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Protein

C-type lectin domain family 1 member A

Gene

CLEC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member A
Alternative name(s):
C-type lectin-like receptor 1
Short name:
CLEC-1
Gene namesi
Name:CLEC1A
Synonyms:CLEC1
ORF Names:UNQ569/PRO1131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000150048.10
HGNCiHGNC:24355 CLEC1A
MIMi606782 gene
neXtProtiNX_Q8NC01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini74 – 280ExtracellularSequence analysisAdd BLAST207

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150048
PharmGKBiPA142672097

Polymorphism and mutation databases

BioMutaiCLEC1A
DMDMi116241301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466091 – 280C-type lectin domain family 1 member AAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 257PROSITE-ProRule annotation
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi236 ↔ 249PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NC01
PeptideAtlasiQ8NC01
PRIDEiQ8NC01
ProteomicsDBi72840

PTM databases

PhosphoSitePlusiQ8NC01

Expressioni

Tissue specificityi

Expressed preferentially in dendritic cells.1 Publication

Gene expression databases

BgeeiENSG00000150048 Expressed in 148 organ(s), highest expression level in placenta
CleanExiHS_CLEC1A
ExpressionAtlasiQ8NC01 baseline and differential
GenevisibleiQ8NC01 HS

Interactioni

Protein-protein interaction databases

BioGridi119421, 2 interactors
IntActiQ8NC01, 13 interactors
STRINGi9606.ENSP00000326407

Structurei

3D structure databases

ProteinModelPortaliQ8NC01
SMRiQ8NC01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 258C-type lectinPROSITE-ProRule annotationAdd BLAST115

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000111777
HOVERGENiHBG103475
InParanoidiQ8NC01
KOiK10069
OMAiKWHGDKC
OrthoDBiEOG091G0K57
PhylomeDBiQ8NC01
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8NC01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV
60 70 80 90 100
ALTLLTLCLV LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL
110 120 130 140 150
QSLQVQNIKL AGSLQHVAEK LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ
160 170 180 190 200
FYKDSKSWED CKYFCLSENS TMLKINKQED LEFAASQSYS EFFYSYWTGL
210 220 230 240 250
LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL NGMIFSKDCK
260 270 280
ELKRCVCERR AGMVKPESLH VPPETLGEGD
Length:280
Mass (Da):31,952
Last modified:October 17, 2006 - v2
Checksum:i138235ED47553F4B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFB4E9PFB4_HUMAN
C-type lectin domain family 1 membe...
CLEC1A
247Annotation score:
E7ESV9E7ESV9_HUMAN
C-type lectin domain family 1 membe...
CLEC1A
188Annotation score:
F8WCT4F8WCT4_HUMAN
C-type lectin domain family 1 membe...
CLEC1A
70Annotation score:
F5H038F5H038_HUMAN
C-type lectin domain family 1 membe...
CLEC1A
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → W in AAF36830 (PubMed:10671229).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05010626G → A4 PublicationsCorresponds to variant dbSNP:rs2306894Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200949 mRNA Translation: AAF36830.1
AY358587 mRNA Translation: AAQ88950.1
AK075114 mRNA Translation: BAC11410.1
BC039072 mRNA Translation: AAH39072.1
BC067746 mRNA Translation: AAH67746.1
CCDSiCCDS8612.1
RefSeqiNP_001284677.1, NM_001297748.1
NP_001284678.1, NM_001297749.1
NP_001284679.1, NM_001297750.1
NP_001284680.1, NM_001297751.1
NP_057595.2, NM_016511.3
UniGeneiHs.29549

Genome annotation databases

EnsembliENST00000315330; ENSP00000326407; ENSG00000150048
GeneIDi51267
KEGGihsa:51267
UCSCiuc001qxb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200949 mRNA Translation: AAF36830.1
AY358587 mRNA Translation: AAQ88950.1
AK075114 mRNA Translation: BAC11410.1
BC039072 mRNA Translation: AAH39072.1
BC067746 mRNA Translation: AAH67746.1
CCDSiCCDS8612.1
RefSeqiNP_001284677.1, NM_001297748.1
NP_001284678.1, NM_001297749.1
NP_001284679.1, NM_001297750.1
NP_001284680.1, NM_001297751.1
NP_057595.2, NM_016511.3
UniGeneiHs.29549

3D structure databases

ProteinModelPortaliQ8NC01
SMRiQ8NC01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119421, 2 interactors
IntActiQ8NC01, 13 interactors
STRINGi9606.ENSP00000326407

PTM databases

PhosphoSitePlusiQ8NC01

Polymorphism and mutation databases

BioMutaiCLEC1A
DMDMi116241301

Proteomic databases

PaxDbiQ8NC01
PeptideAtlasiQ8NC01
PRIDEiQ8NC01
ProteomicsDBi72840

Protocols and materials databases

DNASUi51267
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315330; ENSP00000326407; ENSG00000150048
GeneIDi51267
KEGGihsa:51267
UCSCiuc001qxb.4 human

Organism-specific databases

CTDi51267
EuPathDBiHostDB:ENSG00000150048.10
GeneCardsiCLEC1A
HGNCiHGNC:24355 CLEC1A
MIMi606782 gene
neXtProtiNX_Q8NC01
OpenTargetsiENSG00000150048
PharmGKBiPA142672097
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104266
HOGENOMiHOG000111777
HOVERGENiHBG103475
InParanoidiQ8NC01
KOiK10069
OMAiKWHGDKC
OrthoDBiEOG091G0K57
PhylomeDBiQ8NC01
TreeFamiTF336674

Miscellaneous databases

ChiTaRSiCLEC1A human
GeneWikiiCLEC1A
GenomeRNAii51267
PROiPR:Q8NC01
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150048 Expressed in 148 organ(s), highest expression level in placenta
CleanExiHS_CLEC1A
ExpressionAtlasiQ8NC01 baseline and differential
GenevisibleiQ8NC01 HS

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC1A_HUMAN
AccessioniPrimary (citable) accession number: Q8NC01
Secondary accession number(s): Q8IUW7, Q9NZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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