UniProtKB - Q8NC06 (ACBD4_HUMAN)
Acyl-CoA-binding domain-containing protein 4
ACBD4
Functioni
Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 69 | Acyl-CoA | 1 | |
Binding sitei | 88 | Acyl-CoA | 1 |
GO - Molecular functioni
- fatty-acyl-CoA binding Source: GO_Central
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- fatty acid metabolic process Source: GO_Central
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NC06 |
Reactomei | R-HSA-390918, Peroxisomal lipid metabolism |
SignaLinki | Q8NC06 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA-binding domain-containing protein 4 |
Gene namesi | Name:ACBD4 ORF Names:HMFT0700 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23337, ACBD4 |
neXtProti | NX_Q8NC06 |
VEuPathDBi | HostDB:ENSG00000181513 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79777 |
OpenTargetsi | ENSG00000181513 |
PharmGKBi | PA134897893 |
Miscellaneous databases
Pharosi | Q8NC06, Tdark |
Genetic variation databases
BioMutai | ACBD4 |
DMDMi | 67460567 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214032 | 1 – 268 | Acyl-CoA-binding domain-containing protein 4Add BLAST | 268 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8NC06 |
jPOSTi | Q8NC06 |
MassIVEi | Q8NC06 |
MaxQBi | Q8NC06 |
PeptideAtlasi | Q8NC06 |
PRIDEi | Q8NC06 |
ProteomicsDBi | 72841 [Q8NC06-1] 72842 [Q8NC06-2] 72843 [Q8NC06-3] |
PTM databases
iPTMneti | Q8NC06 |
PhosphoSitePlusi | Q8NC06 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181513, Expressed in right lobe of liver and 172 other tissues |
ExpressionAtlasi | Q8NC06, baseline and differential |
Genevisiblei | Q8NC06, HS |
Organism-specific databases
HPAi | ENSG00000181513, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Isoform 3 [Q8NC06-3]
Protein-protein interaction databases
BioGRIDi | 122878, 13 interactors |
IntActi | Q8NC06, 11 interactors |
Miscellaneous databases
RNActi | Q8NC06, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8NC06 |
SMRi | Q8NC06 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8NC06 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 101 | ACBPROSITE-ProRule annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 32 | Acyl-CoA binding | 10 | |
Regioni | 43 – 47 | Acyl-CoA binding | 5 | |
Regioni | 151 – 175 | DisorderedSequence analysisAdd BLAST | 25 |
Phylogenomic databases
GeneTreei | ENSGT00940000160739 |
HOGENOMi | CLU_034436_1_0_1 |
InParanoidi | Q8NC06 |
OMAi | LQVWAEQ |
OrthoDBi | 1546859at2759 |
PhylomeDBi | Q8NC06 |
TreeFami | TF319446 |
Family and domain databases
CDDi | cd00435, ACBP, 1 hit |
Gene3Di | 1.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit |
PRINTSi | PR00689, ACOABINDINGP |
SUPFAMi | SSF47027, SSF47027, 1 hit |
PROSITEi | View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT
60 70 80 90 100
MGPCLVPRPG FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI
110 120 130 140 150
DTVPLGEVAE DMFGYFEPLY QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG
160 170 180 190 200
AVSEPPCLPK EPAPPSPESH SPRDLDSEVF CDSLEQLEPE LSSGQHLEES
210 220 230 240 250
VIPGTAPCPP QRKRGCGAAR RGPRSWTCGC WGQFEHYRRA CRRCRRGCRA
260
WRACPGPLSS LTLSVRLE
The sequence of this isoform differs from the canonical sequence as follows:
168-191: ESHSPRDLDSEVFCDSLEQLEPEL → ASLWAVTLPTPPQSPIHPGTWTPRFSVIPWSSWSLSWFGQ
260-268: SLTLSVRLE → RGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EM05 | K7EM05_HUMAN | Acyl-CoA binding domain containing ... | ACBD4 hCG_28074 | 269 | Annotation score: | ||
K7EMH4 | K7EMH4_HUMAN | Acyl-CoA-binding domain-containing ... | ACBD4 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 166 | S → G in BAC11403 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055478 | 118 | P → L. Corresponds to variant dbSNP:rs901754Ensembl. | 1 | |
Natural variantiVAR_059109 | 242 | R → G. Corresponds to variant dbSNP:rs16939879Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014088 | 168 – 191 | ESHSP…LEPEL → ASLWAVTLPTPPQSPIHPGT WTPRFSVIPWSSWSLSWFGQ in isoform 3. 2 PublicationsAdd BLAST | 24 | |
Alternative sequenceiVSP_014089 | 192 – 268 | SSGQH…SVRLE → VWTEQRAASGGKRDPRNSPV PPTKKEGLRGSPPGPQELDV WLLGTVRALQESMQEVQARV QSLESMPRPPEQRPQPRPSA RPWPLGLPGPALLFFLLWPF VVQWLFRMFRTQKR in isoform 2. 2 PublicationsAdd BLAST | 77 | |
