75FE95CBC
GO
Isoform 4 (identifier: Q8NC51-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Show »
Length:387
Mass (Da):42,427
Checksum:i8C47134D22C1CCFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti101L → F in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti312N → S in BAC11324 (PubMed:14702039).Curated1
Sequence conflicti376R → C in AAH02488 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011630203 – 208Missing in isoform 2 and isoform 4. 3 Publications6
Alternative sequenceiVSP_011631233 – 247Missing in isoform 3 and isoform 4. 5 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151813 mRNA Translation: AAD34050.1
AL080119 mRNA Translation: CAB45718.1
AK074970 mRNA Translation: BAC11324.1
CR457383 mRNA Translation: CAG33664.1
AL590559 Genomic DNA No translation available.
BC003049 mRNA Translation: AAH03049.1
BC008045 mRNA Translation: AAH08045.1
BC017449 mRNA Translation: AAH17449.1
BC019273 mRNA Translation: AAH19273.1
BC020555 mRNA Translation: AAH20555.1
BC002488 mRNA Translation: AAH02488.1
BC026916 mRNA Translation: AAH26916.1
AY032853 mRNA Translation: AAK51130.1
CCDSiCCDS30746.1 [Q8NC51-1]
CCDS30747.1 [Q8NC51-3]
CCDS30748.1 [Q8NC51-2]
CCDS639.1 [Q8NC51-4]
PIRiT12456
RefSeqiNP_001018077.1, NM_001018067.1 [Q8NC51-1]
NP_001018078.1, NM_001018068.1 [Q8NC51-2]
NP_001018079.1, NM_001018069.1 [Q8NC51-3]
NP_056455.3, NM_015640.3 [Q8NC51-4]
UniGeneiHs.530412

Genome annotation databases

EnsembliENST00000361219; ENSP00000354591; ENSG00000142864 [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864 [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864 [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864 [Q8NC51-1]
GeneIDi26135
KEGGihsa:26135
UCSCiuc001ddv.4 human [Q8NC51-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151813 mRNA Translation: AAD34050.1
AL080119 mRNA Translation: CAB45718.1
AK074970 mRNA Translation: BAC11324.1
CR457383 mRNA Translation: CAG33664.1
AL590559 Genomic DNA No translation available.
BC003049 mRNA Translation: AAH03049.1
BC008045 mRNA Translation: AAH08045.1
BC017449 mRNA Translation: AAH17449.1
BC019273 mRNA Translation: AAH19273.1
BC020555 mRNA Translation: AAH20555.1
BC002488 mRNA Translation: AAH02488.1
BC026916 mRNA Translation: AAH26916.1
AY032853 mRNA Translation: AAK51130.1
CCDSiCCDS30746.1 [Q8NC51-1]
CCDS30747.1 [Q8NC51-3]
CCDS30748.1 [Q8NC51-2]
CCDS639.1 [Q8NC51-4]
PIRiT12456
RefSeqiNP_001018077.1, NM_001018067.1 [Q8NC51-1]
NP_001018078.1, NM_001018068.1 [Q8NC51-2]
NP_001018079.1, NM_001018069.1 [Q8NC51-3]
NP_056455.3, NM_015640.3 [Q8NC51-4]
UniGeneiHs.530412

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Ah1-408[»]
ProteinModelPortaliQ8NC51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117571, 120 interactors
DIPiDIP-33819N
IntActiQ8NC51, 55 interactors
MINTiQ8NC51
STRINGi9606.ENSP00000360034

PTM databases

CarbonylDBiQ8NC51
iPTMnetiQ8NC51
PhosphoSitePlusiQ8NC51
SwissPalmiQ8NC51

Polymorphism and mutation databases

BioMutaiSERBP1
DMDMi52783206

Proteomic databases

EPDiQ8NC51
MaxQBiQ8NC51
PaxDbiQ8NC51
PeptideAtlasiQ8NC51
PRIDEiQ8NC51
ProteomicsDBi72850
72851 [Q8NC51-2]
72852 [Q8NC51-3]
72853 [Q8NC51-4]
TopDownProteomicsiQ8NC51-1 [Q8NC51-1]
Q8NC51-2 [Q8NC51-2]
Q8NC51-3 [Q8NC51-3]
Q8NC51-4 [Q8NC51-4]

Protocols and materials databases

DNASUi26135
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361219; ENSP00000354591; ENSG00000142864 [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864 [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864 [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864 [Q8NC51-1]
GeneIDi26135
KEGGihsa:26135
UCSCiuc001ddv.4 human [Q8NC51-1]

Organism-specific databases

CTDi26135
DisGeNETi26135
EuPathDBiHostDB:ENSG00000142864.14
GeneCardsiSERBP1
HGNCiHGNC:17860 SERBP1
HPAiCAB026297
HPA020559
MIMi607378 gene
neXtProtiNX_Q8NC51
OpenTargetsiENSG00000142864
PharmGKBiPA413
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOVERGENiHBG056357
InParanoidiQ8NC51
KOiK13199
OMAiQNRKREF
OrthoDBiEOG091G0UA9
PhylomeDBiQ8NC51
TreeFamiTF318374

Miscellaneous databases

ChiTaRSiSERBP1 human
GeneWikiiSERBP1
GenomeRNAii26135
PROiPR:Q8NC51
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142864 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_SERBP1
ExpressionAtlasiQ8NC51 baseline and differential
GenevisibleiQ8NC51 HS

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1
PANTHERiPTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAIRB_HUMAN
AccessioniPrimary (citable) accession number: Q8NC51
Secondary accession number(s): Q5VU19
, Q5VU20, Q5VU22, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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