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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

SERBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • mRNA 3'-UTR binding Source: HGNC
  • RNA binding Source: UniProtKB

GO - Biological processi

  • regulation of apoptotic process Source: Ensembl
  • regulation of mRNA stability Source: HGNC

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
SERPINE1 mRNA-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERBP1
Synonyms:PAIRBP1
ORF Names:CGI-55
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142864.14

Human Gene Nomenclature Database

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HGNCi
HGNC:17860 SERBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607378 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NC51

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26135

Open Targets

More...
OpenTargetsi
ENSG00000142864

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA413

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52783206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581822 – 408Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Modified residuei68N6-acetyllysineCombined sources1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei140N6-acetyllysineCombined sources1
Modified residuei165Omega-N-methylarginineBy similarity1
Modified residuei188Omega-N-methylarginineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211N6-acetyllysine; alternateCombined sources1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei216Omega-N-methylarginineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei234PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei329N6-acetyllysineBy similarity1
Modified residuei330PhosphoserineCombined sources1
Modified residuei364Omega-N-methylarginineCombined sources1
Modified residuei367Omega-N-methylarginineCombined sources1
Modified residuei370Omega-N-methylarginineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Isoform 4 (identifier: Q8NC51-4)
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Isoform 3 (identifier: Q8NC51-3)
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NC51

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NC51

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NC51

PeptideAtlas

More...
PeptideAtlasi
Q8NC51

PRoteomics IDEntifications database

More...
PRIDEi
Q8NC51

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72850
72851 [Q8NC51-2]
72852 [Q8NC51-3]
72853 [Q8NC51-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8NC51-1 [Q8NC51-1]
Q8NC51-2 [Q8NC51-2]
Q8NC51-3 [Q8NC51-3]
Q8NC51-4 [Q8NC51-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8NC51

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NC51

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NC51

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NC51

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142864 Expressed in 236 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SERBP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NC51 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NC51 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026297
HPA020559

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SPIN1 (By similarity). Interacts with CHD3 and TDRD3 (PubMed:12505151, PubMed:18632687). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CHD3Q128735EBI-523558,EBI-523590

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117571, 121 interactors

Database of interacting proteins

More...
DIPi
DIP-33819N

Protein interaction database and analysis system

More...
IntActi
Q8NC51, 57 interactors

Molecular INTeraction database

More...
MINTi
Q8NC51

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360034

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NC51

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2945 Eukaryota
ENOG410YBHR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055591

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056357

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NC51

KEGG Orthology (KO)

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KOi
K13199

Identification of Orthologs from Complete Genome Data

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OMAi
QNRKREF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0UA9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NC51

TreeFam database of animal gene trees

More...
TreeFami
TF318374

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1

The PANTHER Classification System

More...
PANTHERi
PTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NC51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGE GKIIDRRPER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNYSDLD
260 270 280 290 300
QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD
310 320 330 340 350
RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND
360 370 380 390 400
ITSQLEINFG DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD

PEAFPALA
Length:408
Mass (Da):44,965
Last modified:September 27, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2289992374FA6A96
GO
Isoform 2 (identifier: Q8NC51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:402
Mass (Da):44,257
Checksum:iB5DBDE629FC4EC7A
GO
Isoform 3 (identifier: Q8NC51-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Note: May be due to a competing acceptor splice site.Combined sources
Show »
Length:393
Mass (Da):43,135
Checksum:iABE09AC75FE95CBC
GO
Isoform 4 (identifier: Q8NC51-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Show »
Length:387
Mass (Da):42,427
Checksum:i8C47134D22C1CCFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55A → T in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti101L → F in AAD34050 (PubMed:10810093).Curated1
Sequence conflicti312N → S in BAC11324 (PubMed:14702039).Curated1
Sequence conflicti376R → C in AAH02488 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011630203 – 208Missing in isoform 2 and isoform 4. 3 Publications6
Alternative sequenceiVSP_011631233 – 247Missing in isoform 3 and isoform 4. 5 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151813 mRNA Translation: AAD34050.1
AL080119 mRNA Translation: CAB45718.1
AK074970 mRNA Translation: BAC11324.1
CR457383 mRNA Translation: CAG33664.1
AL590559 Genomic DNA No translation available.
BC003049 mRNA Translation: AAH03049.1
BC008045 mRNA Translation: AAH08045.1
BC017449 mRNA Translation: AAH17449.1
BC019273 mRNA Translation: AAH19273.1
BC020555 mRNA Translation: AAH20555.1
BC002488 mRNA Translation: AAH02488.1
BC026916 mRNA Translation: AAH26916.1
AY032853 mRNA Translation: AAK51130.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30746.1 [Q8NC51-1]
CCDS30747.1 [Q8NC51-3]
CCDS30748.1 [Q8NC51-2]
CCDS639.1 [Q8NC51-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12456