Alternative sequenceiVSP_014090 | 260 – 268 | SLTLSVRLE → RGRSPGPVLGHGPLGSRGPR CSSSSCGPSSSSGSSECFGP KRGDCQWRGLCSQLRLSCCA LSLPRV in isoform 3. 2 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073387 mRNA Translation: BAD38638.1 AK023384 mRNA Translation: BAB14553.1 AK075104 mRNA Translation: BAC11403.1 CH471178 Genomic DNA Translation: EAW51550.1 CH471178 Genomic DNA Translation: EAW51551.1 CH471178 Genomic DNA Translation: EAW51552.1 BC029164 mRNA Translation: AAH29164.1 BC041143 mRNA Translation: AAH41143.1 |
CCDSi | CCDS42348.1 [Q8NC06-2] CCDS45710.1 [Q8NC06-3] CCDS45711.1 [Q8NC06-1] |
RefSeqi | NP_001129177.1, NM_001135705.2 [Q8NC06-2] NP_001129178.1, NM_001135706.2 [Q8NC06-3] NP_001129179.1, NM_001135707.2 [Q8NC06-1] NP_001308281.1, NM_001321352.1 [Q8NC06-3] NP_001308282.1, NM_001321353.1 [Q8NC06-3] NP_078998.1, NM_024722.3 [Q8NC06-2] XP_016880577.1, XM_017025088.1 [Q8NC06-3] XP_016880580.1, XM_017025091.1 [Q8NC06-2] XP_016880581.1, XM_017025092.1 [Q8NC06-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073387 mRNA Translation: BAD38638.1 AK023384 mRNA Translation: BAB14553.1 AK075104 mRNA Translation: BAC11403.1 CH471178 Genomic DNA Translation: EAW51550.1 CH471178 Genomic DNA Translation: EAW51551.1 CH471178 Genomic DNA Translation: EAW51552.1 BC029164 mRNA Translation: AAH29164.1 BC041143 mRNA Translation: AAH41143.1 |
CCDSi | CCDS42348.1 [Q8NC06-2] CCDS45710.1 [Q8NC06-3] CCDS45711.1 [Q8NC06-1] |
RefSeqi | NP_001129177.1, NM_001135705.2 [Q8NC06-2] NP_001129178.1, NM_001135706.2 [Q8NC06-3] NP_001129179.1, NM_001135707.2 [Q8NC06-1] NP_001308281.1, NM_001321352.1 [Q8NC06-3] NP_001308282.1, NM_001321353.1 [Q8NC06-3] NP_078998.1, NM_024722.3 [Q8NC06-2] XP_016880577.1, XM_017025088.1 [Q8NC06-3] XP_016880580.1, XM_017025091.1 [Q8NC06-2] XP_016880581.1, XM_017025092.1 [Q8NC06-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WH5 | X-ray | 2.60 | A/B/C/D/E/F | 7-110 | [»] | |
AlphaFoldDBi | Q8NC06 | |||||
SMRi | Q8NC06 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122878, 13 interactors |
IntActi | Q8NC06, 11 interactors |
PTM databases
iPTMneti | Q8NC06 |
PhosphoSitePlusi | Q8NC06 |
Genetic variation databases
BioMutai | ACBD4 |
DMDMi | 67460567 |
Proteomic databases
EPDi | Q8NC06 |
jPOSTi | Q8NC06 |
MassIVEi | Q8NC06 |
MaxQBi | Q8NC06 |
PeptideAtlasi | Q8NC06 |
PRIDEi | Q8NC06 |
ProteomicsDBi | 72841 [Q8NC06-1] 72842 [Q8NC06-2] 72843 [Q8NC06-3] |
Protocols and materials databases
Antibodypediai | 29971, 145 antibodies from 28 providers |
DNASUi | 79777 |
Genome annotation databases
Organism-specific databases
CTDi | 79777 |
DisGeNETi | 79777 |
GeneCardsi | ACBD4 |
HGNCi | HGNC:23337, ACBD4 |
HPAi | ENSG00000181513, Tissue enhanced (liver) |
neXtProti | NX_Q8NC06 |
OpenTargetsi | ENSG00000181513 |
PharmGKBi | PA134897893 |
VEuPathDBi | HostDB:ENSG00000181513 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160739 |
HOGENOMi | CLU_034436_1_0_1 |
InParanoidi | Q8NC06 |
OMAi | LQVWAEQ |
OrthoDBi | 1546859at2759 |
PhylomeDBi | Q8NC06 |
TreeFami | TF319446 |
Enzyme and pathway databases
PathwayCommonsi | Q8NC06 |
Reactomei | R-HSA-390918, Peroxisomal lipid metabolism |
SignaLinki | Q8NC06 |
Miscellaneous databases
BioGRID-ORCSi | 79777, 25 hits in 1079 CRISPR screens |
ChiTaRSi | ACBD4, human |
EvolutionaryTracei | Q8NC06 |
GenomeRNAii | 79777 |
Pharosi | Q8NC06, Tdark |
PROi | PR:Q8NC06 |
RNActi | Q8NC06, protein |
Gene expression databases
Bgeei | ENSG00000181513, Expressed in right lobe of liver and 172 other tissues |
ExpressionAtlasi | Q8NC06, baseline and differential |
Genevisiblei | Q8NC06, HS |
Family and domain databases
CDDi | cd00435, ACBP, 1 hit |
Gene3Di | 1.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit |
PRINTSi | PR00689, ACOABINDINGP |
SUPFAMi | SSF47027, SSF47027, 1 hit |
PROSITEi | View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACBD4_HUMAN | |
Accessioni | Q8NC06Primary (citable) accession number: Q8NC06 Secondary accession number(s): D3DX64, Q8IUT1, Q9H8Q4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references