NCBI Reference Sequences

More...
RefSeqi
NP_001018077.1, NM_001018067.1 [Q8NC51-1]
NP_001018078.1, NM_001018068.1 [Q8NC51-2]
NP_001018079.1, NM_001018069.1 [Q8NC51-3]
NP_056455.3, NM_015640.3 [Q8NC51-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.530412

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361219; ENSP00000354591; ENSG00000142864 [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864 [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864 [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864 [Q8NC51-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26135

UCSC genome browser

More...
UCSCi
uc001ddv.4 human [Q8NC51-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151813 mRNA Translation: AAD34050.1
AL080119 mRNA Translation: CAB45718.1
AK074970 mRNA Translation: BAC11324.1
CR457383 mRNA Translation: CAG33664.1
AL590559 Genomic DNA No translation available.
BC003049 mRNA Translation: AAH03049.1
BC008045 mRNA Translation: AAH08045.1
BC017449 mRNA Translation: AAH17449.1
BC019273 mRNA Translation: AAH19273.1
BC020555 mRNA Translation: AAH20555.1
BC002488 mRNA Translation: AAH02488.1
BC026916 mRNA Translation: AAH26916.1
AY032853 mRNA Translation: AAK51130.1
CCDSiCCDS30746.1 [Q8NC51-1]
CCDS30747.1 [Q8NC51-3]
CCDS30748.1 [Q8NC51-2]
CCDS639.1 [Q8NC51-4]
PIRiT12456
RefSeqiNP_001018077.1, NM_001018067.1 [Q8NC51-1]
NP_001018078.1, NM_001018068.1 [Q8NC51-2]
NP_001018079.1, NM_001018069.1 [Q8NC51-3]
NP_056455.3, NM_015640.3 [Q8NC51-4]
UniGeneiHs.530412

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Ah1-408[»]
ProteinModelPortaliQ8NC51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117571, 121 interactors
DIPiDIP-33819N
IntActiQ8NC51, 57 interactors
MINTiQ8NC51
STRINGi9606.ENSP00000360034

PTM databases

CarbonylDBiQ8NC51
iPTMnetiQ8NC51
PhosphoSitePlusiQ8NC51
SwissPalmiQ8NC51

Polymorphism and mutation databases

BioMutaiSERBP1
DMDMi52783206

Proteomic databases

EPDiQ8NC51
MaxQBiQ8NC51
PaxDbiQ8NC51
PeptideAtlasiQ8NC51
PRIDEiQ8NC51
ProteomicsDBi72850
72851 [Q8NC51-2]
72852 [Q8NC51-3]
72853 [Q8NC51-4]
TopDownProteomicsiQ8NC51-1 [Q8NC51-1]
Q8NC51-2 [Q8NC51-2]
Q8NC51-3 [Q8NC51-3]
Q8NC51-4 [Q8NC51-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26135
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361219; ENSP00000354591; ENSG00000142864 [Q8NC51-3]
ENST00000370990; ENSP00000360029; ENSG00000142864 [Q8NC51-2]
ENST00000370994; ENSP00000360033; ENSG00000142864 [Q8NC51-4]
ENST00000370995; ENSP00000360034; ENSG00000142864 [Q8NC51-1]
GeneIDi26135
KEGGihsa:26135
UCSCiuc001ddv.4 human [Q8NC51-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26135
DisGeNETi26135
EuPathDBiHostDB:ENSG00000142864.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SERBP1
HGNCiHGNC:17860 SERBP1
HPAiCAB026297
HPA020559
MIMi607378 gene
neXtProtiNX_Q8NC51
OpenTargetsiENSG00000142864
PharmGKBiPA413

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOVERGENiHBG056357
InParanoidiQ8NC51
KOiK13199
OMAiQNRKREF
OrthoDBiEOG091G0UA9
PhylomeDBiQ8NC51
TreeFamiTF318374

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SERBP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SERBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26135

Protein Ontology

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PROi
PR:Q8NC51

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142864 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_SERBP1
ExpressionAtlasiQ8NC51 baseline and differential
GenevisibleiQ8NC51 HS

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
IPR027205 SERBP1
PANTHERiPTHR12299 PTHR12299, 1 hit
PTHR12299:SF29 PTHR12299:SF29, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAIRB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NC51
Secondary accession number(s): Q5VU19
, Q5VU20, Q5VU22, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: December 5, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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